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11.发明公开A Method of detecting and/or identifying adeno-associated virus (AVV) sequences and isolating novel sequences identified thereby 有权一种用于确定和腺相关病毒（AAV）序列的鉴定，以及用于分离由此确定了新的方法的序列
公开(公告)号：EP1310571A3
公开(公告)日：2003-08-13
申请号：EP02257826.4
申请日：2002-11-12
CPC分类号： C12N15/86 , A61K38/177 , A61K38/4846 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152 , C12N2750/14162 , C12N2750/14171 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12Q1/701 , C12Q2600/158 , C12Y304/21022
摘要： A method for dctecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided. The invention further provides AAV sequences identified by this method, and vectors constructed using these sequences.
摘要翻译： 本发明提供一种用于从组织或细胞获得的DNA样品中dctecting和分离AAV序列的方法。 本发明提供了使用这些序列构建IDENTIFIED通过该方法此外AAV序列，和载体。
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12.发明授权Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use 有权猿猴腺病毒核酸和氨基酸序列，含有它们的载体和使用方法
公开(公告)号：EP2301582B1
公开(公告)日：2017-07-12
申请号：EP10178464.3
申请日：2002-11-20
发明人： Wilson, James M. , Gao, Guangping , Roy, Soumitra
IPC分类号： A61K47/42 , C07H21/00 , C07K14/075 , C12N7/00 , C12N15/33 , C12N15/861
CPC分类号： A61K39/235 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/5256 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10022 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10362 , C12N2710/20022 , C12N2740/16122 , C12N2740/17022 , C12N2750/14122 , C12N2760/14134 , C12N2760/16134 , C12N2760/20122 , C12N2830/002 , C12N2830/55
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13.发明授权Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof 有权腺相关病毒的进化枝，含有这些载体和它们的用途的序列
公开(公告)号：EP2345731B1
公开(公告)日：2015-10-21
申请号：EP10182098.3
申请日：2004-09-30
IPC分类号： C12N15/864 , A61K48/00 , C07K14/015
CPC分类号： A61K48/00 , C07K14/005 , C07K14/705 , C12N7/00 , C12N9/644 , C12N15/86 , C12N2750/14121 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14151 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y304/21022
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公开(公告)号：EP2359865A1
公开(公告)日：2011-08-24
申请号：EP10179260.4
申请日：2006-04-07
IPC分类号： A61K48/00 , C12N15/864 , A61K35/76 , C12N7/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61K48/0091 , C07K14/005 , C12N7/00 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14152
摘要： A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
摘要翻译： 提供了校正选择的AAV序列中的单体以提高所选AAV的包装产量，转导效率和/或基因转移效率的方法。 该方法涉及改变亲代AAV衣壳中的一个或多个单体以使单体与排列的功能性AAV衣壳序列的相应位置中的氨基酸一致。
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15.发明公开A method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby 有权Adenoassoziierten病毒（AAV）Cy.5 Sequenzen，diese enthaltende Vektoren und deren Verwendungen
公开(公告)号：EP2338900A1
公开(公告)日：2011-06-29
申请号：EP10178970.9
申请日：2002-11-12
IPC分类号： C07K14/015 , C12N15/864
CPC分类号： C12N15/86 , A61K38/177 , A61K38/4846 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152 , C12N2750/14162 , C12N2750/14171 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12Q1/701 , C12Q2600/158 , C12Y304/21022
摘要： A method for detecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided. The invention further provides AAV sequences identified by this method, and vectors constructed using these sequences.
摘要翻译： 提供了从组织或细胞获得的DNA样品中检测和分离AAV序列的方法。 本发明还提供了通过该方法鉴定的AAV序列，以及使用这些序列构建的载体。
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16.发明公开Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use 有权由其衍生的猴的腺病毒载体的核酸和氨基酸序列，和使用方法
公开(公告)号：EP2301582A1
公开(公告)日：2011-03-30
申请号：EP10178464.3
申请日：2002-11-20
发明人： Wilson, James M. , Gao, Guangping , Roy, Soumitra
IPC分类号： A61K47/42 , C07H21/00 , C07K14/075 , C12N7/00 , C12N15/33 , C12N15/861
CPC分类号： A61K39/235 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/5256 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10022 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10362 , C12N2710/20022 , C12N2740/16122 , C12N2740/17022 , C12N2750/14122 , C12N2760/14134 , C12N2760/16134 , C12N2760/20122 , C12N2830/002 , C12N2830/55
摘要： A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
摘要翻译： 一种重组载体，包括猿猴腺病毒序列和调控序列的控制下的异源基因。 的细胞系快车哪个猿猴腺病毒基因IST游离缺失盘。 提供了使用所述载体和细胞系的方法。
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17.发明授权Method for direct rescue and amplification of integrated viruses from cellular DNA of tissues 有权用于从细胞组织整合的病毒DNA的直接回收和扩增方法
公开(公告)号：EP1359217B1
公开(公告)日：2006-12-13
申请号：EP03252519.8
申请日：2003-04-22
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2750/14143 , C12N2750/14151
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18.发明授权A Method of identifying unknown adeno-associated virus (AVV) sequences and a kit for the method 有权一种用于鉴定腺相关病毒（AAV）序列和试剂盒进行的方法的方法
公开(公告)号：EP1310571B1
公开(公告)日：2006-02-15
申请号：EP02257826.4
申请日：2002-11-12
CPC分类号： C12N15/86 , A61K38/177 , A61K38/4846 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152 , C12N2750/14162 , C12N2750/14171 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12Q1/701 , C12Q2600/158 , C12Y304/21022
摘要： A method for dctecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided. The invention further provides AAV sequences identified by this method, and vectors constructed using these sequences.
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19.发明公开Method for direct rescue and amplification of integrated viruses from cellular DNA of tissues 有权用于从细胞组织整合的病毒DNA的直接回收和扩增方法
公开(公告)号：EP1359217A1
公开(公告)日：2003-11-05
申请号：EP03252519.8
申请日：2003-04-22
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2750/14143 , C12N2750/14151
摘要： A method for isolating AAV viruses from cellular DNA of mammalian tissues comprises transfecting the digested DNA into cells, rescuing the virus and amplifying it through serial passages in the presence of adenovirus helper functions. Kits useful for performing this method are also provided.
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20.发明公开Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same and uses therefor 审中-公开腺相关病毒（AAV）血清型8，含有这样的序列及其用途矢量的序列
公开(公告)号：EP2359869A3
公开(公告)日：2014-01-08
申请号：EP10189725.4
申请日：2002-11-12
IPC分类号： A61K48/00 , C12N5/10 , C12N7/01 , C12N7/04 , C12N15/63 , C12N15/64 , C12N15/864 , C07H21/04 , C07K14/015 , C07K7/04 , C07K7/06
CPC分类号： C12N15/86 , A61K9/0019 , A61K35/761 , A61K38/177 , A61K38/45 , A61K38/4846 , A61K48/00 , C07K14/005 , C07K14/705 , C07K14/755 , C12N7/00 , C12N9/1018 , C12N9/644 , C12N15/8645 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y201/03003 , C12Y304/21021 , C12Y304/21022
摘要： Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogenic genes is also provided.
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