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公开(公告)号：EP2160392A2
公开(公告)日：2010-03-10
申请号：EP08755035.6
申请日：2008-05-02
发明人： BLATT, Lawrence, M. , PAN, Lin , SEIWERT, Scott , ANDREWS, Steven, W. , MARTIN, Pierre , SCHUMACHER, Andreas , BEIGELMAN, Leonid , LIU, Jyanwei , CONDROSKI, Kevin , JIANG, Yutong , KAUS, Robert , KENNEDY, April , KERCHER, Timothy , LYON, Michael , WANG, Bin
IPC分类号： C07D487/04 , C08H1/00 , A61K31/407 , A61P31/12
CPC分类号： C07D487/04
摘要： The embodiments provide macrocyclic compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
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公开(公告)号：EP3106463B3
公开(公告)日：2020-01-22
申请号：EP16166461.0
申请日：2009-10-21
发明人： HAAS, Julia , ANDREWS, Steven, W. , JIANG, Yutong , ZHANG, Gan
IPC分类号： C07D471/04 , A61K31/519 , A61P29/00
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公开(公告)号：EP3523301A1
公开(公告)日：2019-08-14
申请号：EP17787843.6
申请日：2017-10-10
申请人： Array Biopharma Inc.
发明人： ANDREWS, Steven W. , ARONOW, Sean , BLAKE, James F. , BRANDHUBER, Barbara J. , COOK, Adam , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , MCFADDIN, Elizabeth A. , MCKENNEY, Megan L. , MCNULTY, Oren T. , METCALF, Andrew T. , MORENO, David A. , TANG, Tony P. , REN, Li
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.
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14.发明授权BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN 有权疼痛条件的适当双环脲，硫脲，胍和双氰胺的处理
公开(公告)号：EP2920166B1
公开(公告)日：2016-11-02
申请号：EP13795960.7
申请日：2013-11-13
发明人： ALLEN, Shelley , ANDREWS, Steven, Wade , BLAKE, James, F. , BRANDHUBER, Barbara, J. , HAAS, Julia , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , THOMAS, Allen, A. , WINSKI, Shannon, L.
IPC分类号： C07D401/14 , C07D405/14 , C07D231/40 , C07D231/54 , C07D401/12 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/12 , C07D413/12 , C07D453/02 , A61K31/4155 , A61K31/416 , A61K31/4162 , A61P25/00
CPC分类号： C07D491/048 , C07D231/40 , C07D231/52 , C07D231/54 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D453/02 , C07D471/08
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15.发明公开SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS 有权替米沙米汀 - [1,5-A] -PYRIMIDINVERBINDUNGEN ALS TRK-KINASEHEMMER
公开(公告)号：EP2451812A1
公开(公告)日：2012-05-16
申请号：EP10732606.8
申请日：2010-07-09
发明人： ALLEN, Shelley , ANDREWS, Steven S. , CONDROSKI, Kevin Ronald , HAAS, Julia , HUANG, Lily , JIANG, Yutong , KERCHER, Timothy , SEO, Jeongbeob
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , C07D453/02 , C07D471/22 , C07D498/22 , C07D519/00
摘要： Compounds of Formula II, III and IV, wherein R 3 , R 4 , Y and n are defined in the claims.
摘要翻译： 及其盐，其中R1，R2，R3，R4，X，Y和n具有本说明书中给出的含义，是Trk激酶的抑制剂，可用于治疗可用Trk激酶抑制剂如 疼痛，癌症，炎症，神经变性疾病和某些传染病。
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公开(公告)号：EP3849986A1
公开(公告)日：2021-07-21
申请号：EP19773595.4
申请日：2019-09-06
发明人： BLAKE, James F. , DAI, Donghua , HAAS, Julia , JIANG, Yutong , KAHN, Dean , KOLAKOWSKI, Gabrielle R. , MCFADDIN, Elizabeth A. , MCKENNEY, Megan L. , METCALF, Andrew T. , MORENO, David A. , PRIGARO, Brett , RAMANN, Ginelle A. , REN, Li , WALLS, Shane M. , ZHANG, Hailong
IPC分类号： C07D487/14 , C07D487/22 , C07D498/14 , C07D498/22 , A61P35/00 , A61K31/551
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公开(公告)号：EP3740486A1
公开(公告)日：2020-11-25
申请号：EP19703912.6
申请日：2019-01-18
发明人： WALLS, Shane M. , REN, Li , RAMANN, Ginelle A. , MORENO, David A. , METCALF, Andrew T. , MCFADDIN, Elizabeth A. , KOLAKOWSKI, Gabrielle R. , BLAKE, James F. , DAI, Donghua , HAAS, Julia , JIANG, Yutong , KAHN, Dean
IPC分类号： C07D471/04 , A61P35/00 , A61K31/437
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公开(公告)号：EP3205654B1
公开(公告)日：2019-01-02
申请号：EP17163978.4
申请日：2011-05-13
发明人： ANDREWS, Steven Wade , CONDROSKI, Kevin Ronald , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R. , SEO, Jeongbeob , YANG, Hong-Woon , ZHAO, Qian
IPC分类号： C07D487/04 , A61K31/519 , C07D519/00 , C07D498/22 , C07D487/22 , C07D471/22
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公开(公告)号：EP3372605A1
公开(公告)日：2018-09-12
申请号：EP18151233.6
申请日：2009-10-21
发明人： HAAS, Julia , ANDREWS, Steven, W. , JIANG, Yutong , ZHANG, Gan
IPC分类号： C07D471/04 , A61K31/519 , A61P29/00
CPC分类号： C07D487/04 , A61K9/0053 , A61K31/519 , A61K31/5377 , A61K45/06 , A61P29/00 , C07D471/04 , C07D519/00 , Y02A50/414
摘要： Compounds of Formula I:
in which R 1 , R 2 , R 3 , R 4 , X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor.-
公开(公告)号：EP3322706A1
公开(公告)日：2018-05-23
申请号：EP16741825.0
申请日：2016-07-15
发明人： ANDREWS, Steven W. , BLAKE, James F. , CHICARELLI, Mark J. , GOLOS, Adam , HAAS, Julia , JIANG, Yutong , KOLAKOWSKI, Gabrielle R.
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61P29/00
摘要： and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, D, E, X1, X2, X3 and X4 have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including diseases or disorders mediated by a RET kinase.
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