公开(公告)号：EP1495014A2

公开(公告)日：2005-01-12

申请号：EP03724194.0

申请日：2003-04-18

申请人： Sri International

发明人： ZAVERI, Nurulain ,  CHAO, Wan-Ru

IPC分类号： C07D311/30 ,  C07D311/32 ,  C07C49/84 ,  C07C49/82 ,  A61P35/00

CPC分类号： C07C45/30 ,  C07C45/46 ,  C07C45/71 ,  C07C45/74 ,  C07C49/835 ,  C07C49/84 ,  C07D311/32 ,  C07D311/92 ,  C07D311/94 ,  C07D491/04 ,  C07C47/575 ,  C07C49/83

摘要： Novel compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the structure of formula (I), wherein R1 through R3 and R5 through R11 are defined herein, and α, β and Ϝ are optional bonds, providing that when α is absent, β is present, and when β is absent, α is present. When α is present, preferred R4 moieties are selected from O, S, NH and CH2, and when α is absent, preferred R4 groups are selected from OH, SH, NH2 and CH3. When Ϝ is present, the preferred R5 substituent is O, while when Ϝ is absent, the preferred R5 substituent is OH. Pharmaceutical compositions are provided as well, as are methods of synthesis and use.

公开(公告)号：EP1113726B1

公开(公告)日：2004-03-24

申请号：EP99944890.5

申请日：1999-09-15

申请人： Korea Research Institute of Bioscience and Biotechnology

发明人： BOK, Song, Hae ,  JEONG, Tae, Sook ,  BAE, Ki, Hwan ,  PARK, Yong, Bok ,  CHOI, Myung, Sook ,  MOON, Surk, Sik ,  KWON, Yong, Kook ,  LEE, Eun, Sook ,  HYUN, Byung, Hwa ,  CHOI, Yang, Kyu ,  LEE, Chul, Ho ,  LEE, Sae, Bom ,  PARK, Young, Bae ,  KIM, Hyo, Soo

IPC分类号： A23L1/222 ,  A61K31/35 ,  A21D13/00 ,  C07D311/30 ,  C07H17/07

CPC分类号： A23G9/34 ,  A21D2/181 ,  A23C9/152 ,  A23L2/52 ,  A23L27/36 ,  A23L33/105

摘要： A pharmaceutical composition for treating or preventing an elevated blood lipid or glucose level-related disease such as hyperlipidemia, arteriosclerosis, angina pectoris, stroke, hepatic diseases and hyperglycemia in a mammal, which comprises an effective amount of neohesperidin dihydrochalcone as an active ingredient together with a pharmaceutically acceptable carrier, and a functional food or beverage composition for such a disease, which comprises an effective amount of neohesperidin dihydrochalcone.

公开(公告)号：EP1393733A1

公开(公告)日：2004-03-03

申请号：EP03015616.0

申请日：2003-07-16

申请人： MERCK PATENT GmbH

发明人： Buchholz, Herwig Dr. ,  Wirth, Corinna Dr.

IPC分类号： A61K31/70 ,  A61K31/35 ,  A61K35/78 ,  C07D311/30 ,  C07H17/07 ,  A61P17/04

CPC分类号： C07H17/07 ,  A61K31/352 ,  A61K31/4353 ,  A61K31/573 ,  A61K31/7048 ,  A61K45/06 ,  A61K2300/00

摘要： The invention relates to the use of certain flavonoid derivatives for the preparation of formulations which are suitable for the prophylaxis and/or therapy of eczema. The formulations are particularly suitable for the prophylaxis and/or therapy of atopic eczema.

摘要翻译： 本发明涉及某些类黄酮衍生物在制备适于预防和/或治疗湿疹的制剂中的用途。 该制剂特别适用于特应性湿疹的预防和/或治疗。

公开(公告)号：EP1373243A1

公开(公告)日：2004-01-02

申请号：EP01923228.9

申请日：2001-04-06

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  KYOWA HAKKO KOGYO CO., LTD.

发明人： SNADER, Kenneth, M. ,  VISHNUVAJJALA, B., Rao ,  AKAMA, Tsutomu

IPC分类号： C07D311/30 ,  A61K31/35 ,  A61P35/00

CPC分类号： C07D311/30

摘要： The invention provides an aminoflavone having formula (I), wherein each of R?1 and R2¿ is H, COCH¿2-R?7, wherein R7 is amino, alkylamino, dialkylamino, or alkyl- or dialkylaminoalkyl, or an α-amino acid residue, provided that at least one of R1 or R2 is other than H, and R3 is H, branched or straight-chain alkyl, hydroxyalkyl, alkanoyloxyalkyl, alkanoyloxy, alkoxy, or alkoxyalkyl, or pharmaceutically acceptable salts thereof. The present invention also provides a pharmaceutical composition comprising an aminoflavone as described above, and a method of inhibiting the growth of a tumor in a host by administering a tumor growth-inhibiting amount of an aminoflavone compound having the formula as described above.

公开(公告)号：EP1212312B1

公开(公告)日：2003-04-02

申请号：EP00958505.0

申请日：2000-08-28

申请人： INDENA S.p.A.

发明人： BOMBARDELLI, Ezio ,  VALENTI, Piero

IPC分类号： C07D311/30 ,  C07D311/36 ,  C07D311/16 ,  C07D311/86 ,  A61K31/37 ,  A61P35/00

CPC分类号： C07D311/86 ,  A61K31/35 ,  A61K31/37 ,  A61K31/44 ,  A61K31/52 ,  A61K31/535 ,  C07D311/16 ,  C07D311/30 ,  C07D311/36 ,  A61K31/335 ,  A61K2300/00

公开(公告)号：EP1105384B1

公开(公告)日：2003-03-26

申请号：EP99938646.9

申请日：1999-08-20

申请人： PACIFIC CORPORATION

发明人： JOO, Yung Hyup ,  LEE, Chang Hoon ,  NOH, Min-Soo ,  HA, Jun-Yong ,  CHOI, Jin Kyu ,  LIM, Kyung Min ,  KIM, Jin Kwan ,  KANG, Seon-Hwa

IPC分类号： C07D311/30 ,  C07D405/04 ,  C07D413/04 ,  C07D407/04 ,  C07D409/04 ,  C07D417/04 ,  A61K31/352 ,  A61K31/4433

CPC分类号： C07D405/04 ,  C07D311/26 ,  C07D409/04

公开(公告)号：EP0915864B1

公开(公告)日：2002-09-04

申请号：EP97932032.2

申请日：1997-07-25

申请人： Dong A Pharmaceutical Co. Ltd.

发明人： YOO, Moohi ,  SON, Mi, Won Imkwang Apt. 313-501 ,  KIM, Ik, Yon 668-1, Naeyou-dong Deokyang-ku ,  KIM, Won, Bae Hyundai Apt. 102-503 Kaepo-dong ,  KIM, Soon, Hoe Jookong Apt. 139-106 ,  LEE, Sang, Deuk Eunma Apt. 21-604 Daechi 2-dong ,  LIM, Geun, Jho Myoungsodae Hyundai Apt. 105-1501 ,  LIM, Joong, In ,  AHN, Byoung, Ok ,  BAIK, Nam, Gi ,  KIM, Dong, Sung ,  OH, Tae, Young ,  RYU, Byung, Kwon ,  YANG, Jae, Sung ,  SHIN, Hee, Chan

IPC分类号： C07D311/30 ,  C07D311/32 ,  A61K31/35

CPC分类号： C07D311/30 ,  C07D311/32

摘要： The present invention relates to novel flavone/flavanone compounds or their pharmaceutically acceptable salts and process for preparation thereof for protecting gastrointestinal tracts against gastritis, ulcers and inflammatory bowel disease.

公开(公告)号：EP1222183A1

公开(公告)日：2002-07-17

申请号：EP00975868.1

申请日：2000-10-16

申请人： RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. ,  RECORDATI S.A.CHEMICAL and PHARMACEUTICAL COMPANY

发明人： LEONARDI, Amedeo ,  MOTTA, Gianni ,  RIVA, Carlo ,  SIRONI, Giorgio

IPC分类号： C07D311/24 ,  A61K31/496 ,  A61P9/00 ,  C07D311/30

CPC分类号： C07D311/24 ,  C07D311/30

摘要： Benzopyran derivatives (I) (R = phenyl, alkoxycarbonyl, alkylcarbonyl, CONH2, CONH(alkyl), CON(alkyl)2, CN or alkoxycarbonylamino; R2 = alkyl, alkoxy, polyfluoroalkoxy, OH or CF3SO2O; each of R4 and R5 independently = H, halogen, polyfluoroalkyl, polyfluoroalkoxy, CN or CONH2; n is 0, 1 or 2; but if R = Ph and both of R4 and R5 = H or hologen atoms, then R2 = polyfluoroalkoxy or CF3SO2O) and their N-oxides and pharmaceutically acceptable salts are endowed with adrenergic antagonist activity and, in particular, with high selectivity for the α1-adrenergic receptor as compared to the 5-HT1A receptor. This activity profile suggests the use of these benzopyran derivatives in the treatment of obstructive syndromes of the lower urinary tract, including BPH, without side-effects associated with hypotensive activity.

公开(公告)号：EP1113726A1

公开(公告)日：2001-07-11

申请号：EP99944890.5

申请日：1999-09-15

申请人： Korea Research Institute of Bioscience and Biotechnology

发明人： BOK, Song, Hae ,  JEONG, Tae, Sook ,  BAE, Ki, Hwan ,  PARK, Yong, Bok ,  CHOI, Myung, Sook ,  MOON, Surk, Sik ,  KWON, Yong, Kook ,  LEE, Eun, Sook ,  HYUN, Byung, Hwa ,  CHOI, Yang, Kyu ,  LEE, Chul, Ho ,  LEE, Sae, Bom ,  PARK, Young, Bae ,  KIM, Hyo, Soo

IPC分类号： A23L1/222 ,  A61K31/35 ,  A21D13/00 ,  C07D311/30 ,  C07H17/07

CPC分类号： A23G9/34 ,  A21D2/181 ,  A23C9/152 ,  A23L2/52 ,  A23L27/36 ,  A23L33/105

摘要： A pharmaceutical composition for treating or preventing an elevated blood lipid or glucose level-related disease such as hyperlipidemia, arteriosclerosis, angina pectoris, stroke, hepatic diseases and hyperglycemia in a mammal, which comprises an effective amount of neohesperidin dihydrochalcone as an active ingredient together with a pharmaceutically acceptable carrier, and a functional food or beverage composition for such a disease, which comprises an effective amount of neohesperidin dihydrochalcone.

公开(公告)号：EP1088094A1

公开(公告)日：2001-04-04

申请号：EP98937507.6

申请日：1998-06-18

申请人： CONSIGLIO NAZIONALE DELLE RICERCHE ,  Rao-Erbe di Rao Felice

发明人： NICOLOSI, Giovanni,Ist. per Studio delle Sost. ,  PIATTELLI, Mario,Inst. per lo Studio delle Sost. ,  LAMBUSTA, Daniela,Ist. per Studio delle Sostanze ,  PATTI, Angela,Inst. per lo Studio delle Sostanze

IPC分类号： C12P17/06 ,  C07D311/30 ,  C07D311/62 ,  C09K15/06

CPC分类号： C09K15/06 ,  C07D311/30 ,  C12P7/62 ,  C12P17/06

摘要： The present invention provides a process for the preparation of 3 monoesters of flavonoids comprising the following steps: a) chemical esterification of flavonoid with an aliphatic acyl group having from 1 to 18 carbon atoms to give the corresponding peracetylated flavonoid, or, alternatively, partially acylated flavonoid; b) subsequent alcoholysis with an aliphatic alcohol having from 1 to 8 carbon atoms, in the presence of lipase from Mucor miehei in an organic solvent.