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11.发明授权VECTEURS NAVETTES POUR L'INTRODUCTION D'ADN DANS DES MYCOBACTERIES ET UTILISATION DE CES BACTERIES COMME VACCINS 失效将DNA EINSCHAEUSE矢量，分枝杆菌或使用细菌作为疫苗
公开(公告)号：EP0760859B1
公开(公告)日：2003-11-19
申请号：EP95920967.7
申请日：1995-05-19
CPC分类号： C12N9/0004 , C12N9/88 , C12N15/52 , C12N15/74 , C12Y116/01001
摘要： Shuttle vectors for the introduction of DNA into mycobacteria comprising at least one functional replication origin in said mycobacteria, another functional replication origin in other bacteria, an enzymatic cleavage site providing for the insertion of DNA coding for a protein susceptible of being expressed in the mycobacteria, characterized in that the vectors also carry a gene which makes the mycobacteria resistant to a compound containing a heavy metal.
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12.发明公开VECTEURS NAVETTES POUR L'INTRODUCTION D'ADN DANS DES MYCOBACTERIES ET UTILISATION DE CES BACTERIES COMME VACCINS 失效将DNA EINSCHAEUSE矢量，分枝杆菌或使用细菌作为疫苗
公开(公告)号：EP0760859A1
公开(公告)日：1997-03-12
申请号：EP95920967.0
申请日：1995-05-19
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE
CPC分类号： C12N9/0004 , C12N9/88 , C12N15/52 , C12N15/74 , C12Y116/01001
摘要： Shuttle vectors for the introduction of DNA into mycobacteria comprising at least one functional replication origin in said mycobacteria, another functional replication origin in other bacteria, an enzymatic cleavage site providing for the insertion of DNA coding for a protein susceptible of being expressed in the mycobacteria, characterized in that the vectors also carry a gene which makes the mycobacteria resistant to a compound containing a heavy metal.
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公开(公告)号：EP3590532A1
公开(公告)日：2020-01-08
申请号：EP19176782.1
申请日：2010-04-26
申请人： Institut National de la Santé et de la Recherche Médicale , Institut Pasteur de Lille (IPL) , National University of Ireland, Maynooth
摘要： The present invention relates to a life attenuated Bordetella pertussis vaccine which is deficient for tracheal cytotoxin (TCT), pertussis toxin (PTX), and dermonecrotic toxin (DNT) for prophylaxis or treatment of an allergen-driven airway pathology.
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公开(公告)号：EP3436034A1
公开(公告)日：2019-02-06
申请号：EP17715426.7
申请日：2017-03-29
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15.发明公开
公开(公告)号：EP0918854A1
公开(公告)日：1999-06-02
申请号：EP97937621.0
申请日：1997-08-12
发明人： MAGDALENA, Juana , SUPPLY, Philip , LOCHT, Camille
CPC分类号： C12N15/11 , C07K14/35 , C12Q1/689 , Y10S435/81
摘要： The invention concerns a M. tuberculosis complex mycobacteria specific fragment of nucleic acids, comprising a nucleotide chain selected among the SEQ ID NO. 1 sequence, the SEQ ID No 2 sequence, their complementary sequences or the nucleic acid sequences capable of being hybridised with one of the preceding sequences in conditions of high stringency. The invention also concerns uses of said sequences for the detection and differential diagnosis of mycobacteria members of the M. tuberculosis complex, in particular the BCG differential diagnosis of other members of the complex.
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16.发明公开
公开(公告)号：EP0914437A2
公开(公告)日：1999-05-12
申请号：EP97925109.0
申请日：1997-05-20
发明人： MENOZZI, Franco , LOCHT, Camille
摘要： The invention features peptide sequences enabling mycobacteria adhesion to host cells, in particular to epithelial cells. More particularly, the invention features a mycobacterial antigen of the heparin-binding haemagglutinin type (HBHA) obtained from Mycobacterium bovis BCG or Mycobacterium tuberculosis. The invention also features a recombinant peptide sequence enabling mycobacteria adhesion to host cells. The invention particularly features the expression product of an Escherichia coli strain transformed with a nucleotide sequence coding for a protein enabling mycobacteria adhesion to host cells. These peptide sequences can be used in immunogenic compositions, for preparing vaccines against mycobacterial infections, and for mycobacterial infection serological diagnosis.
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公开(公告)号：EP3697439A1
公开(公告)日：2020-08-26
申请号：EP18815945.3
申请日：2018-10-18
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公开(公告)号：EP2773371B1
公开(公告)日：2020-01-01
申请号：EP12846339.5
申请日：2012-11-02
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19.发明公开INFLUENZA VACCINE, COMPOSITION, AND METHODS OF USE 审中-公开UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG UNG
公开(公告)号：EP2944320A1
公开(公告)日：2015-11-18
申请号：EP15172430.9
申请日：2009-06-15
申请人： National University of Singapore , Institut Pasteur De Lille , Institut National de la Santé et de la Recherche Médicale
发明人： ALONSO, Sylvie , LI, Rui , CHOW, Vincent , LOCHT, Camille
IPC分类号： A61K39/00 , A61K39/10 , A61K39/145 , A61K31/16 , A61P31/16
CPC分类号： A61K39/099 , A61K9/0043 , A61K39/12 , A61K39/145 , A61K2039/521 , A61K2039/522 , A61K2039/523 , A61K2039/543 , A61K2039/55566 , A61K2039/58 , C12N2760/16134
摘要： The invention relates to compositions and vaccines that include a mutated Bordetella strain for treating or preventing an influenza infection in a mammal. In addition, the invention further provides methods for protecting a mammal against infection by influenza and/or eliciting an immune response against an influenza virus in a mammal using the composition or vaccine.
摘要翻译： 本发明涉及组合物和疫苗，其包括用于治疗或预防哺乳动物流感感染的突变的博德特氏菌属菌株。 此外，本发明还提供了使用组合物或疫苗保护哺乳动物免受流感感染和/或在哺乳动物中引起针对流感病毒的免疫应答的方法。
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公开(公告)号：EP2442826A1
公开(公告)日：2012-04-25
申请号：EP09846104.9
申请日：2009-06-15
申请人： National University of Singapore , Institut Pasteur De Lille , Institut National de la Santé et de la Recherche Médicale
发明人： ALONSO, Sylvie , LI, Rui , CHOW, Vincent , LOCHT, Camille
CPC分类号： A61K39/099 , A61K9/0043 , A61K39/12 , A61K39/145 , A61K2039/521 , A61K2039/522 , A61K2039/523 , A61K2039/543 , A61K2039/55566 , A61K2039/58 , C12N2760/16134
摘要： The invention relates to compositions and vaccines that include a mutated Bordetella strain for treating or preventing an influenza infection in a mammal. In addition, the invention further provides methods for protecting a mammal against infection by influenza and/or eliciting an immune response against an influenza virus in a mammal using the composition or vaccine.
摘要翻译： 本发明涉及包含用于治疗或预防哺乳动物流感感染的突变的博代氏杆菌菌株的组合物和疫苗。 此外，本发明进一步提供了使用该组合物或疫苗保护哺乳动物免受流感感染和/或引发针对流感病毒的免疫应答的方法。
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