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公开(公告)号：EP0450472B1
公开(公告)日：1997-05-14
申请号：EP91104816.3
申请日：1991-03-26
申请人： ONCOGEN LIMITED PARTNERSHIP , UNITED STATES GOVERNMENT as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Salahuddin, Syed Zaki , Nakamura, Shuji , Gallo, Robert C. , Radka, Susan F. , Linsley, Peter S. , Shoyab, Mohammed
IPC分类号： C12P21/08 , A61K39/395
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公开(公告)号：EP0458878B1
公开(公告)日：1996-09-04
申请号：EP90903653.5
申请日：1990-01-23
IPC分类号： A61K39/00 , G01N33/53 , G01N33/577 , C07K16/30 , C12P21/08
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K51/1045 , A61K2121/00 , A61K2123/00 , C07K16/30 , C07K2317/34 , C07K2317/73 , Y10S530/828
摘要： The present invention is concerned with a novel monoclonal antibody which binds strongly to a protein antigen associated with human tumors, including carcinomas of the colon, breast, ovary and lung, as well as melanomas and sarcomas. The antibody binds to normal human cells to a much lesser degree than to tumor cells. The antibody finds use both in diagnostic methods such as the detection of malignant cells associated with tumors and in therapeutic methods for treatment of humans with tumors. Also disclosed is a novel 100,000 dalton glycoprotein antigen found on the cell surface of human tumor cells. The amino terminal amino acid sequence of this antigen is (I), in which X represents an unidentified amino acid.
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13.发明公开METHODS FOR CONTROLLING HUMAN ENDOTHELIAL CELL PROLIFERATION AND EFFECTOR FUNCTIONS USING ONCOSTATIN M 失效使用ONCOSTATIN M控制人内皮细胞增殖和效应功能的方法
公开(公告)号：EP0422186A4
公开(公告)日：1993-09-15
申请号：EP90906668
申请日：1990-04-09
IPC分类号： A61K9/127 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/19 , A61K38/22 , A61K38/27 , A61K38/46 , A61K39/395 , A61K47/48 , A61P1/16 , A61P7/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P43/00 , C07K14/52 , C12N20060101 , C12N15/12 , C12P21/02 , A61K37/00 , A01N25/34 , A61K37/22
CPC分类号： A61K38/1841 , A61K38/204 , A61K38/49 , A61K47/642 , A61K47/6813 , A61K2300/00
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14.发明公开NON-REPLICATING RECOMBINANT-MADE RETROVIRAL PARTICLES USED AS ANTIVIRAL AGENTS AND IMMUNOGENS 失效用作抗病毒剂和免疫球蛋白的非重复生物制剂重复生物颗粒
公开(公告)号：EP0502105A4
公开(公告)日：1993-02-24
申请号：EP91900526
申请日：1990-11-20
IPC分类号： A61K39/21 , A61K39/00 , C07K14/005 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/195 , C07K14/705 , C12N5/10 , C12N15/09 , C12P21/02 , C12R1/91 , C07K1/00 , C07K15/04
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/16122
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公开(公告)号：EP0479920A4
公开(公告)日：1993-02-17
申请号：EP90912446
申请日：1990-06-29
IPC分类号： A61K38/00 , A61K20060101 , A61K39/395 , A61K45/00 , A61K47/48 , A61K49/00 , A61K51/10 , A61P35/00 , C07K20060101 , C07K1/22 , C07K14/415 , C07K14/52 , C07K16/00 , C07K16/30 , C07K19/00 , C12N20060101 , C12N5/10 , C12N5/12 , C12N5/18 , C12N5/20 , C12N9/96 , C12N15/09 , C12N15/10 , C12P21/08 , C12Q20060101 , C12R1/91 , G01N20060101 , G01N33/53 , G01N33/531 , G01N33/532 , G01N33/563 , G01N33/574 , G01N33/577 , C07K15/28 , A61K39/00 , A61K43/00 , G01N33/535
CPC分类号： G01N33/57484 , A61K38/00 , A61K47/6809 , A61K47/6811 , A61K47/6829 , A61K47/6851 , A61K51/1045 , A61K51/1087 , A61K2123/00 , C07K14/415 , C07K16/30 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2319/00 , C12N15/10
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公开(公告)号：EP0248642B1
公开(公告)日：1992-10-21
申请号：EP87304883.9
申请日：1987-06-03
CPC分类号： C07K14/4718 , A61K38/00 , C12P1/04 , C12R1/91
摘要： Methods and compositions are provided for production of novel polypeptides having antineoplastic activity. Polypeptides are obtained by lymphokine activation of killer lymphocytes, solubilizing peptides from the cells with acidic ethanolic extraction and purification using chromatography. The resulting peptides may be prepared by other techniques, such as synthesis or expression in nonmammalian or mammalian host cells. The peptides find use in inhibition of neoplastic cell proliferation.
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公开(公告)号：EP0232179B1
公开(公告)日：1992-07-22
申请号：EP87301040.9
申请日：1987-02-05
发明人： Linsley, Peter S. , Ochs, Vincent W. , Horn, Diane , Brown, Joseph P. , Ring, David B. , Frankel, Arthur E.
IPC分类号： G01N33/574 , G01N33/577
CPC分类号： G01N33/57415 , Y10S436/813
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18.发明公开
公开(公告)号：EP0464137A4
公开(公告)日：1992-01-15
申请号：EP90905787
申请日：1990-03-16
IPC分类号： A61K31/505 , A61K20060101 , A61K31/52 , A61K31/522 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61K31/708 , A61K39/21 , A61K45/06 , A61P31/12 , A61P43/00 , C07D405/04 , C07D473/30 , C07D473/34 , C07H20060101 , C07H19/00 , C07H19/04 , C07H19/06 , C07H19/16 , C12N20060101 , C12N7/00 , C12N7/06 , C12N9/00 , C12N15/00
CPC分类号： A61K31/70
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公开(公告)号：EP0268279A3
公开(公告)日：1991-07-03
申请号：EP87116997.5
申请日：1987-11-17
发明人： Linsley, Peter S. , Horn, Diane , Brown, Joseph P.
IPC分类号： C12N5/12 , C07K16/28 , C07K16/30 , C12P21/08 , G01N33/577 , G01N33/68 , A61K39/395 , G01N33/574
CPC分类号： C07K16/3023 , A61K38/00 , C07K16/3015
摘要： Novel hybridoma cell lines producing monoclonal antibodies reactive with purified mucin antigens from normal and tumor sources are generated using mucins, including purified mucins from tumor sources. Epitopes on mucin antigens from normal and tumor sources are demonstrated to be distinct, using these new antibodies. The antibodies may be useful alone or in combination, in the diagnosis and treatment of cancer including malignancies of the breast and lung.
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20.发明公开
公开(公告)号：EP0375562A2
公开(公告)日：1990-06-27
申请号：EP89403631.8
申请日：1989-12-22
IPC分类号： C12P21/08 , A61K39/395
CPC分类号： C07K16/468 , A61K38/00 , A61K47/6851 , A61K47/6877 , A61K49/0004 , C07K16/30 , C07K2317/732 , C07K2317/77
摘要： The present invention relates to a novel monoclonal antibody reactive with human carcinoma cells. More particularly, the antibody of the invention is a monoclonal antibody reactive with a glycolipid cell membrane antigen on the surface of human carcinomas. The antibody displays a high degree of selectivity for carcinoma cells, showing a low degree of reactivity with certain normal human cells and no detectable reactivity with other types of tumors such as lymphomas, sarcomas or melanomas. In addition, the antibody of the invention is capable of internalizing within the carcinoma cells to which it binds and is therefore particularly useful for therapeutic applications, for example, as the antibody component of antibody-drug or antibody-toxin conjugates.
摘要翻译： 本发明涉及与人癌细胞反应的新型单克隆抗体。 更具体地，本发明的抗体是与人类癌的表面上的糖脂细胞膜抗原反应的单克隆抗体。 该抗体对癌细胞显示出高度的选择性，显示与某些正常人细胞的反应性低，并且与其他类型的肿瘤如淋巴瘤，肉瘤或黑素瘤无可检测的反应性。 此外，本发明的抗体能够在其结合的癌细胞内部化，因此特别可用于治疗应用，例如作为抗体药物或抗体 - 毒素缀合物的抗体组分。
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