公开(公告)号：EP4349973A3

公开(公告)日：2024-06-26

申请号：EP24158618.9

申请日：2018-06-08

Applicant: Osaka University

Inventor： MASHIMO, Tomoji ,  TAKEDA, Junji ,  MORISAKA, Hiroyuki ,  YOSHIMI, Kazuto

IPC: C12N15/09 ,  A01H1/00 ,  A01K67/027 ,  C12N5/10

CPC classification number: C12N2310/2020170501 ,  C12N15/102 ,  C12N9/22 ,  C07K2319/0920130101 ,  C12N15/85 ,  C12N15/907 ,  C12N15/8213

Abstract: A CRISPR-Cas3 system was successfully established in a eukaryotic cell.

公开(公告)号：EP4385948A1

公开(公告)日：2024-06-19

申请号：EP22878544.0

申请日：2022-10-05

Applicant: OSAKA UNIVERSITY

Inventor： ASAHARA, Haruyasu ,  MORIGUCHI, Maiko ,  INOUE, Tsuyoshi

IPC: C01B32/194 ,  G01N1/28 ,  H01J37/20

CPC classification number: C01B32/194 ,  G01N1/28 ,  H01J37/20

Abstract: A graphene grid that can reduce or prevent uneven distribution, uneven orientation, and the like of a structural analysis target substance, and can capture the structural analysis target substance with high efficiency and analyze the structural analysis target substance with high resolution, in structural analysis by cryo-electron microscopy. To achieve the above object, the graphene grid has a graphene surface onto which a functional group containing at least one of a silicon atom or a phosphorus atom is introduced.

公开(公告)号：EP4383532A1

公开(公告)日：2024-06-12

申请号：EP21952686.0

申请日：2021-08-02

Applicant: MITSUBISHI ELECTRIC CORPORATION ,  OSAKA UNIVERSITY

Inventor： UCHIDA, Yosuke ,  MIYATAKE, Ryoji ,  YAMAMOTO, Atsushi ,  KOMETANI, Haruyuki ,  NIGUCHI, Noboru ,  HIRATA, Katsuhiro ,  TAKAHARA, Kazuaki ,  SUZUKI, Hironori ,  ITO, Takuya

IPC: H02K16/02

CPC classification number: Y02T10/64 ,  Y02E10/72 ,  H02K49/102 ,  H02K1/223 ,  H02K1/278 ,  H02K21/16

Abstract: Provided is a magnetic strain wave gear device that makes it possible to achieve both improvement of the efficiency of assembly work and suppression of decrease in energy conversion efficiency. A magnetic strain wave gear device (1) includes: a stator (3) having a stator core (31), a stator winding (32), and a stator magnet (33); a first rotor (4); and a second rotor (5). The second rotor includes a second rotor core (51) provided with a plurality of rotor magnet insertion holes and a plurality of rotor magnets (52) inserted into the plurality of respective rotor magnet insertion holes. The first rotor includes a cylindrical first rotor core and a first rotor end plate (42). The first rotor end plate has a rotor magnet passage hole (42b) through which the rotor magnets can be inserted into the rotor insertion holes from outside in a direction of a rotation shaft.

公开(公告)号：EP4382912A1

公开(公告)日：2024-06-12

申请号：EP22849488.6

申请日：2022-07-26

Applicant: OSAKA UNIVERSITY

Inventor： HIKITA, Hayato ,  MYOJIN, Yuta ,  TAKEHARA, Tetsuo

IPC: G01N33/574 ,  C12Q1/6851 ,  C12Q1/686 ,  G01N33/53 ,  G01N33/543 ,  G01N33/576 ,  G01N33/68

CPC classification number: C12Q1/6851 ,  C12Q1/686 ,  G01N33/543 ,  G01N33/53 ,  G01N33/574 ,  G01N33/68 ,  G01N33/576

Abstract: The method of the present invention for evaluating the risk of developing liver cancer in a subject includes (1) a step of measuring a GDF15 level of a subject and (2) a step of relating the GDF15 level to the risk of developing liver cancer. When the GDF15 level measured in step (1) is not less than a cutoff value set in advance, the GDF15 level becomes an indicator that the subject has a high risk of developing liver cancer, and when the GDF15 level is less than the cutoff value, it becomes an indicator that the risk of developing liver cancer is low. The present invention also provides a kit for measuring GDF15 levels in a subject for use in the method of the present invention, and a diagnostic agent for evaluating the risk of developing liver cancer in a subject, which contains an anti-GDF15-specific antibody.

公开(公告)号：EP4375312A1

公开(公告)日：2024-05-29

申请号：EP22845976.4

申请日：2022-07-21

Applicant: OSAKA UNIVERSITY ,  SHIN-ETSU CHEMICAL CO., LTD.

Inventor： TAKASHIMA, Yoshinori ,  HARADA, Akira ,  OSAKI, Motofumi ,  PARK, Junsu ,  YOSHIDA, Daichi ,  NAKAGAWA, Hideo ,  IGARASHI, Minoru ,  KATO, Nobu ,  KAMEI, Masanao ,  OGURA, Kentaro

IPC: C08G77/392 ,  C08K5/01 ,  C08L83/04

CPC classification number: C08K5/01 ,  C08L83/04 ,  C08G77/392

Abstract: Provided are a novel silicone-based polymer compound with excellent mechanical properties and a silicone-based polymer material containing the silicone-based polymer compound. The silicone-based polymer compound of the present invention is a silicone-based polymer compound (H) having a polysiloxane backbone as the main chain, wherein the polysiloxane backbone has at least one host group in a side chain, and the host group is a monovalent group formed by removing one hydrogen atom or one hydroxy group from a cyclodextrin or a cyclodextrin derivative.

公开(公告)号：EP4368629A1

公开(公告)日：2024-05-15

申请号：EP22837707.3

申请日：2022-07-06

Applicant: OSAKA UNIVERSITY

Inventor： TAKAHASHI, Yusuke ,  WATANABE, Masakatsu ,  OKAMOTO, Motoki ,  HAYASHI, Mikako ,  KANIE, Kei ,  KATO, Ryuji ,  NARITA, Yuji ,  OGATA, Aika

IPC: C07K7/06 ,  A61K6/80 ,  A61K38/10 ,  A61P1/02 ,  C07K7/08

CPC classification number: A61K38/10 ,  C07K7/08 ,  C07K7/06 ,  A61K6/80 ,  A61P1/02

Abstract: The present invention addresses the problem of providing a peptide or a composition which can promote the healing of a wound at a dentin-pulp complex.
The problem can be solved by a peptide that comprises an amino acid sequence comprising Lys-Leu-Leu-Glu-Thr-Glu-Cys-Pro-Gln (SEQ ID NO: 28), an amino acid sequence comprising Asn-Thr-Asp-Gly-Ala-Val-Asn-Phe-Gln (SEQ ID NO: 32), an amino acid sequence comprising Glu-Leu-Val-Arg-Lys-Asp-Leu-Gln-Asn (SEQ ID NO: 47), an amino acid sequence comprising Asn-Ala-Asp-Lys-Gln-Leu-Ser-Phe-Glu (SEQ ID NO: 51), an amino acid sequence having such a structure that 1 to 3 amino acid residues in the amino acid sequence represented by SEQ ID NO: 28, SEQ ID NO: 32, SEQ ID NO: 47 or SEQ ID NO: 51 are substituted or deleted, or an amino acid sequence having such a structure that 1 to 3 amino acid residues are inserted into the amino acid sequence represented by SEQ ID NO: 28, SEQ ID NO: 32, SEQ ID NO: 47 or SEQ ID NO: 51, the peptide having a length of 9 to 15 amino acid residues.

公开(公告)号：EP4349986A1

公开(公告)日：2024-04-10

申请号：EP22811320.5

申请日：2022-05-24

Applicant: National University Corporation Tokyo Medical and Dental University ,  OSAKA UNIVERSITY

Inventor： YOKOTA Takanori ,  NAGATA Tetsuya ,  YOSHIOKA Kotaro ,  OBIKA Satoshi

IPC: C12N15/113 ,  A61K9/08 ,  A61K31/713 ,  A61P25/00 ,  A61P29/00 ,  A61P43/00

Abstract: A problem to be solved by the present invention is to provide a double-stranded nucleic acid complex having a reduced toxicity whose effectiveness is not impaired. Provided is a double-stranded nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein: said first nucleic acid strand is capable of hybridizing to at least part of a target gene or a transcription product thereof, and has an antisense effect on said target gene or transcription product thereof, said second nucleic acid strand comprises a base sequence complementary to said first nucleic acid strand, and said first nucleic acid strand and/or said second nucleic acid strand comprises at least one bridged non-natural nucleoside represented by formula (I) or formula (II) (wherein R represents a hydrogen atom or a methyl group).

公开(公告)号：EP4349976A1

公开(公告)日：2024-04-10

申请号：EP22811031.8

申请日：2022-03-31

Applicant: Mican Technologies Inc. ,  Japan as Represented by The Director-General of National Institute of Infectious Diseases ,  OSAKA UNIVERSITY

Inventor： SUZUKI, Ryosuke ,  MATSUDA, Mami ,  MURAMATSU, Masamichi ,  SAITO, Kyoko ,  FUKASAWA, Masayoshi ,  HANADA, Kentaro ,  YAMANAKA, Atsushi ,  MIYAZAKI, Kazuo ,  YAMADA, Misuzu ,  SHIMIZU, Jun

IPC: C12N7/01 ,  C12N5/10 ,  C12N15/33 ,  C12Q1/02 ,  G01N33/53

Abstract: The present invention aims to provide a method for testing the function of antibodies that uses safe antigens and gives results more quickly. The present invention relates to a method for determining antibody-dependent enhancement ability of antibodies, including contacting, in the presence of a test antibody, Fcγ receptor-expressing cell with single round infectious virus particles containing a gene with a region encoding a labeled protein and a region encoding non-structural (NS) proteins 1 to 5 of the yellow fever virus genome, a capsid protein of a virus, and an outer shell protein (Envelope) of a virus, wherein when the measured label is greater than that of a negative control cell, the test antibody is determined to have an antibody-dependent enhancement ability, and the like.

公开(公告)号：EP4336418A1

公开(公告)日：2024-03-13

申请号：EP23185291.4

申请日：2023-07-13

Applicant: FUJITSU LIMITED ,  OSAKA UNIVERSITY

Inventor： Fujisaki, Jun ,  Oshima, Hirotaka ,  Fujii, Keisuke

IPC: G06N10/70 ,  G06N10/60

Abstract: An information processing apparatus determines a combination of a first data qubit and a second data qubit that further reduces the energy represented by an energy equation. The energy equation includes first to third energy terms. The first energy term is used to identify the first data qubit on which a Z error has occurred. The second energy term is used to identify the second data qubit on which an X error has occurred. The third energy term reduces the energy as the number of data qubits each being a third data qubit on which both a Z error and an X error have simultaneously occurred increases. The information processing apparatus determines that a Y error has occurred on the third data qubit.

公开(公告)号：EP4318438A1

公开(公告)日：2024-02-07

申请号：EP22780880.5

申请日：2022-03-29

Applicant: OSAKA UNIVERSITY ,  JMC Corporation

Inventor： OKAYAMA, Keita ,  SAKATA, Yasushi ,  WATANABE, Daichi ,  INADA, Makoto

IPC: G09B9/00 ,  G09B19/24 ,  G09B23/28 ,  A61M25/00

Abstract: Provided is a catheter simulator capable of improving catheter maneuvers for brain diseases with a simple configuration. The catheter simulator has: a container (10); a cerebral blood vessel model (100) held in the container in a state of accommodating a liquid; and a holding means provided on side walls of the container and the cerebral blood vessel model and holding the cerebral blood vessel model in a state of having the container filled with the liquid. The holding means includes a first holding part (21) for holding an end of an ascending aorta (101a) of the cerebral blood vessel model, and a second holding part (22) for holding an end of a descending aorta (101b) of the cerebral blood vessel model, the first holding part (21) includes a liquid introduction port for introducing a liquid into the cerebral blood vessel model, the second holding part (22) includes a catheter introduction port for introducing a catheter into the cerebral blood vessel model, and opening parts (121, 122) for controlling the balance of the liquid circulating inside the cerebral blood vessel model are formed in the outer shell (100A) constituting the cerebral blood vessel model.