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公开(公告)号：EP1595182B1
公开(公告)日：2015-09-30
申请号：EP04709242.4
申请日：2004-02-09
Applicant: BASF SE
Inventor： YAMATO, Hitoshi , ASAKURA, Toshikage , MATSUMOTO, Akira , MURER, Peter , HINTERMANN, Tobias
IPC: C07C251/48 , C07C381/00 , C07D209/86 , C07D307/91 , C07D333/76 , G03F7/004
CPC classification number: C07C251/48 , B33Y70/00 , C07C381/00 , C07C2603/18 , C07C2603/20 , C07C2603/40 , C07D209/86 , C07D307/91 , C07D333/76 , G03F7/0007 , G03F7/0045 , G03F7/0046 , G03F7/0382 , G03F7/0392
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公开(公告)号：EP1769286B1
公开(公告)日：2015-09-09
申请号：EP05774169.6
申请日：2005-07-11
Applicant: BASF SE
Inventor： YAMATO, Hitoshi , ASAKURA, Toshikage , HINTERMANN, Tobias
IPC: C07C309/65 , C07C309/67 , C07C309/73 , C07C309/74 , C07C309/75 , C07C381/00 , C07D209/86 , C07F9/09 , G03F7/00 , G03F7/004 , G03F7/038 , G03F7/039
CPC classification number: C07C309/67 , B33Y70/00 , C07C309/65 , C07C309/73 , C07C309/74 , C07C309/75 , C07C381/00 , C07C2603/18 , C07C2603/20 , C07C2603/66 , C07D209/86 , C07F9/097 , G03F7/0007 , G03F7/0045 , G03F7/0382 , G03F7/0392 , Y10S430/12
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13.发明公开MULTICOMPONENT CRYSTALS COMPRISING IMATINIB MESILATE AND SELECTED CO-CRYSTAL FORMERS 审中-公开用甲磺酸伊马替尼多个组件，液晶与SELECTED共晶体成型机
公开(公告)号：EP2864313A1
公开(公告)日：2015-04-29
申请号：EP13729371.8
申请日：2013-06-18
Applicant: BASF SE
Inventor： CHIODO, Tiziana , HELLMANN, Rolf , VOSSEN, Marcus , SALVADOR, Beate , HAFNER, Andreas , HINTERMANN, Tobias
IPC: C07D401/04 , A61K31/505 , A61P35/02
CPC classification number: C07D401/04 , C07B2200/13 , C07C55/10 , C07C57/15 , C07C63/06
Abstract: Novel solid forms of imatinib mesilate comprising as active ingredient 4-[(4-methyl-1- piperazinyl) methyl] –N –[4-methyl-3-[ [4-(3-pyridinyl)-2-pyrimidinyl] amino]-phenyl]- benzamide methanesulfonic acid saltand as co-crystal former benzoic acid, fumaric acid or succinic acid are described. The said multi-component crystalline forms possess improved physical and biological properties with respect to the crystalline forms of the active pharmaceutical ingredient previously known.
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公开(公告)号：EP2477738B1
公开(公告)日：2019-01-23
申请号：EP10747638.4
申请日：2010-09-01
Applicant: BASF SE
Inventor： HINTERMANN, Tobias , BAUER, Didier , CARROY, Antoine , LORDELOT, Caroline , KOHLI STECK, Rachel
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公开(公告)号：EP3024830A2
公开(公告)日：2016-06-01
申请号：EP14741630.9
申请日：2014-07-22
Applicant: BASF SE
Inventor： HAFNER, Andreas , BLATTER, Fritz , SZELAGIEWICZ, Martin , SIEBENHAAR, Bernd , CHIODO, Tiziana , HINTERMANN, Tobias , SALVADOR, Beate , VOSSEN, Marcus
IPC: C07D417/12 , A61K31/506
CPC classification number: C07D417/12 , C07B2200/13 , C07D275/06
Abstract: The present invention primarily relates to molecular crystalline substances, preferably salts of Dasatinib in crystalline form, comprising a compound of formula 1, preferably a cation of a compound of formula 1, and a second compound selected from the group consisting of glutaric acid, nicotinic acid and saccharin, preferably an anion thereof. The Invention is further related to pharmaceutical compositions comprising such a substance. Furthermore, the Invention relates to processes for preparing said substances. The invention also relates to several aspects of using said substances or pharmaceutical compositions to treat a disease.
Abstract translation: 本发明主要涉及分子结晶物质，优选结晶形式的达沙替尼盐，其包含式1化合物，优选式1化合物的阳离子和选自戊二酸，烟酸的第二化合物 和糖精，优选其阴离子。 本发明进一步涉及包含这种物质的药物组合物。 此外，本发明涉及制备所述物质的方法。 本发明还涉及使用所述物质或药物组合物治疗疾病的若干方面。
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Patent Agency Ranking16.发明公开MULTICOMPONENT CRYSTALLINE SYSTEM COMPRISING DEFERASIROX AND ISONICOTINAMIDE AND A PROCESS FOR THE PREPARATION THEREOF 有权结晶多组分系统和拉罗司ISONIKOTINAMID及其制造方法
公开(公告)号：EP2880019A1
公开(公告)日：2015-06-10
申请号：EP13750525.1
申请日：2013-08-05
Applicant: BASF SE
Inventor： HAFNER, Andreas , BLATTER, Fritz , RÖDEL, Eva , SZELAGIEWICZ, Martin , CHIODO, Tiziana , HINTERMANN, Tobias , SALVADOR, Beate , VOSSEN, Marcus
IPC: C07D249/08 , A61K31/4196 , A61P7/00
CPC classification number: C07D213/81 , C07B2200/13 , C07D249/08
Abstract: The present invention refers to a multicomponent crystalline system (co-crystal) comprising a compound of formula (1) (4-[3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid; INN:Deferasirox) formula (1) and a compound of formula (2) (Isonicotinamide; pyridine-4-carboxamide) formula (2), as well as to a process for obtaining the same.
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公开(公告)号：EP2828001A1
公开(公告)日：2015-01-28
申请号：EP13710436.0
申请日：2013-03-20
Applicant: BASF SE
Inventor： SCHROF, Wolfgang , MEIER, Thomas , JUNG, Christian Michael , CARROY, Antoine , JUNG, Werner-Alfons , HOFFMANN, Peter , HINTERMANN, Tobias , LORDELOT, Caroline , WALLQUIST, Olof
CPC classification number: B05B7/068 , B05B1/3046 , B05B7/067 , B05B7/2435 , B05D1/02 , B05D1/34 , B05D3/067
Abstract: The subject matter of the present invention is a mobile spray gun, with which radiation curing can be initiated without the operator having to be protected from radiation. This is achieved by a mobile spray gun, comprising a feed channel 2 for a radiation-curable coating compound and a needle 1, which is movable in the longitudinal direction and with which the feed channel 2, which forms an annular gap around the needle 1, can be sealed with respect to the mouth 13 of the feed channel 2, wherein the needle 1 is designed such that it is transmissive to electromagnetic radiation with which curing of the radiation-curable coating compound can be initiated and/or the feed line 12 is designed to be transparent to electromagnetic radiation and a lighting unit 10 is fitted to the feed line 12.
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18.发明公开
公开(公告)号：EP2788344A1
公开(公告)日：2014-10-15
申请号：EP12855925.9
申请日：2012-12-03
Applicant: BASF SE
Inventor： HAFNER, Andreas , HINTERMANN, Tobias , BLATTER, Fritz , RODEL, Eva
IPC: C07D403/10 , A61K31/506 , A61P31/10
CPC classification number: A61K31/506 , A61K31/194 , C07D403/10 , A61K2300/00
Abstract: A novel solid form of Voriconazole comprises the active ingredient (2R,3S)-2-(2,4- difluorophenyl)- 3-(5-fluoropyrimidin- 4-yl)-1 -(1H-1,2,4-triazol-1 -yl)butan-2-ol and fumaric acid. The solid composition comprising the two components shows improved properties such as water solubility, crystallization behavior and stability.
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19.发明公开
公开(公告)号：EP2694211A1
公开(公告)日：2014-02-12
申请号：EP12713685.1
申请日：2012-04-02
Applicant: BASF SE
Inventor： HINTERMANN, Tobias , CARROY, Antoine , LORDELOT, Caroline , BAUER, Didier , KOHLI STECK, Rachel , FALLER, Marc
CPC classification number: C09D175/16 , B01J31/0208 , B01J31/2234 , B01J2231/14 , B01J2231/48 , B01J2531/46 , C08G18/222 , C08G18/6229 , C08G18/68 , C08G18/792 , C09J175/04 , Y02P20/52
Abstract: A titanium-oxo-chelate catalyst formulation, comprising: (i) at least one compound of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 independently of each other are for example hydrogen, halogen, C1-C20alkyl, C6-C14aryl which is unsubstituted or substituted; or R1, R2 and R3 and/or R4, R5 and R6 and/or R7, R8 and R9 and/or R10, R11 and R12 together with the C-atom to which they are attached each form a C6-C14aryl group which is unsubstituted or substituted; or R1 and R2 and/or R4 and R5 and/or R7 and R8 and/or R10 and R11 together with the C-atom to which they are attached form a 5- to 7-membered carbocyclic ring; at least one chelate ligand compound of the formula (IIa), (IIb) or (IIc), wherein R1, R2, R3, R4, R5 and R6 are defined as above for formula (I), is suitable as photolatent catalyst formulation for polymerizing compounds, which are capable to crosslink in the presence of a Lewis acid.
Abstract translation: 一种钛 - 氧代 - 螯合催化剂制剂，其包含：（i）至少一种式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12独立地 彼此是例如氢，卤素，未取代或取代的C 1 -C 20烷基，C 6 -C 14芳基; 或R 1，R 2和R 3和/或R 4，R 5和R 6和/或R 7，R 8和R 9和/或R 10，R 11和R 12与它们所连接的C原子一起形成C 6 -C 14芳基， 未取代或取代的; 或R 1和R 2和/或R 4和R 5和/或R 7和R 8和/或R 10和R 11与它们所连接的C原子一起形成5-至7-元碳环; 至少一种式（IIa），（IIb）或（IIc）的螯合配体化合物，其中R 1，R 2，R 3，R 4，R 5和R 6如上文对式（I）所定义，适合作为用于 能够在路易斯酸存在下交联的聚合化合物。
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公开(公告)号：EP3535519A1
公开(公告)日：2019-09-11
申请号：EP17867729.0
申请日：2017-11-02
Applicant: BASF SE
Inventor： GARRIDO SEGURA, Cristobal , HINTERMANN, Tobias , KOSTRO, Andre , VETTER, Tatjana
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