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公开(公告)号：EP0320000B1
公开(公告)日：1994-09-21
申请号：EP88120629.6
申请日：1988-12-09
发明人： Takahashi, Mitsuru , Kitamura, Shigeto , Kawamoto, Isao , Iida, Takao , Sano, Hiroshi , Kase, Hiroshi , Kasai, Masaji , Saito, Hiromitsu , Murakata, Chikara , Yamada, Koji
IPC分类号： C07C239/08 , C07C239/16 , C07C259/04 , A61K31/22 , A61K31/19 , A61K31/16 , A61K31/13
CPC分类号： C07C239/16 , C07C259/06
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12.发明公开Tricyclic compounds and pharmaceutical compositions containing them 失效Trizyklische Verbindungen und diese enthaltende pharmazeutische Zusammenstellungen。
公开(公告)号：EP0588608A2
公开(公告)日：1994-03-23
申请号：EP93307261.3
申请日：1993-09-15
IPC分类号： C07D313/12 , A61K31/335
CPC分类号： C07D313/12 , C07C275/28 , C07C2603/32
摘要： [Purpose]
To provide a tricyclic compound having an ACAT inhibiting activity, which are useful for treatment of hyperlipemia and arteriosclerosis.
[Constitution]
A tricyclic compound represented by formula (I) :
where X¹-X² represents CH=CH-CH=CH, CH=CH-CH=N or S-CH=CH;
Y-Z represents CH₂-O, CH=CH or CH₂-CH₂
L-M represents C=CR⁹ or CH-CR¹⁰R¹¹; W represents NR⁴ or O;
R¹, R², R³, R⁴, R⁵, R⁶, R⁷ and R⁸ independently represents hydrogen or lower alkyl.摘要翻译： 公开了式（I）的三环化合物：其中X 1 -X 2代表基团-CH = CH-CH-CH-，-CH = CH = CH = N-或-S- CH = CH-; Y-Z代表基团-CH2-O-，-CH2-S-，-CH = CH-或-CH2CH2-; W表示-O-或-N（R 4） - 基，其中R 4为H或C 1 -C 6直链或支链烷基; R 1，R 2和R 3各自表示H，C 1 -C 6直链或支链烷基，C 1 -C 6直链或支链烷氧基，卤素，硝基，氨基或烷基氨基，其中烷基取代基 s）为或为C 1 -C 6直链或支链烷基; R 5是H或C 1 -C 6直链或支链烷基; R 6，R 7和R 8各自为H，C 1 -C 6直链或支链烷基，C 1 -C 6直链或支链烷氧基或卤素，并且LM表示C = CR 9 - 基团，其中R 9是H或C 1 -C 6直链或支链烷基，或者> CH-CR 1 R 1 1 - 基团，其中R 1和R 2都是 除了YZ是-CH = CH-或-CH2CH2-基团之外，除1或者1〜C 1直链或支链烷基以外，R 1，R 2， <1>均为C1-C6直链或支链烷基; 及其药学上可接受的盐。
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公开(公告)号：EP0106276A3
公开(公告)日：1984-05-23
申请号：EP83109969
申请日：1983-10-05
发明人： Watanabe, Minoru , Muto, Kenji , Sugaya, Toru , Kuroda, Tokuyuki , Hashimoto, Tamotsu , Yamada, Koji , Nakamizo, Nobuhiro
IPC分类号： C07D211/90 , C07D405/14 , C07D409/14 , A61K31/455 , C07D211/44 , C07D211/72 , C07D211/46
CPC分类号： C07D405/14 , C07D211/46 , C07D211/72 , C07D211/74 , C07D211/90 , C07D409/14
摘要： A 1,4-dihydropyridine derivative having hypotensive activity is represented by the formula (I):
in which one of R, and R 2 represents an alkyl group or a group of the formula (II):
in which R 5 represents an alkoxy group or a substituted or unsubstituted heterocyclic group and n represents 0 or an integer of 1 - 3, and the other of R, and R 2 represents a group of the formula (III):
in which R 6 represents a substituted or unsubstituted aralkyl group and R 7 , R 8 , R 9 , R 10 , R 11 and R 12 are the same or different groups and each represertts hydrogen or an alkyl group, and two alkyl groups may be attached to one carbon atom on the piperidine ring. When R, is an alkyl group and R a is an unsubstituted aralkyl group, at least one of R 7 , R s , R s , R 10 , R 11 and R 12 represents an alkyl group. Also disclosed are pharmaceutically acceptable acid addition salts of compound (I).-
公开(公告)号：EP0106275A2
公开(公告)日：1984-04-25
申请号：EP83109968.4
申请日：1983-10-05
IPC分类号： C07D211/90 , A61K31/455
CPC分类号： C07D211/42 , C07D211/90
摘要： Disclosed are (±)-2,6-dimethyl-4-(3-nitrophanyl)-1,4-dihydropyridine-3.5-dicarboxylic acid-3-(1-benzyl-3-piperidyl) ester-5-methyl ester, the melting point of the hydrochloride of which is 196 to 202°C (referred to as (±)-α-form], from among the diastereomers of 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydrapyridine-3,5-dicarboxylic acid-3-(1-benzyl-3-piperidyll ester-5-methyl ester represented by the formula:
and an optical isomer having an optical rotation degree of (+) from among (±)-α-form or a salt thereof.摘要翻译： 公开了（+/-） - 2,6-二甲基-4-（3-硝基苯基）-1,4-二氢吡啶-3,5-二羧酸-3-（1-苄基-3-哌啶基）酯-5- 甲基酯，其盐酸盐的熔点为196〜202℃（称为（+/-）-α-甲基），2,6-二甲基-4-（3-硝基苯基） - 由下式表示的1,4-二氢吡啶-3,5-二甲酸-3-（1-苄基-3-哌啶基）酯-5-甲酯：旋光度为（+ ）（±）-α型或其盐。
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公开(公告)号：EP0549352B1
公开(公告)日：2000-03-01
申请号：EP92311777.4
申请日：1992-12-24
发明人： Ohshima, Etsuo , Kanai, Fumihiko , Sato, Hideyuki , Obase, Hiroyuki , Kumazawa, Toshiaki , Takahara, Shiho , Ohno, Tetsuji , Ishikawa, Tomoko , Yamada, Koji
IPC分类号： C07D471/04 , A61K31/435 , A61K31/41 , A61K31/55 , A61K31/54 , C07D405/06 , C07D519/00 , C07D405/14 , C07D403/14 , C07D403/06 , C07D401/12
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D471/04
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16.发明授权Tricyclic compounds and intermediates thereof 失效Tricyclische Verbindungen und ihre Zwischenprodukte
公开(公告)号：EP0497201B1
公开(公告)日：1997-01-15
申请号：EP92101012.0
申请日：1992-01-22
发明人： Kumazawa, Toshiaki , Yanase, Masashi , Harakawa, Hiroyuki , Obase, Hiroyuki , Oda, Shoji , Shirakura, Shiro , Yamada, Koji , Kubo, Kazuhiro
IPC分类号： C07D313/12 , C07D491/04 , C07C233/58 , C07D223/20 , C07D337/12 , C07D471/04 , C07D513/04 , C07D213/56
CPC分类号： C07D491/04 , C07C233/65 , C07C2603/32 , C07D223/20 , C07D313/12 , C07D337/12 , Y10S514/824
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公开(公告)号：EP0549352A3
公开(公告)日：1993-07-28
申请号：EP92311777.4
申请日：1992-12-24
发明人： Ohshima, Etsuo , Kanai, Fumihiko , Sato, Hideyuki , Obase, Hiroyuki , Kumazawa, Toshiaki , Takahara, Shiho , Ohno, Tetsuji , Ishikawa, Tomoko , Yamada, Koji
IPC分类号： C07D471/04 , A61K31/435 , A61K31/41 , A61K31/55 , A61K31/54 , C07D405/06 , C07D519/00 , C07D405/14 , C07D403/14 , C07D403/06 , C07D401/12
CPC分类号： C07D249/08 , C07D231/12 , C07D233/56 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/06 , C07D471/04
摘要： Novel tricyclic compounds and salts are disclosed useful as AII receptor antagonists. These are compounds of the formula I and their salts:
R1 represents hudrogen, halogen or C 1 -C 6 alkyl;
A represents cyano, carboxyl, tetrazolyl, cyano-substituted phenyl, carboxyl-substituted phenyl or tetrazolyl-substituted phenyl;
V represents -(CH 2 ) m -, where m is 0,1 or 2;
W represents a group of the formula α, β, γ or δ
where α is:
where R 2 , R 3 and R 4 are each hydrogen, halogen, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, halogenated C 1 -C 6 alkyl, hydroxy, C 1 -C 6 alkoxy, amino, C 1 -C 6 alkylamino, carboxyl or C 1 -C 6 alkoxycarbonyl; and Q 1 -Q 2 -Q 3 -Q 4 represents N=CH-CH=CH, CH=CH-CH=CH or CH 2 -CH 2 -CH 2 -CH 2 :
β is:
wherein R 2 , R 3 and R 4 are as defined above:
γ is:
where R 5 and R 6 each represent hydrogen, C 1 -C 6 alkyl or C 3 -C 6 cycloalkyl, and R 7 represents carboxyl, C 1 -C 6 alkoxycarbonyl, carbamoyl or hydroxymethyl; and
δ is:
where R 8 and R 9 each represent hydrogen or C 1 -C 6 alkyl, and Q represents N or CH;
X 1 -X 2 -X 3 represents the group CH=CH-CH=CH, S-CH=CH or CH=CH-S;
Y represents a single bond, CH 2 , O, S, CH 2 O, OCH 2 , CH 2 S, SCH 2 , CH 2 CH 2 or CH=CH; and
Z 1 -Z 2 represents the group C=CH, CH-CH 2 , CH-CH(COOH)- or N- (CH 2 ) n - (wherein n is an integer of 1 to 3).-
公开(公告)号：EP0093945B1
公开(公告)日：1988-11-23
申请号：EP83104076.1
申请日：1983-04-26
发明人： Watanabe, Minoru , Moto, Kenji , Takemoto, Yoshinori , Hatta, Takao , Hashimoto, Tamotsu , Yamada, Koji
IPC分类号： C07D211/94 , C07D405/12 , C07D409/12 , C07D401/12 , A61K31/445
CPC分类号： C07D405/12 , C07C205/56 , C07D211/90 , C07D211/94 , C07D409/12 , Y10S514/929
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19.发明公开Novel vasodilator compounds, process for the preparation thereof and pharmaceutical compositions containing same 失效新型VASODILATOR化合物，其制备方法和含有其的药物组合物
公开(公告)号：EP0178902A3
公开(公告)日：1987-10-14
申请号：EP85307411
申请日：1985-10-15
IPC分类号： C12P01/06 , C12N01/20 , A61K35/66 , C12R01/465
摘要： A novel physiologically active substance KS-619-1 having a vasodilative activity is produced by culturing a microorganism of the genus Streptomyces.
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20.发明公开Novel vasodilator compounds, process for the preparation thereof and pharmaceutical compositions containing same 失效Vasodilatationsverbindungen，它们的制备方法和它们的药物组合物。
公开(公告)号：EP0178902A2
公开(公告)日：1986-04-23
申请号：EP85307411.0
申请日：1985-10-15
摘要： A novel physiologically active substance KS-619-1 having a vasodilative activity is produced by culturing a microorganism of the genus Streptomyces.
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