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21.发明授权N-(PYRIDIN-2-YL)PYRIMIDIN-4-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP 有权N-（吡啶-2-基），其具有磺基肟嘧啶-4-胺衍生物
公开(公告)号：EP2920164B1
公开(公告)日：2017-02-01
申请号：EP13794844.4
申请日：2013-11-13
发明人： LÜCKING, Ulrich , BÖHNKE, Niels , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , KOSEMUND, Dirk , BOHLMANN, Rolf , ZORN, Ludwig
IPC分类号： C07D401/12 , A61K31/506 , A61P9/00 , A61P35/00
CPC分类号： C07D401/12 , A61K31/506
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公开(公告)号：EP3119787A1
公开(公告)日：2017-01-25
申请号：EP15710498.5
申请日：2015-03-18
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William , GIESE, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PUEHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred , GEISLER, Jens
IPC分类号： C07D491/08 , C07D491/04 , C07D403/04 , C07D237/20 , C07D239/42 , C07D241/20 , C07D241/28 , C07D253/07 , A61K31/496 , A61K31/4965 , A61K31/505 , A61K31/506 , A61K31/53 , A61P35/00
CPC分类号： C07D491/08 , A61K9/0007 , A61K9/0019 , A61K9/0056 , A61K9/08 , A61K9/10 , A61K9/19 , A61K9/2018 , A61K9/205 , A61K9/2054 , A61K9/2063 , A61K9/4858 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K45/06 , C07C205/45 , C07C205/59 , C07C229/64 , C07C233/25 , C07C233/54 , C07D237/20 , C07D239/42 , C07D241/20 , C07D241/24 , C07D241/28 , C07D253/07 , C07D295/15 , C07D401/04 , C07D403/04 , A61K2300/00
摘要： The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper- proliferative disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及如本文所述和定义的通式（I）的Wnt信号传导途径的抑制剂，制备所述化合物的方法，可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合， 使用所述化合物制造用于治疗或预防疾病，特别是高增殖性疾病的药物组合物作为唯一试剂或与其它活性成分组合。
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23.发明公开SUBSTITUTED N-BIPHENYL-3-ACETYLAMINO-BENZAMIDES AND N-[3-(ACETYLAMINO)PHENYL]-BIPHENYL-CARBOXAMIDES AND THEIR USE AS INHIBITORS OF THE WNT SIGNALLING PATHWAY 审中-公开N-BIPHENYL-3-乙酰氨基苯甲酰胺在N- [3-（乙酰氨基）苯基] - 联苯甲酰胺在DEREN VERWENDUNG ALS INHIBITOREN DES WNT-SIGNALTRANSDUKESWEGES
公开(公告)号：EP2976343A2
公开(公告)日：2016-01-27
申请号：EP14711513.3
申请日：2014-03-20
发明人： THEDE, Kai , SCOTT, William Johnston , BENDER, Eckhard , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PÜHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred , RICHTER, Anja , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , ZORN, Ludwig
IPC分类号： C07D491/08 , C07C271/24 , C07D231/12 , C07C317/48 , C07C317/50 , C07D413/12 , C07C323/63 , C07C233/54 , C07C233/80 , C07D205/04 , C07D265/30 , C07D491/10 , A61K31/4418 , A61P35/00 , C07C237/40
CPC分类号： C07D295/15 , C07C233/54 , C07C233/80 , C07C237/40 , C07C237/42 , C07C237/44 , C07C271/24 , C07C317/44 , C07C317/48 , C07C317/50 , C07C323/63 , C07C2601/02 , C07D205/04 , C07D207/12 , C07D211/42 , C07D211/44 , C07D211/46 , C07D231/10 , C07D231/12 , C07D265/30 , C07D267/10 , C07D295/145 , C07D295/26 , C07D307/54 , C07D333/24 , C07D413/12 , C07D491/08 , C07D491/10 , C07D491/107 , C07D498/08
摘要： The present invention relates to substituted N-biphenyl-3-acetylamino-benzamides and N-[3-(acetylamino)phenyl]-biphenyl-carboxamides of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及如本文所述和定义的取代的N-联苯-3-乙酰氨基 - 苯甲酰胺和通式（I）的N- [3-（乙酰氨基）苯基] - 联苯 - 甲酰胺，制备所述化合物的方法， 可用于制备所述化合物的中间体化合物，包含所述化合物的药物组合物和组合，以及所述化合物用于制备用于治疗或预防疾病，特别是过度增殖性疾病的药物组合物作为唯一试剂的用途或 与其他活性成分组合。
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24.发明公开3-ACETYLAMINO-1-(PHENYL-HETEROARYL-AMINOCARBONYL OR PHENYL-HETEROARYL-CARBONYLAMINO)BENZENE DERIVATIVES FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS 有权3-乙酰基氨基-1-（苯基 - 杂芳基 - 氨基羰基，或苯基 - 杂芳基 - 羰基氨基）苯衍生物用于治疗过度增生性疾病的治疗
公开(公告)号：EP2976327A2
公开(公告)日：2016-01-27
申请号：EP14712631.2
申请日：2014-03-17
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William J. , RICHTER, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PUEHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred
IPC分类号： C07D213/75 , C07D498/08 , C07D277/46 , C07D277/56 , C07D333/38 , C07D213/82 , C07D263/34 , C07D207/34 , C07D285/135 , C07D271/06 , C07D231/14 , C07D271/07 , C07D401/12 , C07D417/12 , C07D487/08 , C07D271/113 , A61K31/4418 , A61P35/00
CPC分类号： A61K31/5377 , A61K31/433 , A61K31/4418 , A61K31/4439 , A61K31/496 , A61K31/4995 , A61K31/5386 , A61K31/551 , A61K31/553 , A61K45/06 , C07C205/45 , C07C205/59 , C07C229/64 , C07C233/15 , C07C233/54 , C07C255/56 , C07C317/44 , C07D207/34 , C07D213/73 , C07D213/75 , C07D213/76 , C07D213/82 , C07D231/14 , C07D263/34 , C07D271/06 , C07D271/07 , C07D271/113 , C07D277/46 , C07D277/56 , C07D285/135 , C07D295/15 , C07D295/155 , C07D333/38 , C07D401/12 , C07D417/12 , C07D487/08 , C07D498/08
摘要： The present invention relates to substituted N-(phenyl-heteroaryl)-3-acetylamino-benzamides and N- [3-(acetylamino)phenyl]-phenyl-heteroaryl-carboxamides of general formula(I) as described and defined herein,to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.
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公开(公告)号：EP2928884A1
公开(公告)日：2015-10-14
申请号：EP13798684.0
申请日：2013-12-03
发明人： PETERS, Olaf , BRÄUER, Nico , BLUME, Thorsten , TER LAAK, Antonius , ZORN, Ludwig , NAGEL, Jens , KAULFUSS, Stefan , LANGER, Gernot , KUHNKE, Joachim
IPC分类号： C07D403/04 , A61K31/4184 , A61P5/00
CPC分类号： C07D471/04 , A61K31/4184 , A61K31/437 , A61K31/5377 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14
摘要： The present invention relates to novel benzimidazole derivatives of the general formula (I), processes for their preparation and their use for the production of pharmaceutical compositions for the treatment of diseases and indications that are connected with the receptor EP4.
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公开(公告)号：EP2834245B1
公开(公告)日：2017-12-13
申请号：EP13712784.1
申请日：2013-03-27
发明人： EIS, Knut , PÜHLER, Florian , ZORN, Ludwig , SCHULZE, Volker , SÜLZLE, Detlev , LIENAU, Philip , HÄGEBARTH, Andrea , PETERSEN, Kirstin , BÖMER, Ulf
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D405/04 , A61K31/5025 , A61K31/5377 , A61K45/06 , C07D487/04
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公开(公告)号：EP2920176B1
公开(公告)日：2017-09-13
申请号：EP13795702.3
申请日：2013-11-14
发明人： ZORN, Ludwig , EIS, Knut , SCHULZE, Volker , SÜLZLE, Detlev , PÜHLER, Florian , LIENAU, Philip , BÖMER, Ulf , PETERSEN, Kirstin , HÄGEBARTH, Andrea
IPC分类号： C07D487/04 , A61K31/4355 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06 , C07D519/00
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公开(公告)号：EP3119759A1
公开(公告)日：2017-01-25
申请号：EP15710774.9
申请日：2015-03-18
发明人： THEDE, Kai , BENDER, Eckhard , SCOTT, William , RICHTER, Anja , ZORN, Ludwig , LIU, Ningshu , MÖNNING, Ursula , SIEGEL, Franziska , GOLZ, Stefan , HÄGEBARTH, Andrea , LIENAU, Philip , PUEHLER, Florian , BASTING, Daniel , SCHNEIDER, Dirk , MÖWES, Manfred , GEISLER, Jens
IPC分类号： C07D401/14 , A61K31/427 , A61K31/433 , A61K31/444 , A61K31/497 , A61K31/506 , C07D401/04 , C07D417/04 , C07D417/14
CPC分类号： C07D417/14 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/14 , C07D409/04 , C07D417/04
摘要： The present invention relates to inhibitors of the Wnt signalling pathways of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及如本文所述和定义的通式（I）的Wnt信号传导途径的抑制剂，制备所述化合物的方法，可用于制备所述化合物的中间体化合物，药物组合物和包含所述化合物和 所述化合物用于制造用于治疗或预防疾病，特别是过度增殖性疾病的药物组合物作为单独药剂或与其他活性成分组合的用途。
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29.发明公开5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFOXIMINE GROUP 有权5-氟-N-（吡啶-2-基），其具有磺基肟吡啶-2-胺衍生物
公开(公告)号：EP2928878A1
公开(公告)日：2015-10-14
申请号：EP13792885.9
申请日：2013-11-12
发明人： LÜCKING, Ulrich , BÖHNKE, Niels , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , KOSEMUND, Dirk , BOHLMANN, Rolf , ZORN, Ludwig
IPC分类号： C07D401/12 , A61K31/44 , A61P35/00
CPC分类号： A61K31/444 , C07D213/72 , C07D401/12
摘要： The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
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30.发明公开5-FLUORO-N-(PYRIDIN-2-YL)PYRIDIN-2-AMINE DERIVATIVES CONTAINING A SULFONE GROUP 有权EINE SULFONGRUPPE ENTHALTENDE 5-FLUOR-N-（PYRIDIN-2-YL）PYRIDIN-2-AMIN-DERIVATE
公开(公告)号：EP2909176A2
公开(公告)日：2015-08-26
申请号：EP13782670.7
申请日：2013-10-15
发明人： LÜCKING, Ulrich , BÖHNKE, Niels , SCHOLZ, Arne , LIENAU, Philip , SIEMEISTER, Gerhard , BÖMER, Ulf , KOSEMUND, Dirk , BOHLMANN, Rolf , ZORN, Ludwig
IPC分类号： C07D213/74 , C07D405/14 , A61K31/506 , A61P9/00 , A61P31/12 , A61P35/00
CPC分类号： C07D213/74 , A61K31/444 , C07D405/14
摘要： The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
摘要翻译： 本发明涉及含有本文所述和定义的通式（I）的砜基的5-氟-N-（吡啶-2-基）吡啶-2-胺衍生物及其制备方法，其用于 治疗和/或预防疾病，特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。
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