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11.发明公开
公开(公告)号：EP2720715A1
公开(公告)日：2014-04-23
申请号：EP12741389.6
申请日：2012-06-18
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55566 , A61K2039/55583 , A61K2039/70 , C12N2770/24134 , C12N2770/36121 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , G01N2333/181 , G01N2333/185 , G01N2469/20 , G01N2800/26 , Y02A50/383 , Y02A50/39
摘要： A vaccine composition for prophylaxis and treatment of Chikungunya virus infections is disclosed which is capable of conferring immunity against any genotypic variants of the Chikungunya virus. More particularly the invention discloses particular nucleotide sequences and their translated proteins thereof, which may be expressed as Virus Like Particles which for use as a vaccine antigens against Chikungunya virus infections. The compositions disclosed in this invention are also protective against any genotypic variants of the Chikungunya virus which may be propagated by any suitable vector of the disease including Aedis albopictus and Aedis aegypti.
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公开(公告)号：EP2519266A2
公开(公告)日：2012-11-07
申请号：EP11728540.3
申请日：2011-01-03
申请人： Medigen, Inc.
IPC分类号： A61K48/00
CPC分类号： A61K39/12 , A61K49/0004 , A61K2039/5254 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2770/36121 , C12N2770/36122 , C12N2770/36134 , C12N2770/36151 , Y02A50/383
摘要： Described herein are i-DNA™ vectors and vaccines and methods for using the same. The i-DNA™ generates live attenuated vaccines in eukaryotic cells in vitro or in vivo for pathogenic RNA viruses, particularly chikungunya virus (CHIKV). When iDNA is injected into the vaccine recipient, RNA of live attenuated virus is generated by in vivo transcription in the recipient's tissues. This initiates production of progeny attenuated viruses in the tissues of the vaccine recipient, as well as elicitation of an effective immune response protecting against wild-type, non-attenuated virus.
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13.发明公开CONSENSUS SEQUENCES OF CHIKUNGUNYA VIRAL PROTEINS, NUCLEIC ACID MOLECULES ENCODING THE SAME, AND COMPOSITIONS AND METHODS FOR USING THE SAME 有权OF PROTEINS屈曲病毒共有序列，核酸编码分子和组合物及其使用方法THEREOF
公开(公告)号：EP2274442A4
公开(公告)日：2011-10-05
申请号：EP09727698
申请日：2009-04-06
申请人： UNIV PENNSYLVANIA
CPC分类号： C07K14/005 , A61K39/12 , A61K39/39 , A61K2039/53 , A61K2039/55516 , A61K2039/55522 , A61K2039/55588 , A61K2039/575 , C07H21/04 , C12N7/00 , C12N2770/36121 , C12N2770/36122
摘要： Consensus CHIKV E1 protein, consensus CHIKV E2 protein, consensus CHIKV capsid protein, or fragments and homologues thereof, and nucleic acid molecules that encode the same are disclosed. A consensus CHIKV Env protein which includes CHIKV E1 consensus protein, CHIKV E2 consensus protein, CHIKV E3 consensus protein, or fragments and homologues thereof and nucleic acid molecules that encode the same are also disclosed. Compositions and recombinant vaccines comprising CHIKV consensus proteins, and methods of using them are disclosed.
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14.发明授权RECOMBINANT ALPHAVIRUS-BASED VECTORS WITH REDUCED INHIBITION OF CELLULAR MACROMOLECULAR SYNTHESIS 失效与合成细胞的大分子减少的抑制ALPHA病毒载体
公开(公告)号：EP0907746B1
公开(公告)日：2008-02-20
申请号：EP97922294.0
申请日：1997-04-04
发明人： DUBENSKY, Thomas, W., Jr. , POLO, John, M. , BELLI, Barbara, A. , SCHLESINGER, Sondra , DRYGA, Sergey A. , FROLOV, Ilya
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2770/36121 , C12N2770/36122 , C12N2770/36143 , C12N2770/36162 , C12N2830/003 , C12N2830/006 , C12N2830/15 , C12N2830/32 , C12N2830/42 , C12N2830/48 , C12N2840/203 , C12N2840/44
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15.发明公开
公开(公告)号：EP0755440A1
公开(公告)日：1997-01-29
申请号：EP95914815.0
申请日：1995-03-21
发明人： BROWN, Dennis T.
CPC分类号： C12N7/00 , A61K31/00 , A61K31/095 , A61K39/00 , C07K14/005 , C12N2770/36121 , C12N2770/36122
摘要： The present invention provides a composition of matter, comprising a non-infectious, mutated virus suitable for use in preparing a vaccine. A plasmid adapted for expression in a recombinant cell comprising DNA encoding non-infectious mutated virus protein and regulatory elements necessary for expression of said DNA in the cell. Also provided are methods of inhibiting the spread of infection of a virus comprising the step of contacting said virus with a compound that inhibits thiol-reductase/protein disulfide isomerase activity in said virus.
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16.发明授权
公开(公告)号：EP2720715B1
公开(公告)日：2017-08-09
申请号：EP12741389.6
申请日：2012-06-18
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55566 , A61K2039/55583 , A61K2039/70 , C12N2770/24134 , C12N2770/36121 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , G01N2333/181 , G01N2333/185 , G01N2469/20 , G01N2800/26 , Y02A50/383 , Y02A50/39
摘要： A vaccine composition for prophylaxis and treatment of Chikungunya virus infections is disclosed which is capable of conferring immunity against any genotypic variants of the Chikungunya virus. More particularly the invention discloses particular nucleotide sequences and their translated proteins thereof, which may be expressed as Virus Like Particles which for use as a vaccine antigens against Chikungunya virus infections. The compositions disclosed in this invention are also protective against any genotypic variants of the Chikungunya virus which may be propagated by any suitable vector of the disease including Aedis albopictus and Aedis aegypti.
摘要翻译： 公开了用于预防和治疗基孔肯雅病毒感染的疫苗组合物，其能够赋予针对基孔肯雅病毒的任何基因型变体的免疫性。 更具体地说，本发明公开了特定的核苷酸序列及其翻译的蛋白质，其可以表达为用作针对基孔肯雅病毒感染的疫苗抗原的病毒样颗粒。 本发明公开的组合物还可以保护免受基孔肯雅病毒的任何基因型变体的侵袭，所述基孔肯雅病毒可以通过包括白纹伊蚊和埃及伊蚊在内的任何合适的疾病载体繁殖。
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17.发明授权CONSENSUS SEQUENCES OF CHIKUNGUNYA VIRAL PROTEINS, NUCLEIC ACID MOLECULES ENCODING THE SAME, AND COMPOSITIONS AND METHODS FOR USING THE SAME 有权OF PROTEINS屈曲病毒共有序列，核酸编码分子和组合物及其使用方法THEREOF
公开(公告)号：EP2274442B1
公开(公告)日：2016-06-29
申请号：EP09727698.4
申请日：2009-04-06
CPC分类号： C07K14/005 , A61K39/12 , A61K39/39 , A61K2039/53 , A61K2039/55516 , A61K2039/55522 , A61K2039/55588 , A61K2039/575 , C07H21/04 , C12N7/00 , C12N2770/36121 , C12N2770/36122 , Y02A50/383
摘要： Consensus CHIKV E1 protein, consensus CHIKV E2 protein, consensus CHIKV capsid protein, or fragments and homologues thereof, and nucleic acid molecules that encode the same are disclosed. A consensus CHIKV Env protein which includes CHIKV E1 consensus protein, CHIKV E2 consensus protein, CHIKV E3 consensus protein, or fragments and homologues thereof and nucleic acid molecules that encode the same are also disclosed. Compositions and recombinant vaccines comprising CHIKV consensus proteins, and methods of using them are disclosed.
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18.发明授权NOVEL ISOLATED AND PURIFIED STRAINS OF CHIKUNGUNYA VIRUS AND POLYNUCLEOTIDES AND POLYPEPTIDES SEQUENCES, DIAGNOSTIC AND IMMUNOGENICAL USES THEREOF 有权新的和孤立的AUFGEREIGNIGTECHIKUNGUNYAVIRENSTÄMME，多核苷酸和多肽，其诊断和用途免疫原性
公开(公告)号：EP2001900B1
公开(公告)日：2015-04-29
申请号：EP07734896.9
申请日：2007-03-15
申请人： INSTITUT PASTEUR
发明人： DESPRES, Philippe , BREHIN, Anne-Claire , MARECHAL, Valérie , CHARNEAU, Pierre , SOUQUE, Philippe
IPC分类号： C07K14/18
CPC分类号： G01N33/56983 , A61K38/00 , A61K39/00 , C07K14/005 , C07K16/1081 , C12N7/00 , C12N2770/36121 , C12N2770/36122 , C12N2770/36131 , G01N2333/181 , G01N2800/32 , Y02A50/383 , Y02A50/51
摘要： The present invention concerns wild-strains of Chikungunya virus isolated from patients exhibiting severe forms of infection and stemming from a human arbovirosis epidemy. The present invention also concerns polypeptide sequences and fragment thereof derived from their genome, the polynucleotide encoding same and their use as diagnostic products, as vaccine and/or as immunogenic compositions.
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19.发明公开IDENTIFICATION AND ATTENUATION OF THE IMMUNOSUPPRESSIVE DOMAINS IN FUSION PROTEINS OF ENVELOPED RNA VIRUSES 审中-公开识别和免疫畴的损失融合蛋白包膜RNA病毒
公开(公告)号：EP2763696A2
公开(公告)日：2014-08-13
申请号：EP12781027.3
申请日：2012-10-05
申请人： Skau Aps
CPC分类号： C07K14/005 , A61K39/12 , C07K1/00 , C07K4/02 , C07K7/08 , C07K14/08 , C12N7/00 , C12N2760/12121 , C12N2760/12122 , C12N2760/12221 , C12N2760/12222 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134 , C12N2760/16221 , C12N2760/16222 , C12N2760/16234 , C12N2760/16321 , C12N2760/16322 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , C12N2770/24221 , C12N2770/24222 , C12N2770/24234 , C12N2770/24321 , C12N2770/24322 , C12N2770/28021 , C12N2770/28034 , C12N2770/36121 , C12N2770/36122 , C12N2770/36221 , C12N2770/36222
摘要： The present invention relates to enveloped RNA viruses. The invention in particular relates to the generation of superior antigens for mounting an immune response by first identifying then mutating the immunosuppressive domains in fusion proteins of enveloped RNA viruses resulting in decreased immunosuppressive properties of viral envelope proteins from the viruses.
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公开(公告)号：EP2519266A4
公开(公告)日：2013-08-07
申请号：EP11728540
申请日：2011-01-03
申请人： MEDIGEN INC
发明人： PUSHKO PETER , TRETYAKOVA IRINA , LUKASHEVICH IGOR
CPC分类号： A61K39/12 , A61K49/0004 , A61K2039/5254 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2770/36121 , C12N2770/36122 , C12N2770/36134 , C12N2770/36151
摘要： Described herein are i-DNA™ vectors and vaccines and methods for using the same. The i-DNA™ generates live attenuated vaccines in eukaryotic cells in vitro or in vivo for pathogenic RNA viruses, particularly chikungunya virus (CHIKV). When iDNA is injected into the vaccine recipient, RNA of live attenuated virus is generated by in vivo transcription in the recipient's tissues. This initiates production of progeny attenuated viruses in the tissues of the vaccine recipient, as well as elicitation of an effective immune response protecting against wild-type, non-attenuated virus.
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