公开(公告)号：EP0629707B1

公开(公告)日：1999-03-24

申请号：EP94401313.5

申请日：1994-06-10

申请人： APPLEXION ,  BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

发明人： Lancrenon, Xavier ,  Saska, Michael

IPC分类号： C13J1/06 ,  C13D3/14

CPC分类号： C13B35/06 ,  C13B20/144

公开(公告)号：EP0804219A1

公开(公告)日：1997-11-05

申请号：EP95913576.0

申请日：1995-02-28

申请人： Agritech Technologies, Ltd. ,  THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

发明人： FIORETTI, William, C. ,  KOUSOULAS, Konstantin ,  SATTERLEE, Daniel, G.

IPC分类号： C12N15 ,  A61K35 ,  A61K38 ,  A61K39 ,  A61P15 ,  C07H21 ,  C07K9 ,  C07K14 ,  C07K17 ,  C07K19 ,  C12N5 ,  C12P21 ,  C12R1

CPC分类号： C07K14/575 ,  A01K2217/05 ,  A61K39/0005 ,  A61K2039/6068 ,  C07K2319/00

摘要： The present invention relates to a method of accelerating the onset of puberty in avians, especially ratites and psittaciformes, by administering a heterologous protein comprising inhibin, or a fragment thereof, and a carrier protein. The present invention also relates to a method of increasing egg production in animals, particularly birds, more particularly ratites, via the administration of the heterologous protein. This invention further relates to the heterologous protein and a method for producing the heterologous protein. The heterologous protein can be either inhibin conjugated to the carrier protein or inhibin fused to the carrier protein. The method of producing the fused heterologous protein comprises inserting double stranded cDNA encoding inhibin, or a fragment thereof, into a vector which encodes a carrier protein such as maltose binding protein or bovine serum albumin. After inserting the vector into an expression system, the fused heterologous protein is expressed by the system. After purifying the expressed heterologous protein, an effective amount of the protein is administered to an animal such that an immunological response occurs in the animal against the heterologous protein.

公开(公告)号：EP0533818A1

公开(公告)日：1993-03-31

申请号：EP91912059.0

申请日：1991-06-11

申请人： THE BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

发明人： MEIER, Albert, H. ,  WILSON, John, M.

IPC分类号： A61K31

CPC分类号： A61K31/405 ,  A61K31/195 ,  A61K31/197 ,  A61K31/198 ,  A61K31/216 ,  A61K2300/00

摘要： Procédé d'activation de la reproduction chez des vertébrés d'élevage saisonnier pendant des saisons au cours desquelles la reproduction n'a pas normalement lieu, consistant à administrer de la L-dihydroxyphenylalanine (L-DOPA), augmentant ainsi le niveau de L-DOPA dans le flux sanguin du vertébré jusqu'à un niveau d'activation de la reproduction. On peut également injecter une dose efficace de 5-HTP au vertébré suivie, après une certaine période, d'une injection d'une dose efficace de L-DOPA.

公开(公告)号：EP3746006B1

公开(公告)日：2024-06-26

申请号：EP19747444.8

申请日：2019-02-01

IPC分类号： A61K9/51 ,  C08F220/34 ,  C08F220/14 ,  C08L67/04 ,  C08L33/12 ,  A61P9/00 ,  A61F2/958 ,  A61L29/06 ,  A61L29/08 ,  A61L29/16

CPC分类号： A61F2/958 ,  C08F220/34 ,  A61K9/5153 ,  A61P9/00 ,  A61K9/5138 ,  C08F220/14 ,  C08L67/04 ,  C08L33/12 ,  A61L29/16 ,  A61L29/085 ,  A61L2300/41620130101 ,  A61L2300/62420130101 ,  A61L2300/60820130101 ,  A61L29/06

公开(公告)号：EP3472187B1

公开(公告)日：2022-01-26

申请号：EP17816042.0

申请日：2017-06-20

发明人： MORONEY, James, V. ,  MACHINGURA, Marylou, C. ,  BAJSA-HIRSCHEL, Joanna, N.

IPC分类号： C07K14/405 ,  C12N15/82

公开(公告)号：EP3618850A1

公开(公告)日：2020-03-11

申请号：EP18794658.7

申请日：2018-05-01

申请人： The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： FOSTER, Timothy Paul ,  NICHOLS, Charles David

IPC分类号： A61K38/17 ,  A61K45/06 ,  A61P27/02 ,  C07K14/705

公开(公告)号：EP3582791A1

公开(公告)日：2019-12-25

申请号：EP18754890.4

申请日：2018-02-20

申请人： The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： KEVIL, Christopher G. ,  DOMINIC, Paari

IPC分类号： A61K33/02 ,  A61K33/04 ,  A61K36/31 ,  A61K45/06 ,  C01B17/16 ,  C01B17/22 ,  C01B21/20 ,  C01B21/24

公开(公告)号：EP3472187A1

公开(公告)日：2019-04-24

申请号：EP17816042.0

申请日：2017-06-20

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： MORONEY, James, V. ,  MACHINGURA, Marylou, C. ,  BAJSA-HIRSCHEL, Joanna, N.

IPC分类号： C07K14/405 ,  C12N15/11 ,  C12N15/29 ,  C12N15/82 ,  C07H21/04

公开(公告)号：EP3463296A1

公开(公告)日：2019-04-10

申请号：EP17810867.6

申请日：2017-06-06

申请人： Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： SOIN, Amol ,  KEVIL, Christopher ,  CHAN, Kyle ,  GIORDANO, Anthony

IPC分类号： A61K9/08 ,  A61K9/20 ,  A61K33/00 ,  A61K33/08

公开(公告)号：EP2831581B1

公开(公告)日：2018-10-03

申请号：EP13767904.9

申请日：2013-03-14

申请人： Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College

发明人： KEVIL, Christopher, G. ,  SHEN, Xinggui ,  PETER, Elvis, A.

IPC分类号： G01N33/48 ,  G01N33/483 ,  G01N33/84

CPC分类号： G01N33/50 ,  G01N21/64 ,  G01N33/84 ,  G01N2021/7786 ,  Y10T436/184

摘要： A method to measure all relevant biologic hydrogen sulfide pools, namely free hydrogen sulfide, acid-labile sulfide, and bound sulfane sulfur, has been developed. This new method involves selective liberation, trapping and derivatization of labile hydrogen sulfide. The total labile sulfide, including the contribution of the bound sulfane sulfur pool, the acid-labile pool, and free H2S, was measured by incubating the sample with a reducing agent, TCEP (Tris(2-carboxyethyl)phosphine hydrochloride), to reduce disulfide bonds in an acid solution. This method was used to measure the three sulfide pools in blood samples from mice and from humans. This method can be used for research, environmental, and clinical diagnostic purposes in determining hydrogen sulfide bioavailability in biological or other samples.