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198 条记录 (耗时 0.027 秒)

    CO-EXPRESSION OF PROTEINS
    101.
    发明公开
    CO-EXPRESSION OF PROTEINS 审中-公开
    蛋白质的共表达

    公开(公告)号：EP1141347A1

    公开(公告)日：2001-10-10

    申请号：EP99918663.8

    申请日：1999-04-16

    申请人： NEW MEXICO STATE UNIVERSITY TECHNOLOGY TRANSFER CORPORATION

    发明人： BAGGA, Suman ,  SENGUPTA-GOPALAN, Champa ,  KEMP, John, D.

    IPC分类号： C12N15/82 ,  C07K14/425 ,  C12N15/29 ,  C12N15/62 ,  C07K16/16 ,  C07K16/38 ,  A01H5/00

    CPC分类号： C12N15/8254 ,  C07K14/425 ,  C12N15/8251 ,  C12N15/8253

    摘要： The subject invention pertains to materials and methods for transformed plants and plant tissues that are capable of expressing high levels of stable proteins which are localized as protein bodies within the plant cell. Transformed plants co-expressing high levels of both the 15kD and 10kD zein proteins are disclosed which accumulate to high levels as protein bodies in the vegetative tissue of the plant. Transformed plants co-expressing the 15kD and 10kD zein proteins are useful for providing forage crops containing increased levels of sulfur containing amino acids, such as methionine, in the diet of animals that normally feed on such crops. Also contemplated by the subject invention are transformed plants or plant tissue comprising stable protein bodies which contain heterologous proteinaceous material. In one embodiment, a stable protein body is expressed in a plant or plant tissue as a fusion protein comprising a zein protein and an operably linked protein or peptide. The protein bodies provided in the present invention are resistant to rumin digestion or environmental degradation.

    DISULFIDE CORE POLYPEPTIDES
    103.
    发明公开
    DISULFIDE CORE POLYPEPTIDES 审中-公开
    二硫键核心多肽

    公开(公告)号：EP1084247A1

    公开(公告)日：2001-03-21

    申请号：EP99927247.9

    申请日：1999-06-04

    申请人： ZymoGenetics, Inc.

    发明人： CONKLIN, Darrell C.,Apartment 2

    IPC分类号： C12N15/15 ,  C07K14/81 ,  C07K16/38 ,  C07K16/42

    CPC分类号： C07K14/811

    摘要： The present invention relates to polynucleotide and polypeptide molecules for a disulfide core protein (Zdsc1). The polypeptides, and polynucleotides encoding them, are serine proteinase inhibitors. Also disclosed are expression vectors containing polynucleotides which encode a Zdsc1 polypeptide, antibodies which specifically bind to Zdsc1 polypeptides and anti-idiotypic antibodies which neutralize the antibodies which specifically bind to Zdsc1 polypeptides.

    摘要翻译： 本发明涉及用于二硫键核心蛋白（Zdsc1）的多核苷酸和多肽分子。 多肽和编码它们的多核苷酸是丝氨酸蛋白酶抑制剂。 还公开了含有编码Zdsc1多肽的多核苷酸，特异性结合Zdsc1多肽的抗体和中和特异性结合Zdsc1多肽的抗体的抗独特型抗体的表达载体。

    Method for preparing a monoclonal antibody that provides an equimolar response to free and complexed analyte in a monoclonal/polyclonal sandwich immunoassay
    106.
    发明公开
    Method for preparing a monoclonal antibody that provides an equimolar response to free and complexed analyte in a monoclonal/polyclonal sandwich immunoassay 失效
    一种用于在单克隆/多克隆夹心免疫​​制备的单克隆抗体的equimolärenResponz针对游离和复合测试样品的方法

    公开(公告)号：EP0789032A2

    公开(公告)日：1997-08-13

    申请号：EP97100856.0

    申请日：1997-01-21

    申请人： Bayer Corporation

    发明人： Zhou, Zeqi ,  Armstrong E. Glenn Jr. ,  Yeung, Kwok K.

    IPC分类号： C07K16/40 ,  C07K16/38 ,  G01N33/573 ,  G01N33/53

    CPC分类号： G01N33/57434 ,  C07K16/40

    摘要： A method for preparing a monoclonal antibody which, when used in a monoclonal/polyclonal antibody sandwich immunoassay method for measuring an analyte which can exist in both free and binding protein complexed forms in a biological test sample, provides an equimolar response to the free and complexed forms of the analyte. The monoclonal antibody is selected to have the properties of (i) upon binding to the analyte, rendering the analyte substantially incapable of binding with antibodies that can bind the free form, but not the complexed form, of the analyte, and (ii) binding substantially equivalently with free and complexed analyte. The method is particularly useful in the measurement of prostate-specific antigen (PSA) in blood, serum or plasma.

    摘要翻译： 一种用于制备单克隆抗体的方法，该方法，当在单克隆/多克隆抗体夹心免疫测定方法，用于同时可在自由和生物测试样品中结合蛋白复合的形式，提供在对游离和复合等摩尔响应存在的分析物的测定中使用 分析物的形式。 单克隆抗体被选择在结合于分析物，使该分析物基本上不能与抗体结合也能够结合游离形式为具有（i）所述的特性，而不是复合形式，分析物，和（ii）的结合 实质上等同自由和络合分析。 该方法是在血液，血清或血浆前列腺特异性抗原（PSA）的测量是特别有用的。

    Tissue inhibitor of metalloproteinase type three (TIMP-3)
    107.
    发明公开
    Tissue inhibitor of metalloproteinase type three (TIMP-3) 失效
    GewebeinhibitorfürMetalloproteasen 3型（TIMP-3）。

    公开(公告)号：EP0648838A1

    公开(公告)日：1995-04-19

    申请号：EP94115578.0

    申请日：1994-10-04

    申请人： AMGEN INC.

    发明人： Silbiger, Scott M ,  Koski, Raymond A.

    IPC分类号： C12N15/15 ,  C07K14/81 ,  C12N1/21 ,  C12N5/10 ,  A61K48/00 ,  A61K38/57 ,  A61K38/43 ,  A61K38/17 ,  A61K38/48 ,  C07K16/38

    CPC分类号： A61K38/57 ,  C07K14/8146

    摘要： Provided herein are metalloproteinase inhibitors and polynucleotides encoding such factors. In particular, provided herein are novel mammalian tissue inhibitors of metalloproteinase (designated as type three, or "TIMP-3"), fragments, derivatives, and analogs thereof, polynucleotides encoding the same and methods of producing recombinant TIMP-3's. In a further aspect, pharmaceutical compositions and kits containing TIMP-3's and their use for treating disorders are provided herein. In yet another aspect, antibodies selectively binding TIMP-3's are provided.

    摘要翻译： 本文提供金属蛋白酶抑制剂和编码这些因子的多核苷酸。 特别地，本文提供了新型的金属蛋白酶（称为三型或“TIMP-3”）的哺乳动物组织抑制剂，其片段，衍生物和类似物，编码其的多核苷酸和产生重组TIMP-3的方法。 在另一方面，本文提供了含有TIMP-3的药物组合物和试剂盒及其用于治疗疾病的用途。 在另一方面，提供了选择性结合TIMP-3的抗体。