公开(公告)号：EP1732926B1

公开(公告)日：2008-12-31

申请号：EP05732607.6

申请日：2005-04-06

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： WANG, Weibo, c/o Chiron Corporation ,  CONSTANTINE, Ryan, c/oChiron Corporation ,  LAGNITON, Liana, c/o Chiron Corporation

IPC分类号： C07D471/04 ,  C07D239/36 ,  A61K31/517 ,  A61K31/513 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D239/36

摘要： The present invention relates to compounds that are useful for treating cellular proliferative diseases, for treating disorders mediated, at least in part, by KSP, and for inhibiting KSP. The invention also related to pharmaceutical compositions comprising such compounds, methods of treating cancer by the administration of such compositions, and processes for the preparation of the compounds. Compounds of the invention have the following formula : formula (I).

公开(公告)号：EP1953229A3

公开(公告)日：2008-12-24

申请号：EP07023337.4

申请日：1999-10-14

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Giese, Klaus

IPC分类号： C12N15/12 ,  C12N15/10

CPC分类号： C12N9/0053 ,  C07K14/47 ,  C07K14/4705 ,  C07K14/4711 ,  C07K14/4722 ,  C07K14/4743 ,  C07K14/4748 ,  C07K14/52 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/7055 ,  C07K14/72 ,  C07K14/8121 ,  C07K2319/00 ,  C12N9/0006 ,  C12N9/104 ,  C12N9/6472 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： Gene sequences as shown in SEQ ID NOS: 1 to 85 have been found to be significantly associated with metastatic potential of cancer cells, especially breast and colon cancer cells. Methods are provided for determining the risk of metastasis of a tumor, which involve determining whether a tissue sample from a tumor expresses a polypeptide encoded by a gene as shown in SEQ ID NOS: 1 to 85, or a substantial portion thereof.

公开(公告)号：EP1510580B1

公开(公告)日：2008-12-10

申请号：EP04077562.9

申请日：1995-07-26

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Selby, Mark ,  Houghton, Michael

IPC分类号： C12N15/51 ,  C07K14/18 ,  C12N15/86 ,  A61K39/29

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2770/24222 ,  Y10S530/826

公开(公告)号：EP1980617A1

公开(公告)日：2008-10-15

申请号：EP07075871.9

申请日：1999-12-30

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Barnett, Susan ,  Zur Megede, Jan ,  Srivastava, Indresh ,  Lian, Ying ,  Hartog, Karin ,  Liu, Hong ,  Greer, Catherine ,  Selby, Mark ,  Walker, Christopher

IPC分类号： C12N15/49 ,  A61K48/00

CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/5156 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/53 ,  A61K2039/54 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/16023 ,  C12N2740/16043 ,  C12N2740/16052 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12N2770/24222 ,  C12N2800/108 ,  C12N2840/20 ,  C12N2840/203

摘要： The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression cassettes encoding the HIV Gag-containing polypeptides are described, as are uses of the expression cassettes in applications including DNA immunization, generation of packaging cell lines, and production of Env-, tat- or Gag-containing proteins. The invention provides methods of producing Virus-Like Particles (VLPs), as well as, uses of the VLPs including, but not limited to, vehicles for the presentation of antigens and stimulation of immune response in subjects to whom the VLPs are administered.

公开(公告)号：EP1977245A1

公开(公告)日：2008-10-08

申请号：EP07702744.9

申请日：2007-01-12

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： KOST, Holger

IPC分类号： G01N33/569 ,  C12N7/02

CPC分类号： C12Q3/00 ,  C12N7/00 ,  C12N2760/16011 ,  C12N2760/16111 ,  C12N2760/16211 ,  C12Q1/04 ,  G01N33/56983 ,  G01N2333/07 ,  G01N2333/11

摘要： The invention provides a method for determining the concentration of virus particles and/or virus antigens in a sample. In particular, the invention relates to determining the concentration of influenza virus particles/influenza virus antigens in a sample. The invention further relates to the use of an ion-exchange matrix for the determination of the concentration of virus particles and/or virus antigens in a sample.

公开(公告)号：EP1944371A3

公开(公告)日：2008-10-08

申请号：EP08003373.1

申请日：1999-04-30

申请人： Novartis Vaccines and Diagnostics, Inc. ,  THE INSTITUTE FOR GENOMIC RESEARCH

发明人： Fraser, Claire ,  Galeotti, Cesira ,  Grandi, Guido ,  Hickey, Erin ,  Masignani, Vega ,  Mora, Mariarosa ,  Petersen, Jeremy ,  Pizza, Mariagratia ,  Rappuoli, Rino ,  Ratti, Giulio ,  Scalato, Enzo ,  Scarselli, Maria ,  Tettelin, Hervé ,  Venter, J. Craig

IPC分类号： C12N15/31 ,  C07K14/22 ,  C07K16/12 ,  C12Q1/68 ,  A61K39/095 ,  G01N33/50

CPC分类号： C07K14/22 ,  A61K38/00 ,  A61K39/00 ,  A61K39/095 ,  A61K2039/55505 ,  Y10S530/806 ,  Y10S530/825

摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.

公开(公告)号：EP1141331B1

公开(公告)日：2008-09-17

申请号：EP99967389.0

申请日：1999-12-16

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： REINHARD, Christoph

IPC分类号： C12N15/54 ,  C12N15/62 ,  C12N15/90 ,  C12N5/10 ,  C12N9/12 ,  C07K16/40 ,  C12Q1/68

CPC分类号： C12N9/1205 ,  C07K2319/00

摘要： A human gene encoding a novel cyclin-dependent kinase termed hPNQALRE and its expression products can be used to provide reagents and methods for detecting neoplasia. Compositions and methods for treating proliferative disorders and neoplasia are also provided.

摘要翻译： 编码称为hPNQALRE的新型细胞周期蛋白依赖性激酶及其表达产物的人基因可用于提供用于检测瘤形成的试剂和方法。 还提供了治疗增殖性疾病和瘤形成的组合物和方法。

公开(公告)号：EP1953243A2

公开(公告)日：2008-08-06

申请号：EP08006693.9

申请日：2008-03-31

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Kennedy, Giulia C. ,  Kang, Sanmao ,  Reinhard, Christoph ,  Jefferson, Anne Bennet

IPC分类号： C12Q1/68 ,  C12N15/11 ,  A61K31/00 ,  G01N33/574 ,  G01N33/68

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/136

摘要： The present invention is based on the discovery of polynucleotides that represent genes that are differentially expressed in colon cancer, e.g., adenomatous polyp, colorectal carcinoma, high metastatic potential colon tumor and metastatic colon cancer. The invention features methods of identifying cells affected by such colon diseases by detection of a gene product encoded by such differentially expressed genes, as well as method of modulating expression of such gene products to effect therapy (e.g., to decrease growth and/or affect abnormal characteristics of cancerous or displastic colon cells).

摘要翻译： 本发明基于代表在结肠癌中差异表达的基因的多核苷酸的发现，所述结肠癌例如腺瘤性息肉，结肠直肠癌，高转移潜能结肠肿瘤和转移性结肠癌。 本发明的特征在于通过检测由这种差异表达的基因编码的基因产物来鉴定受这种结肠疾病影响的细胞的方法，以及调节这种基因产物的表达以实现疗法（例如降低生长和/或影响异常 癌性或有代表性的结肠细胞的特征）。

公开(公告)号：EP1932856A2

公开(公告)日：2008-06-18

申请号：EP08000646.3

申请日：1994-09-13

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Tekamp-Olson, Patricia, A. ,  Mullenbach, Guy ,  Wernette-Hammond, Mary, Ellen

IPC分类号： C07K16/28

CPC分类号： C07K16/2866 ,  A61K38/00 ,  A61K2039/505

摘要： Inhibitors, including antibodies, of IL8 binding to its receptors, that interact with the amino-terminal extracellular domain of the IL8 receptor and which compete with IL8 for receptor-binding, are disclosed. The inhibitors are useful modulators of IL8 receptor-mediated biological activity.

摘要翻译： 公开了与IL8受体结合的IL8的抑制剂，其与IL8受体的氨基末端胞外结构域相互作用并与IL8竞争受体结合。 抑制剂是IL8受体介导的生物活性的有用调节剂。

公开(公告)号：EP1919934A2

公开(公告)日：2008-05-14

申请号：EP06784406.8

申请日：2006-05-12

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： SORIANI, Marco ,  SANTI, Isabella

IPC分类号： C07K14/315

CPC分类号： C07K14/315 ,  A61K39/00 ,  A61K2039/505 ,  C07K2319/55 ,  Y02A50/466 ,  Y02A50/478

摘要： A newly identified serum resistance factor of gram positive bacteria can be used to treat or prevent bacterial infection.