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111 条记录 (耗时 0.043 秒)

    NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION
    97.
    发明公开
    NOVEL COMPOUNDS USEFUL FOR MODULATING ABNORMAL CELL PROLIFERATION 审中-公开
    新型化合物可用于调节异常细胞增殖

    公开(公告)号：EP1797064A1

    公开(公告)日：2007-06-20

    申请号：EP05786685.7

    申请日：2005-09-14

    申请人： THE HOSPITAL FOR SICK CHILDREN

    发明人： ROIFMAN, Chaim ,  DEMIN, Peter ,  ROUNOVA, Olga ,  GRUNBERGER, Tom

    IPC分类号： C07D333/24 ,  C07C255/29 ,  C07D307/16 ,  C07D211/60 ,  A61P35/00 ,  A61K31/38 ,  A61K31/34 ,  A61K31/44 ,  A61K31/275

    CPC分类号： C07C255/41 ,  C07D213/40 ,  C07D213/57 ,  C07D307/54 ,  C07D333/24

    摘要： There is described compounds of Formula (I), (II), (III), (IV) and (V), the salts, solvates, and hydrates thereof and pharmaceutical compositions comprising these compounds. In Formula (II), A is a ring chosen from pyridine, pyrazine, pyrimidine, imidazole, furan and thiophene. In Formula (IV), A is a ring chosen from benzene, pyridine, pyrazine, pyrimidine, imidazole, furan and thiophene (either substituted or unsubstituted) and B is a ring chosen from benzene and pyridine. The compounds of Formula (I), (II), (III), (IV) and (V) are useful in therapeutic methods and compositions for modulating and inhibiting cell proliferation, such as cancer cell proliferation, in diagnostic assays and as research tools.

    摘要翻译： 描述了式（I），（II），（III），（IV）和（V）的化合物，其盐，溶剂合物和水合物以及包含这些化合物的药物组合物。 在式（II）中，A是选自吡啶，吡嗪，嘧啶，咪唑，呋喃和噻吩的环。 在式（IV）中，A是选自苯，吡啶，吡嗪，嘧啶，咪唑，呋喃和噻吩（取代或未取代的）的环，并且B是选自苯和吡啶的环。 式（I），（II），（III），（IV）和（V）的化合物可用于治疗方法和用于调节和抑制细胞增殖的组合物，例如癌症细胞增殖，诊断测定和研究工具 。

    A process and intermediates for the preparation of fungicidal 7-alkyl-triazolopyrimidines
    100.
    发明公开
    A process and intermediates for the preparation of fungicidal 7-alkyl-triazolopyrimidines 审中-公开
    方法和中间体杀真菌7- Alkyltriazolopyrimidinen的制备

    公开(公告)号：EP1359150A3

    公开(公告)日：2003-11-19

    申请号：EP03016679.7

    申请日：1999-02-09

    申请人： BASF AKTIENGESELLSCHAFT

    发明人： Pfrengle, Waldemar ,  Pees, Klaus-Juergen ,  Albert, Guido

    IPC分类号： C07D487/04 ,  C07C69/738 ,  C07D307/16 ,  C07D211/70 ,  C07D333/24

    CPC分类号： C07D487/04 ,  A01N43/90

    摘要： A process and intermediates for the preparation of triazolopyrimidine compounds of formula I wherein R 1 , X, L 1 , L 2 , L 3 , L 4 and L 5 are as defined in the description, which comprises reacting alkyl 2-aryl-3-alkyl-3-oxopropionates of formula IV wherein R 1 and L 1 , L 2 , L 3 , L 4 and L 5 are as defined for formula I and R' represents an optionally substituted alkyl group, a) with 2-amino-[1,3,4]-triazole, and treating the resulting 5-hydroxytriazolopyrimidines of formula I, wherein X represents a hydroxy group, with a halogenating agent, and b) optionally treating the resulting 5-hydroxytriazolopyrimidines with an alcohol or a thioalkohol in the presence of a base, or with a metal amide, a metal alkyl amide or a metal dialkylamide, or a metal cyanide.