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公开(公告)号：EP2861574A1
公开(公告)日：2015-04-22
申请号：EP13728748.8
申请日：2013-06-14
发明人： BUETTELMANN, Bernd , CECCARELLI, Simona M. , KUEHNE, Holger , KUHN, Bernd , NEIDHART, Werner , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07D333/66 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D495/04 , C07D495/10 , A61K31/381 , A61P3/10 , A61P35/00
CPC分类号： C07D417/04 , C07D333/50 , C07D333/66 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D495/04 , C07D495/10
摘要： The invention provides novel compounds having the general formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , A, E and n are as described herein, compositions including the compounds and use thereof as fatty-acid binding protein (FABP) 4/5 inhibitors in the treatment of e.g. type 2 diabetes, atherosclerosis or cancer.摘要翻译： 本发明提供了具有通式（I）的新化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，A，E和n如本文所述，包括所述化合物和用途的组合物 作为脂肪酸结合蛋白（FABP）4/5抑制剂在治疗例如， 2型糖尿病，动脉粥样硬化或癌症。
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公开(公告)号：EP2593426B1
公开(公告)日：2014-08-20
申请号：EP11730660.5
申请日：2011-07-08
发明人： BISSANTZ, Caterina , DEHMLOW, Henrietta , ERICKSON, Shawn, David , KIM, Kyungjin , MARTIN, Rainer, E. , MATTEI, Patrizio , OBST SANDER, Ulrike , PIETRANICO-COLE, Sherrie, Lynn , RICHTER, Hans , ULLMER, Christoph
IPC分类号： C07C251/48 , C07D213/53 , C07D213/55 , C07D213/64 , C07D213/89 , C07D215/12 , C07D239/26 , C07D241/12
CPC分类号： C07C251/48 , C07C2601/02 , C07C2601/14 , C07D213/53 , C07D213/55 , C07D213/64 , C07D213/89 , C07D215/12 , C07D239/26 , C07D241/12 , C07D401/10 , C07D413/10 , C07D417/10
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13.发明公开4-PHENOXY-NICOTINAMIDE OR 4-PHENOXY-PYRIMIDINE-5-CARBOXAMIDE COMPOUNDS 有权4-苯氧基 - 烟酰胺或4-苯氧基 - 嘧啶-4-甲酰胺
公开(公告)号：EP2526096A1
公开(公告)日：2012-11-28
申请号：EP11700348.3
申请日：2011-01-18
发明人： BISSANTZ, Caterina , DEHMLOW, Henrietta , ERICKSON, Shawn, David , KIM, Kyungjin , MARTIN, Rainer, E. , OBST SANDER, Ulrike , PIETRANICO-COLE, Sherrie, Lynn , RICHTER, Hans , ULLMER, Christoph
IPC分类号： C07D401/06 , C07D401/12 , C07D401/14 , C07D417/12 , A61K31/44 , A61K31/4427 , A61K31/506 , A61P3/00
CPC分类号： C07D417/14 , C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D417/12
摘要： This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula (I), wherein A
1 , A
2 , B
1 , B
2 and R
1 to R
11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.-
14.发明公开NON-ANNULATED THIOPHENYLAMIDES AS INHIBITORS OF FATTY ACID BINDING PROTEINI(FABP) 4 AND/OR 5 审中-公开NICHT-ANNELIERTE THIOPHENYLAMIDE ALS INHIBITOREN DERFETTSÄUREBINDENDENPROTEINE（FABP）4 UND / ODER 5
公开(公告)号：EP2895481A1
公开(公告)日：2015-07-22
申请号：EP13762429.2
申请日：2013-09-09
发明人： BUETTELMANN, Bernd , CECCARELLI, Simona M. , KUEHNE, Holger , KUHN, Bernd , NEIDHART, Werner , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07D413/14 , C07D333/36 , C07D413/04 , C07D417/04 , C07D417/14 , A61P3/10 , A61P9/10 , A61P35/00 , A61P13/12 , A61P1/16 , A61K31/381 , A61K31/427 , A61K31/4245 , A61K31/433
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A, E and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，A，E和n如本文所述，包括该化合物的组合物和使用该化合物的方法。
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公开(公告)号：EP2681194B1
公开(公告)日：2015-04-15
申请号：EP12706049.9
申请日：2012-02-29
发明人： BISSANTZ, Caterina , DEHMLOW, Henrietta , ERICKSON, Shawn David , KARNACHI, Prabha Saba , KIM, Kyungjin , MARTIN, Rainer, E. , MATTEI, Patrizio , OBST SANDER, Ulrike , PIETRANICO-COLE, Sherrie Lynn , RICHTER, Hans , ULLMER, Christoph
IPC分类号： C07D213/75 , C07D213/81 , C07D213/82 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/107 , A61K31/4418 , A61K31/4433
CPC分类号： C07D213/75 , C07D213/81 , C07D213/82 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/107
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16.发明公开1,2- PYRIDAZINE, 1,6- PYRIDAZINE OR PYRIMIDINE - BENZAMIDE DERIVATIVES AS GPBAR1 MODULATORS 有权作为GPBAR1调节剂的1,2-哒嗪，1,6-哒嗪或嘧啶 - 苯甲酰胺衍生物
公开(公告)号：EP2834226A1
公开(公告)日：2015-02-11
申请号：EP13713197.5
申请日：2013-04-02
IPC分类号： C07D401/04 , A61K31/50 , A61K31/505 , C07D237/20 , C07D239/42 , A61P3/00 , A61P29/00
CPC分类号： C07D239/42 , C07D237/20 , C07D295/26 , C07D401/04
摘要： This invention relates to novel 1,2-pyridazines, 1,6-pyridazines or pyrimidines of the formula I wherein B
1 to B
3 and R
1 to R
7 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may therefore be useful as medicaments for the treatment of diseases such as type II diabetes.摘要翻译： 本发明涉及式I的新1,2-哒嗪，1,6-哒嗪或嘧啶，其中B 1至B 3和R 1至R 7如说明书和权利要求书中所定义，以及药学上可接受的 其盐。 这些化合物是GPBAR1激动剂，因此可用作治疗疾病例如II型糖尿病的药物。
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公开(公告)号：EP2593426A1
公开(公告)日：2013-05-22
申请号：EP11730660.5
申请日：2011-07-08
发明人： BISSANTZ, Caterina , DEHMLOW, Henrietta , ERICKSON, Shawn, David , KIM, Kyungjin , MARTIN, Rainer, E. , MATTEI, Patrizio , OBST SANDER, Ulrike , PIETRANICO-COLE, Sherrie, Lynn , RICHTER, Hans , ULLMER, Christoph
IPC分类号： C07C251/48 , C07D213/53 , C07D213/55 , C07D213/64 , C07D213/89 , C07D215/12 , C07D239/26 , C07D241/12
CPC分类号： C07C251/48 , C07C2601/02 , C07C2601/14 , C07D213/53 , C07D213/55 , C07D213/64 , C07D213/89 , C07D215/12 , C07D239/26 , C07D241/12 , C07D401/10 , C07D413/10 , C07D417/10
摘要： This invention relates to novel 1-hydroxyimino-3-phenyl-propanes of the formula (I) wherein R
1 to R
10 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may be used as medicaments for the treatment of diseases such as type II diabetes.-
18.发明授权1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS 有权1,1-二氧代硫代吗吲哚基甲酮衍生物FOR USE AS H3调节剂
公开(公告)号：EP1968967B1
公开(公告)日：2011-04-27
申请号：EP06830045.8
申请日：2006-11-20
发明人： NETTEKOVEN, Matthias , PLANCHER, Jean-Marc , RICHTER, Hans , ROCHE, Olivier , RODRIGUEZ SARMIENTO, Rosa Maria , TAYLOR, Sven
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , A61K31/445 , A61K31/404 , A61P3/04
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to compounds of formula I wherein R1, R2 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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19.发明公开1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS 有权1,1-二氧代硫代吗吲哚基甲酮衍生物FOR USE AS H3调节剂
公开(公告)号：EP1968967A1
公开(公告)日：2008-09-17
申请号：EP06830045.8
申请日：2006-11-20
发明人： NETTEKOVEN, Matthias , PLANCHER, Jean-Marc , RICHTER, Hans , ROCHE, Olivier , RODRIGUEZ SARMIENTO, Rosa Maria , TAYLOR, Sven
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , A61K31/445 , A61K31/404 , A61P3/04
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to compounds of formula I wherein R1, R2 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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公开(公告)号：EP1966199A1
公开(公告)日：2008-09-10
申请号：EP06829951.0
申请日：2006-11-08
IPC分类号： C07D471/04 , A61K31/4453 , A61K31/4462 , A61K31/4465 , A61P3/04 , A61P3/10
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) wherein R1 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
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