公开(公告)号：EP2305305A4

公开(公告)日：2013-02-13

申请号：EP09750557

申请日：2009-05-19

申请人： KYORIN SEIYAKU KK

发明人： KURIYAMA KAZUHIKO ,  KAGO TOMOYUKI ,  YASUE TOKUTARO

IPC分类号： A61K45/00 ,  A61K31/137 ,  A61K31/42 ,  A61K31/519 ,  A61K31/7056 ,  A61K38/00 ,  A61K38/17 ,  A61K45/06 ,  A61P1/04 ,  A61P11/06 ,  A61P13/12 ,  A61P17/06 ,  A61P19/02 ,  A61P21/04 ,  A61P25/00 ,  A61P29/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00

CPC分类号： A61K31/137 ,  A61K31/42 ,  A61K31/519 ,  A61K31/7056 ,  A61K38/1793 ,  A61K45/06 ,  A61K2300/00

摘要： Disclosed is a method for maintaining induced remission of an immune disease, which can alleviate or reduce any serious side effect and the burdens exerted on a patient suffering from the same. The method comprises carrying out the remission induction for an immune disease by the use of a biological agent or a nucleic acid synthesis-inhibitory agent and then using an agonist for sphingosine-1-phosphate receptor to the patient.

公开(公告)号：EP2260847A4

公开(公告)日：2011-12-28

申请号：EP09727847

申请日：2009-03-30

申请人： KYORIN SEIYAKU KK ,  SENJU PHARMA CO

发明人： SAWA SHIROU

IPC分类号： A61K9/08 ,  A61K31/496 ,  A61K47/36 ,  A61P27/02 ,  A61P31/04

CPC分类号： A61K31/497 ,  A61K9/0048 ,  A61K31/496 ,  A61K45/06 ,  A61K47/36 ,  A61K2300/00

公开(公告)号：EP2060572A4

公开(公告)日：2010-11-17

申请号：EP07828195

申请日：2007-09-05

申请人： KYORIN SEIYAKU KK

发明人： KOHNO YASUSHI ,  TAKITA SATOSHI ,  KOJMA AKIHIKO ,  KISHI TETSUYA

IPC分类号： C07D471/04 ,  A61K31/444 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  A61P19/02 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00

CPC分类号： C07D471/04

公开(公告)号：EP1932522A4

公开(公告)日：2010-07-07

申请号：EP06811299

申请日：2006-10-05

申请人： KYORIN SEIYAKU KK

发明人： KANEKO TAKASHI ,  KOBAYASHI EIJI ,  YASUE TOKUTAROU

IPC分类号： A61K31/137 ,  A61P1/16 ,  A61P3/10 ,  A61P37/06 ,  A61P43/00

CPC分类号： A61K31/137

公开(公告)号：EP1780210A4

公开(公告)日：2009-06-10

申请号：EP05770805

申请日：2005-08-11

申请人： KYORIN SEIYAKU KK

发明人： NOMURA MASAHIRO ,  TAKANO YASUO ,  YUMOTO KAZUHIRO ,  SHINOZAKI TAKEHIRO ,  ISOGAI SHIGEKI ,  MURAKAMI KOJI

IPC分类号： C07D417/12 ,  A61K31/427 ,  A61K31/451 ,  A61K31/454 ,  A61K31/55 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P43/00 ,  C07D211/22 ,  C07D211/26 ,  C07D211/42 ,  C07D211/56 ,  C07D211/60

CPC分类号： C07D417/12 ,  C07D211/22 ,  C07D211/26 ,  C07D211/42 ,  C07D211/56 ,  C07D211/60

摘要： A cyclic aminobenzoic acid derivative and an addition salt thereof which are effective as a human peroxisome proliferator-activated receptor (PPAR) agonist, especially an agonist against a human PPARα isoform, in the treatment of lipid metabolism abnormality, diabetes, etc.; and a medicinal composition containing the derivative or salt. The derivative is a cyclic aminobenzoic acid derivative represented by the general formula (1): [Chemical formula 1] [wherein ring Ar represents optionally substituted aryl, etc.; Y represents C1-4 alkylene, C2-4 alkenylene, C2-4 alkynylene, etc.; Z represents oxygen, sulfur, or -(CH2)n- (n is 0, 1, or 2); X represents hydrogen, halogeno, optionally halogenated lower alkyl, etc.; R represents hydrogen or lower alkyl; and -COOR is bonded in an ortho or meta position to the position where the ring W is bonded]. The salt is a pharmacologically acceptable salt of the derivative.

公开(公告)号：EP1652522A4

公开(公告)日：2008-11-26

申请号：EP04748200

申请日：2004-08-03

申请人： KYORIN SEIYAKU KK ,  ONO PHARMACEUTICAL CO

发明人： HOSHINO RYOUICHI ,  NAKASHIMA KATASHI ,  KAZAMA KAZUO

IPC分类号： A61K31/4174 ,  A61K9/20 ,  A61K9/22 ,  A61K47/38 ,  A61P13/00 ,  A61P43/00 ,  C07D233/61

CPC分类号： A61K9/2054 ,  A61K31/4174

摘要： [PROBLEMS] To provide a sustained release tablet for oral use which causes no rapid increase in the concentration of 4-(2-methyl-1-imidazolyl)-2,2-diphenylbutylamide (KRP-197) in the blood at the early stage of the administration and makes it possible to maintain an appropriate concentration thereof in the blood over a long period of time. [MEANS FOR SOLVING PROBLEMS] A sustained release tablet for oral use characterized by being obtained by adding a gel-forming substance to a medicinal composition containing KRP-197 as the active ingredient.

公开(公告)号：EP1570847A4

公开(公告)日：2008-10-08

申请号：EP03812356

申请日：2003-12-01

申请人： KYORIN SEIYAKU KK

发明人： NAGASAWA MICHIAKI ,  MACKENZIE SIMON JOHN

IPC分类号： A61K31/437 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P43/00 ,  A61P25/18

CPC分类号： A61K31/437

摘要： It is intended to provide PDE10A inhibitors which are useful in preventing or treating Parkinson's disease, Huntington's disease, Alzheimer's disease or integration dysfunction syndrome. A phosphodiesterase 10A inhibitor characterized by containing, as the active ingredient, a pyrazolo[1,5-a]pyridine derivative represented by the following general formula (1) is useful in preventing or treating Parkinson's disease, Huntington's disease, Alzheimer's disease or integration dysfunction syndrome: (1) wherein R and R independently represent each hydrogen or C1-4 lower alkyl; and R represents hydrogen, C1-4 lower alkyl or C1-3 lower alkoxy.

公开(公告)号：EP1285908A4

公开(公告)日：2005-09-21

申请号：EP01932262

申请日：2001-05-25

申请人： KYORIN SEIYAKU KK

发明人： MIYACHI HIROYUKI ,  NOMURA MASAHIRO ,  TAKAHASHI YUKIE ,  TANASE TAKAHIRO ,  MURAKAMI KOUJI ,  SUZUKI MASAHIRO

IPC分类号： A61P3/06 ,  A61P9/10 ,  A61P43/00 ,  C07C59/68 ,  C07C69/734 ,  C07C69/738 ,  C07C229/34 ,  C07C233/51 ,  C07C233/55 ,  C07C233/87 ,  C07C235/34 ,  C07C235/38 ,  C07C235/52 ,  C07C251/48 ,  C07C323/56 ,  A61K31/192 ,  C07C233/81 ,  C07C235/44 ,  C07C235/78

CPC分类号： C07C59/68 ,  C07C69/734 ,  C07C69/738 ,  C07C229/34 ,  C07C233/51 ,  C07C233/55 ,  C07C233/87 ,  C07C235/34 ,  C07C235/38 ,  C07C235/52 ,  C07C251/48 ,  C07C323/56

摘要： Novel substituted phenylpropionic acid derivatives of the general formula (1), which bind to human peroxisome proliferator activated receptor alpha (PPAR alpha ) as ligand to activate the receptor and thereby exhibit a potent lipid-decreasing effect; and use thereof as drugs: (1) wherein R is lower alkyl, lower alkoxy, trifluoromethyl, trifluoromethoxy, optionally substituted phenyl, optionally substituted phenoxy, or optionally substituted benzyloxy; R is hydrogen, lower alkyl, or lower alkoxy; R is lower alkoxy; and A is -CH2CONH-, -NHCOCH2-, -CH2CH2CO-, CH2CH2CH2-, -CH2CH2O-, -CONHCH2-, -CH2NHCH2-, -COCH2O-, -OCH2CO-, -COCH2NH-, or NHCH2CO-.

公开(公告)号：EP1159959A4

公开(公告)日：2005-01-12

申请号：EP98961478

申请日：1998-12-22

申请人： KYORIN SEIYAKU KK ,  NAGATAKE TSUYOSHI

发明人： NAGATAKE TSUYOSHI

IPC分类号： A61K31/198 ,  A61K31/195 ,  A61P11/12

CPC分类号： A61K31/198

摘要： A preventive for respiratory infectious diseases, containing as the active ingredient carbocysteine represented by the following chemical formula (1). It is expected that this preventive serves as a drug capable of preventing infectious diseases in the pre-infective step of respiratory infection, i.e., the step of the adhesion of bacteria to the respiratory tract and thus contributes to the reduction of acute exacerbation frequency in patients with chronic diseases and to the prevention of bacterial infection in those with immune depression, thereby inhibiting the increase in insensible bacteria caused by the frequent use of antimicrobials.

公开(公告)号：EP1025846A4

公开(公告)日：2004-12-29

申请号：EP99938550

申请日：1999-08-20

申请人： SENJU PHARMA CO ,  KYORIN SEIYAKU KK

发明人： YASUEDA SHINICHI ,  INADA KATSUHIRO

IPC分类号： A61K9/00 ,  A61K31/496 ,  A61K47/18 ,  C07D215/56 ,  A61K31/495 ,  A61K9/08 ,  A61P31/04 ,  C07D401/04

CPC分类号： C07D215/56 ,  A61K9/0043 ,  A61K9/0048 ,  A61K31/496 ,  A61K47/183

摘要： Aqueous liquid preparations containing gatifloxacin (chemical name: (±)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-quinolinecarboxylic acid) or its salt and sodium edetate; and a method for enhancing the corneal permeability of gatifloxacin, a method for preventing crystallization of gatifloxacin and a method for preventing coloration of gatifloxacin each by blending gatifloxacin or its salt with sodium edetate.