公开(公告)号：EP1481961A1

公开(公告)日：2004-12-01

申请号：EP02779967.5

申请日：2002-10-31

Applicant: Sumitomo Chemical Company, Limited

Inventor： TANAKA, M. Sumitomo Chemical Company, Limited ,  MATSUI, K. Sumitomo Chemical Company, Limited ,  KATSURA, T. Sumitomo Chemical Company, Limited ,  IWASAKI, M. Sumitomo Chemical Company, Limited ,  MAEDA, H. Sumitomo Chemical Company, Limited ,  ITAYA, N. Sumitomo Chemical Company, Limited

IPC: C07C51/43 ,  C07C59/48 ,  C07C67/343 ,  C07C69/732 ,  C07B57/00

CPC classification number: C07C45/74 ,  C07B2200/07 ,  C07C45/62 ,  C07C45/73 ,  C07C49/213 ,  C07C51/43 ,  C07C51/487 ,  C07C69/732 ,  C07C211/29 ,  C07C217/58 ,  C07C49/217 ,  C07C59/48

Abstract: The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an optically active amine of the formula (VIII)
wherein R 2 is 3,4-dimethoxyphenyl or 2-chlorophenyl. According to the present invention, (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid useful as a starting material of a pharmaceutical agent can be efficiently produced with a high optical purity and a relatively high total yield.

公开(公告)号：EP0350069A2

公开(公告)日：1990-01-10

申请号：EP89112484.4

申请日：1989-07-07

Applicant: NIPPON PETROCHEMICALS COMPANY, LIMITED

Inventor： Shimizu, Isoo ,  Matsumura, Yasuo ,  Iwamoto, Kouichi

IPC: C07C49/213 ,  C07C45/30

CPC classification number: C07C49/255 ,  C07C45/30 ,  C07C49/213

Abstract: This invention relates to a method for manufacturing aromatic compounds having the following formula (II) comprising the step of reacting an unsaturated aromatic compound having the following formula (I) with an aryl compound containing an iodosyl group or the salt thereof within a temperature range of from -50 to 200 o C:

Abstract translation: 本发明涉及一种具有下式（II）的芳族化合物的制备方法，该方法包括下列步骤：使具有下式（I）的不饱和芳族化合物与含有碘代酰基的芳基化合物或其盐在 从-50至200℃：

公开(公告)号：EP0024306B1

公开(公告)日：1986-12-03

申请号：EP80104221.9

申请日：1980-07-18

Applicant: L. Givaudan & Cie Société Anonyme

Inventor： Gonzenbach, Hans Ulrich, Dr. ,  Ochsner, Paul Albert, Dr.

IPC: C07C121/00 ,  C07C69/753 ,  C07C49/553 ,  C11B9/00 ,  A23L1/226 ,  A61K7/46

CPC classification number: C07C255/00 ,  C07C45/004 ,  C07C45/45 ,  C07C45/67 ,  C07C45/673 ,  C07C45/68 ,  C07C49/217 ,  C07C49/563 ,  C11B9/0046 ,  C11B9/0049 ,  C07C49/213

公开(公告)号：EP0164763A2

公开(公告)日：1985-12-18

申请号：EP85108929.2

申请日：1980-07-18

Applicant: L. Givaudan & Cie Société Anonyme

Inventor： Gonzenbach, Hans Ulrich, Dr. ,  Ochsner, Paul Albert, Dr.

IPC: C07C121/00 ,  C07C69/753 ,  C07C49/553 ,  C11B9/00 ,  A23L1/226 ,  A61K7/46

CPC classification number: C07C255/00 ,  C07C45/004 ,  C07C45/45 ,  C07C45/67 ,  C07C45/673 ,  C07C45/68 ,  C07C49/217 ,  C07C49/563 ,  C11B9/0046 ,  C11B9/0049 ,  C07C49/213

Abstract: Die Erfindung betrifft Riech- und/oder Geschmackstoffkompositionen, die durch einen Gehalt an einer Verbindung der Formel
worin die Reste R 2 bis R 8 für Wasserstoff oder Methyl stehen und n = 1 oder 2 ist, gekennzeichnet sind.
Die Erfindung betrifft auch die Verwendung von I als Riech- und/oder Geschmackstoffe.
Die Verbindungen der Formel I sind, mit Ausnahme des 1,1- Dimethyl-3-cyanoindans, neu. Die neuen I bilden ebenfalls Gegenstand der Erfindung.

Abstract translation: 本发明涉及香料和/或调味组合物，其在其中基团R 2至R <8>是由下式的化合物的含量是氢或甲基并且n是1或2，其特征在于。 本发明还涉及到使用我作为添味剂和/或调味剂。 式I化合物是，与1,1-二甲基-3- cyanoindans，新的异常。 新的I也构成本发明的主题。

公开(公告)号：EP0101223A3

公开(公告)日：1984-08-29

申请号：EP83304362

申请日：1983-07-28

Applicant: UBE INDUSTRIES, LTD.

Inventor： Nakai, Mamoru c/o UBE INDUSTRIES, LIMITED ,  Enomiya, Takuji c/o UBE INDUSTRIES, LIMITED

IPC: C07C45/28 ,  C07C45/51 ,  C07C79/36 ,  C07C49/213 ,  C07C49/245 ,  C07C49/255 ,  C07C49/233 ,  C07C43/30 ,  C07C41/54 ,  C07C79/35 ,  C07C97/10

CPC classification number: C07D317/54 ,  C07C43/303 ,  C07C43/315 ,  C07C45/28 ,  C07C45/515 ,  C07C49/213 ,  C07C49/245 ,  C07C49/255 ,  C07C201/12 ,  C07C221/00 ,  C07C225/22 ,  C07C205/45

Abstract: A phenylacetone or its derivative having the general formula (I):
wherein X. Y, and Z are independently a hydrogen atom, a hydroxyl group, a halogen atom, a nitro group, an amino group, a lower alkyl group having 1 to 6 carbon atoms, a lower alkoxy group having 1 to 6 carbon atoms, or a benzyloxy group and any two substituents of X, Y, and Z may form, together with the benzene ring, a heterocycling ring having 5 to 7 members including 1 or 2 oxygen atoms is produced at a high yield and a high selectivity by reacting a 3-phenylpropylene or its derivative having the general formula (II):
wherein X, Y and Z are as defined above, with an alkyl nitrite having the general formula (III): wherein R is an aliphatic, aromatic or alicyclic saturated or unsaturated hydrocarbon group in the presence of (a) water, (b) an alcohol, (c) a palladium catalyst, and (d) an optional amine or copper compound, or by reacting the above-mentioned 3-phenylpropylene or its derivative with the above-mentioned alkyl nitrite in the presence of (a) an alcohol, (b) a palladium catalyst and (c) an optional amine or copper compound to form 1-phemrl-2,2-dialkoxypropane or it derivative having the general formula (IV):
wherein X, Y, Z and R are as defined above, followed by hydrolyzing the reaction product.

公开(公告)号：EP0089592A3

公开(公告)日：1984-04-25

申请号：EP83102478

申请日：1983-03-14

Applicant: BAYER AG

Inventor： Lantzsch, Reinhard, Dr. ,  Elbe, Hans-Ludwig, Dr.

IPC: C07C45/68 ,  C07C49/233 ,  C07C49/203 ,  C07C49/207 ,  C07C49/213 ,  C07C49/84 ,  C07C49/04

CPC classification number: C07D231/12 ,  C07C45/68 ,  C07C49/04 ,  C07C49/203 ,  C07C49/207 ,  C07C49/213 ,  C07C49/223 ,  C07C49/255 ,  C07D213/50 ,  C07D233/56 ,  C07D249/08 ,  C07D333/22

公开(公告)号：EP3233779A1

公开(公告)日：2017-10-25

申请号：EP15828347.3

申请日：2015-12-16

Applicant: Centre National de la Recherche Scientifique (C.N.R.S.) ,  Université de Montpellier

Inventor： GRISON, Claude ,  ESCANDE, Vincent ,  STANOVYCH, Andrii

IPC: C07C45/72 ,  C07C45/75 ,  C07C49/12 ,  C07C49/20 ,  C07C49/21

CPC classification number: C07C45/75 ,  C07C45/72 ,  C07C49/12 ,  C07C49/213 ,  C07C2601/10 ,  C07C49/597 ,  C07C49/203

Abstract: The present invention relates to a process for preparing a product of formula I: characterized in that the reaction is catalyzed both by thiamine or a thiamine salt and by ascorbic acid in a form which is free or salified or an organic acid salt of an alkaline metal, preferably sodium acetate, potassium tartrate, sodium succinate, or a reductone, preferably 2-hydroxypropanedial or 2,3-dihydroxycyclopent-2-ene-1-one in an organic solvent.

Abstract translation: 本发明涉及制备式I产物的方法：其特征在于该反应由硫胺素或硫胺素盐和由游离或成盐形式的抗坏血酸或碱金属的有机酸盐 ，优选乙酸钠，酒石酸钾，琥珀酸钠或还原酮，优选2-羟基丙二醛或2,3-二羟基环戊-2-烯-1-酮的有机溶剂。

公开(公告)号：EP2583958B1

公开(公告)日：2016-08-10

申请号：EP12177241.2

申请日：2003-12-09

Applicant: Massachusetts Institute of Technology (MIT)

Inventor： Buchwald, Stephen ,  Huang, Xiaohua ,  Zim, Danilo

IPC: C07C1/32 ,  C07C17/263 ,  C07C37/11 ,  C07C39/15 ,  C07C41/30 ,  C07C45/68 ,  C07C67/343 ,  C07C205/06 ,  C07C209/10 ,  C07C227/08 ,  C07C231/12 ,  C07C253/30 ,  C07B37/04 ,  C07C29/32 ,  C07C37/18 ,  C07F9/50 ,  C07D295/135 ,  C07D295/023

CPC classification number: C07D295/023 ,  C07B37/04 ,  C07C1/322 ,  C07C17/263 ,  C07C29/32 ,  C07C37/18 ,  C07C41/30 ,  C07C45/68 ,  C07C67/343 ,  C07C205/06 ,  C07C209/10 ,  C07C227/08 ,  C07C231/12 ,  C07C253/30 ,  C07D295/135 ,  C07F9/5018 ,  C07F9/5022 ,  C07C25/18 ,  C07C49/84 ,  C07C49/213 ,  C07C49/215 ,  C07C49/782 ,  C07C49/657 ,  C07C69/616 ,  C07C69/76 ,  C07C69/612 ,  C07C211/52 ,  C07C211/55 ,  C07C211/45 ,  C07C229/60 ,  C07C233/43 ,  C07C237/30 ,  C07C255/58 ,  C07C43/205 ,  C07C43/225 ,  C07C39/15 ,  C07C33/24

公开(公告)号：EP2782447A1

公开(公告)日：2014-10-01

申请号：EP12798652.9

申请日：2012-11-23

Applicant: Bayer Intellectual Property GmbH

Inventor： HELMKE, Hendrik ,  HOFFMANN, Sebastian ,  NISING, Carl, Friedrich ,  SUDAU, Alexander ,  TSUCHIYA, Tomoki ,  BENTING, Jürgen ,  DAHMEN, Peter ,  WACHENDORFF-NEUMANN, Ulrike ,  BERNIER, David ,  BRUNET, Stephane ,  GROSJEAN-COURNOYER, Marie-Claire ,  LACHAISE, Hélène ,  RINOLFI, Philippe

IPC: A01N43/50 ,  C07D233/68 ,  A01P3/00

CPC classification number: A01N43/50 ,  A01N43/76 ,  A01N43/78 ,  A01N55/00 ,  C07C49/213 ,  C07C49/255 ,  C07D233/68 ,  C07D263/32 ,  C07D277/24 ,  C07D303/34 ,  C07D405/06 ,  C07F7/0814

Abstract: The invention relates to novel 2-iodo-imidazole derivatives, to a method for producing said compounds, to agents containing said compounds, and to the use thereof as biologically active compounds, in particular for fighting harmful microorganisms in plant protection, in material protection, and as plant growth regulators.

公开(公告)号：EP2583958A1

公开(公告)日：2013-04-24

申请号：EP12177241.2

申请日：2003-12-09

Applicant: Massachusetts Institute of Technology (MIT)

Inventor： Buchwald, Stephen ,  Huang, Xiaohua ,  Zim, Danilo

IPC: C07C1/32 ,  C07C17/263 ,  C07C37/11 ,  C07C39/15 ,  C07C41/30 ,  C07C45/68 ,  C07C67/343 ,  C07C205/06 ,  C07C209/10 ,  C07C227/08 ,  C07C231/12 ,  C07C253/30 ,  C07B37/04 ,  C07F9/50 ,  C07D295/135 ,  C07D295/023

CPC classification number: C07D295/023 ,  C07B37/04 ,  C07C1/322 ,  C07C17/263 ,  C07C29/32 ,  C07C37/18 ,  C07C41/30 ,  C07C45/68 ,  C07C67/343 ,  C07C205/06 ,  C07C209/10 ,  C07C227/08 ,  C07C231/12 ,  C07C253/30 ,  C07D295/135 ,  C07F9/5018 ,  C07F9/5022 ,  C07C25/18 ,  C07C49/84 ,  C07C49/213 ,  C07C49/215 ,  C07C49/782 ,  C07C49/657 ,  C07C69/616 ,  C07C69/76 ,  C07C69/612 ,  C07C211/52 ,  C07C211/55 ,  C07C211/45 ,  C07C229/60 ,  C07C233/43 ,  C07C237/30 ,  C07C255/58 ,  C07C43/205 ,  C07C43/225 ,  C07C39/15 ,  C07C33/24

Abstract: An aspect of the present application relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.

Abstract translation: 本申请的一个方面涉及包含这些配体的催化剂在过渡金属催化的碳 - 杂原子和碳 - 碳键形成反应中的用途。 本发明方法提供了过渡金属催化反应的许多特征的改进，包括合适底物的范围，反应条件和效率。