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11.发明公开COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE 审中-公开VERBINDUNGEN ZUR NONSENSE-UNTERDRÜCKUNGUND VERFAHREN ZU DEREN VERWENDUNG
公开(公告)号：EP3067053A1
公开(公告)日：2016-09-14
申请号：EP16163831.7
申请日：2005-10-13
发明人： ALMSTEAD, Neil , CHEN, Guangming , KARP, Gary Mitchell , WELCH, Ellen , WILDE, Richard Gerald , CAMPBELL, Jeffrey Allen
IPC分类号： A61K31/4245 , A61K31/433 , A61P35/00 , C07D271/10 , C07D407/04 , C07D413/04 , C07D413/10 , C07D417/10 , C07D513/04 , C07D487/04 , C07D271/06 , C07D263/32 , C07D231/12 , C07D277/30 , C07D285/08 , C07D333/24 , C07D249/08 , C07D409/10
CPC分类号： C07D271/06 , C07D231/12 , C07D233/64 , C07D249/08 , C07D251/24 , C07D261/08 , C07D263/32 , C07D271/10 , C07D271/107 , C07D277/30 , C07D285/12 , C07D307/68 , C07D333/24 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07F9/65306
摘要： The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.
摘要翻译： 本发明涉及通过施用本发明的化合物或组合物来治疗或预防与无义突变相关的疾病的方法，化合物和组合物。 更具体地，本发明涉及用于抑制与mRNA中的无义突变相关的过早翻译终止的方法，化合物和组合物。
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公开(公告)号：EP4288441A1
公开(公告)日：2023-12-13
申请号：EP22750319.0
申请日：2022-02-02
发明人： ARACHCHILAGE, Gayan Mirihana , ARNOLD, Michael A. , BARRAZA, Scott , BHATTACHARYYA, Anuradha , KARP, Gary Mitchell
IPC分类号： C07D487/04
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公开(公告)号：EP3969446A1
公开(公告)日：2022-03-23
申请号：EP20729481.0
申请日：2020-05-12
发明人： SYDORENKO, Nadiya , ALAM, Md Rauful , AMEDZO, Lukiana , ARNOLD, Michael A. , BABU, Suresh , BHATTACHARYYA, Anuradha , KARP, Gary Mitchell , KENTON, Nathaniel T. , LUONG, Tom Tuan , MAZZOTTI, Anthony R. , MOON, Young-Choon , MORRILL, Christie , MSZAR, Nicholas Walter , NARASIMHAN, Jana , PATEL, Jigar S. , REN, Hongyu , TURPOFF, Anthony , WANG, Gang , WOLL, Matthew G. , ZHANG, Nanjing , ZHANG, Xiaoyan
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D487/04 , A61K31/501 , A61K31/53 , A61P25/28
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公开(公告)号：EP3814345A1
公开(公告)日：2021-05-05
申请号：EP19736947.3
申请日：2019-06-25
发明人： ZHANG, Nanjing , BABU, Suresh , BARRAZA, Scott J. , BHATTACHARYYA, Anuradha , CHEN, Guangming , KARP, Gary Mitchell , KASSICK, Andrew J. , MAZZOTTI, Anthony R. , MOON, Young-Choon , NARASIMHAN, Jana , SYDORENKO, Nadiya , TURPOFF, Anthony , WOLL, Matthew, G. , YAN, Wuming
IPC分类号： C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00 , A61P25/00 , A61P25/14 , A61P25/28 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/55 , A61K31/5025 , A61K31/519 , A61K31/46
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公开(公告)号：EP2797592B1
公开(公告)日：2019-08-28
申请号：EP12862080.4
申请日：2012-12-28
发明人： WOLL, Matthew G. , CHEN, Guangming , CHOI, Soongyu , DAKKA, Amal , HUANG, Song , KARP, Gary Mitchell , LEE, Chang-Sun , LI, Chunshi , NARASIMHAN, Jana , NARYSHKIN, Nikolai , PAUSHKIN, Sergey , QI, Hongyan , TURPOFF, Anthony A. , WEETALL, Marla L. , WELCH, Ellen , YANG, Tianle , ZHANG, Nanjing , ZHANG, Xiaoyan , ZHAO, Xin , PINARD, Emmanuel , RATNI, Hasane
IPC分类号： A61K31/353 , C07D413/14 , C07D405/14 , C07D311/16 , C07D311/18 , C07D231/12 , C07D405/04 , C07D405/12 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00 , A61P25/00 , C07D417/14
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公开(公告)号：EP2819519A1
公开(公告)日：2015-01-07
申请号：EP13755032.3
申请日：2013-02-28
IPC分类号： A01N57/00
CPC分类号： C07D519/00 , C07D491/04 , C07D491/052
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
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公开(公告)号：EP2809322A1
公开(公告)日：2014-12-10
申请号：EP13740919.9
申请日：2013-01-25
发明人： CHEN, Guangming , DAKKA, Amal , KARP, Gary Mitchell , LI, Chunshi , NARASIMHAN, Jana , NARYSHKIN, Nikolai , WEETALL, Marla L. , WELCH, Ellen , ZHAO, Xin , WEETAL, Marla L.
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
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公开(公告)号：EP1781289A1
公开(公告)日：2007-05-09
申请号：EP05773284.4
申请日：2005-07-14
IPC分类号： A61K31/4365 , A61P31/14
CPC分类号： A61K31/4365 , A61K31/4743 , A61K31/4745 , A61K31/519 , Y02A50/385 , Y02A50/387 , Y02A50/393 , Y02A50/463 , Y02A50/465
摘要： In accordance with the present invention, compounds that can inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
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