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1.发明授权
公开(公告)号：EP1292333B1
公开(公告)日：2007-02-07
申请号：EP01945376.0
申请日：2001-06-07
CPC分类号： C07K14/235 , A61K39/099 , A61K39/39 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55511 , A61K2039/55516 , Y02A50/412 , Y02A50/423
摘要： The invention concerns the use of the FHA protein or part of the FHA protein, in free form, as adjuvant of the immune response or as immunostimulant in a human or an animal. The invention also concerns adjuvant and immunostimulatory compositions comprising FHA protein or a fragment thereof, and the use of said compositions for making vaccines.
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2.发明授权VECTEURS NAVETTES POUR L'INTRODUCTION D'ADN DANS DES MYCOBACTERIES ET UTILISATION DE CES BACTERIES COMME VACCINS 失效将DNA EINSCHAEUSE矢量，分枝杆菌或使用细菌作为疫苗
公开(公告)号：EP0760859B1
公开(公告)日：2003-11-19
申请号：EP95920967.7
申请日：1995-05-19
CPC分类号： C12N9/0004 , C12N9/88 , C12N15/52 , C12N15/74 , C12Y116/01001
摘要： Shuttle vectors for the introduction of DNA into mycobacteria comprising at least one functional replication origin in said mycobacteria, another functional replication origin in other bacteria, an enzymatic cleavage site providing for the insertion of DNA coding for a protein susceptible of being expressed in the mycobacteria, characterized in that the vectors also carry a gene which makes the mycobacteria resistant to a compound containing a heavy metal.
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3.发明公开VECTEURS NAVETTES POUR L'INTRODUCTION D'ADN DANS DES MYCOBACTERIES ET UTILISATION DE CES BACTERIES COMME VACCINS 失效将DNA EINSCHAEUSE矢量，分枝杆菌或使用细菌作为疫苗
公开(公告)号：EP0760859A1
公开(公告)日：1997-03-12
申请号：EP95920967.0
申请日：1995-05-19
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE
CPC分类号： C12N9/0004 , C12N9/88 , C12N15/52 , C12N15/74 , C12Y116/01001
摘要： Shuttle vectors for the introduction of DNA into mycobacteria comprising at least one functional replication origin in said mycobacteria, another functional replication origin in other bacteria, an enzymatic cleavage site providing for the insertion of DNA coding for a protein susceptible of being expressed in the mycobacteria, characterized in that the vectors also carry a gene which makes the mycobacteria resistant to a compound containing a heavy metal.
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4.发明公开
公开(公告)号：EP0918854A1
公开(公告)日：1999-06-02
申请号：EP97937621.0
申请日：1997-08-12
发明人： MAGDALENA, Juana , SUPPLY, Philip , LOCHT, Camille
CPC分类号： C12N15/11 , C07K14/35 , C12Q1/689 , Y10S435/81
摘要： The invention concerns a M. tuberculosis complex mycobacteria specific fragment of nucleic acids, comprising a nucleotide chain selected among the SEQ ID NO. 1 sequence, the SEQ ID No 2 sequence, their complementary sequences or the nucleic acid sequences capable of being hybridised with one of the preceding sequences in conditions of high stringency. The invention also concerns uses of said sequences for the detection and differential diagnosis of mycobacteria members of the M. tuberculosis complex, in particular the BCG differential diagnosis of other members of the complex.
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5.发明公开
公开(公告)号：EP0914437A2
公开(公告)日：1999-05-12
申请号：EP97925109.0
申请日：1997-05-20
发明人： MENOZZI, Franco , LOCHT, Camille
摘要： The invention features peptide sequences enabling mycobacteria adhesion to host cells, in particular to epithelial cells. More particularly, the invention features a mycobacterial antigen of the heparin-binding haemagglutinin type (HBHA) obtained from Mycobacterium bovis BCG or Mycobacterium tuberculosis. The invention also features a recombinant peptide sequence enabling mycobacteria adhesion to host cells. The invention particularly features the expression product of an Escherichia coli strain transformed with a nucleotide sequence coding for a protein enabling mycobacteria adhesion to host cells. These peptide sequences can be used in immunogenic compositions, for preparing vaccines against mycobacterial infections, and for mycobacterial infection serological diagnosis.
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6.发明授权
公开(公告)号：EP0914437B1
公开(公告)日：2006-05-31
申请号：EP97925109.7
申请日：1997-05-20
发明人： MENOZZI, Franco , LOCHT, Camille
IPC分类号： C12N15/31 , G01N33/569 , C07K14/35 , C07K16/12 , A61K39/04
摘要： The invention features peptide sequences enabling mycobacteria adhesion to host cells, in particular to epithelial cells. More particularly, the invention features a mycobacterial antigen of the heparin-binding haemagglutinin type (HBHA) obtained from Mycobacterium bovis BCG or Mycobacterium tuberculosis. The invention also features a recombinant peptide sequence enabling mycobacteria adhesion to host cells. The invention particularly features the expression product of an Escherichia coli strain transformed with a nucleotide sequence coding for a protein enabling mycobacteria adhesion to host cells. These peptide sequences can be used in immunogenic compositions, for preparing vaccines against mycobacterial infections, and for mycobacterial infection serological diagnosis.
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7.发明公开LIVE ATTENUATED BORDETELLA STRAINS AS A SINGLE DOSE VACCINE AGAINST WHOOPING COUGH 审中-公开LEBENDEABGESCHWÄCHTEBORDETELLASTÄMMEALS EINZELDOSISIMPFSTOFF GEGEN KEUCHHUSTEN
公开(公告)号：EP3045529A1
公开(公告)日：2016-07-20
申请号：EP16155296.3
申请日：2007-03-07
摘要： A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided.
摘要翻译： 提供了至少包含突变的ptx基因，缺失或突变的dnt基因和异源ampG基因的突变的博德氏菌菌株。 减毒的突变型博德特氏菌属菌株可用于免疫原性组合物或用于治疗或预防博德氏杆菌感染的疫苗。 还提供了减毒的博德特氏菌属菌株用于制造疫苗或免疫原性组合物的用途，以及用于保护哺乳动物免受博德特氏菌感染的方法。
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8.发明授权ANTIGENE MYCOBACTERIEN RECOMBINANT DE TYPE HEMAGGLUTININE DE LIAISON A L'HEPARINE (HBHA) METHYLEE 有权甲基化的重组分枝杆菌抗原肝素结合血细胞凝集素（HBHA）符合
公开(公告)号：EP1446422B1
公开(公告)日：2011-08-31
申请号：EP02795382.7
申请日：2002-11-18
发明人： PETHE, Kévin , MENOZZI, Franco , LOCHT, Camille
IPC分类号： C07K14/35
摘要： The invention concerns a methylated immunogenic recombinant peptide sequence comprising mycobacterial heparin-binding hemagglutinin. The invention also concerns chemical and enzymatic methods for preparing such a sequence, said sequence being previously produced in a non-methylated recombinant form then methylated by post-translational modification. The invention further concerns recombinant tools, vectors and host cells for implementing post-translational enzymatic methylation of the recombinant HBHA. The invention finally concerns immunogenic compositions comprising methylated, native or recombinant HBHA, such compositions being useful for preparing vaccines against mycobacterial infections.
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公开(公告)号：EP0941241B1
公开(公告)日：2008-08-06
申请号：EP97944948.5
申请日：1997-10-09
发明人： MIELCAREK, Nathalie , LOCHT, Camille , RIVEAU, Gilles , POULAIN-GODEFROY, Odile , CAPRON, André
IPC分类号： C07K14/235 , C07K19/00 , A61K38/16
CPC分类号： C12R1/01 , A61K39/00 , C07K14/235 , Y02A50/423
摘要： The invention concerns a Bordetella strain deficient in the production of toxin and expressing a hybrid protein comprising at least part of the filamentous hemagglutin (FHA) and at least part of a protein heterologous to FHA. The gene coding for the toxin has been eliminated, or at least partially deleted or mutated so as to produce an inactive toxin. This strain can be used as vaccine. The invention also concerns liposomes containing at least part of the FHA protein and at least one protein heterologous to the FHA protein, and the use of FHA for the stimulation of immune responses.
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10.发明授权
公开(公告)号：EP0755447B1
公开(公告)日：2003-07-02
申请号：EP95918030.8
申请日：1995-04-19
发明人： LOCHT, Camille , RENAULD, Geneviève , CAPRON, André , RIVEAU, Gilles , MENOZZI, Franco , JACOB-DUBUISSON, Françoise
IPC分类号： C12N15/31 , C12N15/62 , C07K14/235 , C12N1/21 , A61K39/10
CPC分类号： C07K14/235 , C07K2319/00
摘要： A recombinant DNA containing a sequence (1) coding for a polypeptide heterologous to a filamentous haemagglutinin of Bordetella (Fha) fused within the same reading frame to a sequence (2) located upstream from the first sequence. Said sequence (2) codes for at least a part of the Fha precursor, which part comprises at least the N-terminal region of a truncated mature Fha protein which contains the interaction site of Fha and heparin, and which, when it is itself subjected on its own to the control of a promoter recognised by the cell polymerases of B. Pertussis, and inserted into a B. Pertussis cell culture, is expressed in said culture under the control of said promoter and excreted into the cell culture medium. The invention uses both the abilities of Bordetella, and particularly B. Pertussis, which does not appear to produce extracellular proteases, and the ease with which filamentous haemagglutinins can be isolated from those of the Bordetella synthesising same.
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