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96 条记录 (耗时 0.035 秒)

    PROCÉDÉ DE TRAITEMENT D'IMAGE POUR ESTIMER UNE DÉFORMATION D'UN CERVEAU D'UN PATIENT
    22.
    发明公开
    PROCÉDÉ DE TRAITEMENT D'IMAGE POUR ESTIMER UNE DÉFORMATION D'UN CERVEAU D'UN PATIENT 审中-公开
    爱尔兰艾滋病毒感染者青少年爱滋病病毒感染者

    公开(公告)号：EP2353144A2

    公开(公告)日：2011-08-10

    申请号：EP09783691.0

    申请日：2009-10-02

    申请人： Universite Joseph Fourier - Grenoble 1 ,  Centre National de la Recherche Scientifique (C.N.R.S)

    发明人： BUCKI, Marek ,  PAYAN, Yohan

    IPC分类号： G06T7/00 ,  A61B19/00

    CPC分类号： G06T7/0038 ,  A61B8/0808 ,  G06T7/38 ,  G06T2207/10072 ,  G06T2207/30016

    摘要： The invention relates to an image processing method for estimating a brain shift in a patient, said method involving: the processing (100) of a three-dimensional image of the brain of a patient, acquired before a surgical operation, in order to obtain a reference cerebral arterial tree structure of the patient; the processing (200) of three-dimensional images of the brain of the patient, acquired during the operation, in order to at least partially reconstitute a current cerebral arterial tree structure of the patient; the determination (300), from the combination of the reference and current cerebral arterial tree structures, of a field of shift of the vascular tree representing the shift of the current vascular tree in relation to the reference vascular tree; the application (400) of the determined field of shift of the vascular tree to a biomechanical model of the brain of the patient in order to estimate the brain shift of the patient; and the generation (500), from the estimated brain shift, of at least one image of the brain of the patient, in which the brain shift is compensated.

    摘要翻译： 本公开涉及一种用于估计患者脑移位的图像处理方法，所述方法涉及：在外科手术之前获取的患者的脑的三维图像的处理，以获得参考大脑动脉 患者的树状结构; 处理在手术期间获取的患者脑部的三维图像，以便至少部分地重建患者的当前大脑动脉树结构; 来自参考和当前脑动脉树结构的组合的确定，表示当前血管树相对于参考血管树的移动的血管树的移动场; 将确定的血管树的移位领域应用于患者脑的生物力学模型，以估计患者的脑移位; 以及来自估计的脑移位的至少一个患者脑的图像的产生，其中脑移位被补偿。

    Sensizitation of cancer cells to therapy using sina targeting genes from the 1p and 19q chromosomal regions
    23.
    发明公开
    Sensizitation of cancer cells to therapy using sina targeting genes from the 1p and 19q chromosomal regions 有权
    使用的siNA靶基因从染色体区域1P和19Q癌细胞对治疗的敏化

    公开(公告)号：EP2336320A1

    公开(公告)日：2011-06-22

    申请号：EP10167455.4

    申请日：2007-07-23

    申请人： UNIVERSITE JOSEPH FOURIER (GRENOBLE 1)

    发明人： Berger François ,  Pelletier, Laurent ,  Issartel, Jean-Paul ,  Boccard, Sandra

    IPC分类号： C12N15/113 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04 ,  A61K31/713

    CPC分类号： C12N15/111 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2320/31

    摘要： The invention relates to the identification of genes involved in resistance of cancer cells to therapy, to short nucleic acid molecules which inhibit the expression of these genes by RNA interference and to their use as adjuvant in cancer therapy, to sensitize cancer cells to conventional anticancer agents ; said short nucleic acid molecules are double-stranded short interfering nucleic acid molecules comprising a sense and an antisense region, wherein the sense region comprises a nucleotide sequence that is selected from the group consisting of: the sequences SEQ ID NO: 15, 11, 13, 14, 30, 31, 38, 46, 64 and 70 and the sequences having at least 70 % identity, preferably at least 80 % identity, more preferably at least 90 % identity with said sequences, and the antisense region comprises a nucleotide sequence that is complementary to the sense region.

    摘要翻译： 本发明涉及在癌细胞对治疗的抗性相关基因的鉴定，一种通过RNA干扰和它们作为在癌症治疗中的佐剂，使用抑制合成的基因的表达致敏癌细胞对常规抗癌剂短的核酸分子 ; 所述短核酸分子是双链短干扰核酸分子包含有义和反义区，worin有义区包含的核苷酸序列并从所述组包括选自：序列SEQ ID NO：15，11，13 ，14，30，31，38，46，64和70，并具有至少70％同一性，优选至少80％的同一性，更优选与所述序列至少90％的同一性，并且所述反义区的序列包含核苷酸序列 确实有义区域互补。

    OUTIL CHIRURGICAL MODULAIRE
    25.
    发明公开
    OUTIL CHIRURGICAL MODULAIRE 有权
    模块化的外科手术仪器

    公开(公告)号：EP2306911A1

    公开(公告)日：2011-04-13

    申请号：EP09781211.9

    申请日：2009-07-28

    申请人： Universite Joseph Fourier - Grenoble 1

    发明人： CINQUIN, Philippe ,  AVILA VILCHIS, Juan, Carlos ,  ZEMITI, Nabil ,  VILCHIS GONZALEZ, Adriana, Herlinda

    IPC分类号： A61B17/28 ,  A61B17/00 ,  A61B19/00

    CPC分类号： A61B17/29 ,  A61B17/00234 ,  A61B34/30 ,  A61B2017/00265 ,  A61B2017/00477 ,  A61B2017/00544 ,  A61B2017/2931 ,  Y10T29/49826

    摘要： The present invention relates to a minimally invasive surgical procedure device comprising a set for forming a modular surgical tool, said set comprising a carrier shaft (5) and a plurality of functional modules (7, 8, 9, 10, 12), in which said each functional module has means (14, 15) for rigid connection to the carrier shaft (5) and/or to another functional module and has dimensions suitable for insertion into the body of a patient through a trocar, wherein said device is characterized in that: - each functional module (7, 8, 9, 10, 12) has at least one degree of rotational or translational freedom and/or a functional end-piece such as a forceps, hook or a scalpel, - the carrier shaft (5) and/or the functional modules (7, 8, 9, 10, 12) comprise means for actuating said functional modules according to the respective degree of freedom thereof and/or the respective function thereof, and in that said device comprises an electromechanical interface capable of controlling the actuating of the assembled functional modules forming the tool.

    Method of producing 6-thio-sialylated glycoproteins and glycoconjugates
    29.
    发明公开
    Method of producing 6-thio-sialylated glycoproteins and glycoconjugates 审中-公开
    Verfahren zur Herstellung von 6-thio-sialierten Glykoproteinen und Glycokonjugaten

    公开(公告)号：EP1911850A1

    公开(公告)日：2008-04-16

    申请号：EP06291569.9

    申请日：2006-10-09

    申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE JOSEPH FOURIER - Grenoble 1

    发明人： Fort, Sébastien ,  Cottaz, Sylvain ,  Birikaki, Lémonia ,  Samain, Eric ,  Driguez, Hugues

    IPC分类号： C12P21/00 ,  C12P19/26 ,  C12P19/18 ,  C12P11/00

    CPC分类号： C12P21/005 ,  C12P11/00 ,  C12P19/18 ,  C12P19/26

    摘要： The present invention relates to a method of preparing 6-thio-sialyl-glycosyl compounds, comprising the step consisting of reacting in vitro or in vivo 6-thio-sialic acid compounds with a CMP-sialic synthetase to form CMP-6-thio sialic acid compounds and with a sialyltransferase to transfer said CMP-6-thio sialic acid compounds as donor substrate to glycosyl compounds as acceptor subtrate leading to the enzymatic coupling of 6-thiosialic acid compounds onto glycosyl compounds. Glycosyl compounds are selected from glycoproteins, glycolipids and oligosaccharides, including monoclonal antibodies.

    摘要翻译： 本发明涉及一种制备6-硫代唾液酸 - 糖基化合物的方法，其包括将体外或体内6-硫代唾液酸化合物与CMP-唾液酸合成酶反应形成CMP-6-硫唾液酸 酸化合物和唾液酸转移酶将所述CMP-6-硫唾液酸化合物作为供体底物转移到糖基化合物作为受体残留物，导致6-硫代酸酸化合物与糖基化合物的酶偶联。 糖苷化合物选自糖蛋白，糖脂和寡糖，包括单克隆抗体。