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公开(公告)号：EP3344618A1
公开(公告)日：2018-07-11
申请号：EP16757904.4
申请日：2016-08-30
发明人： JIMENEZ, Nunez Eloisa , ACKERSTAFF, Jens , ELLERBROCK, Pascal , HILLISCH, Alexander , MEIER, Katharina , HEITMEIER, Stefan , TERSTEEGEN, Adrian , STAMPFUSS, Jan
IPC分类号： C07D403/12 , C07D405/14 , C07D413/14 , A61K31/4412 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , C07D401/12 , C07D403/06 , C07D403/14 , C07D405/06 , C07D409/12 , C07D409/14 , C07D487/04 , C07D213/69 , A61P7/00 , A61P9/00
CPC分类号： A61K31/4412 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61P1/00 , A61P7/02 , A61P27/02 , C07D213/69 , C07D401/12 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D487/04
摘要： The invention relates to substituted oxopyridine derivatives and methods for the production thereof, as well as to the use thereof in the production of medicaments for treating and/or preventing diseases, especially diseases of the cardiovascular system, preferably thrombotic or thromboembolic diseases, as well as oedemas, and also ophthalmological diseases.
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公开(公告)号：EP3319956A1
公开(公告)日：2018-05-16
申请号：EP16734672.5
申请日：2016-07-05
发明人： JIMENEZ NUNEZ, Eloisa , ACKERSTAFF, Jens , RÖHRIG, Susanne , HILLISCH, Alexander , MEIER, Katharina , HEITMEIER, Stefan , TERSTEEGEN, Adrian , STAMPFUSS, Jan , ELLERBROCK, Pascal , MEIBOM, Daniel , LANG, Dieter
IPC分类号： C07D401/14 , C07D413/14 , C07D401/10 , C07D413/10 , A61K31/4439 , A61P9/00 , A61P27/02
CPC分类号： C07D401/10 , A61P7/02 , C07D401/14 , C07D413/10 , C07D413/14
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.
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公开(公告)号：EP3197889A1
公开(公告)日：2017-08-02
申请号：EP15766508.4
申请日：2015-09-22
发明人： RÖHRIG, Susanne , JIMENEZ NUNEZ, Eloisa , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , TELLER, Henrik , HILLISCH, Alexander , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , STAMPFUß, Jan
IPC分类号： C07D413/14 , C07D409/12 , C07D409/14 , A61K31/4436 , A61P1/00 , A61P27/02 , A61P29/00
CPC分类号： C07D413/14 , A61P1/00 , A61P27/02 , A61P29/00 , C07D409/12 , C07D409/14
摘要： The invention relates to substituted oxopyridine derivatives and methods for the production thereof, as well as to the use thereof in the production of medicaments for treating and/or preventing diseases, especially diseases of the cardiovascular system, preferably thrombotic or thromboembolic diseases, as well as oedemas, and also ophthalmological diseases.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及其在制备用于治疗和/或预防疾病，特别是心血管系统疾病，优选血栓形成或血栓栓塞性疾病的药物中的用途，以及 oedemas，还有眼科疾病。
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公开(公告)号：EP3197872A1
公开(公告)日：2017-08-02
申请号：EP15777625.3
申请日：2015-09-22
发明人： RÖHRIG, Susanne , JIMENEZ-NUNEZ, Eloisa , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , TELLER, Henrik , HILLISCH, Alexander , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , ACKERSTAFF, Jens , STAMPFUß, Jan
IPC分类号： C07D213/79 , C07D213/81 , C07D401/12 , C07D405/12 , C07D413/12 , A61K31/4418 , A61K31/4433 , A61K31/4439 , A61P7/02
CPC分类号： C07D413/14 , C07D213/79 , C07D213/81 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12
摘要： The invention relates to substituted oxopyridine derivatives and methods for the production thereof, as well as to the use thereof in the production of medicinal drugs for treating and/or preventing diseases, especially diseases of the cardiovascular system, preferably thrombotic or thromboembolic diseases, as well as oedemas, and also ophthalmological diseases.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及其在制备用于治疗和/或预防疾病，特别是心血管系统疾病，优选血栓形成或血栓栓塞性疾病的药物中的用途， 作为oedemas，还有眼科疾病。
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公开(公告)号：EP3049403A1
公开(公告)日：2016-08-03
申请号：EP14776625.7
申请日：2014-09-24
发明人： RÖHN, Ulrike , ELLERMANN, Manuel , STRAßBURGER, Julia , WENDT, Astrid , RÖHRIG, Susanne , WEBSTER, Robert Alan , SCHMIDT, Martina Victoria , TERSTEEGEN, Adrian , BEYER, Kristin , SCHÄFER, Martina , BUCHMÜLLER, Anja , GERDES, Christoph , SPERZEL, Michael , SANDMANN, Steffen , HEITMEIER, Stefan , HILLISCH, Alexander , ACKERSTAFF, Jens , TERJUNG, Carsten
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , A61K31/16 , A61P7/04
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12
摘要： The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases and/or perioperative heavy blood loss.
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16.发明公开SUBSTITUIERTE PHENYLALANIN-DERIVATE ALS FAKTOR XIA MODULATOREN 审中-公开SUBSTITUIERTE苯丙氨酸衍生物ALS FAKTOR XIA MODULATOREN
公开(公告)号：EP3049394A1
公开(公告)日：2016-08-03
申请号：EP14771913.2
申请日：2014-09-24
发明人： RÖHN, Ulrike , ELLERMANN, Manuel , STRASSBURGER, Julia , WENDT, Astrid , RÖHRIG, Susanne , WEBSTER, Robert Alan , SCHMIDT, Martina Victoria , TERSTEEGEN, Adrian , BEYER, Kristin , SCHÄFER, Martina , BUCHMÜLLER, Anja , GERDES, Christoph , SPERZEL, Michael , SANDMANN, Steffen , HEITMEIER, Stefan , HILLISCH, Alexander , ACKERSTAFF, Jens , TERJUNG, Carsten
IPC分类号： C07D257/04 , C07D413/12 , C07D403/12 , C07D235/26 , C07D401/12 , C07D271/07 , A61K31/41 , A61K31/5377 , A61K31/4184 , A61K31/454 , A61K31/4245 , A61P7/00 , A61P9/00
CPC分类号： C07D413/12 , C07D231/56 , C07D235/10 , C07D235/26 , C07D249/10 , C07D249/12 , C07D257/04 , C07D271/07 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases and/or perioperative heavy blood loss.
摘要翻译： 除了使用所述衍生物制备用于治疗和/或预防疾病，特别是心血管疾病和/或围手术期严重失血的药物之外，本发明涉及取代的苯丙氨酸衍生物和其制备方法。
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17.发明授权
公开(公告)号：EP3197872B1
公开(公告)日：2019-01-30
申请号：EP15777625.3
申请日：2015-09-22
发明人： RÖHRIG, Susanne , JIMENEZ-NUNEZ, Eloisa , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , TELLER, Henrik , HILLISCH, Alexander , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , ACKERSTAFF, Jens , STAMPFUß, Jan
IPC分类号： C07D213/79 , C07D213/81 , C07D401/12 , C07D405/12 , C07D413/12 , A61K31/4418 , A61K31/4433 , A61K31/4439 , A61P7/02
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18.发明公开
公开(公告)号：EP3271332A1
公开(公告)日：2018-01-24
申请号：EP16709921.7
申请日：2016-03-15
发明人： RÖHRIG, Susanne , TELLER, Henrik , HEITMEIER, Stefan , SCHLEMMER, Karl-Heinz , STAMPFUSS, Jan , HILLISCH, Alexander , TERSTEEGEN, Adrian , JIMENEZ NUNEZ, Eloisa
IPC分类号： C07D213/69 , A61K31/4418 , A61P7/00 , A61P9/00
CPC分类号： C07D213/69
摘要： The invention relates to substituted oxo-pyridine derivatives and methods for the production thereof, as well as to the use thereof in the production of medicaments for treating and/or preventing diseases, especially diseases of the cardiovascular system, preferably thrombotic or thromboembolic diseases, as well as oedemas, and also ophthalmological diseases.
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公开(公告)号：EP3197896A1
公开(公告)日：2017-08-02
申请号：EP15771891.7
申请日：2015-09-22
发明人： ROEHRIG, Susanne , HILLISCH, Alexander , STRASSBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , BUCHMÜLLER, Anja , GERDES, Christoph , SCHÄFER, Martina , TELLER, Henrik , JIMÉNEZ NÚNEZ, Eloisa , SCHIROK, Hartmut , KLAR, Juergen , LOBELL, Mario
IPC分类号： C07D471/04 , A61K31/435 , A61K31/437 , A61P7/02
CPC分类号： C07D471/04
摘要： The invention relates to substituted oxopyridine derivatives and methods for the production thereof, as well as to the use thereof in the production of medicinal drugs for treating and/or preventing diseases, especially diseases of the cardiovascular system, preferably thrombotic or thromboembolic diseases, as well as oedemas, and also ophthalmological diseases.
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公开(公告)号：EP3197873A1
公开(公告)日：2017-08-02
申请号：EP15766512.6
申请日：2015-09-22
发明人： ROEHRIG, Susanne , JIMENEZ NUNEZ, Eloisa , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , TELLER, Henrik , HILLISCH, Alexander , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , STAMPFUSS, Jan
IPC分类号： C07D213/85 , C07D401/12 , C07D413/12 , C07D213/64 , A61K31/4427 , A61K31/4412
CPC分类号： C07D413/06 , A61P7/10 , A61P27/02 , C07D213/64 , C07D213/69 , C07D213/85 , C07D401/06 , C07D401/12 , C07D405/06 , C07D413/12
摘要： The invention relates to substituted oxopyridine derivatives and methods for the production thereof, as well as to the use thereof in the production of medicinal drugs for treating and/or preventing diseases, especially diseases of the cardiovascular system, preferably thrombotic or thromboembolic diseases, as well as oedemas, and also ophthalmological diseases.
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