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公开(公告)号：EP1807059A1
公开(公告)日：2007-07-18
申请号：EP05794809.3
申请日：2005-10-05
发明人： LEONARDI, Amedeo , BERLATI, Fabio , PONTELLO, Lino
IPC分类号： A61K9/48 , A61K31/4422
CPC分类号： A61K31/455 , A61K9/4858 , A61K9/4866 , A61K31/4422
摘要： A modified release pharmaceutical composition comprises lercanidipine dissolved in a waxy substance comprising a polyalcohol fatty acid ester, the solution being contained within a pharmaceutically acceptable capsule. Preferably the polyalcohol fatty acid ester is a polyethylene glycol ester, a polypropylene glycol ester, a fatty acid glyceride or a mixture of two or more thereof. Most preferably, the polyalcohol fatty acid ester is a mixture of mono-, di- and triglycerides and polyethylene glycol mono- and diesters. Oral administration of the modified release pharmaceutical compositions to a patient has been shown to result in a mean lercanidipine plasma concentration of greater than 0.5 ng/ml for 24 hours after administration.
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公开(公告)号：EP1799644A1
公开(公告)日：2007-06-27
申请号：EP05776228.8
申请日：2005-08-22
IPC分类号： C07D211/90 , A61K31/4422 , A61P9/12
CPC分类号： C07D211/90
摘要： The invention relates to new addition salts comprising lercanidipine and an acid counterion selected from the group consisting of: (i) inorganic acids, (ii) sulphonic acids, (iii) monocarboxylic acids, (iv) dicarboxylic acids, (v) tricarboxylic acids, and (vi) aromatic sulphonimides, with the proviso that said acid counterion is not hydrochloric acid. In particular, both amorphous and crystalline salts of lercanidipine with benzenesulphonic and naphthalene- 1,5-disulphonic acids are disclosed, as are amorphous salts of lercanidipine with several other acid counterions.
摘要翻译： （i）无机酸，（ii）磺酸，（iii）一元羧酸，（iv）二元羧酸，（v）三元羧酸， 和（vi）芳族磺酰亚胺，条件是所述酸抗衡离子不是盐酸。 具体而言，公开了苯基磺酸和萘-1,5-二磺酸的乐卡地平的无定形盐和结晶盐，以及具有几种其他酸抗衡离子的乐卡地平的无定形盐。
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13.发明公开THE METHOD OF MAKING OPTICALLY ACTIVE ESTER DERIVATIVES AND THEIR ACIDS FROM RACEMIC ESTERS 审中-公开工艺生产光学活性酯衍生物及其氨基酸而RACE混音酯
公开(公告)号：EP1740714A1
公开(公告)日：2007-01-10
申请号：EP05764804.0
申请日：2005-04-27
申请人： Enzytech, Ltd.
发明人： HWANG, Soon Ook , CHUNG, Sun Ho
IPC分类号： C12P41/00
CPC分类号： C12P41/005 , C12P7/62 , C12P13/001 , C12P13/002
摘要： The present invention relates to process for the preparing of optically active ester derivatives and their acid derivatives which are used intensively as important chiral intermediates from racemic β-hydroxybutyl ester derivatives. In more detail, this invention relates to the process for preparing optically active β-hydroxybutyl ester derivatives and their acid derivatives by stere-ospecific hydrolysis of racemic β-hydroxybutyl ester derivatives using Upases or lipase-producing microorganisms in the aqeous phase or organic phase including aqeous solvent. The method of making optically active ester derivatives and their acid derivatives by hydrolysis of β-hydroxybutyl ester derivatives represented by the general formula 1 in scheme 1 is easier and more economical comparing to the conventional methods and the products have high optical purity. Also separation of ester derivatives from acid derivatives is easy after reaction. Thus this method is a useful process on the industrial scale.
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公开(公告)号：EP1315747B1
公开(公告)日：2006-03-29
申请号：EP01980332.9
申请日：2001-09-03
申请人： Cellpep S.A.
IPC分类号： C07K14/435 , A61K38/17 , A01N63/02
CPC分类号： C07K14/43522 , A61K38/00
摘要： Derivatives of Maurotoxin (MTX) in which the native disulfide bridge pattern (Cys3-Cys24, Cys9-Cys29, Cys19, Cys31-Cys34) has been disrupted are useful for the treatment of pathologies associated with dysfunctioning and/or activation of Ca -activated and/or voltage-gated K channel subtypes, such as IKCa1 or Kv1.2. One preferred group of derivatives is that in which one or more of the Cys residues have been replaced with
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公开(公告)号：EP1219143B1
公开(公告)日：2005-06-15
申请号：EP00962065.9
申请日：2000-09-08
CPC分类号： H05B3/845 , A47G1/02 , G02B7/1815 , H05B3/86
摘要： An anti-fogging mirror assembly (10) comprises a mirrored sheet (12), a second sheet (16), and a bonding medium (18) adapted to bond together the mirrored sheet (12) and the second sheet (16). The bonding medium (18) has embedded in it a heating pad (20) in the form of an electrical resistance heating element, which, when it is supplied with electrical energy, heats the mirrored sheet (12) such that any moisture on the mirrored sheet (12) is evaporated, and condensation of moisture on the mirrored sheet (12) is prevented. The heating element (20) may be in the form of a polyester substrate printed with a conductive ink, and electrical energy to the heating element (20) may be supplied through upper (68) and lower (26) bus bars. A thermostat (54) may be provided such that when the heating element (20) reaches a predetermined temperature electrical energy is no longer supplied to the heating element (20).
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17.发明公开METHOD FOR MANUFACTURING ANIMAL FOOD AND PLASTIC BAG TYPE AIR-TIGHT FERMENTATION CONTAINER SUITABLE FOR THE SAME 审中-公开用于生产饲料和确保采取适当PLASTIC BAG LIKE密闭的容器内发酵
公开(公告)号：EP1406511A1
公开(公告)日：2004-04-14
申请号：EP02724811.1
申请日：2002-05-10
申请人： Lee, Suk-Min , Yu, Xian-ze
发明人： Lee, Suk-Min , Yu, Xian-ze
IPC分类号： A23K1/00
CPC分类号： B65D77/225 , A23K30/18
摘要： A method for producing an animal feed has the steps of: cultivating funguses including actinomycess, deotrichum candidum, cellulose mono-saturated bacteria, lactic ferments, phycolmycete, protist, tirchoderma, saccharomyces cerevisiae, candida utilis, and aspergillus niger; producing fermenter by cultivating funguses to be fermented and then drying the cultivated funguses, and then by mixing the cultivated and dried funguses with sodium chloride, catalyzer and calcium oxide; mixing the produced fermenter with a raw material for the animal feed, the raw material being a mixture of one or more of grain, stem of field crop, power of plants, feces of livestock, waste of industrial ferments; and putting the mixture of the raw material and the fermenter in a sealed container, the sealed container being formed of different types of plastic film in multiple layers, and has a check valve formed on one side.
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18.发明公开
公开(公告)号：EP1239628A3
公开(公告)日：2003-05-14
申请号：EP01205056.3
申请日：2001-12-20
申请人： Sega Corporation
发明人： Tanaka, Tetsuya , Hoshino, Kenji
CPC分类号： H04N5/04 , A63F13/12 , A63F13/338 , A63F13/358 , A63F2300/409 , H04H20/67 , H04N5/08 , H04N5/10
摘要： A plurality of terminal devices, e.g., game apparatuses 2 are interconnected to each other through a network 4. The respective game apparatuses 2 receive signals inputted from the outside, e.g., television signals broadcast from a broadcasting antenna and extract synchronizing signals from the broadcasting signals. Based on the extracted synchronizing signals, the respective game apparatuses 2 make synchronization control of operations, data communication among the respective game apparatuses 2. The respective game apparatuses 2 use the common signals to make the synchronization control, whereby the respective game apparatuses 2 can be synchronized with one another suitably without timing shift. The terminal devices synchronizing method can suitably synchronize timings of communication among a plurality of terminal devices.
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公开(公告)号：EP1273840A2
公开(公告)日：2003-01-08
申请号：EP02076749.7
申请日：2002-05-01
申请人： KNI Incorporated
发明人： Klaymar, Edward J.
CPC分类号： F16L1/028
摘要： An improved method for supporting an underground pipeline (12) in an excavated trench (14) is disclosed. The method involves supporting the pipeline (12) on specially-designed support benches (20) at spaced intervals. The benches (20) are designed to fail when exposed to a predetermined load, which load will be placed on the benches (20) at some point during the backfilling of the trench (14) or when the pipeline (12) undergoes hydrostatic testing. When the benches (20) fail, the fill (24) under the pipeline (12) is compacted and thereby supports the pipeline (12) in lieu of the support benches (20).
摘要翻译： 公开了一种用于在挖掘的沟槽（14）中支撑地下管道（12）的改进方法。 该方法涉及以特定设计的支撑台（20）以间隔的间隔支撑管道（12）。 这些长凳（20）被设计成在暴露于预定载荷时失效，该载荷将在回填（14）期间的某个点处或者在管道（12）经历水压试验时被放置在长凳（20）上。 当平台（20）失效时，管道（12）下的填充物（24）被压实，从而支撑管道（12）以代替支撑台（20）。
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公开(公告)号：EP0969435A2
公开(公告)日：2000-01-05
申请号：EP99304924.6
申请日：1999-06-23
申请人： Dhameja, Raj Kumar
CPC分类号： G08B21/0286
摘要： The invention provides a personal tracking system suitable for rapidly and accurately identifying the location of a missing child. The child carries a mobile transmitter unit which is preferably a transceiver, and that transmitter unit communicates with a portable receiver unit carried by the parent or responsible adult. The portable receiver unit is also preferably a transceiver. The mobile transmitter unit is incorporated into a wrist or ankle bracelet to be worn by the child, and is provided with enabling and disabling means. The transmitter unit transmits an emergency signal if the bracelet is severed or removed while the transmitter unit is enabled, and optionally incorporates a panic button for generating the emergency signal even without removal of the bracelet. The transmitter unit also includes means for transmitting a location signal when activated. The receiver unit receives the emergency signal to notify the parent or responsible adult that the child is in need of assistance, and also receives the location signal and translates that signal into a visual display of information.
摘要翻译： 本发明提供了一种个人跟踪系统，适用于快速准确地识别失踪儿童的位置。 儿童携带优选为收发器的移动发射器单元，并且该发射器单元与由父母或负责任的成人携带的便携式接收器单元通信。 便携式接收器单元也优选为收发器。 移动发射器单元被结合到手腕或脚踝手镯中以供儿童佩戴，并且配备有启用和禁用装置。 如果在启用发射器单元的情况下手链被切断或移除，则发送器单元发送紧急信号，并且可选地包含用于即使不移除手镯也生成紧急信号的应急按钮。 发射机单元还包括用于在被激活时发射位置信号的装置。 接收器单元接收紧急信号以通知父母或责任成人该孩子需要帮助，并且还接收该位置信号并将该信号翻译成信息的视觉显示。
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