公开(公告)号：EP2443232A2

公开(公告)日：2012-04-25

申请号：EP10724856.9

申请日：2010-06-15

申请人： Cilian AG

发明人： HARTMANN, Marcus ,  SACHSE, Christine ,  APELT, Jenny ,  BOCKAU, Ulrike

IPC分类号： C12N7/02 ,  C07K14/11 ,  A61K39/145

CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  C07K14/005 ,  C12N2760/16051 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16222 ,  C12N2760/16234

摘要： The present invention relates to a system for the heterologous expression of a viral protein or a fragment thereof, said system comprising a) a ciliate host cell, b) at least one cDNA encoding for a viral protein, or a fragment thereof, and c) a promoter operably linked to said cDNA.

公开(公告)号：EP2402026A3

公开(公告)日：2012-04-18

申请号：EP11166299.5

申请日：2003-08-27

申请人： Intercell AG

发明人： Buschle, Michael ,  Habel, Andre ,  Klade, Christoph ,  Mattner, Frank ,  Otava, Oleksandr ,  Vytvytska, Oresta ,  Zauner, Wolfgang ,  Zinke, Sandra ,  Kirlappos, Helen

IPC分类号： A61K39/12 ,  A61K39/29 ,  A61K39/39 ,  A61K38/00 ,  A61P31/00 ,  A61K39/145 ,  C07K14/11 ,  C07K14/18 ,  A61K38/16 ,  A61K38/08

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/292 ,  A61K2039/525 ,  A61K2039/57 ,  C07K7/08 ,  C07K14/005 ,  C07K2319/00 ,  C12N2710/16122 ,  C12N2760/16122 ,  C12N2770/24222 ,  C12N2770/24234 ,  G01N2500/04 ,  Y10S930/223

摘要： Described is a method for isolating Hepatitis C Virus peptides (HPs) which have a binding capacity to a MHC/HLA molecule or a complex comprising said HCV-peptide and said MHC/HLA molecule characterized by the following steps: - providing a pool of HCV-peptide, said pool containing HCV-peptides which bind to said MHC/HLA molecules and HCV-peptides which do not bind to said MHC/HLA molecule, -contacting said MHC/HLA molecule with said pool of HCV-peptides whereby a HCV-peptide which has a binding capacity to said MHC/HLA molecule binds to said MHC/HLA molecule and a complex comprising said HCV-peptide and said MHC/HLA molecule is formed, -detecting and optionally separating said complex from the HCV-peptide which do not bind to said MHC/HLA molecule and optionally isolating and characterising the HCV-peptide from said complex.

公开(公告)号：EP2201039A4

公开(公告)日：2012-04-11

申请号：EP08830693

申请日：2008-09-12

申请人： TEMASEK LIFE SCIENCES LAB LTD

发明人： QIAN HONG LIANG ,  HE FANG ,  KWANG HWEI-SING

IPC分类号： C07K16/10 ,  A61K39/145 ,  A61P31/16 ,  C12N7/00 ,  G01N33/53 ,  G01N33/577

CPC分类号： C07K16/1018 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/76 ,  C12N2760/16111 ,  G01N33/56983 ,  G01N2333/11

公开(公告)号：EP2431478A1

公开(公告)日：2012-03-21

申请号：EP11006185.0

申请日：2007-04-18

申请人： MedImmune, LLC

发明人： Duke, Gregory ,  Wang, Zhaoti ,  Kemble, George ,  Young, James

IPC分类号： C12P19/34 ,  C12P21/06 ,  G01N33/567 ,  C12Q1/68 ,  C12Q1/70 ,  C12N7/00 ,  A61K39/145 ,  C12N15/85

CPC分类号： C12N15/85 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/525 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2800/107 ,  C12N2830/008 ,  C12N2830/205 ,  C12N2830/85

摘要： The present invention provides novel canine pol I regulatory nucleic acid sequences useful for the expression of nucleic acid sequences in canine cells such as MDCK cells. The invention further provides expression vectors and cells comprising such nucleic acids as well as methods of using such nucleic acids to make influenza viruses, including infectious influenza viruses.

摘要翻译： 本发明提供了可用于在犬细胞如MDCK细胞中表达核酸序列的新型犬pol I调节核酸序列。 本发明还提供了包含这种核酸的表达载体和细胞以及使用这种核酸来制备流感病毒（包括感染性流感病毒）的方法。

公开(公告)号：EP2424879A1

公开(公告)日：2012-03-07

申请号：EP10769178.4

申请日：2010-04-29

申请人： Her Majesty The Queen In Right of Canada as represented by The Minister of Health

发明人： HE, Runtao ,  LI, Xuguang ,  VAN DOMSELAAR, Gary

IPC分类号： C07K14/11 ,  A61K39/145 ,  A61K39/385 ,  A61P31/16 ,  C07K7/08

CPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/505 ,  A61K2039/55566 ,  A61K2039/6081 ,  C07K14/005 ,  C07K16/1018 ,  C07K2317/76 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16222 ,  C12N2760/16234

摘要： The present invention discloses isolated peptides encoding an antigen or fragments thereof from the N-terminus of hemagglutinin protein of influenza, methods for isolating such antigens and specific uses thereof. The peptide can be used as a vaccine to generate an antibody response that neutralizes influenza infectivtty against a variety of influenza strains.

公开(公告)号：EP2421546A1

公开(公告)日：2012-02-29

申请号：EP09743995.4

申请日：2009-10-16

申请人： Bogoch, Samuel ,  Bogoch, Elenore S. ,  Bogoch, Samuel Winston ,  Borsanyi, Anne Elenore

发明人： Bogoch, Samuel ,  Bogoch, Elenore S. ,  Bogoch, Samuel Winston ,  Borsanyi, Anne Elenore

IPC分类号： A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  A61K39/145 ,  C07K7/06 ,  C07K7/08 ,  C07K14/005 ,  C07K14/11 ,  C07K16/10 ,  C12Q1/70 ,  G01N33/569 ,  G01N33/68 ,  A61P31/16

CPC分类号： A61K38/08 ,  A61K38/10 ,  A61K38/162 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16122 ,  C12N2760/16134 ,  G01N33/68 ,  G01N2333/11 ,  G01N2800/325

摘要： The present invention provides methods of differentiating the infectivity and lethality of isolates of influenza virus and provides compounds for diagnosing, preventing, and treating outbreaks of influenza virus including compounds for diagnosing, preventing, and treating across different strains of influenza virus.

公开(公告)号：EP2195019A4

公开(公告)日：2012-02-15

申请号：EP08800134

申请日：2008-10-09

申请人： CSL LTD

发明人： PEARSE MARTIN ,  ROCKMAN STEVE ,  RYAN DAVID

IPC分类号： A61K39/145 ,  A61K39/39 ,  A61P31/16

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/58 ,  A61K2039/70 ,  C12N2760/16134 ,  C12N2760/16234

公开(公告)号：EP2413961A1

公开(公告)日：2012-02-08

申请号：EP10714104.6

申请日：2010-03-31

申请人： Japan As Represented By Director-General Of National Institute Of Infectious Diseases ,  THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY ,  Toko Yakuhin Kogyo Kabushiki Kaisha

发明人： HASEGAWA, Hideki ,  MANABE, Sadao ,  TANIMOTO, Takeshi ,  MIYAZAKI, Takashi ,  KAMISHITA, Taizou

IPC分类号： A61K39/145 ,  A61K39/39 ,  C07K14/11

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/525 ,  A61K2039/5254 ,  A61K2039/543 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/58 ,  A61K2039/6093 ,  C12N2760/16134

摘要： The present invention provides a vaccine composition for transnasal mucous membrane administration, which contains an influenza virus antigen, polyriboinosinic polyribocytidylic acid (poly (I:C)) or a derivative thereof and a carboxyvinyl polymer. The present invention also provides a prophylactic method of influenza, including a step of administering the vaccine composition at least once to the nasal mucosa of a subject in need thereof.

公开(公告)号：EP2411049A2

公开(公告)日：2012-02-01

申请号：EP10756977.4

申请日：2010-03-26

申请人： Academia Sinica

发明人： WONG, Chi-Huey ,  MA, Che ,  WANG, Cheng-Chi ,  CHEN, Juine-Ruey

IPC分类号： A61K39/145 ,  C07K14/11 ,  C07K14/135 ,  C07K14/18 ,  C07K14/155 ,  A61K39/155 ,  A61K39/12 ,  A61K39/29 ,  A61K39/21 ,  C12P21/02 ,  A61P31/12 ,  A61P31/16 ,  A61P31/14 ,  A61P31/18

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/55505 ,  C07K16/1018 ,  C07K2317/76 ,  C12N7/00 ,  C12N2740/11034 ,  C12N2740/16034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2770/24134 ,  Y02A50/386

摘要： Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.

公开(公告)号：EP0791055B1

公开(公告)日：2012-01-25

申请号：EP95937888.6

申请日：1995-11-10

申请人： Baxter Healthcare S.A.

发明人： KISTNER, Otfried ,  BARRETT, Noel ,  MUNDT, Wolfgang ,  DORNER, Friedrich

IPC分类号： C12N7/00 ,  C12P21/00 ,  C12N5/00 ,  A61K39/145 ,  C07K14/11 ,  A61K39/15 ,  A61K39/245

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/245 ,  A61K2039/5252 ,  A61K2039/55505 ,  C12N7/00 ,  C12N2500/95 ,  C12N2710/16634 ,  C12N2710/16651 ,  C12N2710/24151 ,  C12N2720/12351 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16234 ,  C12N2770/24151 ,  Y02A50/388 ,  Y02A50/396 ,  Y02A50/464

摘要： The present invention refers to a method for producing viruses, selected from the group of flaviviridae, poxviridae and reoviridae and vaccines derived therefrom as well as to cells cultured under protein-free conditions. These cells show improved capabilities for propagating viruses, and eliminate the need for costly and time-consuming viral passaging und purification.