公开(公告)号：EP2718713A1

公开(公告)日：2014-04-16

申请号：EP12718193.1

申请日：2012-04-30

申请人： Biocartis SA

发明人： DOBBELAER, Irene ,  NEERKEN, Sieglinde ,  VAN DE WIEL, Paul ,  VAN MEERBERGEN, Bart ,  PENTERMAN, Roel

IPC分类号： G01N33/50 ,  C12N5/00

CPC分类号： C12Q1/689 ,  C12Q1/04

摘要： The present invention discloses methods, kits-of-parts, and devices for the selective lysis of eukaryotic cells in a sample comprising micro-organisms such as bacteria unicellular fungi. The selective lysis is obtained by incubating the sample in an ionic surfactant under alkaline conditions.

公开(公告)号：EP2690057A1

公开(公告)日：2014-01-29

申请号：EP12177715.5

申请日：2012-07-24

申请人： Biocartis SA

发明人： Demierre, Nicolas ,  Gamper, Stephan ,  Tornay, Raphaël ,  Renaud, Philippe

IPC分类号： B81C1/00 ,  G01N15/14 ,  G01N33/543

CPC分类号： B01L3/502707 ,  B01L3/502761 ,  B01L3/545 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0803 ,  B01L2300/0819 ,  B01L2300/0893 ,  B01L2300/16 ,  G01N15/1456

摘要： The present invention relates to a method for producing microcarriers (1), the method comprising the steps of providing a wafer having a bottom layer (16), a top layer and an insulating layer (18), structuring the top layer to define at least one three-dimensional structure (7a) on the top surface of the top layer, etching away the top layer to delineate lateral walls (22) of bodies (6) of the microcarriers, applying a continuous polymer layer over the top surface (4) of the bodies (6) of the microcarriers, removing the bottom layer (16) and the insulating layer (18), structuring the bottom surfaces of the bodies (6) of the microcarriers to define at least one three-dimensional structure on the bottom surface of each body, and removing the polymer layer to release the microcarriers.

摘要翻译： 本发明涉及一种生产微载体（1）的方法，所述方法包括以下步骤：提供具有底层（16），顶层和绝缘层（18）的晶片，构成顶层至少限定 在顶层的顶表面上的一个三维结构（7a），蚀刻掉顶层以描绘微载体的主体（6）的侧壁（22），在顶表面（4）上施加连续的聚合物层， 的微载体的主体（6），去除底层（16）和绝缘层（18），构成微载体的主体（6）的底表面以在底部限定至少一个三维结构 表面，并且除去聚合物层以释放微载体。

公开(公告)号：EP2685262A1

公开(公告)日：2014-01-15

申请号：EP12175954.2

申请日：2012-07-11

申请人： Biocartis SA

发明人： Tornay, Raphaël ,  Demierre, Nicolas ,  De Gil, José ,  Muller, Robin ,  Falconnet, Didier

IPC分类号： G01N33/53

CPC分类号： G01N33/54313 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/086 ,  G01N33/54366 ,  G01N33/54373 ,  Y10T436/2575

摘要： The present invention relates to a method for performing a chemical and/or a biological assay comprising the following successive steps of:
a) providing an assay device (19) with a microchannel (20) having an inlet (28) and an outlet (30) and further comprising restricting means (34) designed to restrict the movement toward the outlet (30) of microparticles (10) introduced in the microchannel while(20) letting a fluid to flow through the restricting means (34),
b) introducing microparticles (10) in the microchannel (20) via the inlet (28),
c) restricting the movement of said microparticles (10) in the microchannel (20) toward the outlet using restricting means (34),
d) flowing a fluid sample through the microchannel (20),
e) performing a biological and/or chemical read-out on each microparticle (10), the method further comprising the steps of:
f) moving the microparticles (101, 102, 103, 104) in the microchannel, and
g) repeating successively the steps d) and e).

摘要翻译： 本发明涉及一种用于进行化学和/或生物测定的方法，包括以下连续步骤：a）提供具有入口（28）和出口（30）的微通道（20）的测定装置（19） ），并且还包括限制装置（34），其被设计成限制朝着引入微通道的微粒（10）的出口（30）的移动，同时（20）使流体流过限制装置（34），b）引入微粒 （20）中的所述微通道（10）通过所述入口（28）在所述微通道（20）中的运动;（c）使用限制装置（34）限制所述微通道（20）在所述微通道（20） 微通道（20），e）在每个微粒（10）上执行生物和/或化学读出，所述方法还包括以下步骤：f）将所述微通道（101,102,103,104）移动到所述微通道 ，g）连续重复步骤d）和e）。

公开(公告)号：EP2665956A1

公开(公告)日：2013-11-27

申请号：EP12700697.1

申请日：2012-01-20

申请人： Biocartis SA

发明人： PENTERMAN, Roel ,  VAN EEMEREN, Johannes ,  WIMBERGER-FRIEDL, Reinhold ,  VAN AMERONGEN, Henrik

IPC分类号： F16K99/00

CPC分类号： F16K51/00 ,  B01L3/502738 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0655 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0057 ,  F16K99/0059 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T137/794

摘要： The invention relates to a micro valve for use in a biosensor, a micro fluidic device, use of such a device, and a micro fluidic element. Biosensors are used for detection of molecules and/or ions, such as protein, drug, DNA, RNA, hormone, glucose, insulin, enzyme, fungus, bacterium, etc., in a biological sample. The sensor can be used for diagnostic application, but for instance also drugs, either therapeutic or abuse, may be detected in for instance blood, urine and saliva.

摘要翻译： 本发明涉及用于生物传感器，微流体装置，这种装置的使用以及微流体元件的微型阀。 生物传感器用于检测生物样品中的分子和/或离子，例如蛋白质，药物，DNA，RNA，激素，葡萄糖，胰岛素，酶，真菌，细菌等。 该传感器可用于诊断应用，但是例如也可以在例如血液，尿液和唾液中检测治疗或滥用的药物。

公开(公告)号：EP2574399A1

公开(公告)日：2013-04-03

申请号：EP11183127.7

申请日：2011-09-28

申请人： Biocartis SA

发明人： Bosma, Rob ,  De Gier, Ronald

IPC分类号： B01L3/00 ,  A61B10/00 ,  G01N33/487

CPC分类号： B01L3/508 ,  A61B10/0096 ,  B01L3/502 ,  B01L3/5023 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/045 ,  B01L2300/069 ,  Y10S435/81 ,  Y10S435/975

摘要： The present invention relates to a sealing device for closing an introduction aperture (1), the sealing device comprising a fixed support (2) and a shutter (3) mounted movably in translation relative to the support between an extended position and a final retracted position, wherein the sealing device is in a final retracted configuration and wherein the shutter closes introduction aperture. The device includes locking means for preventing any movement of the shutter when it is in the final retracted position. The sealing device further comprises an intermediate retracted configuration, wherein the shutter is at least partly retracted. The sealing device also comprises motion guiding means (5,7) for guiding the movement of the shutter and designated so that the extension of the shutter is required to move the shutter from the intermediate retracted position to the final retracted position.

摘要翻译： 本发明涉及一种用于封闭导入孔（1）的密封装置，该密封装置包括一个固定支架（2）和一个挡板（3），该挡板（3）相对于支撑件在延伸位置和最终缩回位置之间可移动地平移 ，其中所述密封装置处于最终缩回构型，并且其中所述快门关闭引入孔。 该装置包括锁定装置，用于防止当其处于最终缩回位置时快门的任何移动。 密封装置还包括中间缩回构型，其中挡板至少部分缩回。 密封装置还包括用于引导快门的运动并被指定的运动引导装置（5,7），使得需要快门的延伸以将快门从中间缩回位置移动到最终缩回位置。

公开(公告)号：EP2419204A2

公开(公告)日：2012-02-22

申请号：EP10713293.8

申请日：2010-04-09

申请人： Biocartis SA

发明人： VAN DOORN, Arie, R. ,  DE JONG, Michiel

IPC分类号： B01F11/02

CPC分类号： G01N1/28 ,  B01F11/0283 ,  B01J19/008 ,  G01N2001/2866 ,  G01N2035/00554 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575

摘要： The invention relates to high intensity focused ultrasound devices. Furthermore the invention relates to an apparatus for irradiating a liquid sample with acoustic energy to generate cavitation in the liquid sample. The apparatus (100) comprises a source and is adapted to receive a cartridge (105) in such a way, that the apparatus focuses the HIFU waves emitted from the source onto a liquid air interface that is present within the cartridge. This focusing is performed when the cartridge is inserted into a receiving section of the apparatus.

公开(公告)号：EP2100143A1

公开(公告)日：2009-09-16

申请号：EP07800648.3

申请日：2007-09-19

申请人： Biocartis SA

发明人： DE GEEST, Bruno ,  DEMEESTER, Joseph ,  DERVEAUX, Stefaan ,  DE SMEDT, Stefaan

IPC分类号： G01N33/543 ,  G01N33/58

CPC分类号： G01N33/54326 ,  G01N33/54333 ,  G01N33/587 ,  Y10T428/2991

摘要： The present invention relates to carriers, which are coated by at least one layer of polyelectrolytes and one layer of magnetic material. These carriers can be manipulated in a magnetic field. The application of the coating of the present invention on microcarriers comprising a fluorescent core results in a carrier with a homogeneous luminescence. Additionally, where the core is provided with a code, this allows improved reading thereof.

公开(公告)号：EP2490812A1

公开(公告)日：2012-08-29

申请号：EP10771203.6

申请日：2010-10-06

申请人： Biocartis SA

发明人： WIMBERGER-FRIEDL, Reinhold ,  PENTERMAN, Roel ,  VAN AMERONGEN, Hendrik, Halling ,  LORING, Theodorus, Antonius, Johannes ,  VAN UDEN, Martijn, Jochem

IPC分类号： B01L3/00 ,  F04B19/00 ,  F16K99/00

CPC分类号： B01L3/502738 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2300/0809 ,  B01L2300/0874 ,  B01L2300/123 ,  B01L2300/1805 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0638 ,  F04B19/006 ,  F04B43/043 ,  F04B43/06 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0059 ,  F16K2099/0084 ,  Y10T137/85978

摘要： The invention relates to a design of an interface plate (101) between a microfluidic cartridge (100) and an instrument (102) for fluid actuation in the disposable cartridge. Pneumatic actuation is carried out through a reversible pneumatic interconnection between instrument and cartridge. Pneumatic drivers are integrated in the instrument for a low cost and reliable solution. The actuation of the fluid in the cartridge is achieved by a flexible membrane (105) attached to the major surface of the disposable cartridge forming closed compartments only when attached to the instrument. The pressure, in these compartments determines the deflection of the membrane which in turn actuates the fluid. This approach takes advantage of the high power and large stroke of pneumatic actuation while at the same time keeping the disposable cartridge simple and low cost and allowing easy introduction of other physical transport across the interface plate, like heat or acoustic vibration. A large number of actuators can be integrated easily into the flat interface plate as no individual fixation, like tubing, is required for the pneumatic actuation.

公开(公告)号：EP2490811A1

公开(公告)日：2012-08-29

申请号：EP10768365.8

申请日：2010-10-20

申请人： Biocartis SA

发明人： DE GIER, Ronald ,  VAN ES, Arthur R. ,  WILNAUER, Peter

IPC分类号： B01L3/00

CPC分类号： B01L3/502738 ,  B01L2300/0861 ,  B01L2400/0644 ,  Y10T137/598 ,  Y10T137/6851 ,  Y10T137/85938

摘要： The invention relates to a manifold system comprising a manifold housing and a manifold core. Means of using an oblique surface inside of the manifold housing onto which a manifold core is to be inserted and by adapting a fluidic channel in the manifold housing the corresponding way, such a manifold housing is producible by manifold casting without having an undercut. Thus, the use of sliders during production of such a manifold housing is avoided. Any need for applying external forces (e.g. by an instrument) for obtaining a seal between the manifold housing and the manifold core is obviated.

公开(公告)号：EP2479466A1

公开(公告)日：2012-07-25

申请号：EP11151705.8

申请日：2011-01-21

申请人： Biocartis SA

发明人： Penterman, Roel ,  van Eemeren, Johannes, Th., W., M. ,  Wimberger-Friedl, Reinhold ,  van Amerongen, Henrik H.

IPC分类号： F16K99/00

CPC分类号： F16K51/00 ,  B01L3/502738 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2400/0655 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0057 ,  F16K99/0059 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T137/794

摘要： The invention relates to a micro valve for use in a biosensor, a micro fluidic device, use of such a device, and a micro fluidic element.
Biosensors are used for detection of molecules and/or ions, such as protein, drug, DNA, RNA, hormone, glucose, insulin, enzyme, fungus, bacterium, etc., in a biological sample. The sensor can be used for diagnostic application, but for instance also drugs, either therapeutic or abuse, may be detected in for instance blood, urine and saliva.

摘要翻译： 本发明涉及用于生物传感器，微流体装置，这种装置的使用以及微流体元件的微型阀。 生物传感器用于检测生物样品中的分子和/或离子，例如蛋白质，药物，DNA，RNA，激素，葡萄糖，胰岛素，酶，真菌，细菌等。 该传感器可用于诊断应用，但是例如也可以在例如血液，尿液和唾液中检测治疗或滥用的药物。