摘要:
Nitrones are produced by reaction of primary amine with aldehyde or ketone, in the presence of a transition metal-containing oxidation catalyst, and a peroxidic compound. The nitrone can then be reacted with a vinylaromatic compound to produce a 2-hydrocarbyl-5-arylisoxazolidine. Both such reactions can be conducted concurrently by including the vinylaromatic compound in the initial reaction mixture. Hydrogenation of the 2-hydrocarbyl-5-arylisoxazolidine, e.g., using hydrogen and a palladium-carbon catalyst, forms an N-hydrocarbyl-3-aryl-3-hydroxypropylamine. Such reactions enable, inter alia, synthesis of the racemic hydrochloride salt of N-methyl-3-phenyl-3-[4-trifluoromethyl]-propylamine, known generically as fluoxetine hydrochloride, a widely used antidepressant.
摘要:
Fluorine-containing compounds, which may be used in lubricating compositions, especially for magnetic recording media, have the formula:
wherein Rf is a fluoroalkylether terminal group having 5-50 carbon atoms; R₁ is an aliphatic alkyl terminal group or an aliphatic alkenyl terminal group; R₂ and R₃ are eachan alkylene group; and m is 0 or 1.
摘要翻译:含氟化合物,其可以在润滑组合物中使用,特别是爱磁记录介质,具有下式: worin Rf为具有5-50个碳原子的fluoroalkylether末端基团; R 1为烷基末端基团或脂肪族脂肪族到末端烯基; R2和R3是亚烷基Eachan基; 且m是0或1
摘要:
The present invention provides a method for synthesizing a fluorine-containing chiral amine compound. The method comprised: reacting an amino donor with a fluorine-containing dihydroxy ketal compound under a catalysis of a transaminase to generate the fluorine-containing chiral amine compound, wherein the transaminase is derived from a plurality of strains. The transaminase of the present application has substrate specificity on the fluorine-containing dihydroxy ketal compound, and may effectively catalyze this type of the substrate to be converted into the fluorine-containing chiral amine compound. In addition, the transaminase has catalytic activity on a plurality of the fluorine-containing dihydroxy ketal compounds, and is relatively high in reaction selectivity and activity. The method catalyzed by the bio-enzyme is not only short in route, but also high in product yield, and the production using the method reduces cost, organic solvents and three wastes.
摘要:
An alkylamino group-terminated fluoroether compound, represented by the following general formula : €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒRfO[CF(CF 3 )CF 2 O] m CF(CF 3 )(CH 2 ) n NR 1 R 2 (where Rf is a perfluoro lower-alkyl group, R 1 is an alkyl group having 1-12 carbon atoms, R 2 is a hydrogen atom, or an alkyl group having 1-12 carbon atoms, m is an integer of 0-10, and n is an integer of 3-8) is a novel compound, and is produced by reaction of an iodide-terminated fluoroether compound, represented by the following general formula : €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒRfO[CF(CF 3 )CF 2 O] m CF(CF 3 )(CH 2 ) n I with an alkylamine compound, represented by the following general formula : €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒNHR 1 R 2