-
公开(公告)号：EP1666591A1
公开(公告)日：2006-06-07
申请号：EP05077545.1
申请日：1996-06-25
申请人： IMMUNEX CORPORATION
IPC分类号： C12N15/09 , C12N15/17 , C12N15/63 , C07H21/04 , C07K1/14 , C07K14/52 , C07K16/24 , C12P21/08
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/70575 , C07K16/2875 , C07K2317/34 , C07K2319/00
摘要： A novel cytokine designated TRAIL induces apoptosis of certain target cells, including cancer cells and virally infected cells. Isolated DNA sequences encoding TRAIL are disclosed, along with expression vectors and transformed host cells useful in producing TRAIL polypeptides. Antibodies that specifically bind TRAIL are provided as well.
摘要翻译： 称为TRAIL的新型细胞因子诱导某些靶细胞（包括癌细胞和病毒感染细胞）的凋亡。 公开了编码TRAIL的分离的DNA序列，以及用于产生TRAIL多肽的表达载体和转化的宿主细胞。 还提供了特异性结合TRAIL的抗体。
-
92.发明公开GENES EXPRESSED IN INTESTINAL EPITHELIUM AND PEYER'S PATCH M CELLS 审中-公开IN和肠上皮细胞集合淋巴小结“PATCH M-细胞表达的基因
公开(公告)号：EP1383929A4
公开(公告)日：2006-06-07
申请号：EP02763973
申请日：2002-04-04
申请人： NEUROME INC
发明人： BRAYDEN DAVID J , BYRNE DARAGH , O'MAHONY DANIEL J , EVANS CLAIRE F , MAH STEVEN P , LO DAVID D
-
公开(公告)号：EP0885961B1
公开(公告)日：2004-12-01
申请号：EP98110889.7
申请日：1998-06-15
CPC分类号： C07K14/62 , A61K38/00 , C07K2319/00 , Y10S514/866
-
公开(公告)号：EP0871474A4
公开(公告)日：2004-08-18
申请号：EP95907193
申请日：1994-12-29
IPC分类号： C12N15/09 , A61K38/00 , A61K38/28 , A61P3/10 , C07K1/107 , C07K1/113 , C07K14/62 , C12N15/17 , C12P21/00 , C12P21/02 , C12P21/06 , C12R1/19
CPC分类号： C07K1/1136 , A61K38/00 , C07K14/62
摘要： An improved and efficient process for the production of recombinant human insulin by folding of a proinsulin hybrid polypeptide is provided.
-
公开(公告)号：EP0843722A4
公开(公告)日：2002-05-02
申请号：EP96924714
申请日：1996-07-26
IPC分类号： C12N15/09 , C12N5/00 , C12N5/10 , C12N15/63 , C12N15/85 , C12P21/02 , C12R1/91 , C12N15/12 , C12N15/17 , C12N15/18 , C12N15/19 , C12N15/52 , C12N15/54
CPC分类号： C12N15/85 , C12N15/635 , C12N2830/002 , C12N2830/42 , C12N2830/85 , C12N2840/20
摘要： Methods of production of desired recombinant proteins, polypeptides and peptides are disclosed which utilise mammalian host cells engineered for autonomous and regulated growth in low cost protein/serum-free culture media. Preferred host cells express insulin or an insulin-like growth factor, and/or transferrin and are engineered so that addition of an inducer (e.g. ZnCl2 + CdCl2) halts growth and simultaneously induces the expression of the desired recombinant protein, polypeptide or peptide.
-
96.发明公开PROCESS FOR PRODUCING RECOMBINANT INSULIN FROM NOVEL FUSED PROTEIN 有权VERFAHREN ZUR HERSTELLUNG VON REKOMBINANTEM INSULIN DURCH FUSIONSPROTEINE
公开(公告)号：EP1179593A1
公开(公告)日：2002-02-13
申请号：EP00921035.2
申请日：2000-04-26
申请人： Itoham Foods Inc.
发明人： OKA, Shusaku Central Res. Inst., Itoham Foods Inc. , SATO, Seiji Central Res. Inst., Itoham Foods Inc. , HIGASHIKUNI, Naohiko Central Res. Inst. , KONDO, Masaaki Central Res. Inst. , KUDO, Toshiyuki Central Research Institute , WATANABE, Shigeaki Central Research Institute , WAKI, Yoshihiro Central Research Institute , YUKI, Hirotaka Central Research Institute
IPC分类号： C12N15/17 , C12N15/03 , C07K19/00 , C07K14/575
CPC分类号： C07K14/62 , C07K14/575 , C07K2319/00
摘要： This invention relates to a DNA encoding a fusion protein of formula (I)
[Y]-[X1]-[B-chain]-[X2]-[Linker]-[X3]-[A-chain] (I)
wherein
Y is a leader peptide sequence for the expression and secretion of the protein, comprising at least one amino acid residue;
X1 is an amino acid sequence which is cleavable enzymatically or chemically;
B-chain is the amino acid sequence of insulin B chain;
X2 is an amino acid sequence which is cleavable enzymatically;
Linker is a linker sequence comprising at least one amino acid residue;
X3 is an amino acid sequence which is cleavable enzymatically; and
A- chain is the amino acid sequence of insulin A chain,
and to a method for producing insulin using an expression system containing the DNA in high efficiency and high yield.摘要翻译： 本发明涉及编码式（I）的融合蛋白的DNA，其中Y是用于蛋白质表达和分泌的前导肽序列，其包含在一个或多个氨基酸残基 至少一个氨基酸残基; X1是可酶切或化学裂解的氨基酸序列; B链是胰岛素B链的氨基酸序列; X2是可酶切的氨基酸序列; 接头是包含至少一个氨基酸残基的接头序列; X3是可酶切的氨基酸序列; A-链是胰岛素A链的氨基酸序列，以及使用含有高效率和高收率的DNA的表达系统产生胰岛素的方法。
-
公开(公告)号：EP1153131A2
公开(公告)日：2001-11-14
申请号：EP00916679.4
申请日：2000-02-22
申请人： During, Matthew John
发明人： During, Matthew John
CPC分类号： A61K48/0058 , A61K38/2264 , A61K38/28 , A61K48/00 , A61K48/0075
摘要： The invention provides methods and compositions for targeting endocrine cells capable of converting an immature expressed protein into a mature protein, and secreting the expressed protein into the systemic circulation. In particular, the invention features methods and compositions for treating disorders, such as diabetes by orally administering a vector expressing insulin to target cells which can subsequently secrete the expressed insulin into the blood circulation.
-
公开(公告)号：EP0367163B1
公开(公告)日：1996-01-03
申请号：EP89120056.0
申请日：1989-10-28
发明人： Koller, Klaus-Peter, Dr. , Riess, Günther, Johannes, Dr. , Uhlmann, Eugen, Dr. , Wallmeier, Holger, Dr.
CPC分类号： C07K14/62 , C07K14/36 , C07K2319/02 , C07K2319/75
-
公开(公告)号：EP0288451B1
公开(公告)日：1994-08-10
申请号：EP88870067.1
申请日：1988-04-22
申请人： Monsanto Company
CPC分类号： C07K14/24 , C07K14/65 , C07K2319/00 , C07K2319/035 , C07K2319/75 , C12N15/70
-
公开(公告)号：EP0123228B1
公开(公告)日：1993-09-29
申请号：EP84104175.9
申请日：1984-04-13
申请人： CHIRON CORPORATION
CPC分类号： C07K14/65 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/81
-
-
-
-
-
-
-
-
-
搜索结果
137 条记录 (耗时 0.017 秒)
