公开(公告)号：EP1915398B1

公开(公告)日：2016-04-20

申请号：EP06787719.1

申请日：2006-07-18

申请人： AMGEN INC. ,  E. R. Squibb & Sons, L.L.C.

发明人： SIU, Gerald ,  SHEN, Wenyan ,  YOSHINAGA, Steven, Kiyoshi ,  HUANG, Haichun

IPC分类号： C07K16/28 ,  A61P37/00 ,  A61P11/06 ,  A61K39/395 ,  G01N33/68 ,  G01N33/577 ,  C12N15/13 ,  C12N5/10 ,  C07K16/18

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/2827 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

公开(公告)号：EP1786837B1

公开(公告)日：2013-05-01

申请号：EP05807469.1

申请日：2005-08-04

申请人： Amgen Inc.,

发明人： LI, Ji ,  SHEN, Wenyan ,  LU, Hsieng Sen ,  RICHARDS, William Gleason

IPC分类号： C07K16/18 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

公开(公告)号：EP2197911A2

公开(公告)日：2010-06-23

申请号：EP08799478.6

申请日：2008-09-11

申请人： Amgen Inc.

发明人： DILLON, Thomas, M. ,  BONDARENKO, Pavel ,  WYPYCH, Jette ,  ALLEN, Martin ,  BALLAND, Alain ,  RICCI, Margaret, Speed ,  GUO, Amy ,  SHEN, Wenyan ,  SUN, Jeonghoon ,  VEZINA, Chris

IPC分类号： C07K16/00 ,  C07K16/28 ,  A61K39/395

CPC分类号： C07K16/245 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2875 ,  C07K2317/53 ,  C07K2317/56

摘要： The present invention is generally directed to methods of producing an increase in the enrichment and/or recovery of preferred forms of monoclonal antibodies. More particularly, the invention relates to methods for eliminating disulfide heterogeneity in the hinge region of recombinant IgG2 antibody proteins.

公开(公告)号：EP2181190A2

公开(公告)日：2010-05-05

申请号：EP08796592.7

申请日：2008-07-25

申请人： Amgen, Inc

发明人： ZHOU, Mingyue ,  BOONE, Thomas ,  MEININGER, David, Park ,  SCHWARTZ, Margrit ,  SHAN, Bei ,  SHEN, Wenyan

IPC分类号： C12N9/10 ,  A61K38/45

CPC分类号： C12N9/1029 ,  A61K47/68 ,  C12Y203/01043

摘要： The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide.

公开(公告)号：EP2010571A2

公开(公告)日：2009-01-07

申请号：EP07756072.0

申请日：2007-04-24

申请人： Amgen Inc.

发明人： NG, Gordon ,  SHEN, Wenyan

IPC分类号： C07K16/28 ,  C07K16/32 ,  A61K39/395

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

摘要： This invention relates to compositions and methods for treating c-Kit associated disorders such as fibrosis, and more particularly, to compositions containing humanized c-Kit antibodies.

摘要翻译： 本发明涉及用于治疗c-Kit相关疾病如纤维化的组合物和方法，更具体地涉及含有人源化c-Kit抗体的组合物。

公开(公告)号：EP1699825A2

公开(公告)日：2006-09-13

申请号：EP04815058.5

申请日：2004-12-21

申请人： Amgen, Inc.

发明人： YAN, Wei ,  SHEN, Wenyan ,  ZHOU, Hongxing ,  ZHOU, Chen ,  COSMAN, David, J ,  CARTER, Paul ,  MARTIN, Francis, H

IPC分类号： C07K16/00 ,  C12N15/10 ,  C12N5/10

CPC分类号： C07K16/005 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2875 ,  C07K16/2878 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/80 ,  C07K2319/00 ,  C12N15/1037 ,  G01N33/6854

摘要： The invention provides methods for screening multimeric antibodies produced by mammalian cells to find those that exhibit a biological function. The methods can be used to screen large numbers of antibodies, which may be cell surface, secreted, or intracellular antibodies. Antibodies can be screened to find those that bind antigen more avidly or those that compete with a ligand that binds to the antigen for binding. Any biological function that can be tested in vitro can be used to screen the antibodies. Nucleic acids encoding the antibodies that exhibit the biological function can be obtained in a number of ways.