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公开(公告)号：EP2301961B1
公开(公告)日：2017-02-22
申请号：EP10014373.4
申请日：2006-04-28
申请人： Amgen Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
摘要： The invention relates to polypeptide fragments of sclerostin and antibodies that bind to the fragments. The antibodies are useful in treating diseases of low bone density, such as osteoporosis, and in accelerating the healing of bone fractures.
摘要翻译： 本发明涉及硬骨素的多肽片段和结合该片段的抗体。 该抗体可用于治疗骨密度低的疾病，如骨质疏松症，以及加速骨折愈合。
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公开(公告)号：EP0297913B1
公开(公告)日：1995-02-15
申请号：EP88306039.4
申请日：1988-06-30
申请人： AMGEN INC.
发明人： Lin, Fu-Kuen , Lu, Hsieng Sen
CPC分类号： C12N9/6445 , A61K38/00 , C12N15/85 , C12N2830/00 , C12N2830/85 , C12Q1/6876 , G01N33/68
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公开(公告)号：EP3569620A1
公开(公告)日：2019-11-20
申请号：EP19181187.6
申请日：2009-12-18
申请人： Amgen Inc.
发明人： Boone, Thomas Charles , Brankow, David W. , Gegg Jr., Colin V. , Hu, Shaw-Fen Sylvia , King, Chadwick T. , Lu, Hsieng Sen , Shi, Licheng , Xu, Cen
IPC分类号： C07K16/28 , A61K39/395 , A61P25/06
摘要： Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
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公开(公告)号：EP2298800B1
公开(公告)日：2016-11-30
申请号：EP10014361.9
申请日：2006-04-28
申请人： Amgen Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
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公开(公告)号：EP2325199B1
公开(公告)日：2015-03-04
申请号：EP10014362.7
申请日：2006-04-28
申请人： AMGEN, INC.
发明人： Paszty, Christopher , Robinson, Martyn Kim , Graham, Kevin , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Lu, Hsieng Sen , Winters, Aaron George , Winkler, David , Shen, Wenyan , Popplewell, Andy
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K47/60 , A61K2039/505 , C07K14/76 , C07K14/79 , C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
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公开(公告)号：EP2336177A1
公开(公告)日：2011-06-22
申请号：EP10013141.6
申请日：2005-08-04
申请人： Amgen, Inc
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.
摘要翻译： 本发明提供特异性结合Dkk-1多肽的抗体及其免疫功能片段。 受试抗体和片段以高亲和力结合位于Dkk-1蛋白的羧基区域的构象表位。 还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。 还公开了使用抗体和片段来治疗各种疾病，包括骨病，炎性疾病，神经疾病，眼病，肾病，肺部疾病和皮肤疾病。
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公开(公告)号：EP2295448B1
公开(公告)日：2017-01-18
申请号：EP10014372.6
申请日：2006-04-28
申请人： Amgen Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
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公开(公告)号：EP2251351B1
公开(公告)日：2017-01-04
申请号：EP10006930.1
申请日：2006-04-28
申请人： Amgen Inc.
发明人： Lu, Hsieng Sen , Paszty, Christopher , Robinson, Martyn Kim , Henry, Alistair James , Hoffmann, Kelly Sue , Latham, John , Lawson, Alastair , Winkler, David , Winters, Aaron George
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/51 , C07K16/22 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C12N15/63
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公开(公告)号：EP0297913A3
公开(公告)日：1990-03-07
申请号：EP88306039.4
申请日：1988-06-30
申请人： AMGEN INC.
发明人： Lin, Fu-Kuen , Lu, Hsieng Sen
CPC分类号： C12N9/6445 , A61K38/00 , C12N15/85 , C12N2830/00 , C12N2830/85 , C12Q1/6876 , G01N33/68
摘要： A recombinant human kallikrein having one or more of the biological properties associated with mammalian kallikreins and is characterized by being the product of procaryotic or eucaryotic host expression of an exogenous DNA. The novel kallikrein polypeptide products are useful as vasodilators and in the treatment of male infertility.
摘要翻译： 具有与哺乳动物激肽释放酶相关的一种或多种生物学性质的重组人激肽释放酶，其特征在于是外源DNA的原核或真核宿主表达的产物。 新型激肽释放酶多肽产物可用作血管扩张剂和治疗男性不育症。
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公开(公告)号：EP0297913A2
公开(公告)日：1989-01-04
申请号：EP88306039.4
申请日：1988-06-30
申请人： AMGEN INC.
发明人： Lin, Fu-Kuen , Lu, Hsieng Sen
CPC分类号： C12N9/6445 , A61K38/00 , C12N15/85 , C12N2830/00 , C12N2830/85 , C12Q1/6876 , G01N33/68
摘要： A recombinant human kallikrein having one or more of the biological properties associated with mammalian kallikreins and is characterized by being the product of procaryotic or eucaryotic host expression of an exogenous DNA. The novel kallikrein polypeptide products are useful as vasodilators and in the treatment of male infertility.
摘要翻译： 具有与哺乳动物激肽释放酶相关联的一种或多种生物学特性的重组人激肽释放酶，其特征在于是外源DNA的原核或真核宿主表达的产物。 新颖的激肽释放酶多肽产物可用作血管扩张剂和治疗男性不育症。
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