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11.发明公开DPP-IV INHIBITORS FOR USE IN THE TREATMENT OF NAFLD 有权VERWENDUNG VON DPP-IV INHIBITOREN ZUR BEHANDLUNG VON NAFLD
公开(公告)号：EP2303262A1
公开(公告)日：2011-04-06
申请号：EP09757506.2
申请日：2009-06-02
发明人： KLEIN, Thomas , MARK, Michael , NIESSEN, Heiko , THOMAS, Leo
IPC分类号： A61K31/40 , A61K31/4025 , A61K31/403 , A61K31/4375 , A61K31/4439 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/513 , A61K31/522 , A61P1/16 , A61P21/00
CPC分类号： A61K31/40 , A61K31/155 , A61K31/403 , A61K31/41 , A61K31/4184 , A61K31/4196 , A61K31/422 , A61K31/4375 , A61K31/4439 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/522 , A61K31/53 , A61K45/06 , A61P1/16 , A61K2300/00
摘要： The present invention relates to the finding that certain DPP-4 inhibitors are particularly suitable for treating and/or preventing non alcoholic fatty liver diseases (NAFLD).
摘要翻译： 本发明涉及某些DPP-4抑制剂特别适用于治疗和/或预防非酒精性脂肪肝疾病（NAFLD）的发现。
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12.发明公开PHARMACEUTICAL COMPOSITION COMPRISING A GLUCOPYRANOSYL-SUBSTITUTED BENZENE DERIVATIVE 有权WITH A吡喃葡萄糖基取代的苯衍生物的药物组合物
公开(公告)号：EP2187879A1
公开(公告)日：2010-05-26
申请号：EP08787264.4
申请日：2008-08-15
发明人： DUGI, Klaus , MARK, Michael , THOMAS, Leo , HIMMELSBACH, Frank
CPC分类号： A61K31/7034 , A61K9/0019 , A61K9/145 , A61K9/1623 , A61K9/2018 , A61K9/2072 , A61K9/4858 , A61K31/70 , A61K2300/00
摘要： The invention relates to a pharmaceutical composition according to the claim 1 comprising a glucopyranosyl-substituted benzene derivative in combination with a DPP IV inhibitor which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.
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13.发明公开GLUCOPYRANOSYL-SUBSTITUTED DIFLUOROBENZYL-BENZENE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE 审中-公开吡喃葡萄糖基取代二氟苄苯衍生物，用这类化合物的药物，它们的用途及其制造方法
公开(公告)号：EP2074130A1
公开(公告)日：2009-07-01
申请号：EP07820370.0
申请日：2007-09-20
IPC分类号： C07H7/04 , C07D309/10 , A61K31/70
CPC分类号： C07H7/04 , C07D309/10
摘要： Glucopyranosyl-substituted difluorobenzyl-benzene derivatives of general formula (I) as defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.
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14.发明授权D-XYLOPYRANOSYL-SUBSTITUIERTE PHENYLE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG 有权D-D-吡喃木糖基 - 取代的苯基，药物含有它们，它们的用途和方法FOR THEIR
公开(公告)号：EP1765842B1
公开(公告)日：2008-01-09
申请号：EP05755962.7
申请日：2005-06-30
发明人： ECKHARDT, Matthias , HIMMELSBACH, Frank , EICKELMANN, Peter , THOMAS, Leo , BARSOUMIAN, Edward, Leon
摘要： The invention relates to D-xylopyranosyl-substituted phenyls of general formula (I) wherein the radicals R
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15.发明公开GLUCOPYRANOSYL-SUBSTITUTED ((HETERO)ARYLETHYNYL-BENZYL)-BENZENE DERIVATIVES AND USE THEREOF AS SODIUM-DEPENDENT GLUCOSE COTRANSPORTER 2 (SGLT2) INHIBITORS 有权GLUCOPYRANOSYLSUBSTITUIERTE（（杂）芳基乙炔 - 苄基）-BENZENDERIVATIVE及其作为钠依赖性葡萄糖协同转运蛋白2型抑制剂（SGLT2）
公开(公告)号：EP1856082A1
公开(公告)日：2007-11-21
申请号：EP06708381.6
申请日：2006-02-20
发明人： HIMMELSBACH, Frank , ECKHARDT, Matthias , EICKELMANN, Peter , THOMAS, Leo , BARSOUMIAN, Edward Leon
IPC分类号： C07D309/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10 , A61K31/351 , A61K31/381 , A61K31/41 , A61K31/4155 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/443 , A61K31/506 , A61K31/501
CPC分类号： C07D309/10 , C07D405/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： Glucopyranosyl-substituted (hetero)arylethynyl-benzene derivatives of the general formula (I) where the groups R1 to R6 as well as R7a, R7b, R7c are defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are SGLT2 inhibitors suitable for the treatment of metabolic disorders.
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16.发明公开D-PYRANOSYL-SUBSTITUIERTE PHENYLE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG 有权D-吡喃取代的苯基，药物含有它们，它们的用途和方法FOR THEIR
公开(公告)号：EP1797107A2
公开(公告)日：2007-06-20
申请号：EP05797250.7
申请日：2005-09-28
发明人： ECKHARDT, Matthias , HIMMELSBACH, Frank , EICKELMANN, Peter , THOMAS, Leo , BARSOUMIAN, Edward Leon
IPC分类号： C07H7/04
CPC分类号： C07H7/04
摘要： Disclosed are D-pyranosyl-substituted phenyls of general formula (I), wherein the radicals R1 to R5, X, Z, and R7a, R7b, R7c are defined as indicated in claim 1. Said phenyls have an inhibitory effect on the sodium-dependent glucose cotransporter SGLT. The invention further relates to medicaments for treating metabolism disorders.
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17.发明公开METHYLIDEN-D-XYLOPYRANOSYL- UND OXO-D-XYLOPYRANOSYL-SUBSTITUIERTE PHENYLE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL, DEREN VERWENDUNG UND VERFAHREN ZU IHRER HERSTELLUNG 审中-公开亚甲基-D-xylopyranosyl-和氧代-D吡喃木糖 - 取代的苯基，药物含有它们，它们的用途和方法FOR THEIR
公开(公告)号：EP1771460A1
公开(公告)日：2007-04-11
申请号：EP05771787.8
申请日：2005-07-13
发明人： ECKHARDT, Matthias , HIMMELSBACH, Frank , EICKELMANN, Peter , THOMAS, Leo , BARSOUMIAN, Edward Leon
CPC分类号： C07H7/04
摘要： D-xylopyranosyl-substituted phenyls of general formula (I), in which radicals R1 to R5, X, Z as well as R7a, R7b and R7c are defined as in Claim 1, exhibit an inhibiting effect upon the sodium-dependent glucose-cotransporter SGLT. The invention also relates to medicaments for treating metabolic diseases.
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18.发明公开NEUE ALKIN-VERBINDUNGEN MIT MCH-ANTAGONISTISCHER WIRKUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL 审中-公开新ALKIN CONNECTIONS MCH拮抗作用及药物含有它们的
公开(公告)号：EP1742939A2
公开(公告)日：2007-01-17
申请号：EP05729108.0
申请日：2005-04-08
发明人： STENKAMP, Dirk , MUELLER, Stephan Georg , LUSTENBERGER, Philipp , LEHMANN-LINTZ, Thorsten , ROTH, Gerald Jürgen , RUDOLF, Klaus , SCHINDLER, Marcus , THOMAS, Leo , LOTZ, Ralf R. H.
IPC分类号： C07D405/14 , A61K31/4433 , A61P3/04
CPC分类号： C07D471/08 , C07D405/06 , C07D405/14
摘要： The invention relates to an alkyne compound of general formula (I) in which A, B, W, X, Y, Z, R1 and R2 groups and residuals have the meanings given in claim 1. Drugs containing at least one type of inventive alkyne are also disclosed. The inventive drugs exhibiting an MCH-receptor antagonistic activity are suitable for treating metabolic disturbances and/or eating disorders, in particular adiposity, bulimia, anorexia, hyperphagia and diabetes.
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19.发明公开
公开(公告)号：EP1740572A1
公开(公告)日：2007-01-10
申请号：EP05716558.1
申请日：2005-04-08
发明人： STENKAMP, Dirk , MUELLER, Stephan Georg , LUSTENBERGER, Philipp , LEHMANN-LINTZ, Thorsten , THOMAS, Leo , SCHINDLER, Marcus , ROTH, Gerald Jürgen , RUDOLF, Klaus , LOTZ, Ralf R. H.
IPC分类号： C07D401/12 , A61P3/04 , C07D213/30 , C07D405/12 , C07D409/14 , C07D213/61 , A61K31/4439
CPC分类号： C07D401/14 , C07D213/30 , C07D213/38 , C07D213/61 , C07D401/10 , C07D401/12 , C07D405/12 , C07D409/06 , C07D409/14
摘要： The invention relates to alkyne compounds of general formula (I), in which the groups and radicals A, B, W, X, Y, Z, R1 and R2 are defined as cited in claim 1. The invention also relates to medicaments containing at least one inventive alkyne. As a result of the antagonistic action against the MCH-receptor, the inventive medicaments are suitable for treating metabolic disorders and/or eating disorders, in particular adiposity and diabetes.
摘要翻译： 本发明涉及通式（I）的炔化合物，其中基团A和基团A，B，W，X，Y，Z，R 1和R 2如权利要求1中所定义。本发明还涉及药物， 至少一种本发明的炔烃。 由于对MCH受体的拮抗作用，本发明药物适用于治疗代谢障碍和/或进食障碍，特别是肥胖症和糖尿病。
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20.发明公开
公开(公告)号：EP4244229A1
公开(公告)日：2023-09-20
申请号：EP21806745.2
申请日：2021-11-12
发明人： ECKHARDT, Matthias , WILLWACHER, Marina, Kristina , PRESTLE, Juergen , KONTES, Ferenc , THOMAS, Leo , TAUTERMANN, Christofer, Siegfried , WIEDENMAYER, Dieter
IPC分类号： C07D495/14 , A61P27/02 , A61K31/495
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