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11.发明公开NOVEL HETEROBICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF LIVER CARNITINE PALMITOYL TRANSFERASE 有权新杂衍生物肝脏肉碱棕榈酰TRANSFERASEHEMMER
公开(公告)号：EP1926711A1
公开(公告)日：2008-06-04
申请号：EP06793207.9
申请日：2006-09-05
发明人： ACKERMANN, Jean , BLEICHER, Konrad , CECCARELLI, Simona Maria , CHOMIENNE, Odile , MATTEI, Patrizio , SCHULZ-GASCH, Tanja
IPC分类号： C07D209/10 , C07D403/12 , C07D413/12 , C07D215/58 , C07D223/16
CPC分类号： C07D223/16 , C07D209/10 , C07D215/58 , C07D403/12 , C07D413/12
摘要： The invention is concerned with novel heterobicyclic derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPTl and can be used as medicaments.
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公开(公告)号：EP2475644B1
公开(公告)日：2014-01-08
申请号：EP10751931.6
申请日：2010-09-07
发明人： ACKERMANN, Jean , CONTE, Aurelia , NEIDHART, Werner , NETTEKOVEN, Matthias , WERTHEIMER, Stanley
IPC分类号： C07D211/62 , C07D211/96 , C07D401/12 , C07D405/12 , A61K31/445 , A61P3/00 , A61P9/10
CPC分类号： C07D211/96 , C07D211/62 , C07D401/12 , C07D405/12
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公开(公告)号：EP2558464A1
公开(公告)日：2013-02-20
申请号：EP11715201.7
申请日：2011-04-12
发明人： ACKERMANN, Jean , CONTE, Aurelia , HUNZIKER, Daniel , NEIDHART, Werner , NETTEKOVEN, Matthias , SCHULZ-GASCH, Tanja , WERTHEIMER, Stanley
IPC分类号： C07D471/10 , A61K31/438 , A61P3/00
CPC分类号： C07D471/10
摘要： The invention provides novel compounds having the general formula (I) wherein R
1 , R
2 and A are as described herein, compositions including the compounds and compounds for the treatment of diabetes, metabolic syndrom and obesity (HSL-inhibitors).-
公开(公告)号：EP1742923B1
公开(公告)日：2009-05-27
申请号：EP05735100.9
申请日：2005-04-20
发明人： ACKERMANN, Jean , AEBI, Johannes , BINGGELI, Alfred , GRETHER, Uwe , HIRTH, Georges , KUHN, Bernd , MAERKI, Hans-Peter , MEYER, Markus , MOHR, Peter , WRIGHT, Matthew, Blake
IPC分类号： C07D231/12 , A61K31/41 , A61P3/00
CPC分类号： C07D231/12
摘要： This invention is concerned with compounds of the formula (I) wherein one of R5, R6 and R7 is (a) and X1, X2, R1 to R15 and n are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐和/或酯，其中R5，R6和R7中的一个是（a）且X1，X2，R1至R15和n如说明书中所定义 。 本发明进一步涉及含有这些化合物的药物组合物，其制备方法及其用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病的用途。
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15.发明公开SPIRO-CONDENSED CYCLOHEXANE DERIVATIVES AS HSL INHIBITORS USEFUL FOR THE TREATMENT OF DIABETES 有权螺稠的环己烷衍生物AS HSL抑制剂适合...糖尿病的治疗
公开(公告)号：EP2488493A1
公开(公告)日：2012-08-22
申请号：EP10770764.8
申请日：2010-10-12
发明人： ACKERMANN, Jean , BRUGGER, Stephan , CONTE, Aurelia , HUNZIKER, Daniel , NEIDHART, Werner , NETTEKOVEN, Matthias , SCHULZ-GASCH, Tanja , WERTHEIMER, Stanley
IPC分类号： C07D209/54 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D413/12 , A61K31/403 , A61P3/00
CPC分类号： C07D209/54 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D413/12
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions as HSL inhibitors for the treatment of diabetes, wherein R
1 ,R
2 , R
3 , C
a and C
b have the significance given in claim 1.-
公开(公告)号：EP2475644A1
公开(公告)日：2012-07-18
申请号：EP10751931.6
申请日：2010-09-07
发明人： ACKERMANN, Jean , CONTE, Aurelia , NEIDHART, Werner , NETTEKOVEN, Matthias , WERTHEIMER, Stanley
IPC分类号： C07D211/62 , C07D211/96 , C07D401/12 , C07D405/12 , A61K31/445 , A61P3/00 , A61P9/10
CPC分类号： C07D211/96 , C07D211/62 , C07D401/12 , C07D405/12
摘要： Compounds of formula (I), as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions, wherein A
1 , A
2 , R
1 ,R
2 R
3 ,R
4 R
5 and R
6 have the significance given in claim 1. Objects of the present invention are the compounds of formula (I) and their aforementioned salts and esters and their use as therapeutically active substances, a process for the manufacture of the said compounds, intermediates, pharmaceutical compositions, medicaments containing the said compounds, their pharmaceutically acceptable salts or esters, the use of the said compounds, salts or esters for the treatment or prophylaxis of illnesses, especially in the treatment or prophylaxis of diabetes, metabolic syndrome, dyslipidemia, atherosclerosis or obesity and the use of the said compounds, salts or esters for the production of medicaments for the treatment or prophylaxis of diabetes, metabolic syndrome, dyslipidemia, atherosclerosis or obesity.-
公开(公告)号：EP1863772A1
公开(公告)日：2007-12-12
申请号：EP06818193.2
申请日：2006-02-07
发明人： ACKERMANN, Jean , AEBI, Johannes , BINGGELI, Alfred , GRETHER, Uwe , KUHN, Bernd , MAERKI, Hans-Peter , MEYER, Markus
IPC分类号： C07D239/28 , A61K31/505 , A61P3/00 , C07D213/80
CPC分类号： C07D213/73 , C07D239/26 , C07D239/28 , C07D239/42
摘要： This invention is concerned with compounds of the formula (I), wherein one of R5, R6 and R7 is formula (II) and R1 to R13, X1, X2, m and n are defined in the description, and all pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
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18.发明公开
公开(公告)号：EP1781608A1
公开(公告)日：2007-05-09
申请号：EP05772210.0
申请日：2005-08-08
发明人： ACKERMANN, Jean , AEBI, Johannes , BINGGELI, Alfred , GRETHER, Uwe , KUHN, Bernd , MAERKI, Hans-Peter , MEYER, Markus
IPC分类号： C07D209/08 , A61K31/405 , A61P3/10 , A61P3/06
CPC分类号： C07D209/08
摘要： This invention is concerned with compounds of the formula (I), wherein one of R6, R7, R8 and R9 is formula (II), and X, R1 to R12, m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
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公开(公告)号：EP1765760A1
公开(公告)日：2007-03-28
申请号：EP05754803.4
申请日：2005-06-21
发明人： ACKERMANN, Jean , BINGGELI, Alfred , GRETHER, Uwe , KUHN, Bernd , MAERKI, Hans-Peter , MEYER, Markus , AEBI, Johannes
IPC分类号： C07C59/68 , C07C59/70 , C07D213/30 , C07D239/26 , C07C323/20 , C07C69/736 , A61P3/10 , A61K31/192 , C07C235/34
CPC分类号： C07D213/30 , C07C69/712 , C07D239/26
摘要： This invention is concerned with compounds of the formula (I) wherein one of R5, R6 and R7 is formula (II) and X1, X2, R1 to R12, m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.
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公开(公告)号：EP1458683B1
公开(公告)日：2006-11-22
申请号：EP02790481.2
申请日：2002-12-11
IPC分类号： C07D213/60 , C07D239/28 , A61P3/00 , A61K31/495 , A61K31/435
CPC分类号： C07D213/74 , C07D213/85 , C07D237/20 , C07D237/22 , C07D239/42 , C07D401/04 , C07D409/04
摘要： The present invention relates to compounds of formula (I) wherein A?1, A2, A3, A4, A5, A6¿, U, V, m, n and o are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualenelanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasit infections, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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