PREPARATION AND USES OF HYDROCARBYLNITRONES
    11.
    发明公开
    PREPARATION AND USES OF HYDROCARBYLNITRONES 审中-公开
    方法和HYDROCARBYLNITRONEN的使用

    公开(公告)号:EP1003717A1

    公开(公告)日:2000-05-31

    申请号:EP98938289.0

    申请日:1998-08-04

    IPC分类号: C07C291/02 C07C217/26

    CPC分类号: C07C291/02 C07C217/26

    摘要: Nitrones are produced by reaction of primary amine with aldehyde or ketone, in the presence of a transition metal-containing oxidation catalyst, and a peroxidic compound. The nitrone can then be reacted with a vinylaromatic compound to produce a 2-hydrocarbyl-5-arylisoxazolidine. Both such reactions can be conducted concurrently by including the vinylaromatic compound in the initial reaction mixture. Hydrogenation of the 2-hydrocarbyl-5-arylisoxazolidine, e.g., using hydrogen and a palladium-carbon catalyst, forms an N-hydrocarbyl-3-aryl-3-hydroxypropylamine. Such reactions enable, inter alia, synthesis of the racemic hydrochloride salt of N-methyl-3-phenyl-3-[4-trifluoromethyl]-propylamine, known generically as fluoxetine hydrochloride, a widely used antidepressant.

    FLUOROETHER HAVING TERMINAL ALKYLAMINO GROUP AND METHOD FOR PRODUCING SAME
    15.
    发明公开
    FLUOROETHER HAVING TERMINAL ALKYLAMINO GROUP AND METHOD FOR PRODUCING SAME 有权
    氟醚与终端烷和方法及其

    公开(公告)号:EP1930312A4

    公开(公告)日:2010-07-21

    申请号:EP06782529

    申请日:2006-08-09

    申请人: UNIMATEC CO LTD

    IPC分类号: C07C217/26 C07C213/02

    CPC分类号: C07C217/26

    摘要: An alkylamino group-terminated fluoroether compound, represented by the following general formula : €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒRfO[CF(CF 3 )CF 2 O] m CF(CF 3 )(CH 2 ) n NR 1 R 2 (where Rf is a perfluoro lower-alkyl group, R 1 is an alkyl group having 1-12 carbon atoms, R 2 is a hydrogen atom, or an alkyl group having 1-12 carbon atoms, m is an integer of 0-10, and n is an integer of 3-8) is a novel compound, and is produced by reaction of an iodide-terminated fluoroether compound, represented by the following general formula : €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒRfO[CF(CF 3 )CF 2 O] m CF(CF 3 )(CH 2 ) n I with an alkylamine compound, represented by the following general formula : €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒNHR 1 R 2