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公开(公告)号：EP1011736A2
公开(公告)日：2000-06-28
申请号：EP98902085.4
申请日：1998-01-29
发明人： WOLFE, Henry , KELLAR, Kenneth
CPC分类号： A61K49/124 , A61K49/0442 , A61K49/085 , C07K7/02 , C07K14/001
摘要： The invention provides compounds comprising a linear, branched or dendrimeric polymer backbone with linked thereto at least one reporter moiety, said polymer backbone comprising a plurality of amine-containing acids. Such compounds may be linked to one or more targeting agents and are useful as therapeutic and diagnostic agents, in particular in medical imaging techniques.
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公开(公告)号：EP1007103A2
公开(公告)日：2000-06-14
申请号：EP98939754.2
申请日：1998-08-19
申请人： NYCOMED IMAGING AS
发明人： OMTVEIT, Tore
CPC分类号： A61K49/223
摘要： The invention provides a process for the preparation of a fluorocarbon-containing lyophilised contrast agent which comprises lyophilising lyophilisable precursor material contained in one or more containers in a lyophilisation or like vacuum chamber, introducing said fluorinated gas into said chamber and effecting sealing closure of said container or containers, characterised in that, following closure of said container or containers, an overpressure of an atmoshperic gas is applied to said chamber and said fluorocarbon gas is allowed to condense in a condensation vessel connected to said chamber.
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公开(公告)号：EP1007101A2
公开(公告)日：2000-06-14
申请号：EP97909512.2
申请日：1997-10-28
发明人： KLAVENESS, Jo , RONGVED, Pal,Nycomed Imaging AS , HOEGSET, Anders , TOLLESHAUG, Helge,Nycomed Imaging AS , CUTHBERTSON, Alan,Nycomed Imaging AS , GODAL, Aslak , HOFF, Lars , GOGSTAD, Geir , BRYN, Klaus,Nycomed Imaging AS , NAEVESTAD, Anne , LOEVHAUG, Dagfinn,Nycomed Imaging AS , HELLEBUST, Halldis , SOLBAKKEN, Magne,Nycomed Imaging AS
CPC分类号： A61K49/0056 , A61K47/542 , A61K47/549 , A61K47/55 , A61K47/554 , A61K47/62 , A61K47/6925 , A61K49/0043 , A61K49/0054 , A61K49/0091 , A61K51/0497 , A61K51/088
摘要： Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.
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14.发明授权Contrast medium containing a non-ionic contrast agent and sodium and calcium salts 失效含有非离子型造影剂的造影剂和钠盐和钙盐
公开(公告)号：EP0521880B2
公开(公告)日：2000-05-31
申请号：EP91905048.4
申请日：1991-03-07
申请人： NYCOMED IMAGING AS
IPC分类号： A61K49/04
CPC分类号： A61K49/0409 , A61K49/0452 , Y10S514/974
摘要： The physiological acceptability of contrast media, especially media for use in angiography, may be enhanced by inclusion of sub-plasma levels of sodium and calcium and, optionally, potassium and/or magnesium, for example 30 mM Na, 0.15 mM Ca, 0.9 mM K and 0.1 mM Mg.
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15.发明公开OVERHAUSER MAGNETIC RESONANCE IMAGING (ORMI) METHOD COMPRISING EX VIVO POLARIZATION OF A MAGNETIC RESONANCE (MR) IMAGING AGENT 失效OVER HAUSER程序磁成像EX VIVO极化的磁成像生产资料
公开(公告)号：EP0990168A1
公开(公告)日：2000-04-05
申请号：EP98930914.1
申请日：1998-06-19
申请人： NYCOMED IMAGING AS
发明人： ARDENKJAER-LARSEN, Jan, HenrikNycomed Imaging AS , GOLMAN, KlaesNycomed Imaging AS , HANSSON, GeorgNycomed Imaging AS , LEUNBACH, IbNycomed Imaging AS , PETERSSON, StefanNycomed Imaging AS , WISTRAND, Lars-GoranNycomed Imaging AS , AXELSSON, OskarNycomed Imaging AS
摘要： This invention provides a method of MR investigation of a sample, said method comprising: (i) placing in a uniform magnetic field a composition comprising an OMRI contrast agent and an MR imaging agent containing nuclei (MR imaging nuclei) capable of emitting magnetic resonance signals (e.g. the primary magnetic field B0) and capable of exhibiting a T1 relaxation time of 6s or more (at 37 °C in D20 in a field of 7T); (ii) exposing said composition to a first radiation of a frequency selected to excite electron spin transitions in said OMRI contrast agent; (iii) optionally but preferably separating the whole, substantially the whole, or a portion of said OMRI contrast agent from said MR imaging agent; (iv) administering said MR imaging agent to said sample; (v) exposing said sample to a second radiation of a frequency selected to excite nuclear spin transitions; (vi) detecting magnetic resonance signals from said sample; and (vii) optionally, generating an image or dynamic flow data from said detected signals.
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公开(公告)号：EP0977598A1
公开(公告)日：2000-02-09
申请号：EP98917437.0
申请日：1998-04-22
发明人： KELLAR, Kenneth
IPC分类号： A61K49/00
CPC分类号： A61K41/0071 , A61K49/06
摘要： The invention relates to the use as a contrast agent in MR imaging of a substance which has a first and a second relaxivity state, which has relaxivities differing by a factor of at least 5 in said first and second states, and which is convertible in vivo from said first to said second state whereby contrast is enhanced in a body region in which conversion to said second electronic state does or does not occur.
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17.发明公开
公开(公告)号：EP0964680A1
公开(公告)日：1999-12-22
申请号：EP97945949.0
申请日：1997-11-26
发明人： OSTENSEN, Jonny , SONSTEVOLD, Anne
CPC分类号： A61K45/06 , A61K31/00 , A61K31/198 , A61K31/216
摘要： The present invention describes the use of a nitric oxide synthetase inhibitor or nitric oxide antagonist to reduce or eliminate unwanted physiological effects encountered with the parenteral administration of particulate drugs.
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公开(公告)号：EP0951267A1
公开(公告)日：1999-10-27
申请号：EP98900302.0
申请日：1998-01-07
申请人： NYCOMED IMAGING AS
CPC分类号： B65D51/222 , A61J1/1406 , A61J1/201 , A61J1/2075 , A61J1/2082 , A61J1/2096 , B65D2251/0012 , B65D2251/0056 , B65D2251/0071 , B65D2251/0093 , Y10S215/03
摘要： A container, particularly for medical preparations, comprises a container body (2) with an integral closure portion (16) and a cap (6) provided over the closure portion which may maintain a sterile region under the cap. The cap is provided with an internal spike (28) which penetrates the closure portion (16) when the cap (6) is screwed towards the container body (2). A Luer connector (26) is provided on the cap (6) and accesses the container contents via a passage through the spike (28). Thus the cap (6) provides a sterile connection to a syringe, for example, and can be moulded separately from the container body.
摘要翻译： 特别是用于医药制剂的容器包括具有整体闭合部分（16）的容器主体（2）以及设置在闭合部分上方的帽（6），其可以保持帽下的无菌区域。 帽设置有内部钉（28），当帽（6）朝容器主体（2）旋拧时，该内部钉刺穿封闭部分（16）。 鲁尔连接器（26）设置在帽（6）上并通过穿过钉（28）的通道接近容器内容物。 因此，帽（6）例如提供与注射器的无菌连接，并且可以与容器主体分开模制。
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公开(公告)号：EP0941126A1
公开(公告)日：1999-09-15
申请号：EP97913321.0
申请日：1997-11-21
发明人： McINTIRE, Gregory, Lynn , LADD, David, Lee , BACON, Edward, Richard , TONER, John, Luke , NA, George, Chao
IPC分类号： A61K49
CPC分类号： A61K49/0054 , A61K49/0433 , A61K49/128
摘要： The invention provides a method for contrast enhanced imaging of at least part of the lymphatic system of a human or animal body which comprises administering a diagnostically effective contrast agent to said body and generating a contrast enhanced image of at least part of the lymphatic system of said body, characterised in that said agent is a water-soluble polymeric material having a molecular weight of at least 1kD and is administered indirectly but parenterally.
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公开(公告)号：EP0930897A2
公开(公告)日：1999-07-28
申请号：EP97934621.0
申请日：1997-07-30
申请人： NYCOMED IMAGING AS
发明人： PETTERSSON, Göran , GOLMAN, Klaes , JACOBSEN, Anne , DEG RDSTUEN, Liv-Ingrid , FAHLVIK, Anne, Kjersti
IPC分类号： A61K49
摘要： The invention provides the use of a physiologically tolerable manganese compound or a salt thereof, substantially free from hydrophilic polymer components containing a significant amount of a Mn2+- chelating unit, in the manufacture of an enterally, e.g. orally or rectally, administrable MRI contrast medium composition for use in a method of imaging of a human or non-human animal body which has fasted for a period of at least 6, preferably at least 10, more preferably at least 12 hours before enteral administration of said composition. It has been found that diagnostically effective levels of uptake of orally or rectally administered manganese may be achieved using this method.
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