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公开(公告)号：EP3302486B1
公开(公告)日：2020-09-30
申请号：EP16804194.5
申请日：2016-05-31
发明人： SHEN, Dong-Ming , DWYER, Michael P. , SINZ, Christopher J. , WANG, Deping , STACHEL, Shawn , PAONE, Daniel V. , FORSTER, Ashley , BERGER, Richard , CHEN, Yili , QIAN, Yimin , XU, Shimin , HU, Chunmei
IPC分类号： A61K31/519 , A61P25/28 , C07D487/04
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公开(公告)号：EP3302484B1
公开(公告)日：2020-09-16
申请号：EP16804001.2
申请日：2016-05-24
发明人： SHEN, Dong-Ming , DWYER, Michael, P. , SINZ, Christopher, J. , WANG, Deping , STACHEL, Shawn, J. , PAONE, Daniel, V. , FORSTER, Ashley , BERGER, Richard , SHIPE, William, D. , CHEN, Yili , QIAN, Yimin , XU, Shimin , HU, Chunmei , FU, Jianmin , GUO, Zhigang , LI, Haitang , BO, Yingjian
IPC分类号： A61K31/519 , A61P25/28 , C07D487/04
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公开(公告)号：EP3087060B1
公开(公告)日：2020-05-13
申请号：EP14873215.9
申请日：2014-12-17
发明人： SHEN, Dong-Ming , EGBERTSON, Melissa , BERGER, Richard , QIAN, XiaoXia , QIAN, Yimin , HARPER, Bart , YANG, Meng , GUO, Zack Zhi Qiang , RADA, Vanessa L. , WANG, Deping , CERNAK, Timothy A. , SINZ, Christopher J. , WANG, Ming , WILSON, Jonathan E. , XU, Shimin
IPC分类号： C07D239/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , A61K31/513 , A61P25/18 , A61P25/22 , A61P25/28
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14.发明授权
公开(公告)号：EP3233859B1
公开(公告)日：2019-08-07
申请号：EP15870726.5
申请日：2015-12-10
发明人： SILIPHAIVANH, Phieng , SLOMAN, David L. , WITTER, David , MANSOOR, Umar Faruk , KOZLOWSKI, Joseph , LIU, Ziping , FU, Jianmin , WAN, Zhilong , LIU, Wei , QIAN, Yimin , HUANG, Xianhai
IPC分类号： C07D471/04
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公开(公告)号：EP3116862B1
公开(公告)日：2019-04-17
申请号：EP15760695.5
申请日：2015-03-06
发明人： WILLIAMS, Peter D. , MCCAULEY, John A. , BUNGARD, Christopher J. , BENNETT, David Jonathan , WADDELL, Sherman T. , MORRIELLO, Gregori J. , CHANG, Lehua , DWYER, Michael P. , HOLLOWAY, M. Katharine , CRESPO, Alejandro , CHU, Xin-Jie , WISCOUNT, Catherine , LOUGHRAN, H. Marie , MANIKOWSKI, Jesse J. , KEERTIKAR, Kartik M. , HU, Bin , ZHONG, Bin , JI, Tao
IPC分类号： C07D513/08 , A61K31/554 , A61P31/18
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公开(公告)号：EP3197452A1
公开(公告)日：2017-08-02
申请号：EP15844485.1
申请日：2015-09-23
发明人： CAI, Jiaqiang , CRESPO, Alejandro , DEBENHAM, John , DU, Xiaoxing , LIU, Ping , LIU, Rongqiang , MADSEN-DUGGAN, Cristina, B. , QUAN, Weiguo , SINZ, Christopher , WANG, Liping
IPC分类号： A61K31/4355
CPC分类号： C07D495/04 , A61P7/06 , C07D491/048
摘要： The present invention concerns compounds of formula I or a pharmaceutically acceptable salt thereof which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
摘要翻译： 本发明涉及抑制HIF脯氨酰羟化酶的式I化合物或其药学上可接受的盐，它们用于增强促红细胞生成素的内源性产生，以及用于治疗与促红细胞生成素内源性产生减少有关的病症，例如贫血等疾病，以及 包含这种化合物和药物载体的药物组合物。
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公开(公告)号：EP3027593A4
公开(公告)日：2017-03-29
申请号：EP14832049
申请日：2014-07-29
发明人： WILLIAMS PETER D , MCCAULEY JOHN A , BENNETT DAVID J , BUNGARD CHRISTOPHER J , CHANG LEHUA , CHU XIN-JIE , DWYER MICHAEL P , HOLLOWAY M KATHERINE , KEERTIKAR KARTIK M , LOUGHRAN H MARIE , MANIKOWSKI JESSE J , MORRIELLO GREGORI J , SHEN DONG-MING , SHERER EDWARD C , SCHULZ JURGEN , WADDELL SHERMAN TIM , WISCOUNT CATHERINE M , ZORN NICOLAS , SATYANARAYANA TUMMANAPALLI , VIJAYASARADHI SIVALENKA , HU BIN , JI TAO , ZHONG BIN
IPC分类号： C07D401/14 , A61K31/496 , A61P31/18 , C07D241/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D241/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
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公开(公告)号：EP3122346A2
公开(公告)日：2017-02-01
申请号：EP15769367.2
申请日：2015-03-23
发明人： MITCHELL, Helen , FRALEY, Mark, E. , COOKE, Andrew, J. , CHEN, Yi-Heng , STUMP, Craig, A. , ZHANG, Xu-Fang , MCCOMAS, Casey, C. , SCHIRRIPA, Kathy , MCWHERTER, Melody , MERCER, Swati, P. , BABAOGLU, Kerim , MENG, Dongfang , WU, Jane , LIU, Ping , WOOD, Harold, B. , BAO, Jianming , LI, Chun Sing , MAO, Qinghua , QI, Zhiqi
IPC分类号： A61K31/166 , C07D471/04
摘要： The present invention is directed to six membered heteroaryl benzamide compounds of formula (I), which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor TrkA.
摘要翻译： 本发明涉及式（I）的六元杂芳基苯甲酰胺化合物，它们是原肌球蛋白相关激酶（Trk）家族蛋白激酶抑制剂，因此可用于治疗疼痛，炎症，癌症，再狭窄，动脉粥样硬化，银屑病 ，血栓形成，与神经生长因子（NGF）受体TrkA的异常活性有关的与髓鞘形成障碍或脱髓鞘有关的疾病，病症，损伤或功能障碍或疾病或病症。
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公开(公告)号：EP3116862A1
公开(公告)日：2017-01-18
申请号：EP15760695.5
申请日：2015-03-06
发明人： WILLIAMS, Peter D. , MCCAULEY, John A. , BUNGARD, Christopher J. , BENNETT, David Jonathan , WADDELL, Sherman T. , MORRIELLO, Gregori J. , CHANG, Lehua , DWYER, Michael P. , HOLLOWAY, M. Katharine , CRESPO, Alejandro , CHU, Xin-Jie , WISCOUNT, Catherine , LOUGHRAN, H. Marie , MANIKOWSKI, Jesse J. , KEERTIKAR, Kartik M. , HU, Bin , ZHONG, Bin , JI, Tao
IPC分类号： C07D281/10 , C07D241/36
CPC分类号： C07D513/08 , A61K31/554 , A61K45/06
摘要： The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
摘要翻译： 本发明涉及式I化合物，包含其的药物组合物，以及它们在抑制HIV蛋白酶，抑制HIV复制，预防HIV感染，治疗HIV感染以及预防， 治疗和延缓艾滋病的发病或进展。
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20.发明公开
公开(公告)号：EP3027593A2
公开(公告)日：2016-06-08
申请号：EP14832049.2
申请日：2014-07-29
发明人： WILLIAMS, Peter D. , MCCAULEY, John A. , BENNETT, David J. , BUNGARD, Christopher J. , CHANG, Lehua , CHU, Xin-Jie , DWYER, Michael P. , HOLLOWAY, M. Katherine , KEERTIKAR, Kartik M. , LOUGHRAN, H. Marie , MANIKOWSKI, Jesse J. , MORRIELLO, Gregori J. , SHEN, Dong-Ming , SHERER, Edward C. , SCHULZ, Jurgen , WADDELL, Sherman Tim , WISCOUNT, Catherine M. , ZORN, Nicolas , SATYANARAYANA, Tummanapalli , VIJAYASARADHI, Sivalenka , HU, Bin , JI, Tao , ZHONG, Bin
IPC分类号： C07D295/088
CPC分类号： C07D241/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
摘要翻译： 本发明涉及哌嗪衍生物，包含它们的药物组合物及其在抑制HIV蛋白酶中的用途，HIV复制的抑制，HIV预防感染，HIV感染治疗以及预防，治疗 ，并延迟艾滋病的发病或进展。
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