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75 条记录 (耗时 0.022 秒)

    TISSUE PLUG
    11.
    发明公开
    TISSUE PLUG 有权
    GEWEBESTECKER

    公开(公告)号：EP2345433A1

    公开(公告)日：2011-07-20

    申请号：EP09819170.3

    申请日：2009-10-06

    申请人： 3-D Matrix, Ltd.

    发明人： TAKAMURA, Kentaro ,  GOJO, Satoshi ,  KOBAYASHI, Satoru

    IPC分类号： A61L17/00 ,  A61K38/00 ,  A61L31/00 ,  A61P7/04

    CPC分类号： A61K38/10 ,  A61K31/7004 ,  A61K31/7016 ,  A61K38/08 ,  A61K38/16 ,  A61L31/047 ,  A61L31/148 ,  A61L2400/04 ,  A61L2430/36 ,  C07K7/06 ,  C07K7/08

    摘要： There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like.
    The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a β-structure in aqueous solution in the presence of physiological pH and/or a cation.

    摘要翻译： 提供了可应用于包括人在内的大型哺乳动物的生物可吸收肽组织封闭剂，通过人工合成获得的肽组织闭塞剂，以避免病毒感染等的担忧。 组织闭塞剂含有肽，其中肽是具有8-200个氨基酸残基的亲水性肽，亲水性氨基酸和疏水性氨基酸交替键合，并且是在水溶液中显示出2-结构的自组装肽 生理pH和/或阳离子的存在。

    WOUND HEALING/SKIN RECONSTRUCTION MATERIAL
    12.
    发明公开
    WOUND HEALING/SKIN RECONSTRUCTION MATERIAL 有权
    材料ZUR WUNDHEILUNG / HAUTREKONSTRUKTION

    公开(公告)号：EP2229960A1

    公开(公告)日：2010-09-22

    申请号：EP08857996.6

    申请日：2008-12-04

    申请人： 3-D Matrix, Ltd.

    发明人： TAKAMURA, Kentaro ,  TAKEI, Jiro

    IPC分类号： A61L15/64 ,  A61L27/00

    CPC分类号： A61K38/10 ,  A61K38/1825 ,  A61L27/227 ,  A61L27/54 ,  A61L27/60 ,  A61L2300/25 ,  A61L2300/412 ,  A61L2300/45

    摘要： The invention relates to a material for wound healing and skin reconstruction containing a peptide, wherein the peptide is a self-assembling peptide which is an amphiphilic peptide having 8 to 200 amino acid residues with periodic repeats of alternating hydrophilic amino acids and hydrophobic amino acids, and forms a stable β-sheet structure in an aqueous solution in the presence of a monovalent ion. The material for wound healing and skin reconstruction of the present invention is capable of healing a wound area of mammals quicker than spontaneous recovery without leaving any scars, wherein the material has no potential risk of infectious disease such as virus transmission.

    摘要翻译： 本发明涉及包含肽的伤口愈合和皮肤重建材料，其中肽是自组装肽，其是具有8至200个氨基酸残基并具有交替的亲水氨基酸和疏水性氨基酸的周期性重复的两亲肽， 并在一价离子的存在下在水溶液中形成稳定的2片结构。 用于本发明的伤口愈合和皮肤重建的材料能够比自发恢复更快地愈合哺乳动物的伤口区域，而不会留下任何疤痕，其中该材料不具有感染性疾病如病毒传播的潜在风险。

    SELF-ASSEMBLING PEPTIDE COMPOSITIONS
    14.
    发明公开
    SELF-ASSEMBLING PEPTIDE COMPOSITIONS 审中-公开

    公开(公告)号：EP3466965A1

    公开(公告)日：2019-04-10

    申请号：EP18203220.1

    申请日：2015-03-10

    申请人： 3-D Matrix Ltd.

    发明人： GIL, Eun Seok ,  GILBERT, Karl ,  MEHTA, Manav

    IPC分类号： C07K7/08 ,  A61L27/22 ,  A61K38/12 ,  A61L27/54 ,  A61L27/58

    摘要： The present disclosure provides peptide compositions (e.g., of self-assembling peptides) with particular attributes (e.g., peptide identity, peptide concentration, pH, ionic strength [including salt identity and/or concentration), etc that show particularly useful material properties. The present disclosure also provides technologies for selecting and/or formulating particular peptide compositions useful in specific contexts. In some embodiments, provided peptide compositions have an elevated pH within the range of about 2.5 to about 3.5 and/or an ionic strength that is above that of a corresponding composition of the same peptide, at the same concentration, in water, but is below a critical salt point for the peptide (e.g., so that the composition is not cloudy).

    TISSUE PLUG
    18.
    发明公开
    TISSUE PLUG 审中-公开
    组织塞

    公开(公告)号：EP3238749A1

    公开(公告)日：2017-11-01

    申请号：EP17152928.2

    申请日：2009-10-06

    申请人： 3-D Matrix Ltd.

    发明人： TAKAMURA, Kentaro ,  GOJO, Satoshi ,  KOBAYASHI, Satoru

    IPC分类号： A61L17/00 ,  A61K38/00 ,  A61L31/00 ,  A61P7/04 ,  A61L31/04 ,  A61L31/14

    CPC分类号： A61K38/10 ,  A61K31/7004 ,  A61K31/7016 ,  A61K38/08 ,  A61K38/16 ,  A61L31/047 ,  A61L31/148 ,  A61L2400/04 ,  A61L2430/36 ,  C07K7/06 ,  C07K7/08

    摘要： There is provided a bioabsorbable peptide tissue occluding agent that can be applied to large mammals including humans, the peptide tissue occluding agent being obtained by artificial synthesis to avoid concerns of infection by viruses and the like.
    The tissue occluding agent contains a peptide, wherein the peptide is an amphiphilic peptide having 8-200 amino acid residues with the hydrophilic amino acids and hydrophobic amino acids alternately bonded, and is a self-assembling peptide exhibiting a β-structure in aqueous solution in the presence of physiological pH and/or a cation.

    摘要翻译： 提供了可应用于包括人在内的大型哺乳动物的生物可吸收肽组织闭塞剂，所述肽组织闭塞剂通过人工合成获得以避免病毒感染等问题。 组织闭塞剂含有肽，其中肽为具有8-200个氨基酸残基且亲水性氨基酸和疏水性氨基酸交替键合的两亲性肽，并且是在水溶液中呈现β-结构的自组装肽 生理pH值和/或阳离子的存在。