公开(公告)号：EP1577310A1

公开(公告)日：2005-09-21

申请号：EP03778791.8

申请日：2003-12-10

申请人： KANEKA CORPORATION

发明人： OHISHI, Takahiro, c/o KANEKA CORPORATION ,  MORI, Kohei, c/o KANEKA CORPORATION ,  KINOSHITA, Koichi, c/o KANEKA CORPORATION ,  MAEHARA, Katsuji, c/o KANEKA CORPORATION ,  KAWASAKI, Hiroaki, c/o KANEKA CORPORATION ,  NAGASHIMA, Nobuo, c/o KANEKA CORPORATION ,  FUSE, Yoshihide, c/o KANEKA CORPORATION

IPC分类号： C07D407/06 ,  C07D317/60 ,  C07D305/12

CPC分类号： C07D305/12 ,  C07C319/14 ,  C07D317/60 ,  C07D407/06 ,  C07C323/56

摘要： The present invention provides a process for simply producing an optically active 2-thiomethyl-3-phenylpropionic acid derivative useful as an intermediate for medicines from inexpensive raw materials. An optically active 2-hydroxymethyl-3-phenylpropionic acid ester derivative which can be relatively easily obtained by asymmetric reduction reaction with an enzyme is cyclized to an optically active β-lactone derivative which is then reacted with a sulfur compound to produce an optically active 2-thiomethyl-3-phenylpropionic acid derivative in high yield.

公开(公告)号：EP1458677A1

公开(公告)日：2004-09-22

申请号：EP02788144.0

申请日：2002-12-18

申请人： Astrazeneca AB

发明人： ALSTERMARK LINDSTEDT, Eva-Lotte ,  BOIJE, Anna, Maria, Persdotter ,  HOLM, Patrik

IPC分类号： C07C323/56 ,  A61K31/192

CPC分类号： C07C323/56

摘要： A compound of formula (I); wherein R1 represents chloro, fluoro or hydroxy as well as optical isomers and racemates thereof as well as pharmaceutically acceptable salts, prodrugs, solvates and crystalline forms thereof, to processes for preparing such compounds, to their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.

公开(公告)号：EP1353903A2

公开(公告)日：2003-10-22

申请号：EP02713419.6

申请日：2002-01-17

申请人： GUILFORD PHARMACEUTICALS INC.

发明人： TSUKAMOTO, Takashi ,  MAJER, Pavel ,  STOERMER, Doris ,  SLUSHER, Barbara, S.

IPC分类号： C07C323/56 ,  A61K31/095 ,  A61P25/00 ,  A61P35/00 ,  C07C323/52 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C323/62 ,  C07C323/65

CPC分类号： C07C323/56 ,  C07C323/52 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C323/62 ,  C07C323/65

摘要： This invention relates to thiol compounds of the formulae I, II or III (in which the variables are as defined in the claims), pharmaceutical compositions and diagnostic kits comprising such compounds and methods of using such compounds for inhibiting NAALADase enzyme activity, detecting diseases where NAALADase levels are altered, effecting neuronal activity, effecting TGF-β activity, inhibiting angiogenesis, and treating glutamate abnormalities, diabetic neuropathy, pain, compulsive disorders, prostate diseases, cancers and glaucoma.

公开(公告)号：EP1324970A2

公开(公告)日：2003-07-09

申请号：EP01969762.2

申请日：2001-09-24

申请人： F. HOFFMANN-LA ROCHE AG

发明人： LAPIERRE, Jean-Marc ,  ROTSTEIN, David, Mark ,  SJOGREN, Eric, Brian

IPC分类号： C07C65/28 ,  C07C323/56 ,  C07D231/12 ,  C07D207/32 ,  C07D307/38 ,  C07C65/19 ,  C07D295/08 ,  C07D239/38 ,  C07D249/12 ,  A61K31/19 ,  A61K31/33

CPC分类号： C07D207/27 ,  C07C65/19 ,  C07C65/28 ,  C07C229/38 ,  C07C233/83 ,  C07C311/13 ,  C07C317/44 ,  C07C323/56 ,  C07C2602/10 ,  C07D207/327 ,  C07D211/76 ,  C07D231/12 ,  C07D231/14 ,  C07D233/56 ,  C07D233/84 ,  C07D239/26 ,  C07D239/38 ,  C07D249/08 ,  C07D249/12 ,  C07D257/04 ,  C07D277/16 ,  C07D277/30 ,  C07D277/74 ,  C07D285/125 ,  C07D295/155 ,  C07D307/38 ,  C07D333/22 ,  C07D333/24 ,  C07D333/60

摘要： The current invention provides novel retinoid compounds and methods for their synthesis, the use of such compounds for the preparation of medicaments for treating or preventing emphysema, cancer and dermatological disorders, methods for such deseases and pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders.

公开(公告)号：EP0178826B2

公开(公告)日：2003-04-09

申请号：EP85307108.2

申请日：1985-10-03

申请人： Syngenta Limited

发明人： Bushell, Michael John ,  Beautement, Kevin ,  Clough, John Martin ,  Defraine, Paul ,  Anthony, Vivienne Margaret ,  Godfrey, Christopher Richard Ayles

IPC分类号： C07C69/734 ,  C07C233/64 ,  A01N37/10 ,  A01N37/18 ,  C07C67/343 ,  C07C69/738 ,  C07D307/54 ,  C07C205/53 ,  C07C211/44 ,  C07C245/06

CPC分类号： C07D213/643 ,  A01N37/36 ,  A01N37/38 ,  A01N37/42 ,  A01N37/44 ,  A01N37/46 ,  A01N37/48 ,  A01N41/10 ,  A01N43/08 ,  A01N43/12 ,  A01N43/40 ,  C07C69/734 ,  C07C69/736 ,  C07C205/56 ,  C07C255/00 ,  C07C317/44 ,  C07C323/56 ,  C07C323/62 ,  C07C2601/14 ,  C07C2603/26 ,  C07D307/54

公开(公告)号：EP0893434B1

公开(公告)日：2003-02-26

申请号：EP98115073.3

申请日：1991-06-03

申请人： Bayer CropScience AG

发明人： Isenring, Hans Peter, Dr. ,  Drechsel-Weiss, Bettina

IPC分类号： C07C251/60

CPC分类号： C07D213/30 ,  A01N37/36 ,  A01N37/50 ,  A01N43/06 ,  A01N43/10 ,  A01N43/30 ,  A01N43/40 ,  C07C251/60 ,  C07C255/13 ,  C07C255/64 ,  C07C323/56 ,  C07C2601/02 ,  C07C2601/14 ,  C07D213/53 ,  C07D279/12 ,  C07D307/52 ,  C07D307/81 ,  C07D307/83 ,  C07D307/84 ,  C07D317/34 ,  C07D317/46 ,  C07D317/58 ,  C07D317/62 ,  C07D317/64 ,  C07D319/08 ,  C07D319/18 ,  C07D319/20 ,  C07D321/02 ,  C07D333/22 ,  C07D333/28

公开(公告)号：EP0825982B1

公开(公告)日：2002-11-27

申请号：EP96914146.4

申请日：1996-04-29

申请人： Bayer CropScience AG

发明人： LIEB, Folker ,  HAGEMANN, Hermann ,  WIDDIG, Arno ,  RUTHER, Michael ,  FISCHER, Reiner ,  BRETSCHNEIDER, Thomas ,  ERDELEN, Christoph ,  WACHENDORFF-NEUMANN, Ulrike ,  DAHMEN, Peter ,  DOLLINGER, Markus ,  SANTEL, Hans-Joachim ,  GRAFF, Alan ,  ANDERSCH, Wolfram ,  MENCKE, Norbert ,  TURBERG, Andreas

IPC分类号： C07D207/38 ,  C07D209/54 ,  C07D307/60 ,  C07D307/94 ,  C07D333/32 ,  C07D333/50 ,  C07D309/38 ,  C07D279/06 ,  A01N43/36 ,  A01N43/02 ,  C07D491/10

CPC分类号： C07D333/50 ,  A01N43/10 ,  A01N43/12 ,  A01N43/16 ,  A01N43/36 ,  A01N43/38 ,  A01N43/40 ,  A01N43/90 ,  A01N47/02 ,  A01N47/06 ,  A01N53/00 ,  C07C69/757 ,  C07C323/56 ,  C07D207/38 ,  C07D209/54 ,  C07D307/94 ,  C07D309/08 ,  C07D309/36 ,  C07D311/46 ,  C07D333/32 ,  C07D333/38 ,  C07D491/10 ,  C07D493/10

公开(公告)号：EP1084103A1

公开(公告)日：2001-03-21

申请号：EP99930059.3

申请日：1999-05-31

申请人： AstraZeneca AB

发明人： ANDERSSON, Kjell

IPC分类号： C07C309/66 ,  A61K31/19

CPC分类号： C07C303/30 ,  C07C217/76 ,  C07C233/25 ,  C07C233/29 ,  C07C233/75 ,  C07C235/42 ,  C07C255/54 ,  C07C271/28 ,  C07C271/38 ,  C07C271/44 ,  C07C271/58 ,  C07C275/34 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C311/08 ,  C07C311/13 ,  C07C311/16 ,  C07C317/22 ,  C07C317/28 ,  C07C323/19 ,  C07C323/44 ,  C07C323/56 ,  C07C335/18 ,  C07C2601/14

摘要： A novel 3-aryl-2-hydroxypropionic acid derivative, having formula (I) and pharmaceutically acceptable salts, solvates, and crystalline forms thereof, a process and intermediate for its manufacture, pharmaceutical preparations containing it and the use of the compound in clinical conditions associated with insulin resistance.

公开(公告)号：EP1084102A1

公开(公告)日：2001-03-21

申请号：EP99930060.1

申请日：1999-05-31

申请人： AstraZeneca AB

发明人： ANDERSSON, Kjell ,  BOIJE, Maria ,  GOTTFRIES, Johan ,  INGHARDT, Tord ,  LI, Lanna ,  LINDSTEDT ALSTERMARK, Eva-Lotte

IPC分类号： C07C309/63 ,  C07C309/29 ,  C07C323/18 ,  C07C311/08 ,  C07C53/132 ,  C07C69/612 ,  C07C271/28 ,  A61K31/00

CPC分类号： C07C233/25 ,  C07B2200/07 ,  C07C217/76 ,  C07C233/29 ,  C07C233/75 ,  C07C235/42 ,  C07C255/54 ,  C07C271/28 ,  C07C271/38 ,  C07C271/44 ,  C07C271/58 ,  C07C275/34 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C311/08 ,  C07C311/13 ,  C07C311/16 ,  C07C317/22 ,  C07C317/28 ,  C07C323/19 ,  C07C323/44 ,  C07C323/56 ,  C07C335/18 ,  C07C2601/14

摘要： Novel 3-aryl proprionic acid derivatives and analogs, having general formula (I) and stereo- and optical isomers and racemates thereof as well as pharmaceutically acceptable salts, solvates and crystalline forms thereof, process for their manufacture, pharmaceutical preparations containing them and the use of the compounds in clinical conditions associated with insulin resistance.

摘要翻译： 新型3-芳基丙酸衍生物及其类似物，其制备方法和中间体，含有它们的药物制剂以及该化合物在与胰岛素抵抗相关的临床病症中的用途。

公开(公告)号：EP1003709A1

公开(公告)日：2000-05-31

申请号：EP98938995.2

申请日：1998-08-08

申请人： Korea Research Institute of Chemical Technology

发明人： PAK, Chwang, Siek ,  KIM, Bum, Tae ,  PARK, No, Kyun ,  CHOI, Gyung, Ja ,  KIM, Heung, Tae

IPC分类号： C07C69/736 ,  C07C235/32 ,  C07C251/16 ,  C07C323/56 ,  A01N37/00

CPC分类号： A01N37/50 ,  A01N37/38 ,  C07C69/736 ,  C07C235/78 ,  C07C251/42 ,  C07C323/56

摘要： A fungicidal compound of formula (I) having a fluorovinyloxyphenyl moiety and stereoisomers thereof are useful for protecting crops from fungal diseases, wherein: X is CH or N; Y is O or S; Z is O or NH; R1 is hydrogen or CF¿3?; and R?2¿ is hydrogen, a C¿1-10?alkyl, naphthyl, thiophenyl or a phenyl group optionally carrying one or more substituents selected from the group consisting of C1-6alkyl, halogen-substituted C1-6alkyl, C1-6alkoxy, phenoxy, halogen, and methylenedioxy radicals.