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1.发明公开
公开(公告)号：EP3087060A1
公开(公告)日：2016-11-02
申请号：EP14873215.9
申请日：2014-12-17
发明人： SHEN, Dong-Ming , EGBERTSON, Melissa , BERGER, Richard , QIAN, XiaoXia , QIAN, Yimin , HARPER, Bart , YANG, Meng , GUO, Zack Zhi Qiang , RADA, Vanessa L. , WANG, Deping , CERNAK, Timothy A. , SINZ, Christopher J. , WANG, Ming , WILSON, Jonathan E. , XU, Shimin
IPC分类号： C07D239/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , A61K31/513 , A61P25/18 , A61P25/22 , A61P25/28
CPC分类号： C07D239/36 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D487/04
摘要： Disclosed are pyrimidine carboxamide compounds of formula (I) which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2), pharmaceutical compositions and uses thereof.
摘要翻译： 公开了式（I）的嘧啶羧酰胺化合物，其可用作治疗与磷酸二酯酶2（PDE2）相关的中枢神经系统疾病，药物组合物及其用途的治疗剂。
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公开(公告)号：EP3087060B1
公开(公告)日：2020-05-13
申请号：EP14873215.9
申请日：2014-12-17
发明人： SHEN, Dong-Ming , EGBERTSON, Melissa , BERGER, Richard , QIAN, XiaoXia , QIAN, Yimin , HARPER, Bart , YANG, Meng , GUO, Zack Zhi Qiang , RADA, Vanessa L. , WANG, Deping , CERNAK, Timothy A. , SINZ, Christopher J. , WANG, Ming , WILSON, Jonathan E. , XU, Shimin
IPC分类号： C07D239/36 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , A61K31/513 , A61P25/18 , A61P25/22 , A61P25/28
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公开(公告)号：EP3368036A1
公开(公告)日：2018-09-05
申请号：EP16860556.6
申请日：2016-10-24
发明人： XU, Jiayi , ALI, Amjad , ZHOU, Wei , GAO, Ying-Duo , EDMONDSON, Scott, D. , MERTZ, Eric , NEELAMKAVIL, Santhosh, F. , LIU, Weiguo , SUN, Wanying , SHEN, Dong-Ming , HARPER, Bart , ZHU, Cheng , BARA, Thomas , LIM, Yeon-Hee , YANG, Meng
IPC分类号： A61K31/44 , A61K31/4418 , A61K31/4427 , C07D213/02 , C07D213/04 , C07D401/06
CPC分类号： C07D401/14 , A61K45/06 , A61P7/02 , C07D401/04 , C07D413/14 , C07D471/08 , C07D487/04 , C07D487/08 , C07D513/08
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma Kallikrein.
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公开(公告)号：EP2274296B1
公开(公告)日：2012-10-17
申请号：EP09726940.1
申请日：2009-03-23
发明人： BERGER, Richard , CHANG, Lehua , EDMONDSON, Scott, D. , GOBLE, Stephen, D. , HARPER, Bart , KAR, Nam, Fung , KOPKA, Ihor, E. , LI, Bing , MORRIELLO, Gregori, J. , MOYES, Chris, R. , SHEN, Dong-ming , WANG, Liping , WENDT, Harvey , ZHU, Cheng
IPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , A61K31/4406 , A61P13/10
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04 , C07D495/04
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公开(公告)号：EP2470021A1
公开(公告)日：2012-07-04
申请号：EP10812498.3
申请日：2010-08-17
发明人： EDMONDSON, Scott, D. , BERGER, Richard , CHANG, Lehua , COLANDREA, Vincent, J. , HALE, Jeffrey, J. , HARPER, Bart , KAR, Nam Fung , LI, Bing , MORRIELLO, Gregori, J. , MOYES, Christopher, R. , SHA, Deyou , SHEN, Dong-Ming , WANG, Liping , WENDT, Harvey, R. , ZHU, Cheng
CPC分类号： C07D403/14 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/048 , C07D491/107 , C07D491/147 , C07D491/20 , C07D495/10 , C07D495/20 , C07D497/10 , C07D498/04 , C07D513/04 , C07D513/20
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
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公开(公告)号：EP2274296A1
公开(公告)日：2011-01-19
申请号：EP09726940.1
申请日：2009-03-23
发明人： BERGER, Richard , CHANG, Lehua , EDMONDSON, Scott, D. , GOBLE, Stephen, D. , HARPER, Bart , KAR, Nam, Fung , KOPKA, Ihor, E. , LI, Bing , MORRIELLO, Gregori, J. , MOYES, Chris, R. , SHEN, Dong-ming , WANG, Liping , WENDT, Harvey , ZHU, Cheng
IPC分类号： C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , A61K31/4406 , A61P13/10
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/14 , C07D487/04 , C07D495/04
摘要： The present invention provides compounds of Formula I, pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor.
摘要翻译： 本发明提供了式I化合物，其药物组合物及其在治疗或预防由β3-肾上腺素受体激活介导的疾病中的使用方法。
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7.发明授权AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 有权氨基哌啶，ALS二肽基肽酶IV抑制剂为糖尿病治疗或预防
公开(公告)号：EP1796669B1
公开(公告)日：2010-09-22
申请号：EP05802868.9
申请日：2005-09-27
IPC分类号： A61K31/445 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/525 , C07D237/26 , C07D239/00 , C07D239/70 , C07D239/72 , C07D241/00 , C07D241/36 , C07D401/04 , C07D471/04 , C07D491/04 , C07D487/00
CPC分类号： C07D401/04 , C07D471/04 , C07D487/04
摘要： The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme ('DPP-IV inhibitors') and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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公开(公告)号：EP3294297B1
公开(公告)日：2019-12-18
申请号：EP16796942.7
申请日：2016-05-10
发明人： SHEN, Dong-Ming , QIAN, XiaoXia , HARPER, Bart , YANG, Meng , WANG, Deping , BO, Yingjian
IPC分类号： A61K31/505 , A61K31/513 , C07D233/96 , C07D239/24
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公开(公告)号：EP3258929A1
公开(公告)日：2017-12-27
申请号：EP16752841.3
申请日：2016-02-12
发明人： MENG, Dongfang , LI, Hong , YANG, Meng , RUIZ, Manuel de Lera , DEWNANI, Sunita, V. , JIAN, Tianying , PARKER, Dann, L., Jr. , ZHANG, Ting , CAMPEAU, Louis-Charles , HARPER, Bart , WOOD, Harold, B. , XU, Jiayi , BERGER, Richard , WU, Jane Yang , ORR, Robert, K. , WALSH, Shawn, P.
IPC分类号： A61K31/33 , A61K31/41 , A61K31/395 , A61K31/4164 , A61K31/4184
CPC分类号： C07D471/04 , C07D403/12 , C07D413/14 , C07D417/14 , C07D471/14 , C07D498/04 , C07D513/04
摘要： The present invention provides a compound of Formula I and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing unstable angina, refractory angina, myocardial infarction, transient ischemic attacks, atrial fibrillation, thrombotic stroke, embolic stroke, deep vein thrombosis, disseminated intravascular coagulation, ocular build up of fibrin, and reocclusion or restenosis of recanalized vessels. The compounds are selective Factor IXa inhibitors.
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10.发明公开
公开(公告)号：EP3097101A1
公开(公告)日：2016-11-30
申请号：EP15740935.0
申请日：2015-01-20
发明人： BERGER, Richard , BLIZZARD, Timothy A. , CAMPBELL, Brian T. , CHEN, Helen Y. , DEBENHAM, John S. , DEWNANI, Sunita V. , DUBOIS, Byron , GUDE, Candido , GUO, Zhiqiang , HARPER, Bart , HU, Zhiyong , LIN, Songnian , LIU, Ping , WANG, Ming , UJJAINWALLA, Feroze , XU, Jiayi , XU, Libo , ZHANG, Rui
IPC分类号： C07D471/04
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D413/12 , C07D417/14 , C07D471/04
摘要： The compounds of Formula I act as MGAT2 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperlipidemia, diabetes mellitus and obesity.
摘要翻译： 式I的化合物作为MGAT2抑制剂，可用于预防，治疗或作为高脂血症，糖尿病和肥胖症的补救剂。
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