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    MUCOSAL VACCINE COMPOSITION
    93.
    发明公开
    MUCOSAL VACCINE COMPOSITION 审中-公开
    粘膜疫苗组合

    公开(公告)号：EP3053595A1

    公开(公告)日：2016-08-10

    申请号：EP14850476.4

    申请日：2014-10-02

    申请人： Nitto Denko Corporation

    发明人： FUKASAKA Masahiro ,  HORI Mitsuhiko ,  OKUBO Katsuyuki ,  ASARI Daisuke ,  OKAZAKI Arimichi ,  KIYOTOH Eiji ,  MATSUSHITA Kyohei

    IPC分类号： A61K39/39 ,  A61K9/06 ,  A61K9/08 ,  A61K9/12 ,  A61K9/20 ,  A61P31/04 ,  A61P31/12 ,  A61P31/16 ,  A61P37/04 ,  A61K39/145

    摘要： The present invention aims at providing a mucosal vaccine composition that can be administered to an intraoral mucous membrane, ocular mucous membrane, ear mucous membrane, genital mucous membrane, pharyngeal mucous membrane, respiratory tract mucous membrane, bronchial mucous membrane, pulmonary mucous membrane, gastric mucous membrane, enteric mucous membrane, or rectal mucous membrane, that is useful as a prophylactic or therapeutic agent for infectious diseases or cancers, and is capable of safely and effectively inducing the systemic immune response and mucosal immune response. The present invention provides a mucosal vaccine composition to be administered to at least one mucous membrane selected from the group consisting of a human or animal intraoral mucous membrane, ocular mucous membrane, ear mucous membrane, genital mucous membrane, pharyngeal mucous membrane, respiratory tract mucous membrane, bronchial mucous membrane, pulmonary mucous membrane, gastric mucous membrane, enteric mucous membrane, and rectal mucous membrane, containing: at least one antigen; and as an adjuvant, a lipopolysaccharide derived from at least one gram-negative bacterium selected from the group consisting of Serratia, Leclercia, Rahnella, Acidicaldus, Acidiphilium, Acidisphaera, Acidocella, Acidomonas, Asaia, Belnapia, Craurococcus, Gluconacetobacter, Gluconobacter, Kozakia, Leahibacter, Muricoccus, Neoasaia, Oleomonas, Paracraurococcus, Rhodopila, Roseococcus, Rubritepida, Saccharibacter, Stella, Swaminathania, Teichococcus, Zavarzinia, Pseudomonas, Achromobacter, Bacillus, Methanoculleus, Methanosarcina, Clostridium, Micrococcus, Flavobacterium, Pantoea, Acetobacter, Zymomonas, Xanthomonas, and Enterobacter, or a salt thereof.

    MULTI PLASMID SYSTEM FOR THE PRODUCTION OF ATTENUATED INFLUENZA B VIRUS
    99.
    发明公开
    MULTI PLASMID SYSTEM FOR THE PRODUCTION OF ATTENUATED INFLUENZA B VIRUS 审中-公开
    多媒体系统FÜRDIE埃及黑人艾滋病感染流行病病毒

    公开(公告)号：EP2995678A1

    公开(公告)日：2016-03-16

    申请号：EP15175068.4

    申请日：2005-05-20

    申请人： MedImmune, LLC

    发明人： HOFFMANN, Erich ,  JIN, Hong ,  KEMBLE, George ,  CHEN, Zhongying

    IPC分类号： C12N7/02 ,  A61K39/145 ,  C12P19/34 ,  A61K39/12 ,  C07K14/005

    CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5254 ,  C12N7/00 ,  C12N2760/16134 ,  C12N2760/16221 ,  C12N2760/16222 ,  C12N2760/16234 ,  C12N2760/16243 ,  C12N2760/16261

    摘要： Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25°C (and immunogenic compositions comprising the same) is also provided.

    摘要翻译： 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强复制特征的流感病毒。 还提供了产生在例如25℃下有效复制的冷适应（ca）流感病毒的方法（以及包含其的免疫原性组合物）。