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公开(公告)号：EP2155748A1
公开(公告)日：2010-02-24
申请号：EP08769442.8
申请日：2008-05-12
发明人： COOK, Brian Nicholas , ELDRUP, Anne Bettina , MUGGE, Ingo Andreas , SOLEYMANZADEH, Fariba , SUN, Sanxing , ZHANG, Yunlong
IPC分类号： C07D471/04 , A61K31/4375 , A61P9/12
CPC分类号： C07D471/04
摘要： Compounds of the formula (I) wherein R1, R2, R3, R4, R5, R6, W, and Y are as described herein, or a tautomer, prodrug, solvate, or salt thereof. These compounds are useful as inhibitors of Urotensin II and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the interaction of Urotensin II with its receptor, including cardiovascular diseases. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds, and intermediates useful in these processes.
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12.发明公开
公开(公告)号：EP1996545A1
公开(公告)日：2008-12-03
申请号：EP07758126.2
申请日：2007-03-08
发明人： DE LOMBAERT, Stephane , ELDRUP, Anne, Bettina , KOWALSKI, Jennifer, A. , MUGGE, Ingo, Andreas , SOLEYMANZADEH, Fariba , SWINAMER, Alan, David , TAYLOR, Steven, John
IPC分类号： C07D207/12 , C07D211/22 , C07D211/46 , C07D211/58 , C07D211/62 , C07D295/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , A61K31/4545 , A61P9/00
CPC分类号： C07D295/215 , C07D207/12 , C07D211/22 , C07D211/46 , C07D211/58 , C07D211/62 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12
摘要： Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.
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公开(公告)号：EP3402789A1
公开(公告)日：2018-11-21
申请号：EP17701778.7
申请日：2017-01-12
发明人： BOSANAC, Todd , BENTZIEN, Joerg , BURKE, Michael Jason , DISALVO, Darren Todd , MAO, Wang , SOLEYMANZADEH, Fariba , WESTBROOK, John , XIONG, Zhaoming
IPC分类号： C07D401/14 , C07D401/04 , C07D401/06 , C07D401/10 , C07D471/04 , A61K31/4725 , A61K31/506 , A61P19/00 , A61P37/00
摘要： The present invention encompasses compounds of the formula (I) wherein the groups R1, R2, R3, R4 and R5 are defined herein, which are suitable for the treatment of diseases related to Bruton's tyrosine kinase (BTK), and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.
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公开(公告)号：EP2882741B1
公开(公告)日：2018-10-24
申请号：EP13752756.0
申请日：2013-08-08
发明人： BENTZIEN, Joerg Martin , BERRY, Angela Kay , BOSANAC, Todd , BURKE, Michael, Jason , DISALVO, Darren, Todd , HORAN, Joshua, Courtney , LIANG, Shuang , MAO, Can , MAO, Wang , SHEN, Yue , SOLEYMANZADEH, Fariba , ZINDELL, Renee, M.
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D231/38 , C07D401/04 , C07D401/06 , C07D403/02 , C07D403/06 , C07D417/02 , C07D417/04 , C07D417/06 , C07D277/56 , C07D403/04 , A61P19/00 , A61P11/00
CPC分类号： C07D417/08 , C07D231/14 , C07D231/38 , C07D231/40 , C07D277/56 , C07D401/02 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/08 , C07D405/14 , C07D413/14 , C07D417/02 , C07D417/04 , C07D417/06
摘要： The present invention encompasses compounds of the formula (I) wherein the groups A, Cy, X1 and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.
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15.发明公开N-CYCLYL-3 - (CYCLYLCARBONYLAMINOMETHYL) BENZAMIDE DERIVATIVES AS RHO KINASE INHIBITORS 有权的N-环基-3-（CYCLYLCARBONYLAMINOMETHYL）苯甲酰胺衍生物作为Rho激酶抑制剂的
公开(公告)号：EP2590950A1
公开(公告)日：2013-05-15
申请号：EP11738871.0
申请日：2011-06-30
发明人： COOK, Brian Nicholas , KOWALSKI, Jennifer A. , LI, Xiang , MARSHALL, Daniel Richard , SCHLYER, Sabine , SIBLEY, Robert , SMITH-KEENAN, Lana Louise , SOLEYMANZADEH, Fariba , SORCEK, Ronald John , YOUNG, Erick Richard Roush , ZHANG, Yunlong
IPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00 , A61K31/472 , A61P9/00
CPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I) : and pharmaceutically acceptable salts thereof, wherein R
1 and R
2 are various ring systems. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of Rho Kinase mediated diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.-
公开(公告)号：EP2321274A1
公开(公告)日：2011-05-18
申请号：EP09789924.9
申请日：2009-06-24
发明人： BENTZIEN, Joerg, Martin , BOYER, Stephen, James , BURKE, Jennifer , ELDRUP, Anne, Bettina , GUO, Xin , HUBER, John, David , KIRRANE, Thomas, Martin , SOLEYMANZADEH, Fariba , SWINAMER, Alan, David
IPC分类号： C07D207/09 , C07D211/34 , C07D211/82 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06
CPC分类号： C07D211/34 , C07D207/09 , C07D211/82 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/06 , C07D413/06 , C07D413/10 , C07D417/06 , C07D471/04
摘要： Disclosed are compounds of formula (I) and compositions of the present invention which are inhibitors of the sodium proton exchanger isoform-1 (NHE-I). Also disclosed are methods of using and making the same.
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17.发明公开N-SUBSTITUTED PYRIDINONE OR PYRIMIDINONE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS 审中-公开可溶性EPOXIDHYDROLASEINHIBITOREN合适的N-取代的吡啶酮嘧啶
公开(公告)号：EP1934182A1
公开(公告)日：2008-06-25
申请号：EP06816368.2
申请日：2006-10-04
IPC分类号： C07D213/82 , C07D413/06 , A61K31/4412 , A61K31/443
CPC分类号： C07D213/82 , C07D413/06
摘要： Disclosed are compounds of the formula (I) with the definitions of A1 D, Q, W, X, Y and Z as indicated in the description, which are active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same. (I)
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公开(公告)号：EP1885697A2
公开(公告)日：2008-02-13
申请号：EP06758966.3
申请日：2006-05-01
发明人： CYWIN, Ch. L. , DE LOMBAERT, Stephane , ELDRUP, Anne, Bettina , INGRAHAM, Richard, Harold , TAYLOR, Steven , SOLEYMANZADEH, Fariba , CARDOZO, Mario G.
IPC分类号： C07D213/00 , C07D217/04 , C07D241/12 , A61K31/495 , A61P9/12
CPC分类号： C07D213/82 , C07D213/56 , C07D213/81 , C07D215/50 , C07D217/26 , C07D231/12 , C07D231/14 , C07D233/90 , C07D241/24 , C07D295/155 , C07D401/04
摘要： Disclosed are compounds of formula (I) or (III) active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using for treating hypertension and making same.
摘要翻译： 公开了对可溶性环氧化物水解酶（sEH）有活性的式（I）或（III）化合物，其组合物以及用于治疗高血压并制备其的方法。
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