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11.发明公开
公开(公告)号：EP2985036A2
公开(公告)日：2016-02-17
申请号：EP14186624.4
申请日：2014-09-26
申请人： Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. , Johann Wolfgang Goethe-Universität, Frankfurt am Main
IPC分类号： A61K45/06 , A61K31/138 , A61K31/198 , A61K31/216 , A61K31/4184 , A61K31/437 , A61K31/445 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/498 , A61K31/517 , A61K31/565 , A61K31/567 , A61K31/573 , A61K31/58 , A61P25/02 , A61P29/00 , A61P35/00
CPC分类号： A61K31/445 , A61K31/138 , A61K31/198 , A61K31/216 , A61K31/4184 , A61K31/437 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/498 , A61K31/517 , A61K31/558 , A61K31/565 , A61K31/567 , A61K31/573 , A61K31/58 , A61K45/06
摘要： The present invention pertains to novel treatments of neuropathic pain; in particular chemotherapy induced peripheral neuropathic pain (CIPNP). The invention provides antagonists cytochrome P450 epoxygenases (CYP), and more specifically antagonists of CYP2J2, as therapeutics for use in the treatment of neuropathic pain such as CIPNP. CYP2J2 antagonists were identified to alleviate CIPNP in-vivo, and therefore are provided additionally in combination with chemotherapeutics for the treatment of diseases such as cancer or other proliferative disorders. The CYP2J2 antagonists reduce chemotherapeutic induced pain and therefore allow for a higher dosing of the chemotherapeutic during cancer treatment. In addition the invention relates to the use of CYP2J2 agonists, or metabolites of CYP2J2, for sensitizing TRPV1. In this context the invention proposes to use combinations of CYP2J2 agonist or metabolites and transient receptor potential vanilloid 1 (TRPV1) agonists to treat disorders that respond to TRPV1 agonists, such as neuropathic pain.
摘要翻译： 本发明涉及神经性疼痛的新型治疗方法; 特别是化疗诱导的周围神经性疼痛（CIPNP）。 本发明提供拮抗剂细胞色素P450环氧化酶（CYP），更具体地说是CYP2J2的拮抗剂作为治疗神经性疼痛如CIPNP的治疗剂。 鉴定CYP2J2拮抗剂以减轻体内CIPNP，因此另外与化学治疗剂组合用于治疗诸如癌症或其它增殖性疾病的疾病。 CYP2J2拮抗剂降低化疗诱导的疼痛，因此允许在癌症治疗期间化学治疗剂的更高剂量。 此外，本发明涉及CYP2J2激动剂或CYP2J2的代谢物用于增感TRPV1的用途。 在本文中，本发明提出使用CYP2J2激动剂或代谢物和瞬时受体潜在香草酸1（TRPV1）激动剂的组合来治疗对TRPV1激动剂如神经性疼痛的反应的疾病。
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公开(公告)号：EP2982745A1
公开(公告)日：2016-02-10
申请号：EP14179989.0
申请日：2014-08-06
IPC分类号： C12N5/078 , A61K35/14 , C12N5/0783
CPC分类号： C12N5/0634 , A61K35/15 , A61K35/17 , C12N5/0646 , C12N2501/065 , C12N2501/23
摘要： The present invention pertains to a method for the in-vitro or ex-vivo expansion of immune cells using a histone acetyl transferase (HAT) modulator as additive in the cell culture medium during the expansion procedure. Immune cells such as natural killer (NK) cells, T cells or cytokine induced killer (CIK) cells are used in adoptive cell therapies for the injection into patients suffering from malignant cancer diseases such as leukemia. Cells expanded using the method of the invention were superior proliferative and viable. Further provided by the invention is a cell culture medium comprising the HAT modulator of the invention as well as cell populations obtained using the method of the invention.
摘要翻译： 本发明涉及在扩增过程中，使用组蛋白乙酰转移酶（HAT）调节剂作为添加剂在细胞培养基中体外或离体扩增免疫细胞的方法。 免疫细胞如天然杀伤（NK）细胞，T细胞或细胞因子诱导的杀伤细胞（CIK）细胞被用于过继细胞疗法中，用于注射患有恶性癌症疾病例如白血病的患者。 使用本发明方法扩增的细胞具有优越的增殖和活力。 本发明进一步提供的是包含本发明的HAT调节剂的细胞培养基以及使用本发明的方法获得的细胞群。
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公开(公告)号：EP2982667A1
公开(公告)日：2016-02-10
申请号：EP14187969.2
申请日：2014-10-07
申请人： Fraunhofer Gesellschaft zur Förderung der angewandten Forschung e.V. , Johann Wolfgang Goethe-Universität, Frankfurt am Main
发明人： Knape, Tilo , von Knethen, Andreas , Parnham, Michael John , Schubert-Zsilavecz, Manfred , Wurglics, Mario , Flesch, Daniel
IPC分类号： C07D215/233 , A61K31/47 , A61P29/00
CPC分类号： C07D215/233 , A61K31/47 , A61K45/06
摘要： The present invention pertains to a new compound E)-2-(5-((4-methoxy-2-(trifluoromethyl)quinolin-6-yl)methoxy)-2-((4-(trifluoromethyl) benzyl)oxy)-benzylidene) hexanoic acid (MTTB), and its derivatives. The compounds of the invention are useful as selective peroxisome proliferator-activated receptor gamma (PPARγ) antagonists and are indicated for the use in the treatment of immune related diseases such as systemic inflammation, sepsis and septic shock.
摘要翻译： 本发明涉及新的化合物E）-2-（5 - （（4-甲氧基-2-（三氟甲基）喹啉-6-基）甲氧基）-2 - （（4-（三氟甲基）苄基）氧基） 亚苄基）己酸（MTTB）及其衍生物。 本发明的化合物可用作选择性过氧化物酶体增殖物激活受体γ（PPAR 3）拮抗剂，并且用于治疗免疫相关疾病如全身性炎症，败血症和败血性休克。
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公开(公告)号：EP2332250B1
公开(公告)日：2014-07-30
申请号：EP09782363.7
申请日：2009-08-28
IPC分类号： H03D9/06
CPC分类号： H03D7/125 , H03D1/18 , H03D9/0675 , H03D2200/0074
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公开(公告)号：EP2347484B1
公开(公告)日：2013-11-27
申请号：EP09778593.5
申请日：2009-09-17
发明人： TESKE, Christian , JACOBY, Joachim
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16.发明公开ANTAGONISTS OF miRNA-29 EXPRESSION AND THEIR USE IN THE PREVENTION AND TREATMENT OF AORTIC ANEURYSMS 有权的miRNA表达29的拮抗剂，它们在主动脉瘤的预防和治疗
公开(公告)号：EP2552454A1
公开(公告)日：2013-02-06
申请号：EP11711597.2
申请日：2011-04-01
IPC分类号： A61K31/7088 , A61P9/10
CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/113 , C12Q1/025
摘要： The present invention relates to antagonists of the expression and/or the function of the micro RNA miRNA-29 for use in the prevention and/or treatment of aortic aneurysms and/or plaque destabilization in atherosclerosis. Further disclosed is a method for the identification of miRNA-29 antagonists, a pharmaceutical composition comprising said miRNA-29 antagonists and a method for preventing and treating age-related aortic aneurysm formation and/or plaque destabilization in atherosclerosis in a subject in need of such a treatment.
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17.发明公开
公开(公告)号：EP2313495A1
公开(公告)日：2011-04-27
申请号：EP09772164.1
申请日：2009-07-01
发明人： BRAT, Dawid , BOLES, Eckhard , KELLER, Marco , WIEDEMANN, Beate
CPC分类号： C12N9/92 , C12P7/06 , C12P7/065 , C12P7/10 , C12P7/16 , C12P19/02 , C12P19/24 , C12Y503/01005 , Y02E50/10 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to the use of nucleic acid molecules coding for a bacterial xylose isomerase (XI), preferably coming from
Clostridium phytofermentans , for reaction/metabolization, particularly fermentation, of recombinant microorganisms of biomaterial containing xylose, and particularly for the production of bioalcohols, particularly bioethanol, by means of xylose fermenting yeasts. The present invention further relates to cells, particularly eukaryotic cells, which are transformed utilizing a nucleic acid expression construct which codes for a xylose isomerase, wherein the expression of the nucleic acid expression construct imparts to the cells the capability to directly isomerize xylose into xylulose. Said cells are preferably utilized for reaction/metabolization, particularly fermentation, of biomaterial containing xylose, and particularly for the production of bioalcohols, particularly bioethanol. The present invention also relates to methods for the production of bioethanol, and to methods for the production of further metabolization products, comprising the metabolization of media containing xylose.-
18.发明公开VERFAHREN ZUM MATERIALABTRAG AN FESTKÖRPERN UND DESSEN VERWENDUNG 有权VERFAHREN ZUM MATERIALABTRAG一个FESTKÖRPERNUND DESSEN VERWENDUNG
公开(公告)号：EP1979122A1
公开(公告)日：2008-10-15
申请号：EP07703032.8
申请日：2007-01-25
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. , Johann Wolfgang Goethe-Universität Frankfurt am Main
IPC分类号： B23K26/00
CPC分类号： B23K26/1224
摘要： The invention relates to a method for removing material from solids, especially for microstructuring and cutting, by liquid jet-guided laser etching, the removed material and non-reacted etching components being highly recoverable. The method according to the invention allows high purity silicon being either recovered in polycrystalline form or being deposited on other substrates in the same process chain by epitaxy.
摘要翻译： 本发明涉及一种通过液体喷射引导激光蚀刻在固体上去除材料，特别是用于微结构和切割的方法，正如未反应的蚀刻部件被高度再循环一样。 以这种方式，可以以多晶的方式回收高纯度的硅，或者以相同的工艺链在其它衬底上外延沉积。
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19.发明公开MULTIVALENT CHELATORS FOR MODIFYING AND ORGANIZING OF TARGET MOLECULES 有权MULTI VALENTE螯合剂进行修改和组织的目标分子
公开(公告)号：EP1778651A2
公开(公告)日：2007-05-02
申请号：EP05768155.3
申请日：2005-07-26
发明人： PIEHLER, Jacob , TAMPÉ, Robert , LATA, Suman
IPC分类号： C07D257/04 , C07C229/04 , B01D15/08
CPC分类号： G01N33/54353 , A61K49/0032 , A61K49/0041 , A61K49/0052 , B01D15/3828 , B01J20/3265 , B01J45/00 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07C237/12 , C07C237/22 , C07D257/02 , C07K7/02
摘要： New compounds of the general formula: Xm-G-Cln are described as well as methods for their production. These constitute multivalent chelator-compounds with an affinity-tag binding to metal-chelator-complexes which can selectively modify and/or immobilize target molecules by a multitude of probes or functional units.
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20.发明公开Infrarotmessvorrichtung, insbesondere für die Spektrometrie wässriger Systeme, vorzugsweise von Mehrkomponentensystemen 审中-公开红外测量装置，特别是用于含水体系优选的多组分系统中，光谱
公开(公告)号：EP1715327A3
公开(公告)日：2007-01-10
申请号：EP06015280.8
申请日：2003-04-03
发明人： Mäntele, Werner , Klein,Oliver , Zscherp, Christian , Barth, Andreas , von Lilienfeld-Toal, Hermann , von Prolius, Hellmuth , von Germar, Frithjof , Offermanns, Heribert
CPC分类号： G01N21/552 , G01J3/45 , G01J2003/425 , G01N21/3577 , G01N21/85
摘要： Die Erfindung betrifft eine Infrarotmeßvorrichtung, insbesondere für die Spektrometrie wässriger Systeme, umfassend mindestens eine Meßeinheit, insbesondere eine Meßzelle, umfassend mindestens einen ATR-Körper und mindestens eine Infrarot-Lichtquelle, wobei die Meßeinheit mindestens einen ATR-Körper enthält, der mindestens zwei ebene, im wesentlichen parallele Begrenzungsflächen umfaßt, der für die Meßstrahlung transparent ist und der einen Brechungsindex aufweist, der größer ist als der eines an mindestens eine Begrenzungsfläche angrenzenden, zu untersuchenden Mediums, insbesondere größer oder gleich 1.5, wobei die IR-Meßstrahlung an mindestens einer der ebenen, parallelen Begrenzungsflächen des ATR-Körpers mindestens sechsmal abgeschwächt totalreflektierbar ist.
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