公开(公告)号：EP0792164B1

公开(公告)日：2004-01-21

申请号：EP95941351.9

申请日：1995-11-01

申请人： ALZA CORPORATION

发明人： GYORY, J.Richard ,  YIEH, Jane ,  HUNTINGTON, James A. ,  CORMIER, Michel

IPC分类号： A61K47/10 ,  A61K9/00

CPC分类号： A61N1/0412 ,  A61K9/0009 ,  A61N1/0428 ,  A61N1/30

公开(公告)号：EP1341452A2

公开(公告)日：2003-09-10

申请号：EP01977721.8

申请日：2001-10-12

申请人： Alza Corporation

发明人： TRAUTMAN, Joseph, C. ,  KEENAN, Richard, L.

IPC分类号： A61B17/20

CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61B2017/00747 ,  A61M2037/0023 ,  A61M2037/0046

摘要： A retainer (34) is provided for holding a microprotrusion member (44) for application of the microprotrusion member (44) to the stratum corneum with an impact applicator (10). The microprotrusion member (44) includes a plurality of microprotrusions (90) which penetrate the stratum corneum to improve transport of an agent across the stratum corneum.

公开(公告)号：EP1341442A1

公开(公告)日：2003-09-10

申请号：EP01977733.3

申请日：2001-10-12

申请人： Alza Corporation

发明人： TRAUTMAN, Joseph, C. ,  KEENAN, Richard, L. ,  CAO, Michael, T.

IPC分类号： A61B5/14

CPC分类号： A61M37/0015 ,  A61B5/1411 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150259 ,  A61B5/150282 ,  A61B5/150824 ,  A61B5/150984 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15142 ,  A61B5/1519 ,  A61B5/15194 ,  A61B17/205 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

摘要： An applicator device (10) is provided for applying a patch (44) having an array of microprotrusions (90) to the stratum corneum. The applicator device (10) includes a device body (12) and a piston moveable within the device body (12). A cap (16) is provided on the device body (12) for activating the device (10) to impact the stratum corneum with a microprotrusion array (44, 90). The device (10) is capable of being cocked by one handed operation of the user which allows the device (10) to be used by patients having neither the strength nor the manual dexterity to cock other types of applicator devices.

公开(公告)号：EP1333880A1

公开(公告)日：2003-08-13

申请号：EP01273947.0

申请日：2001-10-26

申请人： Alza Corporation

发明人： CORMIER, Michel, J., N. ,  YOUNG, Wendy, A. ,  NYAM, Kofi ,  DADDONA, Peter, E.

IPC分类号： A61M37/00 ,  A61N1/30 ,  A61M35/00 ,  A61K9/70

CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0061

摘要： A device (12) and method are provided for percutaneous transdermal delivery of a potent pharmacologically active agent. The agent is dissolved in water to form an aqueous coating solution having an appropriate viscosity for coating extremely tiny skin piercing elements (10). The coating solution is applied to the skin piercing elements (10) using known coating techniques and then dried. The device (12) is applied to the skin of a living animal (e.g., a human), causing the microprotrusions (10) to pierce the stratum corneum and deliver a therapeutically effect dose of the agent to the animal.

公开(公告)号：EP0973499B1

公开(公告)日：2003-08-06

申请号：EP98911690.0

申请日：1998-03-17

申请人： ALZA CORPORATION

发明人： ROORDA, Wouter, E. ,  DIONNE, Keith, E. ,  BROWN, James, E. ,  WRIGHT, Jeremy, C. ,  DAVIS, Craig, R. ,  PRESTRELSKI, Steven, J. ,  TZANNIS, Stelios, T.

IPC分类号： A61K9/00

CPC分类号： A61K9/0024 ,  A61F2250/0067 ,  A61K9/0004 ,  A61K9/145 ,  A61K31/445 ,  A61K31/675 ,  A61K47/26

公开(公告)号：EP1328256A2

公开(公告)日：2003-07-23

申请号：EP00984483.8

申请日：2000-12-13

申请人： Alza Corporation

发明人： CARR, John, P. ,  ECKENHOFF, James, B.

IPC分类号： A61K9/22

CPC分类号： A61K9/0004

摘要： An osmotic delivery system for controlled delivery of a beneficial agent includes an implant capsule having a beneficial agent reservoir, an osmotic agent which expands on contact with fluid imbibed through a permeable membrane retained by the implant capsule, a delivery port, and a valve for opening and closing the delivery port. When the osmotic agent expands, a pressure is exerted against a separating member positioned between the beneficial agent reservoir and the osmotic agent. The separating member moves within the capsule, thereby forcing the valve to move a distance such that the beneficial agent can exit the reservoir through the delivery port.

公开(公告)号：EP0941085B1

公开(公告)日：2003-04-23

申请号：EP97946508.5

申请日：1997-11-03

申请人： ALZA CORPORATION

发明人： LINKWITZ, Andreas ,  CHIN, Ivan, W. ,  GYORY, Richard, J. ,  THOMPSON, Ronald, V. ,  URBANSKI, Paul, J.

IPC分类号： A61K31/165 ,  A61K47/02 ,  A61K47/18 ,  A61N1/30

CPC分类号： A61N1/325 ,  A61K9/0009 ,  A61K31/165 ,  A61K33/04 ,  A61N1/0432 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0448 ,  A61K2300/00

摘要： The invention relates to formulations for the electrically assisted transdermal delivery of lidocaine and epinephrine. The present invention further provides methods and devices for the electrically assisted delivery of local anesthetics, preferably lidocaine.

公开(公告)号：EP0830175B1

公开(公告)日：2003-04-23

申请号：EP96916897.0

申请日：1996-05-31

申请人： ALZA CORPORATION

发明人： JOHNSON, Susan, A. ,  LATTIN, Gary, A. ,  MCNICHOLS, Larry, A.

IPC分类号： A61N1/30

CPC分类号： A61N1/0412 ,  A61N1/0428 ,  A61N1/30

公开(公告)号：EP1140014B1

公开(公告)日：2003-03-19

申请号：EP99967575.4

申请日：1999-12-21

申请人： Alza Corporation

发明人： ECKENHOFF, Bonnie, J. ,  THEEUWES, Felix ,  ECKENHOFF, James, B. DI

IPC分类号： A61K9/00

CPC分类号： A61K9/0004

摘要： An osmotic delivery system having a space efficient piston. The capsule has an interior holding the piston, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a recess that receives at least a portion of the osmotic agent. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and in turn cause delivery of the beneficial agent from the capsule.

公开(公告)号：EP0957972B1

公开(公告)日：2003-03-19

申请号：EP97951729.9

申请日：1997-12-16

申请人： ALZA CORPORATION

发明人： THEEUWES, Felix ,  NEUKERMANS, Armand, P. ,  CORMIER, Michel, J., N.

IPC分类号： A61M37/00 ,  A61N1/30 ,  A61K9/70

CPC分类号： A61K9/0021 ,  A61B17/205 ,  A61B2010/008 ,  A61M37/00 ,  A61M2037/0007 ,  A61N1/306

摘要： An agent delivery or sampling device (2) comprising a member (6) having a plurality of blades (4) for piercing the skin and a connecting medium (65) covering at least a part of the skin contacting side (48) of the member (6) for increasing transdermal flux of an agent.