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    DROPLET CREATION TECHNIQUES
    13.
    发明公开
    DROPLET CREATION TECHNIQUES 审中-公开
    VERFAHREN ZURTRÖPFCHENBILDUNG

    公开(公告)号：EP2493619A1

    公开(公告)日：2012-09-05

    申请号：EP10776469.8

    申请日：2010-10-26

    申请人： President and Fellows of Harvard College

    发明人： WEITZ, David, A. ,  ABATE, Adam, R.

    IPC分类号： B01L3/00 ,  B01F13/00

    CPC分类号： B01L3/502761 ,  B01F3/0807 ,  B01F13/0062 ,  B01F13/0071 ,  B01L3/502784 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2300/0681 ,  Y10T137/0318 ,  Y10T137/8593

    摘要： The present invention is generally related to systems and methods for producing droplets. The droplets may contain varying species, e.g., for use as a library. In some cases, at least one droplet is used to create a plurality of droplets, using techniques such as flow-focusing techniques. In one set of embodiments, a plurality of droplets, containing varying species, can be divided to form a collection of droplets containing the various species therein. A collection of droplets, according to certain embodiments, may contain various subpopulations of droplets that all contain the same species therein. Such a collection of droplets may be used as a library in some cases, or may be used for other purposes.

    摘要翻译： 本发明通常涉及用于产生液滴的系统和方法。 液滴可以含有不同的物质，例如用作文库。 在一些情况下，使用诸如流动聚焦技术之类的技术，使用至少一个液滴来产生多个液滴。 在一组实施例中，包含不同种类的多个液滴可以被分开以形成其中包含各种物质的液滴的集合。 根据某些实施方案，液滴的集合可以包含在其中全部含有相同物质的各种液滴亚组。 这种液滴的集合在某些情况下可以用作文库，也可以用于其它目的。

    MULTIPLE EMULSIONS CREATED USING JETTING AND OTHER TECHNIQUES
    14.
    发明公开
    MULTIPLE EMULSIONS CREATED USING JETTING AND OTHER TECHNIQUES 审中-公开
    更多使用波束和其他技术生产的乳剂

    公开(公告)号：EP2473263A2

    公开(公告)日：2012-07-11

    申请号：EP10814401.5

    申请日：2010-09-01

    申请人： President and Fellows of Harvard College

    发明人： WEITZ, David, A. ,  THIELE, Julian, W.P. ,  ABATE, Adam, R.

    IPC分类号： B01F5/02 ,  B01F5/26 ,  B01F3/08 ,  B01F15/04

    CPC分类号： B01F3/0807 ,  B01F13/0062 ,  B01F13/0084 ,  B01F2003/0838 ,  B01F2215/045 ,  B01F2215/0459 ,  Y10T137/0318 ,  Y10T137/85938

    摘要： The present invention generally relates to emulsions, and more particularly, to multiple emulsions. In one aspect, multiple emulsions are formed by urging a fluid into a channel, e.g., by causing the fluid to enter the channel as a “jet.” Side channels can be used to encapsulate the fluid with a surrounding fluid. In some cases, multiple fluids may flow through a channel collinearly before multiple emulsion droplets are formed. The fluidic channels may also, in certain embodiments, include varying degrees of hydrophilicity or hydrophobicity. As examples, the fluidic channel may be relatively hydrophilic upstream of an intersection (or other region within the channel) and relatively hydrophobic downstream of the intersection, or vice versa. In some cases, the average cross-sectional dimension may change, e.g., at an intersection. For instance, the average cross-sectional dimension may increase at the intersection. Surprisingly, a relatively small increase in dimension, in combination with a change in hydrophilicity of the fluidic channel, may delay droplet formation of a stream of collinearly-flowing multiple fluids under certain flow conditions; accordingly, the point at which multiple emulsion droplets are formed can be readily controlled within the fluidic channel. In some cases, the multiple droplet may be formed from the collinear flow of fluids at (or near) a single location within the fluidic channel. In addition, unexpectedly, systems such as those described herein may be used to encapsulate fluids in single or multiple emulsions that are difficult or impossible to encapsulate using other techniques, such as fluids with low surface tension, viscous fluids, or viscoelastic fluids. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.

    MULTIPLE EMULSIONS CREATED USING JUNCTIONS
    15.
    发明公开
    MULTIPLE EMULSIONS CREATED USING JUNCTIONS 审中-公开
    几种化合物生产的乳液

    公开(公告)号：EP2473262A2

    公开(公告)日：2012-07-11

    申请号：EP10814398.3

    申请日：2010-09-01

    申请人： President and Fellows of Harvard College ,  BASF SE

    发明人： WEITZ, David, A. ,  ROMANOWSKY, Mark ,  HOLTZE, Christian

    IPC分类号： B01F5/00 ,  B01F3/08 ,  B01F15/04

    CPC分类号： B01F13/0084 ,  B01F3/0807 ,  B01F2003/0838 ,  Y10T137/0318 ,  Y10T137/87571

    摘要： The present invention generally relates to emulsions, and more particularly, to multiple emulsions. In one aspect, multiple emulsions are formed using a plurality of channels, such as microfluidic channels, that meet at a common intersection. The multiple emulsions may be created at a single common intersection in some embodiments, unlike other prior art systems where multiple channel intersections are required to create multiple emulsions. For instance, in one set of embodiments, three, four, or more microfluidic channels may intersect at a common intersection, with two or three serving as inlets and one serving as the outlet. In some embodiments, a first fluidic channel may be relatively hydrophobic, while a second fluidic channel is relatively hydrophilic. The third channel, if present, may be relatively hydrophilic or hydrophobic, depending on the application. The outlet channel may be hydrophobic, hydrophilic, or may comprise at least one portion that is relatively hydrophilic and at least one portion that is relatively hydrophilic. By controlling the flow of fluids through the hydrophilic and hydrophobic portions of the channels, multiple emulsions may be created proximate the common intersection, due to interactions between the fluids entering the common intersection. In other embodiments, different patterns of hydrophilic or hydrophobic channels may be used. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.

    EMULSIONS AND TECHNIQUES FOR FORMATION
    16.
    发明公开
    EMULSIONS AND TECHNIQUES FOR FORMATION 有权
    Vorrichtung zur Formung vonTröpfchen

    公开(公告)号：EP2136786A2

    公开(公告)日：2009-12-30

    申请号：EP08742358.8

    申请日：2008-03-28

    申请人： The President and Fellows of Harvard College

    发明人： CHU, Liang-yin ,  SHUM, Ho, Cheung ,  FERNANDEZ-NIEVES, Alberto ,  UTADA, Andrew, S. ,  SANTANACH CARRERAS, Enric ,  WEITZ, David, A.

    IPC分类号： A61K9/113 ,  B01F17/00 ,  B01F5/04

    CPC分类号： A61K9/113 ,  A61K9/5089 ,  B01F3/0807 ,  B01F5/045 ,  B01F13/0062 ,  B01F13/1013 ,  B01F13/1016 ,  B01F17/00 ,  B01F2005/0022 ,  B01J13/14 ,  G01N15/1404 ,  G01N2015/1006 ,  Y10T428/2998

    摘要： The present invention generally relates to emulsions such as multiple emulsions, and to methods and apparatuses for making emulsions, and techniques for using the same. A multiple emulsion generally describes larger droplets that contain one or more smaller droplets therein which, in some cases, can contain even smaller droplets therein, etc. Emulsions, including multiple emulsions can be formed in certain embodiments with generally precise repeatability, and can be tailored to include any number of inner droplets, in any desired nesting arrangement, within a single outer droplet. In addition, in some aspects of the invention, one or more droplets may be controllably released from a surrounding droplet.

    摘要翻译： 本发明一般涉及诸如多重乳液的乳液，以及用于制备乳液的方法和装置以及使用该乳液的技术。 多重乳液通常描述在其中含有一个或多个更小的液滴的较大的液滴，其在一些情况下可以在其中含有甚至更小的液滴等。在某些实施方案中可以形成乳液，包括多个乳液，具有大致精确的重复性，并且可以定制 在任何期望的嵌套布置中包括在单个外部液滴内的任何数量的内部液滴。 此外，在本发明的一些方面，一个或多个液滴可以可控地从周围的液滴中释放。