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    MEASUREMENT DEVICE COMPRISING TRACE SAMPLE-USE HIGH SENSITIVITY LIGHT ABSORBING CELL
    11.
    发明公开
    MEASUREMENT DEVICE COMPRISING TRACE SAMPLE-USE HIGH SENSITIVITY LIGHT ABSORBING CELL 审中-公开
    包含痕量样品的测量装置 - 使用高灵敏度吸光单元

    公开(公告)号：EP3267179A1

    公开(公告)日：2018-01-10

    申请号：EP16759178.3

    申请日：2016-03-04

    申请人： Korea Research Institute Of Standards And Science

    发明人： PARK, Sang-Ryoul ,  YOO, Hee-Bong ,  KIM, Juhwang

    IPC分类号： G01N21/03 ,  G01N21/25

    CPC分类号： G01N21/0303 ,  G01N21/255 ,  G01N21/27 ,  G01N21/3577 ,  G01N21/8507 ,  G01N2021/0346

    摘要： The present invention relates to a measurement device including a trace sample-use high sensitivity light absorbing cell, the device comprising: a light absorbing cell containing a capillary tube of which both ends are open hollow shaped; a light absorbing cell mounting block on which one end of the light absorbing cell is mounted, and which comprises a light emitting unit, disposed on the upper portion of the light absorbing cell, for irradiating light to one end of the light absorbing cell; and a light receiving block which comprises a light metering immersion unit disposed in such a manner that the other end of the light absorbing cell is immersed in a sample contained therein, and which detects light that is irradiated to one end of the light absorbing cell and emitted to the other end thereof.

    摘要翻译： 本发明涉及一种包括痕量样品用高灵敏度光吸收单元的测量装置，该装置包括：含有毛细管的光吸收单元，该毛细管的两端开口为中空形状; 光吸收单元安装块，所述光吸收单元的一端安装在所述光吸收单元安装块上，并且所述光吸收单元安装块包括发光单元，所述发光单元设置在所述光吸收单元的上部，用于将光照射到所述光吸收单元的一端; 以及光接收块，其包括光计量浸入单元，该光计量浸入单元以光吸收池的另一端浸入其中包含的样品的方式设置，并且检测照射到光吸收池的一端的光和 发射到其另一端。

    METHOD OF MANUFACTURING REFERENCE MATERIAL USING PLANT CULTURED CELL LINES
    15.
    发明公开
    METHOD OF MANUFACTURING REFERENCE MATERIAL USING PLANT CULTURED CELL LINES 有权
    使用植物培养细胞系生产参考物质的方法

    公开(公告)号：EP2514816A9

    公开(公告)日：2013-04-17

    申请号：EP10837893.6

    申请日：2010-12-16

    申请人： Korea Research Institute Of Standards And Science

    发明人： KIM, Hyong Ha ,  KIM, Woo Jeong ,  SUH, Jung Keun

    IPC分类号： C12N5/04 ,  C12Q1/68 ,  C12Q1/02 ,  C12N15/09

    CPC分类号： C12Q1/6895 ,  C12Q2600/13 ,  C12Q2600/166 ,  G01N33/5097

    摘要： A method of manufacturing a reference material for determining incorporation of a genetically modified (GM) plant into a sample or analyzing a mixing ratio from a tissue-cultured cell line that is obtained by incubating tissues of either a GM plant or a non-GM plant, and a method of determining incorporation of a GM plant into a sample and analyzing a mixing ratio using the reference material are provided. The reference material for determining the incorporation of a genetically modified (GM) plant a sample or analyzing a mixing ratio using the tissue-cultured cell lines that are obtained by incubating tissues of the GM plant and the non-GM plant can be useful in producing a countless number of populations having the same genetic traits via the tissue culture. Thus, when a culture capacity of the reference material is increased to a large volume, it is possible to obtain a large volume of the reference material having uniform qualities with no quality variation between batches. Unlike the conventional reference materials manufactured using grain powder, a reference material with 100% purity can be obtained as either a GM or non-GM reference material by verifying the purity of the tissue-cultured cell line. Accordingly, it is possible to provide the uniform and stable supply of a reference material having uniform compositions.

    摘要翻译： 一种制造用于确定将基因修饰（GM）植物掺入样品中的参考材料的方法，或者分析来自通过孵育GM植物或非GM植物的组织获得的组织培养细胞系的混合比 以及确定将GM植物并入样品中并使用该参考物质分析混合比的方法。 用于确定将转基因植物和非转基因植物的组织进行培养而获得的组织培养的细胞系用于确定将基因改造的（GM）植物掺入样品或分析混合比例的参考材料可用于生产 通过组织培养具有相同遗传性状的无数个种群。 因此，当参考材料的培养容量增加到大体积时，有可能获得质量均匀的大量参考材料，批次之间没有质量变化。 与使用颗粒粉末制造的常规参考材料不同，通过验证组织培养的细胞系的纯度，可以获得具有100％纯度的参考材料作为GM或非GM参考材料。 因此，可以提供具有均匀组成的参考材料的均匀和稳定的供应。

    APPARATUS USING FOCUSED ULTRASOUND WAVE BY CONTROLLING ELECTRONIC SIGNALS AND USING METHOD THEREOF
    16.
    发明公开
    APPARATUS USING FOCUSED ULTRASOUND WAVE BY CONTROLLING ELECTRONIC SIGNALS AND USING METHOD THEREOF 审中-公开
    聚焦超声波设备通过电子信号控制和使用它们的方法

    公开(公告)号：EP2089109A1

    公开(公告)日：2009-08-19

    申请号：EP06823886.4

    申请日：2006-12-04

    申请人： Korea Research Institute of Standards and Science

    发明人： KIM, Yong Tae ,  JHO, Moon Jae ,  JUNG, Sung Soo ,  KIM, Ho Chul ,  YUN, Yong Hyeon

    IPC分类号： A61N7/00

    CPC分类号： A61N7/02 ,  A61B8/483 ,  A61N2007/0078 ,  G10K11/346

    摘要： The present invention relates to an extracorporeal High Intensity Focused Ultrasound (HIFU) necrosis apparatus through the control of an electronic signal, including oscillation elements for generating ultrasonic beams, an ultrasonic oscillator array having the oscillation elements fixed on a plane and oriented toward a life, delay circuits respectively connected to the oscillation elements for delaying ultrasonic oscillation by a delay time, and control means for controlling the delay time so that the ultrasonic beams are focused, and a method of employing the same. According to the present invention, waved surfaces with a variety of directions and curvatures can be formed using several oscillation elements and several delay circuits disposed on a plane, and a focus can be formed at any desired place. Accordingly, there are advantages in that installation is convenient, and a tissue, such as tumor, which is a target tissue, can be necrotized without damage to normal tissues necrosis. Further, there is no damage to normal tissues other than a target tissue. Accordingly, there are advantages in that a recovery speed of a patient can quicken, a symptom after recovery can be mitigated, and so on.

    METHOD FOR QUANTITATIVE ANALYSIS OF METHYL CYTOSINE IN DNA AND USES THEREOF
    17.
    发明公开
    METHOD FOR QUANTITATIVE ANALYSIS OF METHYL CYTOSINE IN DNA AND USES THEREOF 有权
    定量分析DNA中甲基胞嘧啶的方法及其用途

    公开(公告)号：EP1880023A1

    公开(公告)日：2008-01-23

    申请号：EP06757697.5

    申请日：2006-05-11

    申请人： Korea Research Institute of Standards and Science

    发明人： YANG, In-Chul ,  JANG, Sung-Moon ,  SHI, Lian-Hua, Korea Research Inst. of Standards and Science ,  PARK, Sang-Ryoul

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6869 ,  C12Q2523/125

    摘要： The present invention relates to a method for the quantitative analysis of methyl cytosine in a gene. The method comprises the steps of: (1) treating genomic DNA extracted from a cell or tissue sample with bisulfite so as to maintain methyl cytosine intact and to convert unmethylated cytosine into uracil; (2) selectively amplifying a target gene by PCR using the DNA treated in said step (1) as a template in a reaction mixture containing primers specific for the target gene, dNTP and polymerase; (3) removing non-specific amplification products, the dNTP and the primers from the product amplified in said step (2) to purify the target gene; (4) cleaving the target gene purified in said step (3) into a deoxynucleotide monophosphate (dNMP) level; and (5) separating the dNMP-level product cleaved in said step (4) using capillary electrophoresis, to thereby quantify and measure the content of the methyl cytosine in the target gene. Also, the present invention provides a method for classifying or diagnosing aging, cancer, pathogens, pathogenic contamination, tissues and individuals in a sample, the method comprising measuring the content of methyl cytosine in the sample using the quantitative analysis method of methyl cytosine, and comparing the measured content with the database content of methyl cytosine for aging, cancer, pathogens, tissues or individuals. The inventive method for the quantitative analysis of DNA methylation enables the degree of DNA methylation to be quantified in a highspeed, high-sensitivity and automatable platform, which has not yet been achieved by any of the prior methods.

    摘要翻译： 本发明涉及定量分析基因中的甲基胞嘧啶的方法。 该方法包括以下步骤：（1）用亚硫酸氢盐处理从细胞或组织样品提取的基因组DNA，以保持甲基胞嘧啶完整并将未甲基化的胞嘧啶转化为尿嘧啶; （2）使用所述步骤（1）中处理的DNA作为模板，在含有靶基因特异性引物，dNTP和聚合酶的反应混合物中通过PCR选择性扩增靶基因; （3）从所述步骤（2）中扩增的产物中去除非特异性扩增产物，dNTP和引物以纯化靶基因; （4）将在所述步骤（3）中纯化的靶基因切割成脱氧核苷酸单磷酸（dNMP）水平; 和（5）使用毛细管电泳分离在所述步骤（4）中裂解的dNMP水平的产物，从而定量和测量靶基因中甲基胞嘧啶的含量。 此外，本发明提供了一种用于分类或诊断样品中老化，癌症，病原体，病原体污染，组织和个体的方法，所述方法包括使用甲基胞嘧啶的定量分析方法测量样品中的甲基胞嘧啶的含量，以及 将测量的内容与用于衰老的甲基胞嘧啶的数据库内容进行比较，癌症，病原体，组织或个体。 用于定量分析DNA甲基化的本发明方法使DNA甲基化的程度能够在高速，高灵敏度和可自动化的平台中量化，这尚未通过任何现有方法实现。

    DIRECT CURRENT VOLTAGE FUNCTION CALIBRATION DEVICE AND METHOD
    20.
    发明公开
    DIRECT CURRENT VOLTAGE FUNCTION CALIBRATION DEVICE AND METHOD 审中-公开

    公开(公告)号：EP3435106A1

    公开(公告)日：2019-01-30

    申请号：EP17770473.1

    申请日：2017-01-23

    申请人： Korea Research Institute Of Standards And Science

    发明人： JUNG, Jae Kap ,  KIM, Kyu Tae

    IPC分类号： G01R35/00 ,  G01R15/12 ,  G01R19/25 ,  G01R19/257 ,  G01R19/14

    摘要： The inventive concept relates to a DC voltage function calibration device of a multifunction meter and a meter calibrator. The DC voltage function calibration device includes, a first meter calibrator configured to be calibrated to a reference value for a reference point and having a first plus terminal and a first minus terminal, a second meter calibrator configured to be calibrated to the reference value for the reference point and having a second plus terminal and a second minus terminal connected to the first minus terminal, a digital multi meter having a third plus terminal connected to the first plus terminal and a third minus terminal connected to the second plus terminal, and a DC voltage calibration circuit configured to control to calibrate a DC voltage for other points through up-converting or down-converting a voltage value using the digital multi meter based on the reference value set in the first meter calibrator and the second meter calibrator.