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121.发明公开Compositions and methods of monoclonal and polyclonal antibodies specific for T cell subpopulations 有权组合物和单克隆或多克隆抗体的用途，其是特异性的T细胞亚群
公开(公告)号：EP2336187A3
公开(公告)日：2012-01-11
申请号：EP10012392.6
申请日：2001-06-19
IPC分类号： C07K16/28 , C07K16/46 , C12N5/20 , G01N33/53 , G01N33/577 , G01N33/68 , A61K39/395 , A61K47/48 , A61K51/10 , A61K35/14 , A61P37/00 , A61P31/00 , A61P11/06 , A61P35/00 , A61P15/00
CPC分类号： C07K16/2809 , A61K2035/124 , A61K2039/505 , A61K2039/5158 , C07K16/2833 , C07K16/2851 , C07K16/2896 , C07K2317/31 , C07K2317/34 , C07K2317/50 , C07K2317/74 , C07K2317/76 , C12N5/0636 , C12N5/0646 , C12N2501/515 , C12N2501/599 , Y02A50/466
摘要： The invention provides compounds and methods for the ex vivo or in vivo cells, and the modulation of their activities. These compounds and methods have diagnostic and therapeutic applications.
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122.发明公开Assays for screening anti-pd-1 antibodies and uses thereof 审中-公开Screeningverfahren zur Isolierung von Anti-pd1Antikörperund deren Verwendungen
公开(公告)号：EP2360254A1
公开(公告)日：2011-08-24
申请号：EP10075561.0
申请日：2000-08-23
发明人： Wood, Clive , Freeman, Gordon J.
IPC分类号： C12N15/12 , C07K14/705 , C12N5/10 , A61K38/17 , A61K39/395 , G01N33/50 , C07K16/28
CPC分类号： C07K14/70532 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/06 , A61K2039/55516 , C07K14/70503 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/622 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2319/00 , C07K2319/30 , G01N2333/70503 , G01N2500/04 , A61K2300/00
摘要： The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in an immune cell resulting in modulation of the immune response.
摘要翻译： 本发明将PD-1鉴定为B7-4的受体。 B7-4可以在结合免疫细胞上的抑制性受体时抑制免疫细胞活化。 因此，本发明提供用于调节PD-1，B7-4以及B7-4和PD-1之间的相互作用的试剂，以便调节免疫细胞中的共刺激或抑制性信号，导致免疫应答的调节。
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123.发明公开Stabilized alpha helical peptides derived from the BCL2-family for therapy. 有权Fir Aktivierung oder Inhibierung von Zelltod geeigneteα-螺旋肽
公开(公告)号：EP2332968A1
公开(公告)日：2011-06-15
申请号：EP10195495.6
申请日：2004-11-05
CPC分类号： C07K7/08 , A61K38/00 , C07K1/113 , C07K1/1136 , C07K7/64 , C07K14/001 , C07K14/435 , C07K14/4747
摘要： Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ("hydrocarbon stapling") moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.
摘要翻译： 本文描述了新颖的多肽及其制备和使用方法。 多肽包括交联（“烃装订”）部分，以提供限制多肽的二级结构的两个氨基酸部分之间的系链。 本文所述的多肽可用于治疗以过度或不充分的细胞死亡为特征的疾病。
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公开(公告)号：EP2321426A1
公开(公告)日：2011-05-18
申请号：EP09803264.2
申请日：2009-07-29
发明人： KUNG, Andrew , BANERJEE, Pallab
IPC分类号： C12Q1/32
CPC分类号： C12Q1/32 , G01N33/5011 , G01N2510/00
摘要： The invention provides compounds and methods of their use in the detection of apoptosis and necrosis both in vitro and in vivo. Also provided are compounds and methods of their use in selective delivery of agents to cells undergoing apoptosis or necrosis. The compounds and methods are based on conjugates formed with a dehydrogenase such as lactate dehydrogenase, alcohol dehydrogenase, aldehyde dehydrogenase, and malate dehydrogenase. The compounds and methods are useful in the diagnosis and treatment of conditions characterized by apoptosis, including cancer, cardiac disease, neurologic disease including stroke, and autoimmunity. The compounds and methods offer distinct advantages over corresponding compounds and methods based on Annexin V. Also provided are methods for screening for compounds that modulate, i.e., inhibit or promote, apoptosis.
摘要翻译： 本发明提供了它们用于检测体外和体内细胞凋亡和坏死的化合物和方法。 还提供了它们用于将试剂选择性递送至经历细胞凋亡或坏死的细胞的化合物及其使用方法。 化合物和方法基于与脱氢酶形成的缀合物，如乳酸脱氢酶，醇脱氢酶，醛脱氢酶和苹果酸脱氢酶。 这些化合物和方法可用于诊断和治疗以细胞凋亡为特征的病症，包括癌症，心脏病，包括中风在内的神经系统疾病和自身免疫性。 与相应的基于膜联蛋白V的化合物和方法相比，化合物和方法提供了明显的优点。还提供了用于筛选调节，即抑制或促进细胞凋亡的化合物的方法。
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公开(公告)号：EP2315594A1
公开(公告)日：2011-05-04
申请号：EP09767337.0
申请日：2009-05-28
发明人： PELLMAN, David
IPC分类号： A61K31/7088 , A61K31/7105 , A61P35/00
CPC分类号： G01N33/5011 , A61K31/7088 , A61K31/7105 , G01N33/5026 , G01N33/57496 , G01N2333/914 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： The invention provides methods of treating a meiotic kinase-associated disease, preferably the meiotic kinase HSET, by administering an inhibitor of the meiotic kinase. Preferably, the disease is associated with the presence of supernumerary centrosomes, such as cancer. Methods of inhibiting the growth of a tumor cell by contacting the cell with an inhibitor of a meiotic kinase, preferably HSET, are also provided. Screening methods for identifying inhibitors of the meiotic kinase HSET are also provided. Methods of selecting subjects for treatment with an inhibitor of a meiotic kinase, such as HSET, are also provided.
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公开(公告)号：EP2296650A1
公开(公告)日：2011-03-23
申请号：EP09747530.5
申请日：2009-05-14
发明人： ZAWEL, Leigh , DRANOFF, Glenn , DOUGAN, Michael , STRAUB, Christopher, S. , FIRESTONE, Brant, G.
IPC分类号： A61K31/437
摘要： The present invention is directed to immune adjuvants containing IAP inhibitors, including Smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an IAP inhibitor and an antigen. Methods of enhancing an immune response by administration of an IAP inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods of potentiating cytokine or antibody production are also provided.
摘要翻译： 本发明涉及含有IAP抑制剂（包括Smac模拟物）的免疫佐剂。 本发明还提供含有IAP抑制剂和抗原的药物组合物和疫苗。 还提供了通过施用IAP抑制剂来增强免疫应答的方法，治疗或预防癌症的方法，治疗或预防感染的方法，治疗自身免疫疾病的方法，以及增强细胞因子或抗体产生的方法。
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公开(公告)号：EP2279246A2
公开(公告)日：2011-02-02
申请号：EP09739232.8
申请日：2009-05-01
申请人： Massachusetts Institute of Technology , The General Hospital Corporation , Dana-Farber Cancer Institute Inc.
CPC分类号： C12N5/0663 , A61K39/0008 , A61K2035/122 , A61K2035/124
摘要： The invention provides compositions and methods for modulating immune responses using mesenchymal stem cells. The invention further provides methods for inducing tolerance to self antigens using mesenchymal stem cells.
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公开(公告)号：EP1784506B1
公开(公告)日：2010-08-25
申请号：EP05783489.7
申请日：2005-05-23
发明人： MARASCO, Wayne, A.
CPC分类号： C12N15/86 , A61K48/00 , C07K16/00 , C07K16/1072 , C07K16/18 , C07K16/2866 , C07K2317/21 , C07K2317/622 , C07K2319/00 , C07K2319/035 , C07K2319/60 , C12N7/00 , C12N15/1037 , C12N2740/15043 , C12N2740/16043 , C12N2740/16045 , C12N2800/30 , C12N2810/6054 , C12N2810/6081 , C12N2830/003 , C12N2830/48 , C12N2830/50 , C12N2830/60 , C12N2840/203 , C12N2840/44 , G01N33/6854 , G01N33/6857
摘要： The invention relates to compositions containing polynucleotide vectors capable of expressing a nucleic acid encoding a fusion polypeptide on the surface of a viral particle and/or a eukaryotic cell.
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129.发明公开EXPRESSION PROFILES OF BIOMARKER GENES IN NOTCH MEDIATED CANCERS 审中-公开BIOMARKERGENEN作者NOTCH介导的癌症表达模式
公开(公告)号：EP2195451A1
公开(公告)日：2010-06-16
申请号：EP08795537.3
申请日：2008-08-22
发明人： BERGSTROM, Donald , DAI, Xudong , HARDWICK, James , LIBERATOR, Cole , LOOK, A. Thomas , O'NEIL, Jennifer , RAO, Sudhir , STRACK, Peter , WINTER, Christopher , ZHANG, Theresa
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106
摘要： The invention relates to the identification and use of gene expression profiles with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant Notch signaling using a Notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with a Notch mediated cancer who will likely respond to treatment with a gamma-secretase inhibitor or another Notch inhibiting agent. The same markers may be used in the classification of patients being treated with other Notch inhibitors. The methods may further comprise providing diagnostic, prognostic, or predictive information based on the classifying step. The methods may further comprise selecting a treatment based on the classifying step.
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130.发明授权
公开(公告)号：EP1410799B1
公开(公告)日：2010-03-31
申请号：EP03078539.8
申请日：1997-12-11
IPC分类号： A61K31/425
CPC分类号： A61K31/425 , A61K31/426 , A61K31/427 , A61K45/06 , Y10S514/908
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