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公开(公告)号：EP2167499B1
公开(公告)日：2011-12-14
申请号：EP08773422.4
申请日：2008-06-13
发明人： ALLERHEILIGEN, Swen , BAUSER, Marcus , SCHIROK, Hartmut , HÄRTER, Michael , SIEGEL, Stephan , RESTER, Ulrich , GERDES, Christoph , HEITMEIER, Stefan , VON DEGENFELD, Georges , BUCHMÜLLER, Anja , DITTRICH-WENGENROTH, Elke , SAATMANN, Uwe , STRASSBURGER, Julia , GNOTH, Mark, Jean , LANG, Dieter
IPC分类号： C07D413/14 , A61K31/4439 , A61P7/02
CPC分类号： C07D413/14
摘要： The invention relates to novel, substituted oxazolidinones, methods for the production thereof, use thereof for the treatment and/or prophylaxis of diseases, and the use thereof for producing medicaments for the treatment and/or prophylaxis of diseases, in particular thromboembolic disorders.
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公开(公告)号：EP3515947A1
公开(公告)日：2019-07-31
申请号：EP17769050.0
申请日：2017-09-18
发明人： WILMEN, Andreas , BUCHMÜLLER, Anja , TUCKER, Erik
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公开(公告)号：EP3197896B1
公开(公告)日：2019-01-30
申请号：EP15771891.7
申请日：2015-09-22
发明人： ROEHRIG, Susanne , HILLISCH, Alexander , STRASSBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , BUCHMÜLLER, Anja , GERDES, Christoph , SCHÄFER, Martina , TELLER, Henrik , JIMÉNEZ NÚNEZ, Eloisa , SCHIROK, Hartmut , KLAR, Juergen , LOBELL, Mario
IPC分类号： C07D471/04 , A61K31/435 , A61K31/437 , A61P7/02
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公开(公告)号：EP2847228B1
公开(公告)日：2018-07-25
申请号：EP13721746.9
申请日：2013-05-08
发明人： WILMEN, Andreas , STRAßBURGER, Julia , DITTMER, Frank , STRERATH, Michael , BUCHMÜLLER, Anja , GRUDZINSKA-GOEBEL, Joanna , FINNERN, Ricarda , SCHÄFER, Martina , GERDES, Christoph , JÖRIßEN, Hannah , ITAKURA, Asako , Y. LEUNG, Philberta , TUCKER, Erik
IPC分类号： C07K16/36
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： The present invention relates to antibodies capable of binding to the coagulation Factor XI and/or its activated form factor XIa and methods of use thereof, particularly methods of use as agents inhibiting platelet aggregation and by this inhibits thrombus formation.
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公开(公告)号：EP3063150B1
公开(公告)日：2017-11-22
申请号：EP14789580.9
申请日：2014-10-28
发明人： RÖHRIG, Susanne , HILLISCH, Alexander , STRASSBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina, Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , BUCHMÜLLER, Anja , GERDES, Christoph , SCHÄFER, Martina , TELLER, Henrik , JIMENEZ NUNEZ, Eloisa , SCHIROK, Hartmut , KLAR, Jürgen
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
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公开(公告)号：EP3083593A1
公开(公告)日：2016-10-26
申请号：EP14812505.7
申请日：2014-12-16
发明人： BECKER-PELSTER, Eva Maria , BUCHGRABER, Philipp , BUCHMÜLLER, Anja , ENGEL, Karen , GEIß, Volker , GÖLLER, Andreas , HIMMEL, Herbert , KAST, Raimund , KNORR, Andreas , LANG, Dieter , REDLICH, Gorden , SCHMECK, Carsten , TINEL, Hanna , WUNDER, Frank
IPC分类号： C07D401/14 , C07D413/14 , C07D491/107 , C07D495/10 , A61K31/4725
CPC分类号： C07D401/14 , A61K31/4725 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D413/14 , C07D491/107 , C07D495/10
摘要： The present invention relates to novel substituted piperidinyl-tetrahydroquinolines, to a method for the production thereof, to the use thereof for treating and/or preventing diseases, and to the use thereof for producing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for the promotion of wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular diseases of the heart, peripheral and cardiac vascular diseases, thromboembolic diseases and ischaemia, peripheral circulatory disorders, Raynaud's phenomenon, CREST syndrome, micro-circulation disorders, intermittent claudication, and peripheral and autonomic neuropathies.
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公开(公告)号：EP3049410A1
公开(公告)日：2016-08-03
申请号：EP14772148.4
申请日：2014-09-24
发明人： RÖHN, Ulrike , ELLERMANN, Manuel , STRASSBURGER, Julia , WENDT, Astrid , RÖHRIG, Susanne , WEBSTER, Robert Alan , SCHMIDT, Martina Victoria , TERSTEEGEN, Adrian , BEYER, Kristin , SCHÄFER, Martina , BUCHMÜLLER, Anja , GERDES, Christoph , SPERZEL, Michael , SANDMANN, Steffen , HEITMEIER, Stefan , HILLISCH, Alexander , ACKERSTAFF, Jens , TERJUNG, Carsten
IPC分类号： C07D413/12 , C07D257/04 , C07D401/12 , A61K31/41 , A61K31/454 , A61K31/496 , A61P7/00 , A61P9/00
CPC分类号： C07D257/04 , C07D249/08 , C07D401/12 , C07D405/12 , C07D413/12
摘要： The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases and/or perioperative heavy blood loss.
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公开(公告)号：EP3049408A1
公开(公告)日：2016-08-03
申请号：EP14772147.6
申请日：2014-09-24
发明人： RÖHN, Ulrike , ELLERMANN, Manuel , STRASSBURGER, Julia , WENDT, Astrid , RÖHRIG, Susanne , WEBSTER, Robert Alan , SCHMIDT, Martina Victoria , TERSTEEGEN, Adrian , BEYER, Kristin , SCHÄFER, Martina , BUCHMÜLLER, Anja , GERDES, Christoph , SPERZEL, Michael , SANDMANN, Steffen , HEITMEIER, Stefan , HILLISCH, Alexander , ACKERSTAFF, Jens , TERJUNG, Carsten
IPC分类号： C07D403/12 , C07D231/56 , C07D401/12 , C07D235/26 , C07D405/12 , C07D249/10 , C07D257/04 , A61P7/02
CPC分类号： C07D405/12 , C07D231/56 , C07D235/26 , C07D249/08 , C07D249/10 , C07D257/04 , C07D401/12 , C07D403/12
摘要： The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing drugs for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases and/or perioperative heavy blood loss.
摘要翻译： 本发明涉及取代的苯丙氨酸衍生物及其制备方法，以及其用于生产用于治疗和/或预防特别是心血管疾病和/或严重围手术期失血的疾病的药物的用途。
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19.发明公开SUBSTITUIERTE OXOPYRIDIN-DERIVATE UND IHRE VERWENDUNG ALS FAKTOR XIA / PLASMA 有权替代亚硫酸酯衍生物在IHRE VERWENDUNG ALS FAKTOR XIA UND PLASMAKALLIKREIN INHIBITOREN
公开(公告)号：EP3024822A1
公开(公告)日：2016-06-01
申请号：EP14741869.3
申请日：2014-07-21
发明人： RÖHRIG, Susanne , HILLISCH, Alexander , STRASSBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina, Victoria , SCHLEMMER, Karl-Heinz , BUCHMÜLLER, Anja , GERDES, Christoph , TELLER, Henrik , SCHÄFER, Martina , TERSTEEGEN, Adrian
IPC分类号： C07D215/227 , C07D221/04 , C07D401/12 , C07D413/12 , C07D471/04 , A61K31/435 , A61K31/4704 , A61K31/4709 , A61P1/00 , A61P7/02 , A61P7/10 , A61P27/02 , A61P29/00
CPC分类号： A61K31/438 , A61K31/437 , C07D215/227 , C07D221/04 , C07D401/12 , C07D413/12 , C07D471/04
摘要： The invention relates to substituted oxopyridine derivatives of formula (I), in which n stands for the number 1 or 2, A stands for -N(R2)- or -CH2-, R
1 stands for a group of formula (II), R
3 and R
4 stand for hydrogen, and R
5 stands for a group of formula (III) or (IV), methods for producing said substituted oxopyridine derivatives, and use of said substituted oxopyridine derivatives to produce drugs for treating and/or preventing diseases, in particular cardiovascular diseases, preferably thrombotic or thromboembolic diseases, and edemas and ophthalmologic diseases.摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及odemas以及眼科疾病的药物的用途 。
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20.发明公开SUBSTITUIERTE OXOPYRIDIN-DERIVATE UND IHRE VERWENDUNG BEI DER BEHANDLUNG VON HERZ-KREISLAUF-ERKRANKUNGEN 审中-公开取代氧吡啶衍生物及其在心血管疾病的治疗
公开(公告)号：EP2978756A1
公开(公告)日：2016-02-03
申请号：EP14713452.2
申请日：2014-03-27
发明人： RÖHRIG, Susanne , HILLISCH, Alexander , STRAßBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , BUCHMÜLLER, Anja , GERDES, Christoph , SCHÄFER, Martina , KINZEL, Tom , TELLER, Henrik , SCHIROK, Hartmut , KLAR, Jürgen , JIMENEZ NUNEZ, Eloisa
IPC分类号： C07D413/14 , C07D213/85 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/12 , C07D417/12 , C07D213/64 , C07D213/69 , A61K31/4427 , A61K31/4412 , A61K31/4418 , A61P7/00 , A61P9/00
CPC分类号： C07D405/06 , C07B2200/05 , C07D213/64 , C07D213/69 , C07D213/84 , C07D213/85 , C07D401/12 , C07D409/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention relates to substituted oxopyridine derivatives of the formula in which R
1 is a group of the formula, where * is the attachment site to the oxopyridine ring, R
6 is bromine, chlorine, fluorine, methyl, difluoromethyl, trifluoromethyl, methoxy, difluoromethoxy or trifluoromethoxy, R
7 is bromine, chlorine, fluorine, cyano, nitro, hydroxyl, methyl, difluoromethyl, trifluoromethyl, methoxy, ethoxy, difluoromethoxy, trifluoromethoxy, ethynyl, 3,3,3-trifluoroprop-l-yn-l-yl or cyclopropyl, and to processes for preparation thereof and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular diseases, preferably thrombotic or thromboembolic diseases and of oedemas, and also of ophthalmological disorders.摘要翻译： 本发明涉及substituiertem氧代吡啶衍生物和它们的制备方法，并因此它们用于制备药物用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性病症，和水肿，因此眼科疾病使用 ，
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