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公开(公告)号：EP4357361A1
公开(公告)日：2024-04-24
申请号：EP22824301.0
申请日：2022-06-17
发明人： LONG, Xi , XU, Hongjiang , SHI, Wei , WANG, Liangliang , LU, Zhenzhen
IPC分类号： C07K16/24 , C07K16/28 , G01N33/564 , A61P17/06 , A61P37/06
CPC分类号： C07K16/24 , C07K16/28 , A61P37/06 , G01N33/564 , A61P17/06
摘要： Provided are an anti-IL-36R antibody and a use thereof. In particular, a mouse, chimeric or humanized antibody or an antigen-binding fragment thereof binding to IL-36R is provided; further provided are a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, as well as an expression vector and host cell used to express the antibody or the antigen-binding fragment thereof. In addition, a preparation method and a use of the antibody or the antigen-binding fragment thereof are provided, comprising treatment and prevention of IL-36/IL-36R-mediated diseases and disorders.
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公开(公告)号：EP3865483A1
公开(公告)日：2021-08-18
申请号：EP19870704.4
申请日：2019-10-12
发明人： XU, Hongjiang , ZHANG, Mincheng , ZHANG, Ying , SONG, Wei , YANG, Ling , ZHANG, Xiquan
IPC分类号： C07D487/04 , A61P35/00 , A61K31/519
摘要： Disclosed are a compound of formula I as a toll-like receptor 7 (TLR7) agonist or a pharmaceutically acceptable salt thereof for treating colorectal cancer, a pharmaceutical combination for treating colorectal cancer comprising the TLR7 agonist and a tyrosine kinase inhibitor, and the use of the compound of formula I or the pharmaceutically acceptable salt thereof and the pharmaceutical combination for treating colorectal cancer.
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13.发明公开
公开(公告)号：EP3443954A1
公开(公告)日：2019-02-20
申请号：EP17781942.2
申请日：2017-04-14
发明人： GU, Hongmei , WANG, Shanchun , ZHANG, Xiquan , HUANG, Lei , XU, Hongjiang , SONG, Wei , DONG, Ping , SUN, Zhongying , ZHANG, Ying , CHEN, Deyang
IPC分类号： A61K9/72 , A61K9/12 , A61K31/704 , A61P1/16 , A61P31/12
摘要： The present invention belongs to the field of medicine, relates to an inhaled preparation of isoglycyrrhizic acid or a salt thereof, and in particular relates to an inhaled preparation of magnesium isoglycyrrhizinate and the use thereof in preparing drugs for treating respiratory system diseases.
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公开(公告)号：EP4406971A1
公开(公告)日：2024-07-31
申请号：EP22872081.9
申请日：2022-09-23
发明人： LU, Zhenzhen , WANG, Yujie , ZHANG, Zhengping , XU, Hongjiang , ZHAO, Wei
摘要： Provided are an anti-CD40 antibody and a use thereof, such as a mouse, human, chimeric, or humanized antibody specifically binding to CD40, and an antigen-binding fragment thereof, and further provided are a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, and an expression vector and a host cell for expressing the antibody or the antigen-binding fragment thereof. Further provided are a preparation method and a use method for the antibody or the antigen-binding fragment thereof, comprising treating and preventing immune diseases.
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公开(公告)号：EP4130042A1
公开(公告)日：2023-02-08
申请号：EP21780305.5
申请日：2021-04-01
发明人： GUI, Qiu , ZHU, Hong , WANG, Liangliang , ZHANG, Xiaoyun , ZOU, Xiaofang , SHEN, Hengqiao , XU, Hongjiang , YANG, Ling
摘要： Provided are an antigen-binding polypeptide binding to CD47 or an antigen-binding portion thereof, nucleic acids encoding the polypeptide, vector, cell or pharmaceutical composition. The polypeptide can reduce a tumor or inhibit the growth of tumor cells, treat cancer, promote macrophage phagocytosis, and the like.
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公开(公告)号：EP4110816A1
公开(公告)日：2023-01-04
申请号：EP21712942.8
申请日：2021-02-25
发明人： CHEN, Mingjiu , TAN, Wei , ZHONG, Cathy Xiaoyan , MA, Mark Zhiqing , XIA, Shukai , ZHANG, Zhengping , XU, Hongjiang , LU, Zhijian
IPC分类号： C07K16/28
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公开(公告)号：EP3858832A1
公开(公告)日：2021-08-04
申请号：EP19878278.1
申请日：2019-10-29
发明人： LIU, Fei , FENG, Weiwei , WANG, Bin , XU, Hongjiang , WANG, Jinan , ZHANG, Xiquan , WANG, Shanchun , LIU, Yanlong , ZHANG, Jianqing , YAO, Yiyan , TANG, Xujing , SHI, Wei , ZHANG, Hongying , LI, Yang , TANG, Song , ZHU, Yizhong , LIU, Limin , GU, Hongmei , YANG, Ling
IPC分类号： C07D471/04 , C07D211/96 , C07D215/20 , A61K31/404 , A61P35/00
摘要： Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.
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公开(公告)号：EP3851439A1
公开(公告)日：2021-07-21
申请号：EP19861061.0
申请日：2019-09-12
发明人： ZHANG, Yinsheng , XU, Hongjiang , REN, Jing , WANG, Qinglin , WU, Zheyang , JIN, Chao , SHI, Wei , WANG, Xiaojin , HE, Xiangyi , CHANG, Xiayun , WANG, Jie , ZHAO, Tianxiao
IPC分类号： C07D487/04 , A61K31/4985 , A61P19/02
摘要： The present application belongs to the field of pharmaceutical chemistry, and relates to a furo[3,4-b]pyrrole-containing BTK inhibitor, and in particular, to a compound of formula (I), a stereisomer or pharmacologically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition containing the compound, and use thereof in treating BTK-related diseases.
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公开(公告)号：EP3248968A1
公开(公告)日：2017-11-29
申请号：EP16739808.0
申请日：2016-01-22
发明人： CHEN, Shuhui , DING, Charles Z. , YAN, Xiaobing , HUANG, Wei , HU, Guoping , LI, Jian , ZHANG, Xiquan , YANG, Ling , XU, Hongjiang
IPC分类号： C07D413/04 , C07D487/08 , C07D495/04 , C07D513/04 , C07D471/04 , C07D417/04 , C07D413/14 , A61K31/4725 , A61K31/422 , A61K31/4365 , A61K31/437
CPC分类号： C07D413/04 , A61K31/422 , A61K31/4365 , A61K31/437 , A61K31/4725 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04 , C07D487/08 , C07D495/04 , C07D513/04 , Y02P20/55
摘要： The present invention relates to a compound represented by formula (I) of a resorcinol derivative as an HSP90 inhibitor or pharmaceutically accepted salts thereof. The compound in the present invention has the activity of inhibiting heat shock protein HSP90. Therefore, the compound in the present invention is used to treat proliferative diseases such as cancer and neurodegenerative diseases. The present invention further provides the compounds and preparation methods for pharmaceutical compositions comprising the compounds, a method for treating diseases, and pharmaceutical compositions comprising the compounds.
摘要翻译： 本发明涉及作为HSP90抑制剂的间苯二酚衍生物或其药学上可接受的盐的式（I）所示的化合物。 本发明中的化合物具有抑制热休克蛋白HSP90的活性。 因此，本发明中的化合物用于治疗增殖性疾病如癌症和神经退行性疾病。 本发明进一步提供了用于包含所述化合物的药物组合物的化合物和制备方法，治疗疾病的方法以及包含所述化合物的药物组合物。
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公开(公告)号：EP4289833A1
公开(公告)日：2023-12-13
申请号：EP22749196.6
申请日：2022-01-30
发明人： LIU, Fei , LIU, Yanlong , WANG, Bin , XU, Hongjiang , TANG, Xujing
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/501 , A61P29/00 , A61P37/00
摘要： A TYK2 inhibitor compound containing a bicyclic ring and the use thereof in the preparation of a drug for treating or preventing TYK2-related diseases.
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