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11.发明公开AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS 审中-公开AMINOTHIAZOLDERIVATE ALS人硬脂酰辅酶A DESATURASEHEMMER
公开(公告)号：EP2029138A1
公开(公告)日：2009-03-04
申请号：EP06784578.4
申请日：2006-06-05
发明人： FU, Jianmin , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , POKROVSKAIA, Natalia , RAINA, Vandna , SUN, Shaoyi , SVIRIDOV, Serguei , ZHANG, Zaihui
IPC分类号： A61K31/426 , A61K31/427 , A61K31/4439 , A61P3/00 , A61P9/12 , A61P17/06 , A61P17/10 , A61P19/06 , C07D277/82 , C07D417/12
CPC分类号： C07D277/587 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/5377 , A61K31/616 , A61K38/26 , A61K38/28 , A61K45/06 , C07D277/56 , C07D417/06 , C07D417/12
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I), where V, W, R1, R2, R3 and R4 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP1888595A2
公开(公告)日：2008-02-20
申请号：EP06750402.7
申请日：2006-04-11
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , HOU, Duanjie , LIU, Shifeng , BAGHERZADEH, Mehran Seid , SVIRIDOV, Serguei , SUN, Shaoyi , SUN, Jianyu , CHAKKA, Nagasree , HSIEH, Tom , RAINA, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
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13.发明公开PYRIDAZINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS 审中-公开PYRIDAZINDERIVATE UND DEREN VERWENDUNG ALS THERAPEUTISCHE WIRKSTOFFE
公开(公告)号：EP3042895A1
公开(公告)日：2016-07-13
申请号：EP16000190.5
申请日：2004-07-29
发明人： Abreo, Melwyn , Chafev, Mikhail , Chakka, Nagasree , Chowdhury, Sultan , FU, Jian-Min , Gschwend, Heinz W. , Holladay, Mark W. , HOU, Duanjie , Kamboj, Rajender , Kodumuru, Vishnumurthy , LI, Wenbao , LIU, Shifeng , Raina, Vandna , SUN, Sengen , SUN, Shaoyi , Sviridov, Serguei , TU, Chi , Winther, Michael D. , Zhang, Zaihui
IPC分类号： C07D237/20 , C07D237/22 , A61K31/501 , A61P3/06
CPC分类号： A61K31/00 , A61K31/501 , A61K31/551 , C07D237/20 , C07D237/24
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I):
where x, y, W, V, R 2 , R 3 , R 4 , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , R 8a , R 9 and R 9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.摘要翻译： 公开了治疗哺乳动物，优选人类的SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，W，V，R 2，R 3，R 4，R 5，R 6，R 6a，R 7，R 7a，R 8，R 8a，R 9和R 9a如本文所定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：EP2073806B1
公开(公告)日：2012-02-15
申请号：EP07868434.7
申请日：2007-10-12
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , HOU, Duanjie , LIU, Shifeng , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , SUN, Shaoyi , SUN, Jianyu , CHAKKA, Nagasree , HSIEH, Tom , RAINA, Vandna
IPC分类号： A61K31/437 , A61K31/407 , A61P3/06 , A61P13/08 , A61P17/04 , A61P35/00
CPC分类号： A61K31/407 , A61K31/437
摘要： This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.
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公开(公告)号：EP1888595B1
公开(公告)日：2012-02-01
申请号：EP06750402.7
申请日：2006-04-11
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , HOU, Duanjie , LIU, Shifeng , BAGHERZADEH, Mehran Seid , SVIRIDOV, Serguei , SUN, Shaoyi , SUN, Jianyu , CHAKKA, Nagasree , HSIEH, Tom , RAINA, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
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公开(公告)号：EP1648874B1
公开(公告)日：2011-10-05
申请号：EP04779562.0
申请日：2004-07-29
发明人： ABREO, Melwyn , CHAFEEV, Mikhail , CHAKKA, Nagasree , CHOWDHURY, Sultan , FU, Jian-Min , GSCHWEND, Heinz W. , HOLLADAY, Mark W. , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , LI, Wenbao , LIU, Shifeng , RAINA, Vandna , SUN, Sengen , SUN, Shaoyi , SVIRIDOV, Serguei , TU, Chi , WINTHER, Michael D. , ZHANG, Zaihui
IPC分类号： C07D237/20 , C07D237/24 , A61K31/501 , A61P3/06
CPC分类号： A61K31/00 , A61K31/501 , A61K31/551 , C07D237/20 , C07D237/24
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I), where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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公开(公告)号：EP2073806A2
公开(公告)日：2009-07-01
申请号：EP07868434.7
申请日：2007-10-12
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , HOU, Duanjie , LIU, Shifeng , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , SUN, Shaoyi , SUN, Jianyu , CHAKKA, Nagasree , HSIEH, Tom , RAINA, Vandna
IPC分类号： A61K31/437 , A61K31/407 , A61P3/06 , A61P13/08 , A61P17/04 , A61P35/00
CPC分类号： A61K31/407 , A61K31/437
摘要： This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.
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公开(公告)号：EP2029572A2
公开(公告)日：2009-03-04
申请号：EP07798049.8
申请日：2007-06-04
发明人： DALES, Natalie , FONAREV, Julia , FU, Jianmin , HOU, Duanjie , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , POKROVSKAIA, Natalia , RAINA, Vandna , SUN, Shaoyi , ZHANG, Zaihui
IPC分类号： C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D417/04 , C07D417/14 , A61K31/4178 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439
CPC分类号： A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/497 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14 , C07F7/0834
摘要： The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed.
摘要翻译： 本发明提供调节硬脂酰辅酶A去饱和酶活性的杂环衍生物。 还包括使用这些衍生物来调节硬脂酰辅酶A去饱和酶活性的方法和包含此类衍生物的药物组合物。
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19.发明公开HETEROCYCLIC DERIVATIVES AND THEIR USE AS STEAROYL-COA DESATURASE INHIBITORS 有权杂环衍生物和它们作为硬脂酰辅酶A去饱和酶抑制剂的用途
公开(公告)号：EP1807085A2
公开(公告)日：2007-07-18
申请号：EP05815243.0
申请日：2005-09-20
发明人： KAMBOJ, Rajender , ZHANG, Zaihui , FU, Jian-Min , KODUMURU, Vishnumurthy , SVIRIDOV, Serguei , SADALAPURE, Kashinath , LIU, Shifeng , SUN, Shaoyi , HOU, Duanjie , CHAKKA, Nagasree
IPC分类号： A61K31/501 , A61K31/496 , A61P3/00 , A61P3/04 , A61P3/10 , A61P3/06 , A61P1/16 , C07D403/00
CPC分类号： A61K31/496 , A61K31/501
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, V R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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20.发明授权Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors 有权杂环衍生物和它们作为硬脂酰辅酶A去饱和酶抑制剂的用途
公开(公告)号：EP1807085B1
公开(公告)日：2013-08-21
申请号：EP05815243.0
申请日：2005-09-20
发明人： KAMBOJ, Rajender , ZHANG, Zaihui , FU, Jian-Min , KODUMURU, Vishnumurthy , SVIRIDOV, Serguei , SADALAPURE, Kashinath , LIU, Shifeng , SUN, Shaoyi , HOU, Duanjie , CHAKKA, Nagasree
IPC分类号： A61K31/501 , A61K31/496 , A61P3/00 , A61P3/04 , A61P3/10 , A61P3/06 , A61P1/16 , C07D403/00
CPC分类号： A61K31/496 , A61K31/501
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