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    Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives
    22.
    发明公开
    Process for producing erythro-3-amino-2-hydroxybutyric acid derivatives 审中-公开
    Verfahren zur Herstellung von Erythro 3-Amino-2-Hydroxybuttersäurederivaten

    公开(公告)号：EP1464638A1

    公开(公告)日：2004-10-06

    申请号：EP04290652.9

    申请日：2000-06-22

    Applicant: DAISO CO., LTD.

    Inventor： Furukawa, Yoshiro, Daiso Co., Ltd. ,  Yaegashi, Keisuke, Daiso Co., Ltd. ,  Hinoue, Kazumasa, Daiso Co., Ltd.

    IPC: C07C227/18 ,  C07C227/32 ,  C07C229/34 ,  C07C255/43 ,  C07C253/08 ,  C07C269/06 ,  C07C271/16

    CPC classification number: C07D209/48 ,  C07C227/18 ,  C07C227/32 ,  C07C229/34 ,  C07C253/00 ,  C07C269/06 ,  C07C229/22 ,  C07C255/43 ,  C07C271/22

    Abstract: A process for producing an erythro-3-amino-2-hydroxybutyric acid derivative characterized in that an erythro-3-amino-2-hydroxybutyronitrile derivative represented by the general formula [II]
    (wherein R 1 is a straight-chain, branched or cyclic alkyl group having one to six carbon atoms, an alkylthio group or an arylthio group having one to eight carbon atoms, or a substituted or unsubstituted aryl group, P 1 and P 2 are, the same or different, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aralkyloxycarbonyl group, a substituted or unsubstituted arylcarbonyl group, or a substituted or unsubstituted arylsulfonyl group, and R 2 is an alkylcarbonyl group, or a substituted or unsubstituted arylcarbonyl group), is treated with an acid in water or in a water-containing solvent to convert it into an erythro-3-amino-2-hydroxybutyric acid derivative represented by the general formula [III]
    (wherein R 1 is the same as mentioned above, R 3 is hydrogen, Q 1 and Q 2 are, the same or different, hydrogen, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted arylsulfonyl group), or the nitrile derivative is treated with an acid in an alcoholic solvent represented by the general formula of R 3 OH to convert it into an ester of the butyric acid represented by the above general formula [III] (R 3 is a straight-chain, branched or cyclic alkyl group having one to six carbon atoms, or a substituted or unsubstituted aralkyl group).

    Abstract translation: 一种制备赤式3-氨基-2-羟基丁酸衍生物的方法，其特征在于由通式ÄIIÜ表示的赤式-3-氨基-2-羟基丁腈衍生物（其中R 1是直链，支链或 具有1至6个碳原子的环烷基，具有1-8个碳原子的烷硫基或芳硫基，或取代或未取代的芳基，P1和P2相同或不同，取代或未取代的芳烷基， 取代或未取代的芳烷氧基羰基，取代或未取代的芳基羰基或取代或未取代的芳基磺酰基，R 2为烷基羰基或取代或未取代的芳基羰基）用酸在水中或含水 溶剂将其转化成由通式ÄIIIÜ表示的赤式3-氨基-2-羟基丁酸衍生物（其中R 1与上述相同，R 3是氢，Q 1 和Q2是相同或不同的氢，取代或未取代的芳烷基或取代或未取代的芳基磺酰基），或者腈衍生物用酸在通式R3OH表示的醇溶剂中进行处理以将其转化 由上述通式（III）表示的丁酸的酯（R3是具有1-6个碳原子的直链，支链或环状烷基或取代或未取代的芳烷基）。

    Process for preparation of (R)-1,2-propanediol by microbes
    28.
    发明公开
    Process for preparation of (R)-1,2-propanediol by microbes 有权
    Verfahren zur Herstellung von（R）-1,2-丙二醇手套Mikroben

    公开(公告)号：EP1219715A1

    公开(公告)日：2002-07-03

    申请号：EP01130920.0

    申请日：2001-12-27

    Applicant: DAISO CO., LTD.

    Inventor： Suzuki, Toshio ,  Idogaki, Hideaki ,  Nakagawa, Atsushi ,  Ueda, Miki

    IPC: C12P7/18 ,  C12P41/00 ,  C12N1/20

    CPC classification number: C12R1/38 ,  C12P7/18 ,  C12P41/001

    Abstract: A process for preparation of (R)-1,2-propanediol which comprises cultivating a microorganism belonging to genus Pseudomonas or genus Alcaligenes which has ability to assimilate (S)-1,2-propanediol as a single carbon source, in a culture medium containing racemic 1,2-propanediol as a single carbon source and then isolating the remaining (R)-1,2-propanediol from the culture broth.

    Abstract translation: 一种制备（R）-1,2-丙二醇的方法，其包括在培养基中培养属于具有同化（S）-1,2-丙二醇作为单一碳源的能力的假单胞菌属或产碱杆菌属的微生物 含有外消旋1,2-丙二醇作为单一碳源，然后从培养液中分离剩余的（R）-1,2-丙二醇。

    PROCESS FOR PREPARING 1,3-DIOXOLANE-4-METHANOL COMPOUNDS
    30.
    发明公开
    PROCESS FOR PREPARING 1,3-DIOXOLANE-4-METHANOL COMPOUNDS 失效
    VERFAHREN ZUR HERSTELLUNG VON 1,3-DIOXOLAN-4-METHANOL-VERBINDUNGEN

    公开(公告)号：EP0926147A4

    公开(公告)日：2002-01-16

    申请号：EP97939228

    申请日：1997-09-09

    Applicant: DAISO CO LTD

    Inventor： HINOUE KAZUMASA ,  FURUKAWA YOSHIRO

    IPC: C07D317/20 ,  C07D317/72

    CPC classification number: C07D317/20

    Abstract: A process for preparing 1,3-dioxolane-4-methanol compounds in a racemic modification form and an optically active form having a high purity in a high yield in a simple and cost-effective manner. The process comprises reacting a 3-halogeno-1,2-propanediol (1a) (wherein X represents a halogen atom) or a glycidol with an alcohol in the presence of a base, acetalating the resultant 3-alkoxy-1,2-propanediol in the presence of an acid catalyst, and further conducting hydrogenation in the presence of a reduction catalyst to prepare a 1,3-dioxolane-4-methanol compound (5) (wherein R?1 and R2¿ represent each hydrogen, an alkyl group having 1 to 4 carbon atoms, or a phenyl group, or R?1 and R2¿ together with the adjacent carbon atom may form a three- to six-membered ring).

    Abstract translation: 以简单和成本有效的方式以高产率制备外消旋改性形式的1,3-二氧戊环-4-甲醇化合物和高纯度光学活性形式的方法。 该方法包括使3-卤代-1,2-丙二醇（1a）（其中X代表卤原子）或缩水甘油与醇在碱存在下反应，将所得3-烷氧基-1,2-丙二醇 在酸催化剂存在下进一步在还原催化剂存在下进行氢化以制备1,3-二氧戊环-4-甲醇化合物（5）（其中R 1和R 2各自代表氢，烷基 具有1至4个碳原子或苯基，或R 1和R 2与相邻碳原子一起可形成三至六元环）。

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