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21.发明授权COMPOSITIONS FOR THE TREATMENT OF ARDS OR IRDS CONTAINING 3-(CYCLOPROPYLMETHOXY)-N-(3,5-DICHLORO-4-PYRIDINYL)-4-(DIFLUOROMETHOXY)BENZAMIDE AND LUNG SURFACTANT 无效FOR治疗ARDS的组合物或IRDS 3-（CALCOPROPYLMETHOXY）-N-（3,5-二氯-4-吡啶基）-4-（二氟甲氧基）苯甲酰胺和肺表面活性剂CONTAIN
公开(公告)号：EP0977577B1
公开(公告)日：2006-08-16
申请号：EP98910670.3
申请日：1998-02-14
申请人： ALTANA Pharma AG
发明人： GERMANN, Paul-Georg , KILIAN, Ulrich , BEUME, Rolf , AMSCHLER, Hermann , KRÜGER, Uwe , HÄFNER, Dietrich , EISTETTER, Klaus
CPC分类号： A61K31/685 , A61K31/44 , A61K38/1709 , A61K45/06 , A61K2300/00
摘要： Composition for the treatment of infant or adult respiratory distress syndrome (IRDS and ARDS) contains N-(3,5-dichloropyrid-4-yl)-3- cyclopropylmethoxy-4- difluoromethoxybenzamide (II) (and/or its salts) and a lung surfactant.
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22.发明授权
公开(公告)号：EP1276495B1
公开(公告)日：2006-04-19
申请号：EP01943250.9
申请日：2001-04-12
申请人： ALTANA Pharma AG
发明人： HÄFNER, Dietrich , KELLER, Andreas , RATHGEB, Frank , SCHAFFER, Peter , WURST, Wilhelm , KARL, Christoph
CPC分类号： A61K38/1709
摘要： The invention describes the novel use of pulmonary surfactant preparations for the prophylaxis or early treatment of acute pulmonary diseases.
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公开(公告)号：EP1176960B1
公开(公告)日：2004-09-29
申请号：EP00927094.3
申请日：2000-04-27
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , BEUME, Rolf , HÄFNER, Dietrich , SCHUDT, Christian , HATZELMANN, Armin , KILIAN, Ulrich
CPC分类号： A61K31/415 , A61K31/44 , A61K45/06 , A61K2300/00
摘要： The invention relates to the combined use of the PDE4 inhibitor N- (3,5-dichloropyrid-4-yl)- 3-cyclopropylmethoxy- 4-difluoromethoxybenzamide, its pharmacologically tolerable salts or its N- oxide with a PDE3 inhibitor for the treatment of certain disease conditions such as, for example, acute or chronic obstructions of the bronchi.
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公开(公告)号：EP0764172B1
公开(公告)日：2004-09-01
申请号：EP95920906.5
申请日：1995-05-27
申请人： ALTANA Pharma AG
发明人： NAVE, Rüdiger , ULRICH, Wolf-Rüdiger , STURM, Ernst , KRÜGER, Uwe , HÄFNER, Dietrich , SCHÄFER, Klaus, P. , MELCHERS, Klaus
IPC分类号： C07K14/785 , A61K38/17
CPC分类号： C07K14/785 , A61K38/00
摘要： The disclosure concerns novel polypeptides of formula (I) with lung activity properties. These polypeptides can be produced in large quantities and in highly pure form and are as effective as natural lung surfactants. They can be used in the production of pharmaceutical composition for the treatment of respiratory distress syndrome in premature babies and adults. In said formula (I): A represents H or Phe, B represents Phe or Trp, and C represents Ile, Leu or Ser.
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25.发明公开COMBINATION OF SELECTIVE COX-2 INHIBITOR AND LUNG SURFACTANT FOR RESPIRATORY SYNDROME 审中-公开选择性COX-2抑制剂的组合，一个用于呼吸综合征LUNGENFLÜGELTENSIDS
公开(公告)号：EP1414484A1
公开(公告)日：2004-05-06
申请号：EP02772103.4
申请日：2002-07-23
申请人： ALTANA Pharma AG
发明人： HÄFNER, Dietrich
CPC分类号： A61K38/1709
摘要： Novel compositions for the treatment of IRDS and ARDS are indicated which contain a selective COX-2 inhibitor, and/or a pharmaceutically acceptable salt thereof and lung surfactant.
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公开(公告)号：EP0937075B1
公开(公告)日：2003-12-17
申请号：EP97950116.0
申请日：1997-11-05
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , MARTIN, Thomas , FLOCKERZI, Dieter , SCHMIDT, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , BOSS, Hildegard , HÄFNER, Dietrich , KLEY, Hans-Peter , BEUME, Rolf , BÄR, Thomas , ULRICH, Wolf-Rüdiger
IPC分类号： C07D471/04 , C07D491/04 , A61K31/435
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I), wherein A, B, D, E, R1, R2, R3 and Y have the meanings cited in the description, said compounds being new effective bronchial therapeutic agents.
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公开(公告)号：EP0968211B1
公开(公告)日：2003-08-27
申请号：EP98913621.3
申请日：1998-03-03
申请人： ALTANA Pharma AG
发明人： SCHMIDT, Beate , AMSCHLER, Hermann , ULRICH, Wolf-Rüdiger , MARTIN, Thomas , BÄR, Thomas , HUMMEL, Rolf-Peter , HATZELMANN, Armin , BOSS, Hildegard , BEUME, Rolf , KLEY, Hans-Peter , HÄFNER, Dietrich , GOEBEL, Karl-Josef , FLOCKERZI, Dieter
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： Compounds of formula (I) in which R is a phenyl radical substituted by R , where R is a tetrazole-5-yl radical optionally substituted by a radical R , are novel efficacious PDE3/4 inhibitors.
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28.发明授权ZUSAMMENSETZUNGEN ZUR BEHANDLUNG VON IRDS UND ARDS, DIE MINDESTENS EIN GLUCOCORTICOSTEROID IN KOMBINATION MIT EINEM LUNGEN SURFACTANT ENTHALTEN 失效组合物治疗IRDS和ARDS至少一个糖皮质激素结合肺含有表面活性剂
公开(公告)号：EP0783314B1
公开(公告)日：2003-05-28
申请号：EP95935387.1
申请日：1995-09-27
申请人： ALTANA Pharma AG
CPC分类号： A61K35/42 , A61K38/1709 , A61K31/58 , A61K31/57 , A61K2300/00
摘要： Novel compositions are disclosed for the treatment of IRDS and ARDS, containing at least one glucocorticosteroid and a pulmonary surfactant. The duration of treatment and the mortality associated with these syndromes can be significantly reduced with the proposed novel compositions.
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公开(公告)号：EP0882021B1
公开(公告)日：2003-03-05
申请号：EP97904354.4
申请日：1997-01-30
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , FLOCKERZI, Dieter , ULRICH, Wolf-Rüdiger , BÄR, Thomas , MARTIN, Thomas , SCHUDT, Christian , HATZELMANN, Armin , BEUME, Rolf , HÄFNER, Dietrich , BOSS, Hildegard , KLEY, Hans-Peter , GOEBEL, Karl-Josef , SCHMIDT, Beate
IPC分类号： C07D221/12 , A61K31/47
CPC分类号： C07D221/12
摘要： Compounds of formula (I), where R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings given in the description, are new active bronchial therapeutic agents.
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公开(公告)号：EP0828727B1
公开(公告)日：2003-01-02
申请号：EP96914207.4
申请日：1996-05-14
申请人： ALTANA Pharma AG
发明人： AMSCHLER, Hermann , BÄR, Thomas , FLOCKERZI, Dieter , SCHMID, Beate , THIBAUT, Ulrich , HATZELMANN, Armin , BOSS, Hildegard , HÄFNER, Dietrich , KLEY, Hans-Peter , BEUME, Rolf , ULRICH, Wolf-Rüdiger , MARTIN, Thomas
IPC分类号： C07D307/94 , C07D307/86 , A61K31/34
CPC分类号： C07D307/94 , C07D307/86 , Y10S514/826 , Y10S514/886 , Y10S514/889 , Y10S514/914
摘要： Compounds having the formula (I), in which R1, R2, R3, R4 and R5 have the meanings given in the description, are new powerful PDE inhibitors.
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