公开(公告)号：EP2912055A1

公开(公告)日：2015-09-02

申请号：EP13848800.2

申请日：2013-10-28

申请人： Duke University ,  Sloan Kettering Institute For Cancer Research ,  Dana-Farber Cancer Institute, Inc.

发明人： HAYNES, Barton, F. ,  LIAO, Hua-xin ,  ALAM, S., Munir ,  DANISHEFSKY, Samuel ,  AUSSEDAT, Baptiste ,  PARK, Peter, K. ,  VOHRA, Yusuf ,  SODROSKI, Joseph

IPC分类号： C07K14/155 ,  C07K16/10

CPC分类号： A61K39/21 ,  A61K39/12 ,  C07K14/005 ,  C07K16/1063 ,  C07K2317/34 ,  C07K2317/76 ,  C12N7/00 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus- ! (HIV- 1), and, in particular to a vaccine for HiV-l and to methods of making and using same. The present invention provides synthetic glycosylated HIV-1 peptides, method for their preparation and use.

公开(公告)号：EP2694533A2

公开(公告)日：2014-02-12

申请号：EP12768170.8

申请日：2012-04-09

申请人： Duke University

发明人： SPICER, Leonard, D. ,  REARDON, Patrick, N. ,  HAYNES, Barton, F. ,  ALAM, S., Munir

IPC分类号： C07K14/16 ,  A61K39/21 ,  A61K47/42

CPC分类号： A61K39/21 ,  A61K9/0019 ,  A61K9/1075 ,  A61K9/127 ,  A61K39/12 ,  A61K2039/505 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/55572 ,  C07K16/1045 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/21 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.

公开(公告)号：EP2566884A2

公开(公告)日：2013-03-13

申请号：EP11777718.5

申请日：2011-05-09

申请人： Duke University ,  Los Alamos National Security, LLC ,  Musonda, Rosemary

发明人： MUSONDA, Rosemary ,  HAYNES, Barton, F. ,  GAO, Feng ,  KORBER, Bette, T. ,  MONTEFIORI, David

IPC分类号： C07K14/155 ,  C12N15/49 ,  A61K39/21 ,  A61K39/42 ,  A61P29/00 ,  A61P31/18

CPC分类号： A61K39/42 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  C07K14/005 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to HIV-1 and, in particular, to immunogens that elicit broadly neutralizing antibodies against HIV-1 subtype C envelope glycoproteins, and compositions comprising same. The invention further relates to methods of inducing the production of such antibodies in a subject.

公开(公告)号：EP2477658A2

公开(公告)日：2012-07-25

申请号：EP10817555.5

申请日：2010-09-16

申请人： Duke University ,  The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services ,  The Feinstein Institute for Medical Research

发明人： HAYNES, Barton, F. ,  TOMARAS, Georgia ,  SHEN, Shaunna ,  DIMITROV, Dimiter, S. ,  ZHU, Zhongyu ,  HWANG, Kwan-Ki ,  CHIORAZZI, Nicholas

IPC分类号： A61K39/42 ,  C07K16/10 ,  C12N5/07 ,  A61P31/18

CPC分类号： C07K16/1063 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76

摘要： The present invention relates, in general, to HIV-1 specific antibodies and, in particular, to broadly neutralizing HIV-1 specific antibodies that target the gp41 membrane-proximal external region (MPER). The present invention also relates to a cell culture system, more specifically, to a method of rendering chronic lymphocytic leukemia B-cells immortal and to a method of isolating anti-viral antibodies from clones of such cells.

公开(公告)号：EP2413905A2

公开(公告)日：2012-02-08

申请号：EP10759167.9

申请日：2010-04-05

申请人： Duke University ,  Children's Medical Center Corporation

发明人： ALAM, Munir ,  HAYNES, Barton, F. ,  HARRISON, Stephen ,  CHEN, Bing

IPC分类号： A61K9/127 ,  A61K39/395 ,  A61P31/18 ,  A61P31/12

CPC分类号： A61K9/127 ,  A61K39/12 ,  A61K39/21 ,  A61K47/62 ,  A61K47/6911 ,  A61K2039/55511 ,  A61K2039/55522 ,  A61K2039/55555 ,  A61K2039/55561 ,  C12N2740/16134

公开(公告)号：EP2331133A2

公开(公告)日：2011-06-15

申请号：EP09811854.0

申请日：2009-09-08

申请人： Duke University

发明人： HAYNES, Barton, F. ,  MOODY, M., Anthony ,  LIAO, Hua-Xin

IPC分类号： A61K39/395 ,  A61P31/18

CPC分类号： C07K16/44 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/76

摘要： The present invention relates, in general, to anti-lipid antibodies and, in particular, to methods of inhibiting HIV-I infection using anti-lipid (e.g. anti-phospholipid) antibodies.

公开(公告)号：EP2318430A2

公开(公告)日：2011-05-11

申请号：EP09806982.6

申请日：2009-08-14

申请人： Los Alamos National Security, LLC ,  Beth Israel Deaconess Medical Center ,  Duke University ,  The University of Alabama at Birmingham Research Foundation

发明人： KORBER, Bette, T. ,  FISCHER, William ,  LETVIN, Norman ,  LIAO, Hua-xin ,  HAYNES, Barton, F. ,  HAHN, Beatrice, H.

IPC分类号： C07K14/155 ,  C12N15/49 ,  A61K39/21

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/24143 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16234 ,  C12N2740/16334

摘要： The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same. The invention further relates to methods that use a genetic algorithm to create sets of polyvalent antigens suitable for use, for example, in vaccination strategies.

摘要翻译： 本发明涉及马赛克进化枝M HIV-1 Env多肽和包含其的组合物。 本发明的多肽适用于诱导人体对HIV-1的免疫应答。

公开(公告)号：EP2265732A2

公开(公告)日：2010-12-29

申请号：EP09733216.7

申请日：2009-04-15

申请人： Duke University ,  Université de Lausanne

发明人： GOLDSTEIN, David, B. ,  TELENTI, Amalio ,  FELLAY, Jacques ,  SHIANNA, Kevin, V. ,  GE, Dongliang ,  HAYNES, Barton, F. ,  NEED, Anna

IPC分类号： C12Q1/68 ,  C12N15/11

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV) and, in particular, to genetic variants associated with restriction of HIV disease progression.

公开(公告)号：EP2139516A1

公开(公告)日：2010-01-06

申请号：EP08742782.9

申请日：2008-04-11

申请人： Duke University

发明人： HAYNES, Barton, F. ,  ALAM, S., Munir ,  LIAO, Hua-Xin

IPC分类号： A61K39/21 ,  A61K39/385

CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K39/385 ,  A61K47/6911 ,  A61K2039/545 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/575 ,  A61K2039/6018 ,  A61K2039/62 ,  A61K2039/625 ,  A61K2039/627 ,  A61K2039/64 ,  C07K14/005 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/76 ,  C12N7/00 ,  C12N2740/15022 ,  C12N2740/16122 ,  C12N2740/16134

摘要： The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions suitable for use in such a method.

摘要翻译： 本发明涉及诱导患者抗HIV抗体产生的方法。 该方法包括向有需要的患者施用足以实现该诱导的量的至少一种脂质体 - 肽缀合物。 肽包含膜外接近区（MPER）表位，脂质体包含溶血磷脂酰胆碱或磷脂酰丝氨酸。

公开(公告)号：EP1121147A1

公开(公告)日：2001-08-08

申请号：EP99951772.5

申请日：1999-10-06

申请人： DUKE UNIVERSITY

发明人： STAATS, Herman, F. ,  HAYNES, Barton, F. ,  PATEL, Dhavalkumar, D. ,  SEMPOWSKI, Gregory, D.

IPC分类号： A61K39/00 ,  A61K47/00 ,  C07K14/52 ,  C07K14/54 ,  C07K14/545

CPC分类号： A61K39/39 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55522 ,  A61K2039/55527 ,  A61K2039/55533 ,  A61K2039/55538 ,  Y10S514/885

摘要： A method of eliciting an immune response against an antigen in a vertebrate subject, the method comprising the steps of providing an antigen-adjuvant composition comprising the antigen and a substantially non-toxic adjuvant molecule having biological activity in mucosal tissues, and administering said antigen-adjuvant composition to the vertebrate subject in a manner such that initial contact occurs in mucosal tissue of the vertebrate subject, whereby an immune response is elicited. Cytokines are preferred adjuvants. Preferred cytokines are interleukin-1α (IL-1α) and interleukin-1β (IL-1β).