公开(公告)号：EP1540010B8

公开(公告)日：2010-07-14

申请号：EP03767259.9

申请日：2003-08-05

申请人： THE JOHNS HOPKINS UNIVERSITY ,  Ciphergen Biosystems, Inc.

发明人： CHAN, Daniel, W. ,  ZHANG, Zhen ,  FUNG, Eric ,  MENG, Xiao-Ying

IPC分类号： G01N33/574 ,  G01N33/68

CPC分类号： G01N33/543 ,  G01N33/57449 ,  Y10S435/807 ,  Y10S435/967 ,  Y10S435/973 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S436/815 ,  Y10S436/824 ,  Y10S436/825 ,  Y10T436/24 ,  Y10T436/255

摘要： The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.

公开(公告)号：EP2145897A3

公开(公告)日：2010-03-03

申请号：EP08007695.3

申请日：1993-09-30

申请人： Yale University

发明人： Artavanis-Tsakonas, Spyridon ,  Fehon, Richard Grant ,  Zagouras, Panayiotis ,  Blaumueller, Christine Marie

IPC分类号： C07K14/435 ,  A61K38/17 ,  A61K48/00 ,  C12N15/12

CPC分类号： A61K31/70 ,  A61K38/00 ,  C07K14/43581 ,  C07K14/47 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/20 ,  C07K2319/23 ,  C07K2319/70 ,  C07K2319/95 ,  C12N15/62 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57484 ,  G01N33/6893 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S436/815

摘要： The present invention relates to pharmaceutical compositions comprising a fragment of Serrate protein or a derivative or analog of said fragment, or comprising a derivative or analog of a Serrate protein, or comprising a protein comprising such a fragment, derivative or analog, the fragments, derivatives, analogs and proteins being characterized by the ability in vitro, when expressed on the surface of a first cell, to bind to a Notch protein expressed on the surface of a second cell. The invention also relates to chimeric proteins comprising said Serrate fragments joined via a peptide bond to a protein sequence of a protein different from the Serrate protein, and to nucleic acids encoding said fragments of a Serrate protein, and encoding said chimeric proteins. According to the invention, said fragments, derivatives, analogs, and proteins, said chimeric proteins and said nucleic acids may be used as a medicament, for example, in treating or preventing malignancy in a subject.

公开(公告)号：EP1197220A3

公开(公告)日：2009-04-15

申请号：EP01120662.0

申请日：1993-09-30

申请人： Yale University

发明人： Artavanis-Tsakonas, Dr. ,  Fehon, Richard Grant ,  Zagouras, Panayiotis ,  Blaumüller, Christine Marie, Dr.

IPC分类号： A61K38/16 ,  A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  C07K19/00 ,  A61P35/00

CPC分类号： A61K31/70 ,  A61K38/00 ,  C07K14/43581 ,  C07K14/47 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/20 ,  C07K2319/23 ,  C07K2319/70 ,  C07K2319/95 ,  C12N15/62 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57484 ,  G01N33/6893 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S436/815

摘要： The present invention relates to pharmaceutical compositions comprising a fragment of a Delta protein or a derivative or analog of said fragment, or comprising a derivative or analog of a Delta protein, or comprising a protein comprising such a fragment, derivative or analog, the fragments, derivatives, analogs and proteins being characterized by the ability in vitro, when expressed on the surface of a first cell, to bind to a second protein expressed on the surface of a second cell, which second protein is a Notch protein or a second Delta protein. The invention also relates to chimeric proteins comprising said Delta fragments joined via a peptide bond to a protein sequence of a protein different from the Delta protein, and to nucleic acids encoding said fragments of a Delta protein, and encoding said chimeric proteins. According to the invention, said fragments, derivatives, analogs and proteins, said chimeric proteins and said nucleic acids may be used as a medicament, for example, in treating or preventing malignancy in a subject.

公开(公告)号：EP1720999B1

公开(公告)日：2009-01-28

申请号：EP05713781.2

申请日：2005-02-18

申请人： Baxter International Inc. ,  Baxter Healthcare S.A.

发明人： MARTIS, Leo ,  PATEL, Mehul ,  GIERTYCH, Joseph A. ,  MONGOVEN, James W. ,  KUNZLER, Jacqueline A. ,  OWEN, William F., Jr.

IPC分类号： C12Q1/37 ,  C12Q1/26 ,  G01N33/569

CPC分类号： A61K31/716 ,  C12Q1/04 ,  G01N2333/4722 ,  Y10S436/815

摘要： Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. A novel cause of aseptic peritonitis is provided--aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

公开(公告)号：EP1756575B1

公开(公告)日：2008-10-22

申请号：EP05748983.3

申请日：2005-06-10

申请人： Cozart Bioscience Limited

发明人： JEHANLI, Ahmed, Mohammed, Taki

IPC分类号： G01N33/558 ,  A61K47/48 ,  G01N33/94

CPC分类号： G01N33/558 ,  G01N33/946 ,  Y10S436/808 ,  Y10S436/81 ,  Y10S436/815 ,  Y10S436/816

摘要： The present invention provides immunoassays which are highly specific for detection in biological samples of methamphetamine and other drugs of abuse of the methamphetamine group such as ecstasy and other ecstasy class drugs. More particularly, competitive assays are provided comprising: (a) contacting said sample with (i) a pseudoephedrine/carrier conjugate in which pseudoephedrine is linked via its hydroxyl group to the carrier and (ii) an antibody which is capable of binding both one or more drugs of the methamphetamine group and said conjugate; and (b) determining whether the binding of said antibody to said conjugate is reduced by the presence of said sample, a reduction in binding being indicative that the sample contains a methamphetamine group drug.

公开(公告)号：EP1875237A4

公开(公告)日：2008-09-24

申请号：EP06738937

申请日：2006-03-20

申请人： SALADAX BIOMEDICAL INC

发明人： SALAMONE SALVATORE ,  COURTNEY JODI BLAKE ,  STOCKER DENNIS ,  EISOHLY MAHMOUD AHMED ,  GUL WASEEM

IPC分类号： G01N33/53 ,  C07D305/14 ,  C07K1/04 ,  C07K1/13 ,  C07K16/00 ,  G01N33/532 ,  G01N33/551

CPC分类号： C07D305/14 ,  C07K16/44 ,  G01N33/532 ,  G01N33/94 ,  G01N2407/02 ,  Y10S436/815

公开(公告)号：EP0986757B1

公开(公告)日：2008-02-20

申请号：EP98928894.9

申请日：1998-06-04

申请人： SENSOR TECHNOLOGIES, INC.

发明人： WOLF, David, E.

IPC分类号： G01N33/542 ,  A61B5/00 ,  A61K49/00 ,  G01N33/66

CPC分类号： G01N33/6842 ,  A61B5/14532 ,  A61B5/1455 ,  G01N33/5308 ,  G01N33/66 ,  G01N33/68 ,  G01N2400/00 ,  Y10S436/805 ,  Y10S436/807 ,  Y10S436/815 ,  Y10S436/827 ,  Y10T436/104998 ,  Y10T436/144444

摘要： A method of evaluating a carbohydrate in a sample. The method includes providing a low valency carbohydrate binding ligand, providing a glycoconjugate which includes a label, and a carbohydrate moiety, contacting the low valency carbohydrate binding ligand and the glycoconjugate with the sample, determining the extent of binding of the low valency carbohydrate binding ligand with the glycoconjugate, the binding of the low valency carbohydrate binding ligand with the glycoconjugate being correlated with the amount of carbohydrate in the sample.

公开(公告)号：EP1828106A2

公开(公告)日：2007-09-05

申请号：EP05825390.7

申请日：2005-12-15

申请人： Roche Diagnostics GmbH ,  F. Hoffmann-Roche AG

发明人： HUI, Raymond, A. ,  VITONE, Stephen, S.

IPC分类号： C07C233/31 ,  C07C217/06 ,  C07D207/36 ,  A61K31/16 ,  A61K31/40 ,  A61K31/135

CPC分类号： C07C331/28 ,  C07C233/18 ,  C07C271/16 ,  C07D207/404 ,  C07K16/44 ,  Y02P20/55 ,  Y10S436/815 ,  Y10S436/901 ,  Y10T436/13 ,  Y10T436/173845

摘要： Compounds of methamphetamine derivatives having a meta-substituted alkyl linker on the benzene ring and a protective group on the nitrogen of the methamphetamine hapten. Such compounds have the structure (I) wherein R1 is an alkyl linker comprising 2-15 carbon atoms and 0-6 heteroatoms, R2 is a leaving group, and R3 is a protecting group. Compounds having the formula (II), wherein R1 is an alkyl linker comprising 2-15 carbon atoms and 0-6 heteroatoms and R2 is a polysaccharide or a microparticle. Immunoassays for determining metamphetamine in a sample and test kits for use in determining methamphetamine in a sample.

摘要翻译： 在苯环上具有间位取代的烷基连接体并且在甲基苯丙胺半抗原的氮上具有保护基团的甲基苯丙胺衍生物化合物。 这样的化合物具有结构（I），其中R 1是包含2-15个碳原子和0-6个杂原子的烷基连接基，R 2是离去基团，并且R 3是保护基。 具有式（II）的化合物，其中R 1是包含2-15个碳原子和0-6个杂原子的烷基连接基，并且R 2是多糖或微粒。 用于测定样品中甲基苯丙胺的免疫分析和用于测定样品中甲基苯丙胺的测试试剂盒。

公开(公告)号：EP1602923A4

公开(公告)日：2007-07-25

申请号：EP03786241

申请日：2003-12-24

申请人： NARD KENKYUSHO KK

发明人： KOIKE TOHRU ,  MINAMI NORIO ,  KAWASAKI AKIHIKO

IPC分类号： G01N27/62 ,  C07F3/06 ,  G01N33/68

CPC分类号： G01N33/6818 ,  G01N2458/15 ,  Y10S436/815 ,  Y10T436/16

摘要： A method capable of even with respect to, for example, any biological sample containing multiple compounds, not only confirming the presence of a compound having been converted to a phosphoric acid monoester (peptide, sugar, etc.) among them but also easily identifying the molecular weight thereof; and an additive for mass spectrum measurement which can be used in this method. In this method, use is made of a complex compound exhibiting extremely high coordination capacity for phosphoric acid monoester groups, configured of a single zinc isotope, and multiple mass spectrum data are collected and compared with each other.

公开(公告)号：EP0742438B1

公开(公告)日：2007-06-20

申请号：EP96106717.0

申请日：1996-04-29

申请人： BAYER CORPORATION

发明人： Buettner, Joseph A.

IPC分类号： G01N33/68 ,  G01N33/543 ,  C07K1/04 ,  C07K1/22

CPC分类号： C40B30/04 ,  C07K1/047 ,  G01N33/53 ,  G01N33/6845 ,  Y10S435/962 ,  Y10S435/967 ,  Y10S436/807 ,  Y10S436/808 ,  Y10S436/815