公开(公告)号：EP1664282A1

公开(公告)日：2006-06-07

申请号：EP04761291.6

申请日：2004-09-17

申请人： Unisearch Limited, University of New South Wales

发明人： MORRIS, David, L.

IPC分类号： C12N5/06 ,  G01N33/483 ,  G01N33/50

CPC分类号： G01N33/54326 ,  A61K35/12 ,  C12N5/067

摘要： The present invention provides a method for isolating normal hepatocytes, the method comprising the steps of: recovering liver tissue from a patient during a hepatectomy; and isolating normal hepatocytes from unwanted cells present in the recovered tissue by magnetic separation. The invention further provides a method of prepuing hepatocytes for transplantation, the method comprising the steps of: recovering liver tissue from a patient during a hepatectomy; and isolating normal hepatocytes from unwanted cells present in the recovered tissue by magnetic separation.

公开(公告)号：EP1608235A1

公开(公告)日：2005-12-28

申请号：EP03816525.4

申请日：2003-03-31

申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH

发明人： MALLESHI, Nagappa Gurusiddappa ,  SINGH, Ushakumari Rambahadur ,  ALI, Syee Zakiuddin

IPC分类号： A23L1/30 ,  A23L1/29 ,  A23L1/10 ,  A61P3/10

CPC分类号： A23L33/22 ,  A23L7/101 ,  A23L7/117 ,  A23L7/135 ,  A23L7/198 ,  A23L11/05 ,  A23L11/07 ,  A23L19/01 ,  A23L19/09 ,  A23L27/14 ,  A23L33/105 ,  A23L33/15 ,  A23L33/16 ,  A23L33/19 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/328

摘要： A process for preparation of hypoglycemic foods and formulations thereof, useful as snacks, wholesome or supplementary foods, especially to the Type II diabetics, and a hypoglycemic foods and formulations product of composition with concentration of toasted cereals is ranging between 50-60%, concentration of toasted legumes is ranging between 6-12%, concentration of soy is ranging between 7-15%, concentration of fenugreek is ranging between 2-6%, concentration of spice mix is ranging between 3-7%, concentration of amla fruit pulp is ranging between 0.5-2%, concentration of Garcinia combogia rinds is ranging between 1.5 to 3%, concentration of dry skimmed milk is ranging between 3-6%, concentration of edible oil is ranging between 2-6%, and concentration of vitamin and mineral premix is ranging between 1-3%.

公开(公告)号：EP1594892A2

公开(公告)日：2005-11-16

申请号：EP04709923.9

申请日：2004-02-10

申请人： Agensys, Inc.

发明人： JAKOBOVITS, Aya ,  MORRISON, Robert, Kendall ,  RAITANO, Arthur, B. ,  CHALLITA-EID, Pia, M. ,  PEREZ-VILLAR, Juan, J. ,  MORRISON, Karen, Jane, Meyrick ,  FARIS, Mary ,  GE, Wangmao ,  GUDAS, Jean ,  KANNER, Steven, B.

IPC分类号： C07K14/47

CPC分类号： C07K14/47 ,  A61K38/00

摘要： A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 158P1D7 provides a diagnostic and/or therapeutic target for cancers. The 158P1D7 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.

公开(公告)号：EP0731174B1

公开(公告)日：2004-11-17

申请号：EP96101620.1

申请日：1990-07-10

申请人： Gen-Probe Incorporated

发明人： Kacian, Daniel Louis ,  Fultz, Timothy J.

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/706 ,  C12Q1/6865 ,  C12Q1/689 ,  C12Q1/70 ,  C12Q1/703 ,  C12Q2600/156 ,  C12Q2600/158

公开(公告)号：EP0706563B1

公开(公告)日：2004-10-06

申请号：EP94916597.1

申请日：1994-04-28

申请人： CHIRON CORPORATION

发明人： GOSPODAROWICZ, Denis, J. ,  MASIARZ, Frank

IPC分类号： C12N15/12 ,  C07K14/50 ,  A61K38/18 ,  A61K47/48

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K47/6415 ,  A61K47/642

摘要： The present invention relates to a keratinocyte growth factor fragment, KGFdes1-23, that is composed of a portion of an amino acid sequence of mature, full length keratinocyte growth factor, KGF163. The portion possesses at least a 2-fold increase in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-D-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R- of the KGF163 N-terminus. The present invention also relates to a DNA molecule encoding KGFdes1-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGFdes1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGFdes1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGFdes1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes.

公开(公告)号：EP1390502A2

公开(公告)日：2004-02-25

申请号：EP02735579.1

申请日：2002-05-22

申请人： Pharma Pacific Pty. Ltd.

发明人： MERITET, Jean-François ,  DRON, Michel ,  TOVEY, Michael, Gerard

IPC分类号： C12N15/12

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00

摘要： The present invention relates to identification of a gene upregulated by interferon-α administration corresponding to the cDNA sequence set forth in SEQ.ID.N0. 1. Determination of expression products in this gene is proposed as having utility in predicting responsiveness to treatment with interferon-α and other interferons which act at the Type 1 interferon receptor. Therapeutic use of the protein encoded by the same gene is also envisaged.

公开(公告)号：EP1377165A2

公开(公告)日：2004-01-07

申请号：EP02726648.5

申请日：2002-03-14

申请人： MYRIAD GENETICS, INC.

发明人： WETTSTEIN, Daniel, Albert ,  MORHAM, Scott ,  ZAVITZ, Kenton

IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H21/04 ,  C07K1/00

CPC分类号： C07K14/005 ,  C07K14/4703 ,  C07K2319/00 ,  C12N15/1055 ,  C12N2740/16222 ,  Y02P20/582

摘要： Isolated protein complexes are provided comprising Tsg101 and HIV GAG or GAGp6. The protein complexes are useful in screening assays for selecting compounds effective in modulating the Tsg101-HIV GAG or GAGp6 interaction within the protein complexes.

公开(公告)号：EP1357796A2

公开(公告)日：2003-11-05

申请号：EP02729465.1

申请日：2002-01-11

申请人： Biocontrol Limited

发明人： HARPER, DavidBiocontrol Limited ,  Sommerville, ChristinaInstitute of Aquaculture

IPC分类号： A01N63/00

CPC分类号： C12N1/10 ,  A01N63/00 ,  A01N63/02 ,  A61K35/68 ,  A61K35/74 ,  A61K35/76 ,  C12N1/14 ,  C12N1/20 ,  C12N7/00 ,  C12N2710/14021 ,  C12R1/645 ,  C12R1/90 ,  Y02A50/492

摘要： The present invention relates to the development of novel agents for the control of sea lice. The invention provides the use of a microbiological agent other than a fungus for the manufacture of a biological control agent for treating or preventing sea louse infestation.

摘要翻译： 本发明涉及用于控制海虱的新型试剂的开发。 本发明提供了除真菌以外的微生物制剂用于制造用于治疗或预防海虱侵染的生物防治剂的用途。

公开(公告)号：EP0617132B1

公开(公告)日：2003-06-25

申请号：EP94302196.4

申请日：1994-03-28

申请人： Gen-Probe Incorporated

发明人： McDonough, Sherrol H.. ,  Ryder, Thomas B. ,  Yang, Yeasing

IPC分类号： C12Q1/70 ,  C12Q1/68

CPC分类号： C12Q1/703 ,  Y10S435/81

公开(公告)号：EP1294754A1

公开(公告)日：2003-03-26

申请号：EP01945496.6

申请日：2001-06-29

申请人： Pharma Pacific Pty. Ltd.

发明人： MERITET, Jean-François ,  DRON, Michel ,  TOVEY, Michael, Gerard

IPC分类号： C07K14/47 ,  C12N15/12 ,  C12N5/10 ,  C07K16/28 ,  A61K38/17 ,  A61P31/00 ,  G01N33/50 ,  C12N15/11 ,  C12Q1/68 ,  A01K67/027 ,  C07K14/56

CPC分类号： C07K14/4718 ,  A01K2217/05 ,  A61K38/00 ,  A61K2039/505 ,  G01N2500/20 ,  Y02A50/412

摘要： The present invention relates to identification of a gene upregulated by interferon-alpha administration corresponding to he cDNA sequence set forth in SEQ. ID. No. 1. Determination of expression products of this gene is proposed as having utility in predicting responsiveness to treatment with interferon-alpha and other interferons which act at the Type 1 interferon receptor. Therapeutic use of the protein encoded by the same gene is also envisaged.